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Journal of Natural Gas Chemistry 2010年第2期19卷 123-133页

作者： sébastien Paul Elise Berrier Marcia Cristina Kaezer Frana Jean-Guillaume Eon Univ Lille Nord de France F-59000 LilleFrance ECLille UCCSF-59650 Villeneuve d'AscqFrance CNRs UMR 8181F-59650 Villeneuve d'AscqFrance UsTL UCCSF-59650 Villeneuve d'AscqFrance Instituto de Quimíca Universidade Federal do Rio de Janeiro-Cidade UniversitáriaIlha do Fundo21945-970 Rio de JaneiroBrazil

An integrated approach combining the development of an innovative catalyst and the research of a set of adequate operating conditions for the propane oxidative dehydrogenation （ODH） is *** experimental set-up,specially designed for steady-state and transient studies is *** preparation method,the characterization and the performances in steady-state and transient regimes of catalysts based on V2W4O194-Lindqvist isopolyanion used as a precursor and supported on alumina are *** influence of the preparation method of the catalyst and the role of water in the feed gas are more particularly discussed.

关键词： propane oxidative dehydrogenation (ODH) transient regime pulsed reactor Lindqvist isopolyanion in-situ Raman

Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay vincentÉmond Martine saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal DOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

Algorithm-based care for early recognition and management of complications after pancreatic resection:toward standardization of postoperative care

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Hepatobiliary surgery and Nutrition 2022年第5期11卷 718-720页

作者： Charles de Ponthaud sébastien Gaujoux Department of Hepato-Biliary and Pancreatic surgery and Liver Transplantation AP-HPPitié-Salpêtrière HospitalParisFrance sorbonne University ParisFrance

This stepped-wedge cluster randomized study(1)included all pancreatectomies performed from 17 Dutch pancreatic surgery centers(all realizing>20 pancreaticoduodenectomies per year)over 22 *** aim was to demonstrate the value of an algorithm for the early diagnosis and management of postoperative *** algorithm determined when to do abdominal computed tomography(CT)scan,radiological drainage,start antibiotic treatment,and remove abdominal *** was calculated every day from postoperative day 3 to *** primary endpoint was a composite of bleeding that required invasive intervention,organ failure and 90-day mortality.

关键词： postoperative diagnosis remove

Matrix metalloproteinase-9:A deleterious link between hepatic ischemia-reperfusion and colorectal cancer

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World Journal of Gastroenterology 2012年第48期18卷 7131-7133页

作者： sébastien Lenglet Franois Mach Fabrizio Montecucco Cardiology Division Department of MedicineGeneva University HospitalFoundation for Medical Research1211 GenevaSwitzerland

Despite the advent of improved surgical techniques and the development of cytotoxic chemotherapeutic agents useful for the treatment of colorectal cancer,the primary clinical challenge remains that of preventing and combating metastatic *** resection is the best treatment for colorectal metastases isolated to the ***,in rodent models,the hepatic ischemia-reperfusion(I/R) applied during the surgery accelerates the outgrowth of implanted *** the adverse effects of I/R on cellular function,several studies have demonstrated an over expression of the matrix metalloproteinase-9(MMP-9) in the ischemic *** several studies showed high local levels of expression and activity of this proteolytic enzyme in the primary colorectal adenocarcinoma,the role of MMP-9 might be considered as a potential common mediator,favoring both growth of local tumor and the dissemination of colorectal carcinoma metastases.

