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A Simple Approach to Achieve Organic Radicals with Unusual Solid-State Emission and Persistent Stability

CCS Chemistry 2022年第6期4卷 1912-1920页

作者： Xueqian Zhao Junyi Gong Parvej Alam Chao Ma Yanpei Wang Jing Guo Zebin Zeng Zikai He Herman H.Y.Sung Ian D.Williams kam Sing wong Sijie Chen Jacky W.Y.Lam Zheng Zhao Ben Zhong Tang Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced Study and Guangdong-Hong Kong-Macro Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsHong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 Department of Physics Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong 999077 State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan Province 410082 School of Science Harbin Institute of TechnologyShenzhenHIT Campus of University TownShenzhenGuangdong Province 518055 Ming wai Lau Centre for Reparative Medicine Karolinska InstitutetHong Kong 999077 School of Science and Engineering Chinese University of Hong KongShenzhenGuangdong Province 518172 HKUST-Shenzhen Research Institute South Area Hi-Tech ParkNanshanShenzhenGuangdong Province 518057 Center for Aggregation-Induced Emission SCUTHKUST Joint Research InstituteState Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhouGuangdong Province 510640 AIE Institute Guangzhou Development DistrictHuangpuGuangzhouGuangdong Province 510530

Sable organic radicals are promising materials for information storage,molecular magnetism,electronic devices,and biological *** organic radicals have been prepared,but most are non-or weakly emissive and degrade easily upon *** remains challenging to produce stable and efficient luminescent radicals because of the absence of general guidelines for their ***,we present a photoactivation approach to generate a stable luminescent radical from tris(4-chlorophenyl)phosph ine(TCPP)with red emission in the crystal *** mechanistic study suggests that the molecular symmetry breaking in the crystal causes changes of molecular conformation,redox properties,andmolecular packing that facilitates radical generation and *** design strategy demonstrates a straightforward approach to develop stable organic luminescent radicals that will open new doors to photoinduced luminescent radical materials.

关键词： luminescent radicals symmetry breaking tris(4-chlorophenyl)phosphine anticounterfeiting photoinduced electron transfer

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帕金森病患者跌倒的危险因素分析

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广东医学 2011年第9期32卷 1117-1119页

作者：陈仰昆邓伟光肖卫民黄家星莫仲棠广东省东莞市人民医院神经内科 523000 香港中文大学精神科学系香港中文大学内科及药物治疗学系

目的回顾性研究帕金森病(PD)患者跌倒的危险因素。方法选择香港3所医院133例的神经科专科门诊PD患者纳入研究。收集患者的人口学及临床资料,并进行躯体功能、精神、智能及跌倒方面的评估。应用logistic多元回归分析研究PD患者跌倒的危... 详细信息

目的回顾性研究帕金森病(PD)患者跌倒的危险因素。方法选择香港3所医院133例的神经科专科门诊PD患者纳入研究。收集患者的人口学及临床资料,并进行躯体功能、精神、智能及跌倒方面的评估。应用logistic多元回归分析研究PD患者跌倒的危险因素。结果 44例(33.1%)患者在最近1年内有1次以上的跌倒,平均跌倒的次数为(1.9±0.7)次。logistic多元回归显示,婚姻状况(丧偶、离异或未婚)(OR=1.965,95%CI1.203～3.208,P=0.007)、Schwab和England日常生活能力评分低(OR=0.973,95%CI 0.955～0.991,P=0.003)及服用3种以上抗PD药物(OR=0.973,95%CI 0.955～0.991,P=0.026)是跌倒的独立危险因素。结论跌倒是PD患者一个很常见的问题。服用多种抗PD药物、日常生活能力及婚姻状况对跌倒均有明显的影响,提示在跌倒的预防与评估中,疾患内在因素和社会因素均需考虑。

关键词：帕金森病跌倒危险因素

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An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 386-403,I0014-I0016页

作者： Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler vincent wai-Sun wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng Department of Nephrology Jiangnan University Medical CenterWuxiChina Affiliated Wuxi Clinical College of Nantong University WuxiChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineAzienda Ospedaliera Universitaria Integrata VeronaVeronaItaly Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southamptonand Southampton General HospitalUniversity of SouthamptonSouthamptonUK Department of Renal Medicine University College LondonLondonUK Department of Medicine and Therapeutics Chinese University of Hong KongHong KongChina Center for Fatty Liver Department of GastroenterologyXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Internal Medicine I GastroenterologyEndocrinology&MetabolismMedical University InnsbruckInnsbruckAustria Department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Division of Nephrology Department of MedicineWürzburg University ClinicWürzburgGermany Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghaiChina Section of Gastroenterology Boston Medical CenterBoston University School of MedicineBostonMAUSA Division of Nephrology Department of Medicine(M.K.)Koc University School of MedicineIstanbulTurkey Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCAUSA Section of Nephrology and Institute of Clinical and Translational Research Baylor College of Medicineand Michael E.DeBakey VA Medical CenterHoustonTXUSA Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRizeTurkey Department of Cardiology Shunde HospitalSouthern Medical UniversityFoshanChina Division of Hepat

Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly *** 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without ***,to date,there is no appropriate guidance on CKD in individuals with ***,there has been little attention paid to the link between MAFLD and CKD in the Nephrology *** and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and ***:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases.

