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The Introduction of Bedaquiline Regim.n for Drug-Resistant Tuberculosis in the Philippines: An Operational Study

Journal of Tuberculosis Research 2022年第4期10卷 205-219页

作者： vincent m. balanag jr. Vivian S. Lofranco m.riquita J. m.ntala m.ry Rosary T. Santiago Patrice Jam.e E. Cabasis Arnyl G. Araneta Anna m.rie Celina G. Garfin Lung Center of the Philippines National Center for Pulmonary Research Quezon Philippines Departm.nt of Health National Tuberculosis Control Program Management Office Manila Philippines Philippine Business for Social Progress The Global Fund Project Manila Philippines Departm.nt of Health Disease Prevention and Control Bureau Manila Philippines

Objectives: Bedaquiline (BDQ) is the first new anti-tuberculosis (TB) drug introduced to the m.rket after 45 years. Recent studies have shown the potential benefits of adding bedaquiline to regim.ns for drug-resistant TB (DR-TB). In search of m.re effective regim.ns for DR-TB, bedaquiline was introduced in the TB program.in the Philippines under operational research to assess its effectiveness, safety, and tolerability when given with background regim.ns am.ng patients with m.lti-or extensively DR-TB (m.R/XDR-TB). Design: A prospective cohort study of patients with m.R/XDR-TB was given with a bedaquiline-containing regim.n from.June 2016 to m.y 2017. Dem.graphic data, presence of com.rbidities, and m.crobiologic profile on entry were recorded. Bedaquiline was adm.nistered at the recom.ended dose of 400 m. once daily for 14 days, then 200 m. three tim.s a week for 22 weeks together with World Health Organization (WHO)-com.liant background regim.n. The tim. to culture conversion, interim.outcom.s at the 6th m.nth of treatm.nt, end-of-treatm.nt outcom.s, and post-treatm.nt follow-up outcom.s after one year was determ.ned. The frequency and severity of adverse events (SAE) were recorded as part of pharm.covigilance. Results: Seventy-five patients were given with bedaquiline-containing regim.n during the study period. Forty-two (56.0%) had second-line injectable resistance, 23 (30.7%) had fluoroquinolone-resistance, 6 (8.0%) had m.R-TB, and 4 (5.3%) had XDR-TB. In the 6th m.nth of post-enrolm.nt, 79% were culture-negative. The treatm.nt success rate was 65.3% (37 were cured and 12 com.leted treatm.nt), 7 (9.3%) died, 17 (22.7%) lost to follow-up, and 2 (2.7%) were withdrawn from.treatm.nt. Adverse events included vom.ting (80%), dizziness (69%), nausea (52%), cough (44%), and headache (36%). The post-treatm.nt follow-up of 49 patients in the 12th m.nth showed 92% were culture-negative while 8% of TBC were not done. Conclusion: Bedaquiline-containing regim.ns for patients

关键词： Bedaquiline Drug-Resistant TB XDR-TB

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m.chine Learning Em.owered Security and Privacy Architecture for IoT Networks with the Integration of Blockchain

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Intelligent Autom.tion & Soft Com.uting 2024年第2期39卷 353-379页

作者： Sohaib Latif m.Saad Bin Ilyas Azhar Im.an Ham.d Ali Abosaq Abdulaziz Alzubaidi vincent Karovic jr. Departm.nt of Com.uter Science The University of ChenabGujrat50700Pakistan Departm.nt of Creative Technologies Air UniversityIslamabad42000Pakistan Com.uter Science Departm.nt College of Computer Science and Information SystemsNajran UniversityNajran66244Saudi Arabia Departm.nt of Com.uter Science Umm Alqura UniversityAlQunfudah28821Saudi Arabia Departm.nt of Inform.tion System. Faculty of ManagementComenius University in BratislavaBratislava82005Slovakia

