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Indication of lower neck irradiation in nasopharyngeal carcinoma without nodal metastasis： the potential impact of tumor volume

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Chinese Medical Journal 2013年第11期126卷 2120-2124页

作者： FU Jie ZHOU Jia-yin vincent FH chong James BK Khoo Department of Radiation Oncology Affiliated No. 6 People'sHospital of Shanghai Jiao Tong University Shanghai 200233 China Neural & Biomedical Technology Department Institute forInfoeomm Research Singapore Singapore Department of Diagnostic Radiology Yong Loo Lin School ofMedicine National University of Singapore Singapore Singapore Depa~ment of Oncologic Imaging National Cancer CentreSingapore Singapore

Background Elective radiation of lower neck is controversial for nasopharyngeal carcinoma （NPC） without lymph node metastasis （NO disease）. Tumor volume is an important prognostic indicator. The objective of this study is to explore the potential impact of tumor volume on the indication of the lower neck irradiation for N0-NPC, by a qualitative evaluation of the relationship between tumor volume and nodal metastasis. Methods Magnetic resonance （MR） images of 99 consecutive patients with NPC who underwent treatment were retrospectively reviewed. Primary tumor volumes of NPC were semi-automatically measured, nodal metastases were N-classified and neck level involvements were examined. Distributions of tumor volumes among N-category-based groups and distributions of N-categories among tumor volume-based groups were analyzed, respectively. Results The numbers of patients with NO to N3 disease were 12, 39, 32, and 16, respectively. The volumes of primary tumor were from 3.3 to 89.6 ml, with a median of 17.1 ml. For patients with nodal metastasis, tumor volume did not increase significantly with the advancing of N-category （P 〉0.05）. No significant difference was found for the distribution of N1, N2, and N3 categories among tumor volume-based groups （P 〉0.05）. Nevertheless patients with nodal metastasis had significantly larger tumor volumes than those without metastasis （P 〈0.05）. Patients with larger tumor volumes were associated with an increased incidence of nodal metastasis. Conclusions Certain positive correlations existed between tumor volume and the presence of nodal metastasis. The tumor volume （〉10 ml） is a potential indicator for the lower neck irradiation for N0-NPC.

关键词： nasopharyngeal carcinoma lymph node metastasis magnetic resonance imaging tumor volume measurement

A nanotherapeutic strategy to target drug-tolerant cells and overcome EGFR tyrosine kinase inhibitor resistance in lung cancer

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Cancer Communications 2023年第4期43卷 503-507页

作者： Tatiana Shaurova Lingyue Yan Yafei Su Laurie James Rich Vui King vincent-chong Hannah Calkins Saraswati Pokharel Martin Petkovich Mukund Seshadri Yun Wu Pamela Anne Hershberger Department of Pharmacology and Therapeutics Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Department of Biomedical Engineering University at Buffalothe State University of New YorkBuffaloNew YorkUSA Cell Stress and Biophysical Oncology Graduate Program Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Fujifilm-Visual Sonics Corporation TorontoOntarioCanada Department of Oral Oncology Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Department of Pathology Roswell Park Comprehensive Cancer CenterBuffaloNew YorkUSA Cancer Research Institute School of MedicineQueens UniversityKingstonOntarioCanada

Dear Editor,For patientswith epidermal growth factor receptor(EGFR)mutant non-small cell lung cancer(NSCLC),EGFR tyrosine kinase inhibitors(TKIs)are used as the first-line treatment[1,2].Despite initial therapeutic responses,patients invariably experience disease progression due to acquired drug resistance[3].Resistance arises,in part,because a subset of cancer cells undergoes epithelial-mesenchymal transition(EMT)and remains viable despite exposure to EGFR TKI concentrations that eliminate the bulk population[4].The surviving cells can be re-sensitized to treatment by prolonged culture in the absence of EGFR TKIs,indicating a transient.

关键词： therapeutic viable resistance

CT、MRI及PET/CT在鼻咽癌第七版UICC分期中的价值

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中国癌症杂志 2011年第12期21卷 906-912页

作者：丁忠祥张福兴浙江省人民医院放射科浙江杭州310014 新加坡国立大学医院放射科新加坡119074

CT作为基本的鼻咽癌影像学评估手段,在鼻咽癌分期中发挥着重要作用。MRI具有较高的软组织分辨率,在原发肿瘤的侵犯范围、颅底骨质破坏及咽后淋巴结的界定方面明显优越于CT。PET/CT融合了功能影像和解剖成像,对原发灶的累及范围、远处转... 详细信息

