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A multirate DSP structure for the identification of protein-coding regions

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International Journal of Biomathematics 2017年第8期10卷 125-139页

作者： Malaya kumar Hota vinay kumar srivastava School of Electronics EngineeringVIT University Vellore 632014 Tamilnadu India Department of Electronics and Communication Engineering Motilal Nehru National Institute of Technology Allahabad 211004 Uttar Pradesh India

The identification of protein-coding regions in DNA sequence using digital signal processing methods is one of the central issues in bioinformatics. In this paper, a multirate structure is proposed for the identification of protein-coding regions whose input sampling rate is same as output sampling rate. The multirate structure consists of cascade combination of decimation filter, kernel filter and interpolation filter. The decimation filter is a complex filter, the kernel filter is an FIR lowpass filter and the interpolation filter isa moving average filter. Polyphase decomposition is applied on both decimation filter and interpolation filter for computationally efficient implementation. The potential of the proposed method is evaluated in comparison with existing methods using standard datasets. The results show that the proposed method improves the identification accuracy of protein-coding regions to a great extent compared to its counterparts.

关键词： Bioinformatics protein-coding regions multirate structure polyphase decomposition period-3 property

Crystal structure and luminescence dynamics of highly pure LiM(PO_(3))_(3):Eu^(3+)(M=Sr,Ca) red phosphors for white light emitting diodes

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Journal of Rare Earths 2024年第8期42卷 1470-1478,I0002页

作者： Payal Khajuria M.Manhas A.K.Bedyal Ankush Vij H.C.Swart vinay kumar Department of Physics and Astronomical Sciences Central University of JammuRahy-Suchani.Samba1143J&KIndia Department of Physics School of SciencesCluster University of JammuCanal RoadJammu180001India Department of Physics University of Petroleum and Energy StudiesDehradunUttarakhand248007India Department of Physics University of the Free StatePO.Box 339BloemfonteinZA 9300South Africa

Highly pure red phosphors LiM(PO_(3))_(3):Eu^(3+)(M=Sr,Ca) doped with Eu^(3+)(1 mol%) were synthesized via solution combustion method and their crystal structure and luminescence dynamics were studied to explore its suitability in white light emitting *** Rietveld refinement analysis of the powder Xray diffraction patterns reveals that the phosphors belong to the pure triclinic phase of LiSr(PO_(3))_(3) and LiCa(PO_(3)) with space group P-1(2).The scanning electron microscopy images showed the agglomerated *** photoluminescence emission spectra under 393 nm show an orange band at 594 nm and a red band at 613 nm ascribed to ^(5)D_(0)→^(7)F_(1).^(5)D_(0)→^(7)F_(2) transitions of Eu^(3+)ion in both the ***,the spectroscopic properties such as luminescence behaviour,and Stark splitting were used to examine the symmetry of Eu^(3+)ions in LiM(PO_(3))_(3):Es^(3+)(M=Sr,Ca) phosphors in terms of distortion induced upon *** Stark splitting shows that the actual site symmetry for Eu^(3+)ion was estimated to be D_(2) type for both *** photometric properties of LiCa(PO_(3))_(3):Eu^(3+)such as Commission International de l'Eclairage coordinates(x=0.64,y=0.36) near to the standard one(red),high color purity(95%) and higher brightness reveal that the phosphor has the capability of acting as a red component in n-UV white light emitting diodes.

关键词： Photoluminescence Phosphate WLEDs Stark splitting Rare earths

Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease

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World Journal of Diabetes 2024年第7期15卷 1603-1614页

作者： Dharmsheel Shrivastav Satyam kumar Kumbhakar Shivangi srivastava Desh Deepak Singh Amity Institute of Biotechnology Amity University RajasthanJaipur 303002RajasthanIndia Department of Biotechnology Govt Veer Surendra Say P.G.CollegeGariaband 493889ChhattisgarhIndia Department of Life Science Chhatrapati Shahu ji Maharaj UniversityKanpur 208024Uttar PradeshIndia

BACKGROUND Type 2 diabetes(T2D)is a metabolic disease of impaired glucose utilization and a major cause of cardiovascular disease(CVD).The pathogenesis of both diseases shares common risk factors and mechanisms,and both are significant contributors to global morbidity and *** of natural products for T2D mellitus(T2DM)and CVD can be seen as a potential preventive and effective therapeutic *** To critically evaluate the therapeutic potential of natural products in T2D and coronary artery disease(CAD).METHODS By using specific keywords,we strategically searched the PubMed *** controlled trials(RCTs)were searched as the primary focus that examined the effect of natural products on glycemic control,oxidative stress,and antioxidant *** focused on outcomes such as low blood glucose levels,adjustment on markers of oxidative stress and *** screening fulllength papers,we included 9 RCTs in our review that met our inclusion *** In the literature search on the database,we found that various natural products like plant secondary metabolites play a diverse role in the management of *** ginseng,sesame oil and cocoa flavanols proved effective in lowering blood glucose levels and controlling blood pressure,which are key factors in managing T2DM and *** diabetic patients Melissa officinalis effectively reduce inflammation and shows diabetes *** fish oil and flaxseed oil reduced insulin levels and inflammatory markers,suggesting benefits for both *** lipid profile and endothelial function were enhanced by Nigella sativa oil and Terminalia chebula,which is significant for the management of cardiovascular risk factors in *** Bilberry extract also showed promise for improving glycemic control in patients with *** The high level of antioxidant,anti-inflammatory,and anti-angiogenic properties found in natural products makes them promising therapeutic opt