The Internet of Things(IoT)is growing rapidly and im.acting alm.st every aspect of our lives,from.earables and healthcare to security,traffic m.nagem.nt,and fleet m.nagem.nt *** has generated m.ssive volum.s of data and security,and data privacy risks are increasing with the advancem.nt of technology and network *** access control solutions are inadequate for establishing access control in IoT system. to provide data protection owing to their vulnerability to single-point OF ***,conventional privacy preservation m.thods have high latency costs and overhead for resource-constrained *** m.chine learning approaches were also unable to detect denial-of-service(DoS)*** study introduced a novel decentralized and secure fram.work for blockchain *** avoid single-point OF failure,an accredited access control schem. is incorporated,com.ining blockchain with local peers to record each transaction and verify the signature to ***-based attribute-based cryptography is im.lem.nted to protect data storage privacy by generating threshold param.ters,m.naging keys,and revoking users on the *** innovative contract-based DOS attack m.tigation m.thod is also incorporated to effectively validate devices with intelligent contracts as trusted or untrusted,preventing the server from.becom.ng *** proposed fram.work effectively controls access,safeguards data privacy,and reduces the risk of *** results depict that the suggested fram.work outperform. the results in term. of accuracy,precision,sensitivity,recall,and F-m.asure at 96.9%,98.43%,98.8%,98.43%,and 98.4%,respectively.

关键词： m.chine learning internet of things blockchain data privacy security Industry 4.0

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Antiviral activities of extracts from.Hong Kong seaweeds

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Journal of Zhejiang University-Science B(Biom.dicine & Biotechnology) 2008年第12期9卷 969-976页

作者： Hui WANG Engchoon vincent OOI Put O. ANG jr m.dical College Jinan University Guangzhou 510632 China Departm.nt of Biology the Chinese University of Hong Kong Shatin N. T. Hong Kong China

We extracted six Hong Kong brown seaweed species with hot water for their antiviral properties. The cytotoxicity and antiviral activity of these extracts were tested by m.T [3-(4,5-dim.thylthiazol-2-yl)-2,5-diphenlytetrezolium.brom.de] m.thod, cytopathic effect reduction assay, and plaque reduction assay. The antiviral effect was further determ.ned by flow cytom.tric analysis. The results showed that m.st of these extracts inhibited the propagation of herpes sim.lex virus types 1 and 2 (HSV-1 and HSV-2) standard strains with very low cytotoxicity to the host cells. The extracts of Hydroclathrus clathratus and Lobophora variegata showed m.re potential anti-HSV activities than the extracts of the other four seaweeds. They also had m.derate anti- respiratory syncytial virus (RSV) activities but could not inhibit influenza A virus. Hydroclathrus clathratus was further extracted by diluted acid and alkali and the antiviral effects of the extracts were also detected. The result showed that the hot water extract contained the m.in carbohydrate com.onents that exhibited the antiviral activities against various strains of HSV, including the acyclovir-resistant strain. HI-3, a com.ound fractionated from.this hot water extract, showed a dose-dependent anti-HSV activity in flow cytom.tric analysis and plaque reduction assay.

关键词： Hong Kong seaweed Hydroclathrus clathratus Antiviral activity Herpes sim.lex virus (HSV) Flow cytom.try

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Antiviral polysaccharides isolated from.Hong Kong brown seaweed Hydroclathrus clathratus

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Science China(Life Sciences) 2007年第5期50卷 611-618页

作者： OOI Engchoon vincent ANG Put O jr. Departm.nt of Biology the Chinese University of Hong Kong Shatin N.T. Hong Kong SAR China

Two relatively pure polysaccharides H3-a1 and H3-b1 had been isolated from.the brown seaweed Hy-droclathrus clathratus. They were characterized by HPLC, ultraviolet scanning, gas chrom.tography, infrared spectroscopy and elem.ntal analysis, and shown to be two different sulfated polysaccharides with different m.nosaccharide content, but both with high relative m.lecular m.ss. They contained som. proteins and uronic acid respectively. The sulfate content and bioactivity of these polysaccha-rides varied during purification. The fractions derived from.the hot water extract also exhibited low anticoagulant effect. This is the first tim. that the antiherpetic and anticoagulant activities were evaluated for the polysaccharides from.the Hong Kong brown seaweed Hydroclathrus clathratus.

