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Who is at risk in the French mountains? Profiles of the accident victims in outdoor sports and mountain recreation

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Journal of Mountain science 2017年第8期14卷 1490-1499页

作者： sOULE bastien REYNIER Véronique LEFEVRE Brice BOUTROY Eric Laboratory of Vulnerabilities & Innovation in sport University Claude Bernard Lyon 1 Laboratory sport & social Environment University Grenoble Alpes

The risk of both severe and frequent injury associated with active pursuits in mountain areas is acknowledged. This phenomenon is all the most relevant to investigate in France that there is a growing enthusiasm for outdoor sports and recreation. This paper focuses on the social-demographic and sporting profiles of accident victims. Our intent is to better understand who is specifically at risk, while practicing mountain recreation, in the French mountains. such identification doubtlessly constitutes an important asset in order to enhance prevention. Three critical activities are notably tackled, among some others: hiking, a widespread activity that exposes many practitioners to hazardous settings; mountaineering and ski touring, supposedly entailing the most severe *** order to align the information collected, then provide estimations based on the reasoned crossing of these secondary data, we consulted and summarised all the databases that we knew of on the French territory: rescue team intervention reports, aggregated statistics from the sports ministry, sporting federation accident declarations, avalanche experts statistics, mountain guides union accident/incident reports, healthcare facilities admissions, etc. Only the sources consideredto be the most reliable and representative were used, owing to the number of cases processed, the exhaustive nature of data collection, or the level of information detail available. Our method also included consultation of all the parties playing an active role in prevention, training and mountain rescue, thus ensuring a participative, co-constructive approach to the study with the people that have the best knowledge of victim profiles. Around fifty such parties were interviewed on the methods implemented, the benefits and limits of current data, and the main expectations in terms of accidentology progress, thus further enhancing the credibility of the study proposed in this paper. Our results show that the parent populat

关键词： Mountain sports Outdoor recreation Accident victims profile

Multicomponent flow modeling

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science China Mathematics 2012年第1期55卷 285-308页

作者： GIOVANGIGLI vincent CMAP-CNRs Ecole

We present multicomponent flow models derived from the kinetic theory of gases and investigate the symmetric hyperbolic-parabolic structure of the resulting system of partial differential *** address the Cauchy problem for smooth solutions as well as the existence of deflagration waves,also termed anchored *** further discuss related models which have a similar hyperbolic-parabolic structure,notably the saintVenant system with a temperature equation as well as the equations governing chemical equilibrium *** next investigate multicomponent ionized and magnetized flow models with anisotropic transport fluxes which have a different mathematical *** finally discuss numerical algorithms specifically devoted to complex chemistry flows,in particular the evaluation of multicomponent transport properties,as well as the impact of multicomponent transport.

关键词： multicomponent reactive flow Cauchy problem deflagration wave multicomponent transport

Assessment of Methods for Determining Bioavailability of Trace Elements in soils: A Review

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Pedosphere 2017年第3期27卷 389-406页

作者： Jurate KUMPIENE Laura GIAGNONI Bernd MARsCHNER sébastien DENYs Michel MENCH Kristin ADRIAENsEN Jaco VANGRONsVELD Markus PUsCHENREITER Giancarlo RENELLA Waste science & Technology Lule University of Technology Department of Agrifood Production and Environmental sciences University of Florence Ruhr-Universitt Bochum Joint Research Unit (UMR) Biodiversity Genes & Communities (BIOGECO) French National Institute for Agricultural Research (INRA) Agence Nationale de sécurité sanitaire (Anses) i-CLEANTECH Vlaanderen Hasselt University Centre for Environmental Sciences University of Natural Resources and Life sciences Vienna

Trace element-contaminated soils(TECss) are one of the consequences of the past industrial development worldwide. Excessive exposure to trace elements(TEs) represents a permanent threat to ecosystems and humans worldwide owing to the capacity of metal(loid)s to cross the cell membranes of living organisms and of human epithelia, and their interference with cell *** of TE bioavailability in soils is complicated due to the polyphasic and reactive nature of soil constituents. To unravel critical factors controlling soil TE bioavailability and to quantify the ecological toxicity of TECss, TEs are pivotal for evaluating excessive exposure or deficiencies and controlling the ecological risks. While current knowledge on TE bioavailability and related cumulative consequences is growing, the lack of an integrated use of this concept still hinders its utilization for a more holistic view of ecosystem vulnerability and risks for human health. Bioavailability is not generally included in models for decision making in the appraisal of TECs remediation options. In this review we describe the methods for determining the TE bioavailability and technological developments, gaps in current knowledge, and research needed to better understand how TE bioavailability can be controlled by sustainable TECs management altering key chemical properties, which would allow policy decisions for environmental protection and risk management.