关键词： Metabolic dysfunction-associated fatty liver disease(MAFLD) non-alcoholic fatty liver disease(NAFLD) chronic kidney disease(CKD) consensus

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氣管切開患者右肺癌根治術氣道處理1例

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镜湖医学 2014年第1期14卷 53-54页

作者：李濤潘慧李海英曾俊傑黃鍇亮曹麗勤澳門鏡湖醫院麻醉科中國

患者女性,62歲,30多年前曾行甲狀腺手術,1年多前因復發性甲狀腺腫,再行雙側甲狀腺次全切除術。術後患者出現呼吸不暢、嗆咳等症狀,診斷為“雙側聲帶麻痺”,於2個月前行氣管切開術,同時胸部CT檢查發現右下肺惡性腫瘤。現患者擬行“胸腔... 详细信息

患者女性,62歲,30多年前曾行甲狀腺手術,1年多前因復發性甲狀腺腫,再行雙側甲狀腺次全切除術。術後患者出現呼吸不暢、嗆咳等症狀,診斷為“雙側聲帶麻痺”,於2個月前行氣管切開術,同時胸部CT檢查發現右下肺惡性腫瘤。現患者擬行“胸腔鏡下右肺癌根治術”,血常規、生化,心電圖等檢查無異常,氣管切開套管管端位於胸3椎體水平。

关键词：胸部CT 次全切除肺癌根治

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澳門地區某巴士公司男性司機健康狀況的回顧性研究

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镜湖医学 2023年第2期23卷 6-9,40页

作者：張振榮楊金桃何慧芳黃春燕林肇聰澳門鏡湖醫院家庭醫學科中國澳門

目的分析澳門地區巴士司機的生活習慣及健康指標,評估其出現心血管疾病的風險,並制定合適的定期健康檢查項目。方法納入澳門地區某巴士公司在本院常規體檢符合條件的司機,通過病史採集及相關體檢項目結果,建立風險模型,預測出現心血管... 详细信息

目的分析澳門地區巴士司機的生活習慣及健康指標,評估其出現心血管疾病的風險,並制定合適的定期健康檢查項目。方法納入澳門地區某巴士公司在本院常規體檢符合條件的司機,通過病史採集及相關體檢項目結果,建立風險模型,預測出現心血管疾病的風險。結果1.共納入398名司機,均為男性。超重及肥胖佔比為60.6%,吸煙佔比為33.7%,飲酒佔比為34.4%。高血壓病、糖尿病和代謝綜合征的佔比分別為22.9%、9.1%和23.4%。2.司機高血壓、糖尿病的檢出率、體重及甘油三脂水平,以及吸煙檢出率和飲酒檢出率在不同年齡組別的差別具有統計學意義。3.進行十年心血管疾病風險評估(China-PAR模型),發現各年齡組之間的差別具有統計學意義。結論本地區司機超重和肥胖是一個值得關注的問題,司機高血壓、糖尿病的控制情況未能達至預期目標,需要積極干預。年齡對司機的健康狀況影響明確,建議可在50歲以上司機的體檢方案中常規加入HDL-C檢測項目,並利用China-PAR模型和代謝綜合征概念對司機進行心血管病風險預測。

关键词：巴士司機健康狀況心血管病風險健康促進

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Real-world Effectiveness and Tolerability of Interferonfree Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C:A Multinational Cohort Study