关键词： Matrix metalloproteinase-9 Ischemia-reperfusion Colorectal cancer Metastasis

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Urine-derived stem/progenitor cells:A focus on their characterization and potential

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World Journal of stem Cells 2020年第10期12卷 1080-1096页

作者： Perrine Burdeyron sébastien Giraud Thierry Hauet Clara steichen INsERM U1082 IRTOMIT CHU de PoitiersPoitiers 86021France Facultéde Médecine et Pharmacie Universite de PoitiersPoitiers 86021France

Cell therapy,i.e.,the use of cells to repair an affected tissue or organ,is at the forefront of regenerative and personalized *** the multiple cell types that have been used for this purpose[including adult stem cells such as mesenchymal stem cells or pluripotent stem cells],urine-derived stem cells(UsCs)have aroused interest in the past *** display classical features of mesenchymal stem cells such as differentiation capacity and ***,they have the main advantage of being isolable from one sample of voided urine with a cheap and unpainful procedure,which is broadly applicable,whereas most adult stem cell types require invasive ***,UsCs can be differentiated into renal cell *** is of high interest for renal cell therapy-based regenerative *** review will firstly describe the isolation and characterization of *** will specifically present UsC phenotype,which is not an object of consensus in the literature,as well as detail their differentiation *** the second part of this review,we will present and discuss the main applications of *** include use as a substrate to generate human induced pluripotent stem cells,but we will deeply focus on the use of UsCs for cell therapy approaches with a detailed analysis depending on the targeted organ or ***,we will also focus on the applications that rely on the use of UsC-derived products such as microvesicles including exosomes,which is a strategy being increasingly *** the last section,we will discuss the remaining barriers and challenges in the field of UsC-based regenerative medicine.

关键词： Urine-derived stem cells Urine progenitor cells Exosomes Cell therapy Kidney injury and repair Regenerative medicine

sampled-Data Hamilton-Jacobi Reachability Based safe Motion Planning in Dynamic Environments

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Sampled-Data Hamilton-Jacobi Reachability Based Safe Motion ...

作者： sébastien KLEFF 上海交通大学

学位级别：硕士

随着机器人系统的广泛应用,如何在不确定条件下获取安全的运动轨迹是其面临的重要问题。传统鲁棒运动规划(Motion Planning,MP)不能保证机器人系统运行的性能和鲁棒安全性。对于具有不确定性,状态约束和安全性要求的系统,可达性分析是... 详细信息

随着机器人系统的广泛应用,如何在不确定条件下获取安全的运动轨迹是其面临的重要问题。传统鲁棒运动规划(Motion Planning,MP)不能保证机器人系统运行的性能和鲁棒安全性。对于具有不确定性,状态约束和安全性要求的系统,可达性分析是解决其控制问题的有效方法,但未被广泛应用到MP问题求解中。因此,本文基于可达性分析提出了一套系统的方法,用以解决不确定环境下的鲁棒MP问题。首先,本文进行了静态环境下MP问题的求解。离线部分,通过采样数据(sampled Data,sD)汉密尔顿-雅可比(Hamilton-Jacobi,HJ)可达性分析方法计算得到系统运动轨迹,然后基于递归算法将原始问题分解成为一系列微分博弈问题。在线部分,给出了一种具有鲁棒安全性和目标可达的反馈控制方法。第二,通过用时间维度对状态进行扩充,本文将上述方法在时变系统中进行了测试。第三,为了解决对抗性环境下的鲁棒MP问题,本文将上述算法引入到高维的联合状态空间下进行推理,并证明了在不失有效性的情况下,方法的维数灾可以通过向低维空间映射得到解决。第四,通过将算法转换到组态空间,我们讨论了其在非质点机器人系统中的应用。本文提出的方法都用仿真示例证明了有效性。特别地,我们以机器人手臂的追踪任务为例对算法进行了验证,该追踪任务要求机器人手臂在避免与移动的障碍物碰撞的情况下追踪移动目标。该仿真案例将之前讨论的所有方面结合到了同一场景,从而验证了本文提出算法的有效性、通用性和灵活性。最后,本文对基于可达性的鲁棒MP算法的研究进行了展望。

关键词：鲁棒运动规划可达性分析数据采样系统 Reach-Avoid博弈 Hamilton-Jacobi-Isaacs方程

Genetic characterization and potential molecular dissemination mechanism of tet(31) gene in Aeromonas caviae from an oxytetracycline wastewater treatment system

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Journal of Environmental sciences 2019年第2期31卷 259-266页

