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Jetting-based bioprinting:process,dispense physics,and applications

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Bio-Design and Manufacturing 2024年第5期7卷 771-799页

作者： Wei Long Ng viktor shkolnikov singapore Centre for 3D Printing(sC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore HP Inc. Palo AltoCA 94304USA

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a highly automated layer-by-layer fabrication *** to its immense versatility,jetting-based bioprinting has been used for various applications,including tissue engineering and regenerative medicine,wound healing,and drug development.A lack of in-depth understanding exists in the processes that occur during jetting-based *** review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based *** first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting,laser-induced forward transfer bioprinting,electrohydrodynamic jet bioprinting,acoustic bioprinting and microvalve ***,we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition,print chamber design,droplet formation and droplet ***,we highlight recent accomplishments in jetting-based *** present the advantages and challenges of each method,discuss considerations relating to cell viability and protein stability,and conclude by providing insights into future directions of jetting-based bioprinting.

关键词： 3D bioprinting Biofabrication Jetting-based Dispense physics Machine learning

Elements of Electromagnetic Matter

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Journal of Modern Physics 2024年第3期15卷 250-270页

作者： viktor Ariel Independent Researcher Modiin Israel

Originally, Maxwell attempted to express his electromagnetic theory using four-dimensional mathematics of quaternions. Maxwell’s equations were later re-written in a three-dimensional real vector form, which is how the theory is presented today. Thus, an interesting question remains whether we can derive electromagnetic equations analytically from the basic mathematical principles of quaternion algebra and calculus, resulting in general and analytic matter equations. This question seems highly intriguing. Previously, we developed a mathematical theory of time using a normed division algebra of real quaternions [1]. In this study, we extend the theory of time by presenting a new analytical derivation of electromagnetic matter equations using the calculus of real quaternions, as originally intended by Maxwell. Therefore, we propose a novel mathematical definition of the quaternion path derivative using the properties of quaternion division. We then apply the quaternion derivative to an external electromagnetic potential and assume that the first quaternion derivative represents the quaternion electromagnetic force. Next, we assume that the second derivative, or quaternion Laplacian operator, applied to an external electromagnetic potential leads to the quaternion electromagnetic current density. The new analytical expressions are similar to the original empirical Maxwell equations, except for an additional scalar electric field, which allows for a novel formulation of Ohm’s conductivity law. We demonstrate that the resulting analytical equations can be written equivalently using either electromagnetic potentials or fields. Finally, we summarize the key postulates and equations of the new electromagnetic matter theory, which were based on normed division algebra and the calculus of quaternions. The resulting theory appears to be a useful analytical enhancement of the original Maxwell equations, and therefore, seems highly comprehensive, logical, and compelling.

关键词： Maxwell’s Equations Relativistic Electrodynamics Quaternion Calculus

Olefin Polymerization Behavior of Titanium(IV) Complexes with Fluorinated and Non-fluorinated Aliphatic Phenoxyimine Ligands

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Chinese Journal of Polymer science 2024年第1期42卷 52-62,I0007页

作者： Vladislav A.Tuskaev Kasim F.Magomedov svetlana Ch.Gagieva Dmitry A.Kurmaev Yulia V.Nelyubina Evgenii K.Golubev Maria D.Evseeva viktor G.Vasil'ev Galina G.Nikiforova Mikhail I.Buzin Vyacheslav s.Bogdanov Boris M.Bulychev Department of Chemistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesMoscow119991Russian Federation Enikolopov Institute of synthetic Polymer Materials Russian Academy of SciencesMoscow 117393Russian Federation