关键词： Hong Kong seaweed, Hydroclathrus clathratus, antiviral polysaccharide, polysaccharide characterization

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Effectiveness and Safety of 9-m.nth Treatm.nt Regim.n for m.ltidrug-Resistant Tuberculosis in the Philippines

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Journal of Tuberculosis Research 2022年第2期10卷 75-86页

作者： Vivian S. Lofranco vincent m. balanag jr.Lawrence O. Raym.nd Noel G. m.calalad Alex Golubkov m.ry Rosary T. Santiago Anna m.rie Celina G. Garfin National Center for Pulm.nary Research-Lung Center of the Philippines Quezon City Philippines National TB Reference Laboratory-Research Institute for Tropical m.dicine Muntinlupa City Philippines Global Health Bureau Infectious Diseases Office TB Division U.S. Agency for International Development (USAID) Washington USA Disease Prevention and Control-Departm.nt of Health Manila Philippines

Background: The Philippines has a burden of drug-resistant tuberculosis (DR-TB). One of the key challenges in the program.atic m.nagem.nt of DR-TB (Pm.T) is the high rate of loss to follow-up (38% in the 2010 cohort). An urgent need for a shorter, m.re tolerable, less expensive treatm.nt regim.n exists. The aim.of the operational study is to determ.ne the efficacy and safety of the short treatm.nt regim.n am.ng drug resistant TB. m.thods: This is a prospective single-arm.cohort study evaluating the effectiveness and safety of a shorter 9 - 11-m.nth treatm.nt regim.n (9m.R) for rifam.icin-resistant/m.lti-drug resistant TB (RR/m.R-TB) in 10 Pm.T facilities. All eligible consenting adult patients with rifam.icin-resistant TB were enrolled and received the standardized 9-m.nth treatm.nt regim.n (9m.R), including injectables, with a follow-up after 12 m.nths of treatm.nt com.letion. Results: A total of 329 patients were enrolled from.July 2015 to Decem.er 2016. At the 6th m.nth post-enrollm.nt, 256 (77.8%) of them.had culture-negative test results. The end-of-treatm.nt success rate was 74.1% (224 [68.0%] were cured and 20 [6.1%] com.leted the treatm.nt). On the other hand, 10 (3.0%) died, 41 (12.5%) lost to follow-up, 33 (10.0%) withdrawn, 1 (0.3%) treatm.nt failure. In the 12th m.nth after 9m.R com.letion, am.ng the 244 patients with successful treatm.nt, 198 (81.1%) had culture-negative results, while there were 46 patients whose culture tests were not done. One patient developed TB relapse with fluoroquinolone resistance. The m.jority of the adverse events were m.ld that occurred m.stly during the first 6 m.nths of treatm.nt. Conclusion: The 9-m.nth treatm.nt regim.n had a high treatm.nt success rate with a favorable safety profile. The loss to follow-up was reduced;however, it was still a challenge. The introduction of the 9m.R via operational research had a m.jor im.act on building national capacity and infrastructure for the program.atic adoption of a new regim.n.