CT作为基本的鼻咽癌影像学评估手段,在鼻咽癌分期中发挥着重要作用。MRI具有较高的软组织分辨率,在原发肿瘤的侵犯范围、颅底骨质破坏及咽后淋巴结的界定方面明显优越于CT。PET/CT融合了功能影像和解剖成像,对原发灶的累及范围、远处转移的筛查及肿瘤复发的诊断具有独特的优势。本文综述了这3种影像学检查手段的优缺点及对鼻咽癌第七版UICC分期、复发后再分期的价值。

关键词：鼻咽肿瘤影像诊断分期 MRI CT PET/CT

钙三醇的临床前预防试验:干预阶段和治疗持续时间对口腔癌变的影响

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中国口腔颌面外科杂志 2019年第4期17卷 315-315页

作者： vincent-chong VK DeJong H Attwood K 赵泽亮不详

在临床前模型中广泛报道了1,25-二羟基维生素D3(1,25(OH)2D3或骨化三醇)的抗癌活性。然而,尚未对钙三醇对口腔癌发生谱的化学预防潜力进行系统研究。为了解决这方面的知识差距,我们在4-硝基喹啉-1-氧化物(4NQO)口腔癌发生模型中进行了... 详细信息

在临床前模型中广泛报道了1,25-二羟基维生素D3(1,25(OH)2D3或骨化三醇)的抗癌活性。然而,尚未对钙三醇对口腔癌发生谱的化学预防潜力进行系统研究。为了解决这方面的知识差距,我们在4-硝基喹啉-1-氧化物(4NQO)口腔癌发生模型中进行了钙三醇的临床前预防试验。将C57BL/6小鼠暴露于饮用水中的致癌物质4NQO 16周,并随机分配到对照组(仅4NQO)或钙三醇组。

关键词：口腔癌变预防试验钙三醇治疗持续时间临床前 4-硝基喹啉-1-氧化物 C57BL/6小鼠抗癌活性

Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson’s disease

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Signal Transduction and Targeted Therapy 2021年第3期6卷 596-598页

作者： An-Guo Wu Rong Pan Betty Yuen-Kwan Law Wen-Qiao Qiu Jian-Ming Wu Chang-Long He vincent Kam-Wai Wong chong-Lin Yu Xiao-Gang Zhou Da-Lian Qin Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaSchool of PharmacyDepartment of Human AnatomySchool of Preclinical MedicineEducation Ministry Key Laboratory of Medical ElectrophysiologySouthwest Medical UniversityLuzhou 646000China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacaoChina

Dear Editor,PD is characterized by the loss of dopaminergic neurons in substantia nigra,and the loss of dopamine resulting in motor deficit.1 Its main pathological hallmarks include the genetic mutations of gene such as a-synudein.2 Increasing study showed that the dopaminergic neurons in midbrain are sensitive and damaged by the PD toxins.

关键词： nude dopamine therapeutic

Emotionless Holism:Factor and Rasch Analysis of the Chinese Integrative Medicine Attitude Questionnaire

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Chinese Journal of Integrative Medicine 2012年第6期18卷 457-465页

作者： vincent Chung Marc chong Lau Chun Hong Polly HX Ma Samuel YS Wong Sian M Griffiths School of Public and Primary Care Chinese University of Hong Kong

T Objective： To examine the Eastem-Westem difference in the interpretation of Integrative Medicine Attitude Questionnaire （IMAQ） by assessing the psychometric properties of a revised Chinese medicine （CM）- specific version of IMAQ （CM-IMAQ）. Methods： Factor and Rasch analysis were performed with data collected from a mail survey of 165 Hong Kong Western medical doctors （WMD） randomly sampled from the official registry. The structural validity, unidimensionality, item fit, and differential item functioning （DIF） of the Hong Kong CM-IMAQ were evaluated. Results： Confirmatory factor analysis （CFA） demonstrated that the original IMAQ factor structure was not concordant with our data on Chinese WMD, and subsequent explanatory factor analysis （EFA） validated a new three-factor model for CM-IMAQ：（1） attitude towards tonification , （2） attitude towards the effectiveness of CM, and （3） attitude towards CM knowledge. The original IMAQ factor on holism and doctor-patient relationship disappeared. Rasch analysis confirmed the unidimensionality of tonification and the effectiveness domains, but further refinement of the knowledge domain is needed. Coaclusions： Cultural adaptation of the IMAQ has demonstrated differences between Eastern and Westem doctors trained in allopathic medicine in their interpretations of hoiism in healthcare. For Chinese WMD, the emphasis of holistic care is placed on tonifying＇ the body rather than on nurturing the mind and spidt. Confucian and Taoist conceptualizations of mental health as well as the persistent stigma towards mental illness within modern Chinese culture may explain why Chinese WMD do not regard mental health promotion as part of routine healthcare.