A series of Ti(Ⅳ) dichloride and dialkoxide com plexes with phenoxyimine ligands containing fluorinated and nonfluorinated aliphatic imine fragments have been *** molecular structures of complexes 1 and 4 were established by single-crystal X-ray diffraction *** complexes adopt a distorted octahedral coordination structure around the titanium atom and two oxygen atoms are situated in trans position while two nitrogen atoms and two outgoing ligands(Cl or iPrO) are situated in cis *** of activators(MMAO-12 and combinations Et_nAICl_(3-n)+Bu_(2)Mg) and outgoing ligand(Cl or iPrO) nature on the catalytic activity and properties of the resulting polymers was *** Ti complexes,despite the nature of the outgoing ligands(Cl or iPrO) in the presence of Al/Mg activators,was found to display a high ethylene polymerization activity in the range 1600-3830 kg_(polymer)·mol_(Ti)^(-1)·h^(-1)·atm^(-1) with a viscosity average molecular weight(M_v) value in the range 1.1×10~6-7.1×10~6 Dalton(Da).The resulting UHMWPE can be processed by a solventless method into high-strength and high-modulus oriented *** rheological characteristics of a polymer melt have been *** absence of a cross-over point did not allow to compare the values of the molecular weight distribution of polymers obtained on fluorinated and non-fluorinated pre-catalysts,however,the estimation of the entanglement density is in good agreement with the mechanical characteristics of oriented film *** activation with methylalumoxane,the activity of the com plexes decreased very significantly;however,a polymer with a molecular weight of about 12 million Da was *** the process of ethylene/octene-1 copolymerization,fluorine-containing precatalysts showed a clear advantage over non-fluorinated analogues both in activity and in comonomer content.

关键词： FI catalysts Titanium(IV) (Co)polymerization Al/Mg co-catalyst Ultra-high molecular weight polyethylene

Correction:Jetting-based bioprinting:process,dispense physics,and applications

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Bio-Design and Manufacturing 2024年第5期7卷 823-823页

The article Jetting-based bioprinting:process,dispense physics,and applications,written by Wei Long Ng and viktor shkolnikov,was originally published electronically on the publisher’s internet portal on 12 July 2024 ... 详细信息

关键词： printing pens internet

Virtual brain twins: from basic neuroscience to clinical use

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National science Review 2024年第05期 72-86页

作者： Huifang E.Wang Paul Triebkorn Martin Breyton Borana Dollomaja Jean-Didier Lemarechal spase Petkoski Pierpaolo sorrentino Damien Depannemaecker Meysam Hashemi viktor K.Jirsa Aix Marseille Université Institut National de la Santéet de la Recherche Médicale Institut de Neurosciences des Systèmes(INS) UMR1106 service de Pharmacologie Clinique et Pharmacosurveillance AP–HM

Virtual brain twins are personalized, generative and adaptive brain models based on data from an individual's brain for scientific and clinical use. After a description of the key elements of virtual brain twins,we present the standard model for personalized whole-brain network models. The personalization is accomplished using a subject's brain imaging data by three means:(1) assemble cortical and subcortical areas in the subject-specific brain space;(2) directly map connectivity into the brain models, which can be generalized to other parameters; and(3) estimate relevant parameters through model inversion, typically using probabilistic machine learning. We present the use of personalized whole-brain network models in healthy ageing and five clinical diseases: epilepsy, Alzheimer's disease, multiple sclerosis, Parkinson's disease and psychiatric disorders. specifically, we introduce spatial masks for relevant parameters and demonstrate their use based on the physiological and pathophysiological hypotheses. Finally, we pinpoint the key challenges and future directions.

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Desorption isotherms and isosteric heat of anaerobic fermentation residues

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2510-2517页

作者： Tibor Poós viktor szabó Department of Building services and Process Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsBertalan Lajos u.4-6H-1111 BudapestHungary

This paper presents the equilibrium desorption isotherms and the isosteric heat of sorption of a mixture containing mechanically dewatered fermentation residue(obtained from a blend of chicken,swine and cattle manure)used in biogas plants and corn spoiled silage in a ratio of 2:*** moisture desorption isotherms of the fermentation residue were determined at 32°C,40°C and 80°C and in the relative humidity range of 0.057/1 using static gravimetric *** equations were used to analyze the desorption data of Modified Henderson,Modified Halsey,Modified Oswin,Modified Chung–Pfost and Modified GAB *** constants of the model equations were calculated by non-linear regression *** Modified Henderson model fitted to the desorption isotherm data *** the proposed function,the final moisture content of the material can be determined as long as it can be dried in infinite time with the drying gas in the given *** isosteric heat of desorption was calculated by using the Modified Henderson model in the studied temperature range based on the Clausius–Clapeyron *** isosteric heat varied between 46 k J·mol-1 and 67 k J·mol-1 at moisture levels 1.91 b Xe<4.05 kgH2O·kgdP-1 for the material.