关键词： Type 2 diabetes mellitus Cardiovascular disease Natural products Antioxidants Oxidative stress Therapeutic impact Global burden

Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2885-2900页

作者： Porkizhi Arjunan Durga Kathirvelu Gokulnath Mahalingam Ashish kumar Goel Uday George Zacharaiah Alok srivastava Srujan Marepally Center for Stem Cell Research(A Unit of inStem Bengaluru)Christian Medical College CampusBagayamVellore 632002Tamil NaduIndia Manipal academy for higher education Mangalore 576104KarnatakaIndia Department of Hematology Christian Medical College&HospitalVellore 632004Tamil NaduIndia Department of Hepatology Christian Medical College&HospitalVellore 632004Tamil NaduIndia

Inherited genetic disorders of the liver pose a significant public health *** transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive *** overcome these limitations,nucleic acid therapy provides a hopeful alternative that enables gene repair,gene supplementation,and gene silencing with suitable *** viral vectors are the most efficient and preferred for gene therapy,pre-existing immunity debilitating immune responses limit their *** a potential alternative,lipid nanoparticle-mediated vectors are being explored to deliver multiple nucleic acid forms,including pDNA,mRNA,siRNA,and ***,we discuss the broader applications of lipid nanoparticles,from protein replacement therapy to restoring the disease mechanism through nucleic acid delivery and gene editing,as well as multiple preclinical and clinical studies as a potential alternative to liver transplantation.

关键词： Lipid nanoparticle Liver disorders Gene therapy Gene editing Nucleic acid delivery pDNA mRNA siRNA ASO Clinical trials

From source to emplacement:The origin of leucogranites from the Sikkim-Darjeeling Himalayas,India

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Geoscience Frontiers 2024年第1期15卷 384-401页

作者： Tanya srivastava Nigel Harris Catherine Mottram kumar Batuk Joshi Nishchal Wanjari Department of Geology Sikkim UniversityGangtokIndia School of Environment Earth&Ecosystem SciencesOpen UniversityMiltonKeynesUK School of the Environment Geography and GeosciencesUniversity of PortsmouthUK National Centre for Earth Science Studies ThiruvananthapuramKeralaIndia

Himalayan leucogranites are important for understanding the tectonic evolution of collision zones in general and the causes of crustal melting in the Himalayan orogen in *** paper aims to understand the melt source and emplacement age of the leucogranites from Sikkim in order to decipher the deep geodynamic processes of the eastern *** U-Pb analysis of the Higher Himalayan Sequence(HHS)metamorphic core reveals a prolonged period of crustal melting between>33 Ma and ca.14 *** and trace element abundances are presented for 27 leucogranites from North Sikkim that are classified into two-mica and tourmaline leucogranite *** are peraluminous in composition,characterized by high SiO2(70.91-74.9 wt.%),Al2O3(13.69-15.82 wt.%),and low MgO(0.13-0.74 wt.%).Elemental abundances suggest that Sikkim Himalayan leucogranites are derived from crustal *** two-mica leucogranites are derived from a metagreywacke source,whereas the tourmaline leucogranites are sourced from metapelitic sources,with inherited zircons indicating an HHS origin for both types.U-Pb zircon geochronology of the two mica leucogranites indicates ages of ca.19-15 Ma,consistent with crustal melting recorded in HHS gneisses from *** from both the two-mica and tourmaline leucogranites yield a crystallization age of ca.15-14 Ma,coeval with movement on the Main Central Thrust and South Tibetan Detachment System which further provides constraints on the timing and mechanism of petrogenesis of leucogranites in the Sikkim Himalayas.

关键词： Leucogranites Gneiss U-Pb geochronology Zircon Monazite Sikkim-Darjeeling Himalayas

Multiple Forgery Detection in Video Using Convolution Neural Network

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Computers, Materials & Continua 2022年第10期73卷 1347-1364页

作者： vinay kumar Vineet Kansal Manish Gaur Centre for Advanced Studies Dr.A P J Abdul Kalam Technical UniversityLucknowIndia Institute of Engineering and Technology Dr.A P J Abdul Kalam Technical UniversityLucknowIndia

With the growth of digital media data manipulation in today’s era due to the availability of readily handy tampering software,the authenticity of records is at high risk,especially in *** is a dire need to detect such problem and do the necessary *** this work,we propose an approach to detect the interframe video forgery utilizing the deep features obtained from the parallel deep neural network model and thorough analytical *** proposed approach only uses the deep features extracted from the CNN model and then applies the conventional mathematical approach to these features to find the forgery in the *** work calculates the correlation coefficient from the deep features of the adjacent frames rather than calculating directly from the *** divide the procedure of forgery detection into two phases–video forgery detection and video forgery *** video forgery detection,this approach detect input video is original or *** the video is not original,then the video is checked in the next phase,which is video forgery *** the video forgery classification,method review the forged video for insertion forgery,deletion forgery,and also again check for *** proposed work is generalized and it is tested on two different *** experimental results of our proposed model show that our approach can detect the forgery with the accuracy of 91%on VIFFD dataset,90%in TDTV dataset and classify the type of forgery–insertion and deletion with the accuracy of 82%on VIFFD dataset,86%on TDTV *** work can helps in the analysis of original and tempered video in various domain.