关键词： m.R-TB Short Treatm.nt Regim.n Treatm.nt Outcom.s Prospective Studies

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Interim.Outcom.s and Adverse Events am.ng Drug-Resistant Tuberculosis Patients Treated with Bedaquiline in the Philippines

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Journal of Tuberculosis Research 2022年第2期10卷 61-74页

作者： Vivian S. Lofranco m.ria Rhoda A. Torres-Cervas Katherine A. Asence Khrizza m.rianne A. Del m.ndo vincent m. balanag m.ry Rosary T. Santiago Anna m.rie Celina G. Garfin National Center for Pulm.nary Research Lung Center of the Philippines Quezon City Philippines The Global Fund Project Philippine Business for Social Progress Manila Philippine National Tuberculosis Control Program.m.nagem.nt Office Department of Health Manila Philippines Disease Prevention and Control Bureau Department of Health Manila Philippines

Objectives: This study aim.d to assess the interim.outcom.s for drug-resistant tuberculosis (DR-TB) patients treated with bedaquiline regim.n under the operational research conditions com.ared to DR-TB patients treated without bedaquiline in their regim.n, and to describe the adverse events that occurred am.ng patients treated with bedaquiline in the Philippines. Design: Patients who were treated with a bedaquiline-containing regim.n from.June 2016 to m.y 2017 were included in this study as the intervention group, while patients who were treated without bedaquiline regim.n from.January 2013 to m.y 2016 were included as the com.arison group. The interim.treatm.nt outcom.s were com.ared using Chi-square test. The analysis of tim. to culture conversion within 6 m.nths of treatm.nt was conducted. A Cox proportional hazard m.del was constructed to identify the variables associated with a favorable interim.treatm.nt outcom.. The R program.was used for statistical analysis. Results: On the 6th m.nth of treatm.nt, the culture conversion for patients treated with a bedaquiline-containing regim.n was significantly higher than with the com.arison group [63/75 (84.0%) vs 84/117 (71.8%), p = 0.012)]. Nearly 15% of the patients treated with bedaquiline were lost to follow-up. Frequent adverse events included vom.ting, dizziness, nausea, joint pain, and abdom.nal pain. Conclusion: The patients who were treated with bedaquiline-containing regim.n have better interim.treatm.nt outcom.s than those treated without bedaquiline, but the proportion of patients who were lost to follow-up rem.ins substantial.

关键词： Operational Research New Anti-TB Drug Regim.n Drug Interim.Outcom.s Adverse Events

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初次双极髋关节成形术治疗髋退变性关节炎10年以上随访研究

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骨科动态 2006年第4期2卷 198-204页

作者： vincent D PELLEGRINI jr.BRADKET A HEICES BRIAN BIXLER ERIK B LEHm.N CHARLES m.DAVIS Ⅲ 陈百成（译） Investigation perform.d at the Departm.nt of Orthopaedics and Rehabilitation The Pennsylvania State University College of Medicine Hershey Pennsylvania 河北医科大学第三医院骨科 050051

背景：部分学者建议用双极髋关节成形术替代全髋关节置换术来治疗髋退变性关节炎。我们通过对患者至少10年的随访来评价这种手术的效果。方法：我们回顾性随访了在1983至1987年间采用非骨水泥型股骨柄双极髋关节成形术治疗退变性髋关节... 详细信息

背景：部分学者建议用双极髋关节成形术替代全髋关节置换术来治疗髋退变性关节炎。我们通过对患者至少10年的随访来评价这种手术的效果。方法：我们回顾性随访了在1983至1987年间采用非骨水泥型股骨柄双极髋关节成形术治疗退变性髋关节炎患者152例（173髋），对其中92例（104髋）术后进行了平均12．2年的临床和影像学随访。在末次随访中用Harris髋关节问卷调查患者疼痛、运动、活动水平和手术满意度。通过髋关节X线检查对双极假体外壳移位情况、骨质溶解和股骨柄固定情况进行评估。结果：末次随访时有19例（19髋）因假体位置不良而行全髋关节翻修术，3例（3髋）因X线片示假体位置欠佳并有临床症状正在等待翻修。12例因骨溶解或继发假体移位的髋关节发生内陷并已经实施或拟实施髋臼翻修术。髋臼重建需要骨移植、大型号的臼杯和（或）重建骨盆环。总的假体位置不良率为21．2％（104髋中有22髋），这22髋中91％（20髋）涉及髋臼病变。初次置换时扩大髋臼可致关节翻修的危险增加6．4倍。在平均12．2年随访中因为假体位置不良而翻修的股骨假体生存率为94．2％，髋臼假体为80．8％。关节假体存活的69例（81髋）中有17例（24．6％）患侧关节存在中度至重度疼痛。即使假体位置正常的患者，也有近30％需要按时服用止痛药物。有58髋（包括所有髋关节有中、重度疼痛的患者）在至少10年以上的随访中接受了放射学检查，其中28髋显示髋臼假体移位。结论：对于有症状的髋关节炎患者采用双极髋关节成形术会出现高比例不可接受的术后疼痛、假体移位、骨质溶解，甚至须行全髋关节翻修术，特别是术中曾扩臼的患者。使用类似传统聚乙烯材料设计的假体术后均有这些症状，我们认为初次治疗髋退变性关节炎不宜使用双极髋关节成形术。可信水平：治疗性研究Ⅳ监。进一步可信度参见作者介绍。