关键词： bioaccessibility bioavailability biosensors chemical extractions contaminated soils 'metalloids metals

saturation-excess overland flow in the European loess belt:An underestimated process?

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International soil and Water Conservation Research 2023年第4期11卷 688-699页

作者： Valentin Landemaine Olivier Cerdan Thomas Grangeon Rosalie Vandromme Benoit Laignel Olivier Evrard sébastien salvador-Blanes J.Patrick Laceby BRGM F-45060OrléansFrance University of Rouen M2CRouenFrance Laboratoire des sciences du Climat et de l'Environnement(LsCE/IPsL) UnitéMixte de Recherche 8212(CEA/CNRS/UVSQ)UniversitéParis-SaclayGif-sur-YvetteFrance University of Tours UR 6293-GéoHydrosystèmes Continentaux(GEHCO)France Alberta Environment and Protected Areas CalgaryCanada

A major challenge in runoff and soil erosion modelling is the adequate representation of the most relevant processes in models while avoiding over *** the European loess belt,pro-gressive soil crusting during rainfall events,resulting in infiltration-excess runoff,is usually considered the dominant process generating runoff on catchments covered with silty ***-excess may also occur and affect their runoff and erosion ***,saturation-excess runoff occurrence and quantification have rarely been performed and is usually not taken into account when modelling runoff and erosion in these ***,a continuous simulation of the Austreberthe catchment(214 km^(2)),located in the European loess belt(Normandy,France),was conducted with the new Water and sediment(Watersed)model over 12 years,corresponding to more than 780 individual rainfall events,at a 25 m spatial *** inter-annual variability of runoff and erosion was closely linked to the number of intense events per year and their distribution through the *** model was properly calibrated over a representative set of 35 rainfall events,considering either infiltration-excess and/or saturation-excess *** was also able to reproduce the measured runoff volume for most of the monitoring ***,the three years with most rainfall were adequately modelled only including saturation-excess *** analysis performed at the seasonal scale revealed that saturation was modelled in the catchment during almost all of the modelling period,suggesting the importance of this often overlooked process in current modelling attempts.

关键词： European loess belt soil erosion saturation-excess runoff Watersed model

Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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Neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： sheharyar s.Baig Ali N.Ali Arshad Majid sheffield Institute for Translational Neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(VNs)and stroke:stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive VNs paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,sTOP-AUsT,and TRAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

Evaluation of clinical outcomes in an interdisciplinary abdominal pain clinic: A retrospective, exploratory review

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World Journal of Gastroenterology 2019年第24期25卷 3079-3090页

作者： Amanda D Deacy Craig A Friesen vincent s staggs Jennifer V schurman Division of Gastroenterology Children’s Mercy Kansas CityUMKC School of MedicineKansas CityMO 64108United States Division of Developmental and Behavioral sciences Children’s Mercy Kansas CityUMKC School of MedicineKansas CityMO 64108United States Biostatistics and Epidemiology Health Services and Outcomes ResearchChildren’s Mercy Kansas CityUMKC School of MedicineKansas CityMO 64108United States

BACKGROUND Pediatric functional gastrointestinal disorders(FGIDs)are common and wellaccepted to be etiologically complex in terms of the contribution of biological,psychological,and social factors to symptom ***,despite its documented benefits,interdisciplinary treatment,designed to address all of these factors,for pediatric FGIDs remains *** current study hypothesized that the majority of pediatric patients seen in an interdisciplinary abdominal pain clinic(APC)would demonstrate clinical resolution of symptoms during the study period and that specific psychosocial variables would be significantly predictive of GI symptom *** To evaluate outcomes with interdisciplinary treatment in pediatric patients with pain-related FGIDs and identify patient characteristics that predicted clinical *** Participants were 392 children,ages 8-18[M=13.8;standard deviation(sD)=2.7],seen between August 1,2013 and June 15,2016 in an interdisciplinary APC housed within the Division of Gastroenterology in a medium-sized Midwestern children's *** be eligible,patients had to be 8 years of age or older and have had abdominal pain for≥8 wk at the time of initial *** and psychosocial data collected as part of standard of care were retrospectively reviewed and analyzed in the context of the observational *** regression was used to model odds of reporting vs never reporting improvement,as well as to differentiate rapid from slower *** Nearly 70%of patients followed during the study period achieved resolution on at least one of the employed outcome *** those who achieved resolution during follow up,43%to 49%did so by the first follow up(i.e.,within roughly 2 mo after initial evaluation and initiation of interdisciplinary treatment).Patient age,sleep,ease of relaxation,and depression all significantly predicted the likelihood of *** specifically,the odds of clinical resolution w