关键词： Desorption Equilibrium Model Measurement Isosteric heat

sARs-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance:Implications for Antibody Therapy and Vaccinations against COVID-19

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Research 2024年第3期2023卷 1-15页

作者： Xiaoying Ma Jady Liang Guangheng Zhu Preeti Bhoria Aron A.shoara Daniel T.MacKeigan Christopher J.Khoury sladjana slavkovicl Lisha Lin Danielle Karakas Ziyan Chen viktor Prifti Zhenze Liu Chuanbin shen Yuchong Li Cheng Zhang Jiayu Dou Zack Rousseau Jiamin Zhang Tiffany Ni Xi Lei Pingguo Chen Xiaoyu Wu Hamed shaykhalishahi samira Mubareka Kim AConnelly Haibo Zhang Ori Rotstein Heyu Ni Department of Laboratory Medicine and Pathobiology University of TorontoTorontoONCanada Department of Laboratory Medicine Keenan Research Centre for Biomedical Science of St.Michael’s HospitalTorontoONCanada Toronto Platelet Immunobiology Group TorontoONCanada Department of Physiology University of TorontoTorontoONCanada CCOA Therapeutics Inc. TorontoONCanada Canadian Blood services Centre for Innovation TorontoONCanada The state Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Laboratory Medicine The Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Advanced Pharmaceutics&Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoTorontoONCanada Department of Medical Microbiology and Infectious Disease Sunnybrook Health Science CentreToronto ONCanada Department of Medicine University of TorontoTorontoONCanada Division of Cardiology.st.Michael's Hospital TorontoONCanada Department of Anesthesiology and Pain Medicine and Division of Critical Care Medicine University of TorontoTorontoONCanada interdepartmental Division of Critical Care Medicine University of TorontoTorontoONCanada Department of surgery University of Toronto TorontoONCanada.

The COVID-19 pandemic caused by sARs-CoV-2 virus is an ongoing global health *** cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-thrombotic-thrombocytopenia(VITT)are both associated with thrombosis and thrombocytopenia;however,the underlying mechanisms remain inadequately *** infection and vaccination utilize the spike protein receptor-binding domain(RBD)of *** found that intravenous injection of recombinant RBD caused significant platelet clearance in *** investigation revealed the RBD could bind platelets,cause platelet activation,and potentiate platelet aggregation,which was exacerbated in the Delta and Kappa *** RBD–platelet interaction was partially dependent on theβ3 integrin as binding was significantly reduced inβ3−/−***,RBD binding to human and mouse platelets was significantly reduced with relatedαIIbβ3 antagonists and mutation of the RGD(arginine-glycine-aspartate)integrin binding motif to RGE(arginine-glycine-glutamate).We developed anti-RBD polyclonal and several monoclonal antibodies(mAbs)and identified 4F2 and 4H12 for their potent dual inhibition of RBD-induced platelet activation,aggregation,and clearance in vivo,and sARs-CoV-2 infection and replication in Vero E6 *** data show that the RBD can bind platelets partially thoughαIIbβ3 and induce platelet activation and clearance,which may contribute to thrombosis and thrombocytopenia observed in COVID-19 and *** newly developed mAbs 4F2 and 4H12 have potential not only for diagnosis of sARs-CoV-2 virus antigen but also importantly for therapy against COVID-19.

关键词： Antibody diagnosis vaccine

New Record Ocean Temperatures and Related Climate Indicators in 2023

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Advances in Atmospheric sciences 2024年第6期41卷 1068-1082页