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 646-658页

作者： Fanpu Ji Sally Tran Eiichi Ogawa Chung-Feng Huang Takanori Suzuki Yu Jun wong Hidenori Toyoda Dae Won Jun Liu Li Haruki Uojima Akito Nozaki Makoto Chuma Cheng-Hao Tseng Yao-Chun Hsu Masatoshi Ishigami Takashi Honda Masanori Atsukawa Hiroaki Haga Masaru Enomoto Huy Trinh Carmen Monica Preda Phillip Vutien Charles Landis Dong Hyun Lee Tsunamasa Watanabe Hirokazu Takahashi Hiroshi Abe Akira Asai Yuichiro Eguchi Jie Li Xiaozhong Wang Jia Li Junping Liu Jing Liang Carla Pui-Mei Lam Rui Huang Qing Ye Hongying Pan Jiajie Zhang Dachuan Cai Qi Wang Daniel Q.Huang Grace wong vincent wai-Sun wong Junyi Li Son Do Norihiro Furusyo Makoto Nakamuta Hideyuki Nomura Eiji Kajiwara Eileen L.Yoon Sang Bong Ahn Koichi Azuma Kazufumi Dohmen Jihyun An Do Seon Song Hyun Chin Cho Akira Kawano Toshimasa Koyanagi Aritsune Ooho Takeaki Satoh Kazuhiro Takahashi Ming-Lun Yeh Pei-Chien Tsai Satoshi Yasuda Yunyu Zhao Yishan Liu Tomomi Okubo Norio Itokawa Mi Jung Jun Toru Ishikawa Koichi Takaguchi Tomonori Senoh Mingyuan Zhang Changqing Zhao Raluca Ioana Alecu Wei Xuan Tay Pooja Devan Joanne Kimiko Liu Ritsuzo Kozuka Elena Vargas-Accarino Ai-Thien Do Mayumi Maeda Wan-Long Chuang Jee-Fu Huang Chia-Yen Dai Ramsey Cheung Maria Buti Junqi Niu Wen Xie Hong Ren Seng Gee Lim Chao Wu Man-Fung Yuen Jia Shang Qiang Zhu Yoshiyuki Ueno Yasuhito Tanaka Jun Hayashi Ming-Lung Yu Mindie H.Nguyen Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of General Internal Medicine Kyushu University HospitalFukuokaJapan Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Hepatitis Research Center College of Medicine and Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical SciencesNagoyaJapan Gastroenterology&Hepatology Changi General HospitalSinghealthSingapore Singhealth Duke-NUS Medicine Academic Clinical Program Singapore Department of Gastroenterology Ogaki Municipal HospitalOgakiJapan Department of Internal Medicine Hanyang UniversityCollege of MedicineSeoulKorea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoulKorea Department of Hepatology The Third People's Hospital of Kunming CityKunmingYunnanChina Department of Gastroenterology Internal MedicineKitasato University School of MedicineSagamiharaJapan Gastroenterological Center Yokohama City University Medical CenterYokohamaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineE-Da Cancer HospitalKaohsiung Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoyaJapan Division of Gastroenterology and Hepatology Nippon Medical SchoolTokyoJapan Department of Gastroenterology Yamagata University Faculty of MedicineYamagataJapan Department of Transfusion Medicine and Department of Hepatology Osaka Metropolitan University Graduate School of MedicineOsakaJapan San Jose Gastroenterology San JoseCAUSA Gastroenterology&Hepatology Department Clinic Fundeni InstituteBucharestRomania Division of Gastroenterology and Hepatology University of WashingtonSeattleWAUSA Department of

Background and Aims:As practice patterns and hepatitis C virus(HCV)genotypes(GT)vary geographically,a global real-world study from both East and West covering all GTs can help inform practice policy toward the 2030 HCV elimination *** study aimed to assess the effectiveness and tolerability of DAA treatment in routine clinical practice in a multinational cohort for patients infected with all HCV GTs,focusing on GT3 and ***:We analyzed the sustained virological response(SVR12)of 15,849 chronic hepatitis C patients from 39 Real-World Evidence from the Asia Liver Consortium for HCV clinical sites in Asia Pacific,North America,and Europe between 07/01/2014–07/01/***:The mean age was 62±13 years,with 49.6%*** demographic breakdown was 91.1%Asian(52.9%Japanese,25.7%Chinese/Taiwan residents,5.4%Korean,3.3%Malaysian,and 2.9%Vietnamese),6.4%White,1.3%Hispanic/Latino,and 1%Black/***,34.8%had cirrhosis,8.6%had hepatocellular carcinoma(HCC),and 24.9%were treatment-experienced(20.7%with interferon,4.3%with direct-acting antivirals).The largest group was GT1(10,246[64.6%]),followed by GT2(3,686[23.2%]),GT3(1,151[7.2%]),GT6(457[2.8%]),GT4(47[0.3%]),GT5(1[0.006%]),and untyped GTs(261[1.6%]).The overall SVR12 was 96.9%,with rates over 95%for GT1/2/3/6 but 91.5%for ***12 for GT3 was 95.1%overall,98.2%for GT3a,and 94.0%for ***12 was 98.3%overall for GT6,lower for patients with cirrhosis and treatment-experienced(TE)(93.8%)but≥97.5%for tretment-naive patients regardless of cirrhosis *** multivariable analysis,advanced age,prior treatment failure,cirrhosis,active HCC,and GT3/4 were independent predictors of lower SVR12,while being Asian was a significant predictor of achieving ***:In this diverse multinational realworld cohort of patients with various GTs,the overall cure rate was 96.9%,despite large numbers of patients with cirrhosis,HCC,TE,and GT3/***12 for GT3/6 with cirrhosis and TE was lower but st

关键词： Hepatitis C virus Liver cirrhosis Hepatocellular carcinoma Genotype DAA REAL-C

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