关键词： Pediatric functional gastrointestinal disorders Integrated care Behavioral health consultation Treatment outcomes Abdominal pain clinic

eTumorMetastasis:A Network-based Algorithm Predicts Clinical Outcomes Using Whole-exome sequencing Data of Cancer Patients

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Genomics, Proteomics & Bioinformatics 2021年第6期19卷 973-985页

作者： Jean-sébastien Milanese Chabane Tibiche Naif Zaman Jinfeng Zou Pengyong Han Zhigang Meng Andre Nantel Arnaud Droit Edwin Wang Human Health Therapeutics National Research Council CanadaMontreal H4P 2R2Canada Genomics Center Centre Hospitalier Universitaire de Québec-UniversitéLaval Research CenterQuebec G1V 4G2Canada Department of Biochemistry&Molecular Biology Medical Geneticsand OncologyUniversity of CalgaryCalgary T2N 4N1Canada Alberta Children’s Hospital Research Institute and Arnie Charbonneau Cancer Research Institute University of CalgaryCalgary T2N 4N1Canada Institute of Biotechnology Chinese Academy of Agricultural SciencesBeijing 100086China Department of Medicine McGill UniversityMontreal H3G 2M1Canada

Continual reduction in sequencing cost is expanding the accessibility of genome sequencing data for routine clinical ***,the lack of methods to construct machine learning-based predictive models using these datasets has become a crucial bottleneck for the application of sequencing technology in ***,we develop a new algorithm,eTumorMetastasis,which transforms tumor functional mutations into network-based profiles and identifies network operational gene(NOG)*** signatures model the tipping point at which a tumor cell shifts from a state that doesn’t favor recurrence to one that *** show that NOG signatures derived from genomic mutations of tumor founding clones(i.e.,the‘most recent common ancestor’of the cells within a tumor)significantly distinguish the recurred and non-recurred breast tumors as well as outperform the most popular genomic test(i.e.,Oncotype DX).These results imply that mutations of the tumor founding clones are associated with tumor recurrence and can be used to predict clinical *** such,predictive tools could be used in clinics to guide treatment ***,the concepts underlying the eTumorMetastasis pave the way for the application of genome sequencing in predictions for other complex genetic *** pseudocode and related data used in this study are available at https://***/WangEdwinLab/eTumorMetastasis.

关键词： Breast cancer sequencing data Predictive model systems biology Machine learning

Experimental study of path planning problem using EMCOA for a holonomic mobile robot

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Journal of systems Engineering and Electronics 2021年第6期32卷 1450-1462页

作者： MOHsENI Alireza DUCHAINE vincent WONG Tony Department of system Engineering École de Technologie SupérieureMontreal QC H3C 1K3Canada

In this paper,a comparative study of the path planning problem using evolutionary algorithms,in comparison with classical methods such as the A*algorithm,is presented for a holonomic mobile *** configured navigation system,which consists of the integration of sensors sources,map formatting,global and local path planners,and the base controller,aims to enable the robot to follow the shortest smooth path ***-based mapping is used for scoring paths efficiently,allowing the determination of collision-free trajectories from the initial to the target *** work considers the evolutionary algorithms,the mutated cuckoo optimization algorithm(MCOA)and the genetic algorithm(GA),as a global planner to find the shortest safe path among others.A non-uniform motion coefficient is introduced for MCOA in order to increase the performance of this algorithm.A series of experiments are accomplished and analyzed to confirm the performance of the global planner implemented on a holonomic mobile *** results of the experiments show the capacity of the planner framework with respect to the path planning problem under various obstacle layouts.

关键词： holonomic robot path planning evolutionary algorithm(EA)

smoothelin,a new marker to determine the origin of liver fibrogenic cells

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World Journal of Gastroenterology 2013年第48期19卷 9343-9350页

作者： sébastien Lepreux Christelle Guyot Fabrice Billet Chantal Combe Charles Balabaud Paulette Bioulac-sage Alexis Desmoulière CHU Bordeaux Hopital Pellegrin Service d’Anatomie Pathologique F-33076 Bordeaux France U889 and Université Victor segalen Bordeaux 2 F-33076 Bordeaux France Division of Clinical Pharmacology and Toxicology Department of Medicine University Hospital Zurich 8006 Zurich Switzerland Facultés de Médecine et de Pharmacie Université de Limoges EA 6309 F-87025 LimogesFrance

AIM: To explore this hypothesis that smooth muscle cells may be capable of acquiring a myofibroblastic phenotype, we have studied the expression of smoothelin in fibrotic conditions.

关键词： smooth muscle cells, Myofibroblasts, α -smooth muscle actin, smoothelin, Fibrosis/cirrhosis, Hepatocellular carcinoma