作者： Lijing CHENG John ABRAHAM Kevin E.TRENBERTH Tim BOYER Michael EMANN Jiang ZHU Fan WANG Fujiang YU Ricardo LOCARNINI John FAsULLO Fei ZHENG Yuanlong LI Bin ZHANG Liying WAN Xingrong CHEN Dakui WANG Licheng FENG Xiangzhou sONG Yulong LIU Franco REsEGHETTI simona sIMONCELLI viktor GOURETsKI Gengxin CHEN Alexey MIsHONOV Jim REAGAN Karina VON sCHUCKMANN Yuying PAN Zhetao TAN Yujing ZHU Wangxu WEI Guancheng LI Qiuping REN Lijuan CAO Yayang LU International Center for Climate and Environment sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of st.Thomas School of EngineeringMinnesota 55105USA NsF National Center for Atmospheric Research BoulderColorado 80307USA University of Auckland Auckland 1010New Zealand National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA Department of Earth and Environmental science University of PennsylvaniaPhiladelphiaPennsylvania 19104USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine Environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China Oceanographic Data Center Chinese Academy of SciencesQingdao 266071China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information service Tianjin 300171China Italian National Agency for New Technologies Energy and Sustainable Economic DevelopmentS.Teresa Research CenterLerici 19032Italy Istituto Nazionale di Geofisica e Vulcanologia Sede di BolognaBologna 40128Italy south China sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China EssIC/CIsEss-MD University of MarylandCollege ParkMD20740USA Mercator Ocean International Toulouse 31400France Eco-Environmental Monitoring and Research Center Pearl River Valley and South China Sea Ecology and Environment AdministrationMinistry of Ecology and EnvironmentPRCGuangzhou 510611China National Meteorological Information Center China Meteorological AdministrationBeijing 100081China International Research Center of Big Data for sustainable Development Goals Beijing 100094China

The global physical and biogeochemical environment has been substantially altered in response to increased atmospheric greenhouse gases from human *** 2023,the sea surface temperature(ssT)and upper 2000 m ocean heat content(OHC)reached record *** 0–2000 m OHC in 2023 exceeded that of 2022 by 15±10 ZJ(1 Zetta Joules=1021 Joules)(updated IAP/CAs data);9±5 ZJ(NCEI/NOAA data).The Tropical Atlantic Ocean,the Mediterranean sea,and southern oceans recorded their highest OHC observed since the *** with the onset of a strong El Niño,the global ssT reached its record high in 2023 with an annual mean of~0.23℃ higher than 2022 and an astounding>0.3℃ above 2022 values for the second half of *** density stratification and spatial temperature inhomogeneity indexes reached their highest values in 2023.

关键词： ocean heat content salinity stratification global warming climate

Evolutionary Process from Mockina bidentata to Parvigondolella andrusovi:Evidence from the Pizzo Mondello section,sicily,Italy

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Journal of Earth science 2021年第3期32卷 667-676页

作者： Yixing Du Tetsuji Onoue viktor Karadi Ian s.Williams Manuel Rigo Department of Geosciences University of Padova35131 PadovaItaly Department of Earth and Planetary sciences Kyushu UniversityFukuokaJapan Department of Palaeontology Eotvos Lorand UniversityBudapest 1117Hungary Research school of Earth sciences The Australian National UniversityACT 2601 CanberraAustralia Institute of Geosciences and Earth Resources National Research Council of Italy35131 PadovaItaly

During their last phase of evolution,the pectiniform conodont elements manifested an evident trend of simplification and *** phase started from the late Norian(sevatian)in the Late Triassic and the evolutionary process of genus Mockina to Parvigondolella,in particular between Mockina bidentata and Parvigondolella andrusovi,is one of the most significant *** has been reported worldwide since it was first described in the early ***,it has recently been suggested that genus Parvigondolella is an ecostratigraphic morphotype of genus Mockina,and thus a phenotype controlled by the environmental conditions,and not an independent *** the Pizzo Mondello section(sicily,Italy),transitional forms between *** and *** have been found at different evolutionary *** have investigated the oceanic conditions at the time by using redox-sensitive elements(Mn,Fe,V,Cr,and Ni)and seawater temperatures from biogenetic δ^(18)Ophos to understand the possible environmental influences on the phylogenetic evolution between Mockina and *** geochemical and isotope analyses indicate that the redox condition and temperature were stable during the evolution of genus Parvigondolella in Pizzo Mondello,confirming that genus Parvigondolella is a real taxon and not a phenotype.A new conodont species named Parvigondolella ciarapicae *** described here for the first time.

关键词： conodont Late Triassic evolution oxygen isotope geochemistry