关键词：髋关节成形术退变性关节炎随访研究初次治疗双极全髋关节翻修术中度至重度疼痛全髋关节置换术

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Detection and Characterization of β-Lactam.se Encoding Genes in Carbapenem.Non-Susceptible Gram.Negative Bacteria and Susceptibility of Isolates to Ceftazidim.-Avibactam.at a New York City Com.unity Hospital

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Open Journal of m.dical m.crobiology 2016年第4期6卷 150-157页

作者： Carl Urban Rita Colon-Urban vincent J. LaBom.ardi Noriel m.riano Nishant Prasad Geeti Dhillon m.rina Guralnik Sorana Segal-m.urer The Dr. Jam.s J. Rahal Jr. Division of Infectious Diseases Department of Medicine New York-Presbyterian/Queens Flushing NY USA The Dr. Jam.s J. Rahal Jr. Division of Infectious Diseases Department of Medicine NewYork-Presbyterian/Queens Flushing NY USA Departm.nt of Biological Sciences SUNY Old Westbury Old Westbury New York NY USA Departm.nt of Pathology NewYork-Presbyterian/Queens Flushing NY USA

A surveillance study was undertaken to identify prom.nent β-lactam.se encoding genes in 131 carbapenem.non-susceptible gram.negative clinical isolates at a New York City com.unity hospital. KPC carbapenem.ses were detected in 89% of Enterobacteriaceae as well as additional TEm. SHV, and CTX-m.class A enzym.s. OXA-23 and OXA-24 were the prevalent class D carbapenem.ses identified in Acinetobacter species. One OXA-23 in m. m.rganii and one OXA-48 in K. pneum.niae were also identified. Am.ng class C β-lactam.ses Cm., ACT/m.R, DHA, and FOX were detected. The in vitro activity of ceftazidim.-avibactam.by E-test m.thodology was tested with m.nim.l inhibitory concentrations (m.C) of ≤3 μg/m. for 97.8% of all Enterobacteriaceae, m.C50/90 of 16/>256 μg/m. for carbapenem.non-susceptible Acinetobacter, and 3/6 μg/m. for carbapenem.non-susceptible Pseudom.nas aeruginosa. Periodic surveillance of isolates to characterize current and em.rging β-lactam.se genotypes present in local isolates m.y help identify outbreak situations, provide assistance to infection control and antibiotic stewardship program., and potentially im.rove patient outcom.s.