关键词： Digital forensic forgery detection video authentication video interframe forgery video processing deep learning

A Thorough Investigation on Image Forgery Detection

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1489-1528页

作者： Anjani kumar Rai Subodh srivastava Department of Electronics&Communication Engineering NITPatnaIndia

Image forging is the alteration of a digital image to conceal some of the necessary or helpful *** cannot be easy to distinguish themodified region fromthe original image in *** demand for authenticity and the integrity of the image drive the detection of a fabricated *** have been cases of ownership infringements or fraudulent actions by counterfeiting multimedia files,including re-sampling or *** work presents a high-level view of the forensics of digital images and their possible detection *** work presents a thorough analysis of digital image forgery detection techniques with their steps and *** methods have identified forgery and its type and compared it with state of the *** work will help us to find the best forgery detection technique based on the different *** also shows the current issues in other methods,which can help researchers find future scope for further research in this field.

关键词： Forgery detection digital forgery image forgery localization image segmentation image forensics multimedia security

Fusion of Region Extraction and Cross-Entropy SVM Models for Wheat Rust Diseases Classification

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Computers, Materials & Continua 2023年第11期77卷 2097-2121页

作者： Deepak kumar vinay Kukreja Ayush Dogra Bhawna Goyal Talal Taha Ali Department of Computer Science&Engineering Chitkara University Institute of Engineering and TechnologyChitkara UniversityPunjab140401India Department of Electronics&Communication Engineering Chandigarh UniversityPunjab140413India Department of Dental Industry Techniques Al-Noor University CollegeNineveh41018Iraq

Wheat rust diseases are one of the major types of fungal diseases that cause substantial yield quality losses of 15%–20%every *** wheat rust diseases are identified either through experienced evaluators or computerassisted *** experienced evaluators take time to identify the disease which is highly laborious and too *** wheat rust diseases are predicted at the development stages,then fungicides are sprayed earlier which helps to increase wheat yield *** solve the experienced evaluator issues,a combined region extraction and cross-entropy support vector machine(CE-SVM)model is proposed for wheat rust disease *** the proposed system,a total of 2300 secondary source images were augmented through flipping,cropping,and rotation *** augmented images are preprocessed by histogram *** a result,preprocessed images have been applied to region extraction convolutional neural networks(RCNN);Fast-RCNN,Faster-RCNN,and Mask-RCNN models for wheat plant patch *** layers of region extraction models construct a feature vector that is later passed to the CE-SVM *** a result,the Gaussian kernel function in CE-SVM achieves high F1-score(88.43%)and accuracy(93.60%)for wheat stripe rust disease classification.

关键词： Wheat rust diseases agricultural region extraction models intercropping image processing feature extraction precision agriculture

Performance Analysis of Multilayer Coil Based MI Waveguide Communication System

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Computers, Materials & Continua 2022年第9期72卷 5287-5300页

作者： Sandeep N.Dandu vinay kumar Joydeep Sengupta Neeraj D.Bokde Department of Electronics and Communications Engineering Visvesvaraya National Institute of TechnologyNagpur440010India Department of Electronics and Communications Engineering Motilal Nehru National Institute of TechnologyPrayagraj211002India Department of Civil and Architectural Engineering-Design and Construction 8000AarhusDenmark

In the non-conventional media like underwater and underground,the Radio Frequency(RF)communication technique does not perform well due to large antenna size requirement and high path *** such media,magnetic induction(MI)communication technique is very promising due to small coil size and constant channel *** the RF technique,the communication range in MI technique is relatively *** enhance this range,a waveguide technique is already brought in *** technique employs single layer coils to enhance the performance of MI *** further enhance the system functioning,in this paper,we investigated the performance of multi-layer coil(MLC)antenna based MI waveguide communication system in terms of transmission range,path loss,bit error rate(BER)and ***,the system performance is quantitatively evaluated in three different non-conventional media viz.,dry soil,fresh water and wet *** compared with the single layer counterpart,the MLC system shows a significant improvement in transmission range,BER even in loosely coupled scenarios and shows a corresponding reduction in path ***,the bandwidth is observed to be low(<1 KHz).In this analysis,the eddy current effects and parasitic capacitance are compared for single and multilayer *** is observed that the proposed system performs better in dry soil medium due to less medium conductivity.

关键词： Communication magnetic induction multilayer coil waveguide system