关键词： psychometrics questionnaires Chinese medicine holistic health attitude of health personnel

汶川地震同震滑坡物质在震区的滞留和运移及其对龙门山地形演化的影响

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地球物理学报 2018年第5期61卷 1970-1983页

作者：王伟刘静 vincent Godard 张金玉许冲李志刚徐心悦许强王鹏谢克家中国地震局地质研究所、地震动力学国家重点实验室北京100029 Aix-Marseille Universite CNRSIRDCollege de FranceCEREGEAix en Provence 13100France 中国地震局地质研究所活动构造与火山重点实验室北京100029 中山大学地球科学与工程学院、广东省地球动力作用与地质灾害重点实验室广州510275 中国科学院青藏高原研究所北京100101 河南省有色金属矿产探测工程技术研究中心郑州450016

2008年M_W7.9汶川地震导致龙门山断裂发生强烈地壳变形,同时引发的巨量同震滑坡加速了该地区的地表剥蚀和河流侵蚀.然而,目前尚缺少系统的数据定量研究滑坡物质的运移以及河流侵蚀速率随时间的演化规律,这些对理解龙门山前缘物质的再分... 详细信息

2008年M_W7.9汶川地震导致龙门山断裂发生强烈地壳变形,同时引发的巨量同震滑坡加速了该地区的地表剥蚀和河流侵蚀.然而,目前尚缺少系统的数据定量研究滑坡物质的运移以及河流侵蚀速率随时间的演化规律,这些对理解龙门山前缘物质的再分配以及强震对活动造山带地形塑造的作用至关重要.为此,本研究在汶川地震后的6年间,对震区沱江上游3条支流湔江、石亭江、绵远河流域进行了多期次的定点现代河沙采样.通过系统测量河沙中的石英10Be浓度,并与震前已发表的数据进行对比,发现如下基本特点:(1)震后河沙10 Be浓度均有明显降低,表明同震滑坡物质对河沙的稀释作用;(2)震后河流对河沙的运移量增加为震前的1.3~18.5倍,因此震后龙门山地区侵蚀速率短期显著增加;(3)初步估计得到汶川地震产生的滑坡物质被完全运移出造山带所需要的时间至少为100~4000年,接近龙门山地区强震复发周期;(4)震间和同震产生的构造变形和地表剥蚀在空间上具有互补性.考虑到地表剥蚀引起的地壳均衡反弹效应,认为类似汶川地震的强震有利于龙门山的隆升.认识震前、震时和震后的地壳变形及侵蚀过程有助于更好地理解单次强震事件对高原边界龙门山地形演化的作用.

关键词：龙门山汶川地震同震滑坡河流卸载地形演化

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基于成像的转移性淋巴结体积测量

中华放射学杂志 2006年第1期40卷 99-103页

作者：张福兴周佳音邱文庆黄晶新加坡中央医院诊断放射科 169608 新加坡南洋理工大学生物医学工程研究中心新加坡国立癌症中心肿瘤成像科

目的评价一种半自动淋巴结体积测量方法对转移性颈部淋巴结体积测量的应用价值。方法18例病理证明的鼻咽癌患者于治疗前行MRT2WI,2名头颈部放射医师使用人工勾画边界法和基于区域变形的半自动图像分割算法测量患者增大的颈淋巴结体积,... 详细信息

目的评价一种半自动淋巴结体积测量方法对转移性颈部淋巴结体积测量的应用价值。方法18例病理证明的鼻咽癌患者于治疗前行MRT2WI,2名头颈部放射医师使用人工勾画边界法和基于区域变形的半自动图像分割算法测量患者增大的颈淋巴结体积,每一组MR图像由这2名放射医师独立处理。测量结果被记录并进行操作者间差异和可靠性分析。结果共测量45个增大的淋巴结或者淋巴结块。人工勾画所得的淋巴结体积和用区域变形方法所得淋巴结体积间差异无统计学意义(P=0.743),2名放射医师所得的体积数据之间差异无统计学意义(P=0.967)。另外,在操作者和体积测量方法之间没有显著的相关性(P=0.984)。同时,两种方法的操作者间可靠性差异无统计学意义(认同指数分别为0.88±0.09,0.90±0.07;P=0.181)。结论基于区域变形分割算法的半自动测量方法可以作为一种有用的工具来评价转移性淋巴结的体积,应用于淋巴结分期或对治疗效果进行监测。

关键词：体积测量磁共振成像鼻咽癌淋巴结转移

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鼻咽癌原发病灶体积与淋巴结转移研究

鼻咽癌原发病灶体积与淋巴结转移研究