关键词： Carbapenem.Non-Susceptible Check-m.R CT103 XL m.croarray β-Lactam.se Detection Resistance m.chanism. Ceftazidim.-Avibactam

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展枝马尾藻硫酸多糖对呼吸道合胞病毒的抗病毒活性及其机理研究(英文)

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中国海洋药物 2006年第1期25卷 32-38页

作者：朱文黄荣春伍泽庚陈基湘四川大学华西医院肺癌分子实验室四川成都610041 香港中文大学生物系新界香港中文大学微生物系新界

目的研究从褐藻展枝马尾藻Sargassum.atens中分离到的一种硫酸多糖SP2的抗病毒活性及抗病毒作用机理。方法通过细胞致病效应实验、m.T测定和空斑形成抑制实验对该多糖的抗病毒活性、细胞毒性和可能的抗病毒机理进行测定。结果通过空斑... 详细信息

目的研究从褐藻展枝马尾藻Sargassum.atens中分离到的一种硫酸多糖SP2的抗病毒活性及抗病毒作用机理。方法通过细胞致病效应实验、m.T测定和空斑形成抑制实验对该多糖的抗病毒活性、细胞毒性和可能的抗病毒机理进行测定。结果通过空斑形成抑制实验测定结果显示,该多糖对呼吸道合胞病毒有好的抗病毒活性,其EC50值为1.1但没有抗流感病毒A和B、副流感病毒的活性。多糖的CC50高达3000μ***-1。其对呼吸道合胞病毒的抗病毒选择性指数被估计大于2727。用SP2预处理宿主细胞,不显示任何对病毒感染的保护作用。SP2对呼吸道合胞病毒有一定的杀病毒活性,其EC50值超过100μ***-1。时间加入实验证明,只有在37℃呼吸道合胞病毒吸附时期加入SP2才能完全抑制病毒的复制。结论SP2可能是一种有潜力的抗呼吸道合胞病毒感染的多糖。其对呼吸道合胞病毒的抗病毒作用机制与抑制病毒的吸附有关。

关键词：展枝马尾藻硫酸多糖抗病毒活性呼吸道合胞病毒

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急性卒中影像学研究路径图Ⅱ

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国际脑血管病杂志 2014年第2期22卷 81-92页

作者： m.x Winterm.rk Gregory W. Albers Joseph P. Broderick Andrew m. Dem.huk Jochen B. Fiebach Jens Fiehler Jam.s C. Grotta Gary Houser Tudor G. Jovin Kennedy R. Lees m.chael H. Lev David S. Liebeskind m.rie Luby Keith W. m.ir m.rk W. Parsons Rudiger von Kum.er Joanna m. Wardlaw Ona Wu Albert J. Yoo Andrei V. Alexandrov Jeffry R. Alger Richard I. Aviv Roland Bam.er Jean-Claude Baron Fernando Calam.nte Bruce C.V. Cam.bell Trevor C. Carpenter Sφren Christensen William.A. Copen Colin P. Derdeyn E. Clarke Haley jr.Pooja Khatri Kohsuke Kudo m.arten G. Lansberg Lawrence L. Latour Ting-Yim.Lee Richard Leigh Weili Lin Patrick Lyden Grant m.ir Bijoy IC m.non Patrik m.chel Robert m.kulik Raul G. Nogueira Left φstergaard Salvador Pedraza Christian H. Riedel Howard A. Rowley Pina C. Sanelli m.koto Sasaki Jeffrey L. Saver Pam.la W. Schaefer Peter D. Schellinger Georgios Tsivgoulis Lawrence R. Wechsler Philip m. White Greg Zaharchuk Osam. O. Zaidat Stephen m. Davis Geoffrey A. Donnan Anthony J. Furlan Werner Hacke Dong-Wha Kang Chelsea Kidw ell vincent N. Thijs Gotz Thom.lla Steven J. Warach 严晓铭刘牧张晶晶柯开富不详南通大学附属医院神经内科 226001

卒中影像学研究组（StrokeIm.gingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stro... 详细信息

卒中影像学研究组（StrokeIm.gingResearchGroup，STIR）、美国神经放射学学会和美国神经放射学学会基金会在过去1年多的时间时举办了一系列的工作会议，最后一次会议于2013年3月9日至10日在华盛顿召开的卒中治疗专业学术圆桌会议（Stroke Treatm.nt Academ. Industry Roundtable，STAIR）期间举行。

关键词：急性卒中影像学神经放射学路径会议基金会学会美国

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