作者： Yanhong shi Zhe Tian sébastien Olivier Leclercq Hong Zhang Min Yang Yu Zhang state Key Laboratory of Environmental Aquatic Chemistry Research Centre for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of sciences INRA UMR1282 Infectiology and Public Health Fran?ois Rabelais University UMR1282 Infectiology and Public Health

Recently, the rarely reported tet(31) tetracycline resistance determinant was commonly found in Aeromonas salmonicida, Gallibacterium anatis, and Oblitimonas alkaliphila isolated from farming animals and related environment. However, its distribution in other bacteria and potential molecular dissemination mechanism in environment are still unknown. The purpose of this study was to investigate the potential mechanism underlying dissemination of tet(31) by analysing the tet(31)-carrying fragments in A. caviae strains isolated from an aerobic biofilm reactor treating oxytetracycline bearing wastewater. Twenty-three A. caviae strains were screened for the tet(31) gene by polymerase chain reaction(PCR). Three strains(two harbouring tet(31), one not) were subjected to whole genome sequencing using the PacBio RsII platform. seventeen A. caviae strains carried the tet(31) gene and exhibited high resistance levels to oxytetracycline with minimum inhibitory concentrations(MICs)ranging from 256 to 512 mg/L. tet(31) was comprised of the transposon Tn6432 on the chromosome of A. caviae, and Tn6432 was also found in 15 additional tet(31)-positive A. caviae isolates by PCR. More important, Tn6432 was located on an integrative conjugative element(ICE)-like element, which could mediate the dissemination of the tet(31)-carrying transposon Tn6432 between bacteria. Comparative analysis demonstrated that Tn6432 homologs with the structure IsCR2-ΔphzF-tetR(31)-tet(31)-ΔglmM-sul2 were also carried by A. salmonicida, G. anatis, and O. alkaliphila, suggesting that this transposon can be transferred between species and even genera. This work provides the first report on the identification of the tet(31) gene in A. caviae, and will be helpful in exploring the dissemination mechanisms of tet(31) in water environment.

关键词： Aeromonas caviae tet(31) gene IsCR2 ICE-like element Wastewater

spinal alignment evolution with age:A prospective gait analysis study

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World Journal of Orthopedics 2017年第3期8卷 256-263页

作者： sébastien Pesenti Benjamin Blondel Emilie Peltier Elke Viehweger vincent Pomero Guillaume Authier stéphane Fuentes Jean-Luc Jouve Pediatric orthopedics Timone Enfants Aix-Marseille University Institute of Movement sciences (CNRs UMR 7287) Gait Analysis Laboratory Hopital Timone Enfants Aix-Marseille University spine Unit Hopital de la Timone spine unit Timone Aix-Marseille University Neurosurgery Timone Enfants Aix-Marseille University

AIM To describe,using gait analysis,the development of spinal motion in the growing *** Thirty-six healthy children aged from 3 to 16 years old were included in this study for a gait analysis(9m-walk).Various kinematic parameters were recorded and analyzed such as thoracic angle(TA),lumbar angle(LA)and sagittal vertical axis(sVA).The kinetic parameters were the net reaction moments(N.m/kg)at the thoracolumbar and lumbosacral *** TA and LA curves were not statistically correlated to the age(respectively,P=0.32 and P=0.41).sVA increased significantly with age(Ps in sagittal plane at the lumbosacral junction were statistically correlated to the age(P=0.003),underlining the fact that sagittal mechanical constraints at the lumbosacral junction increase with *** in transversal plane at the thoracolumbar and lumbosacral junctions were statistically correlated to the age(P=0.0002and P=0.0006),revealing that transversal mechanical constraints decrease with *** The kinetic analysis showed that during growth,a decrease of torsional constraint occurs while an increase of sagittal constraint is *** changes in spine biomechanics are related to the crucial role of the trunk for bipedalism acquisition,allowing stabilization despite lower limbs *** the acquisition of mature gait,the spine will mainly undergo constraints in the sagittal plane.

关键词： sagittal balance spine biomechanics Gait analysis Thorcic kyphosis spine growth