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Floral extract of Tecoma stans:A potent inhibitor of gentamicin-induced nephrotoxicity in vivo

Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 680-685页

作者： Raju S Kavimani S Uma Maheshwara rao v Sreeramulu reddy K vasanth Kumar G vijaya College of Pharmacy MunaganoorRanga Reddy DistAndhra PradeshIndia-505511 Mather Theresa Post Graduate Institute of Health Sciences.Gorimedu PuducherryIndia Nulla Narsimha reddy College of Pharmacy KorremulaRanga Reddy DistAndhra Pradesh.India Assistant manager - Clinical R&D Shantha Biotechnics LimitedHyderabadAndhra Pradesh.India -500004 Health Management and Research Institute HyderabadAndhra PradeshIndia

Objective:To highlight the nephroprotective activity of ethyl acetate extract of dried flowers of Tecomu stans for its protective effects on genlamicin-induced nephrotoxicity in albino rats. Methods:For studying acute toxicity study,single oral dose of 5（KM） mg ethyl acetate floral extract/kg hodv weight was administered to albino rats（five females,five males）.Nephrotoxicity was induced in albino rats by intraperitoneal administration of gentamicin 80 mg/kg/day for eight *** of concurrent administration of ethyl acetate floral extract of Tecoma stans at a dose of 100.200 and 300 mg/kg/day given by oral mute was determined using serum creatinine,serum uric acid,blood urea nitrogen and serum urea as indicators of kidney *** study groups contained six rats in each *** nephrotoxicity of gentamicin is known to involve induction of oxidative stress,in vitro antioxidant aclivity and free radical-scavenging activity of this extract was also ***:For acute toxicity testing both female and male rats administered with the extract at a dose of 5 000 mg/*** results showed no toxicity in terms of general behavior change,mortality,or change in gross appearance of internal organs(LD50>5 000 mg/kg). It was observed that the ethyl acetate floral extract of Tecoma stans significantly protected rat kidneys from gentamicin-induced histopathological ***-induced glomerular congestion,peritubular and blood vessel congestion,epithelial desquamation,accumulation ol inflamnialoiy cells and necrosis of the kidney cells were found to be reduced in the groups receiving the ethyl acetate floral extract of Tecoma starts along with gentamicin in a dose dependent *** floral extract also reduced the gentamicin-induced increase in serum creatinine,serum uric acid,blood urea nitrogen and serum urea levels（P>0.01）.Conclusions: The present study indicates a verv important role of reactive oxygen species（BOS） and the relation to re

关键词： Gentamicin Tecoma stans Rats Nephrotoxicity Serum urea Creatinine

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Dynamic Fracture Toughness of Armour Grade Quenched and Tempered Steel Joints Fabricated Using Low Hydrogen Ferritic Fillers

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Journal of Iron and Steel Research(International) 2010年第5期17卷 51-56页

作者： G Magudeeswaran v Balasubramanian S Sathyanarayanan G Madhusudhan reddy A Moitra S venugopal G Sasikala Department of Mechanical Engineering Pannaikkadu Veerammal Paramasivam College of Engineering andTechnology for Women Department of Manufacturing Engineering Annamalai University Materials Mechanics Section Indira Gandhi Center for Atomic Research Metal JoiningSection Defence Metallurgical Research Laboratory

The armour grade quenched and tempered steel joints fabricated using low hydrogen ferritic steel （LHF） filler exhibited superior joint efficiency owing to preferential ferrite microstructure in the welds and also they offered required resistance to HIC. However, the combat vehicles used in military operations will be required to operate under a wide range of road conditions ranging from first class to cross country. Structural components in combat vehicles are subjected to dynamic loading with high strain rates during operation. Stress loadings within the vehicle hull of these vehicles are expected to fluctuate considerably and structural cracking especially in welds during the service life of these vehicles can lead to catastrophic failures. Under these conditions, fracture behaviour of high strain rate sensitive structural steels can be better understood by dynamic fracture toughness （K1d）. Hence, an attempt was made to study dynamic fracture toughness of the armour grade quenched and tempered steel and their welds fabricated using LHF consumables. The experimental results indicate that the K1d values of the joints fabricated by shielded metal arc welding （SMAW） are higher than those of the joints fabricated using flux cored arc welding （FCAW） process.

关键词： quenched steel tempered steel low hydrogen ferritic steel dynamic fracture toughness

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Numerical modeling of friction stir welding using the tools with polygonal pins

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Defence Technology（防务技术） 2015年第3期11卷 229-236页

作者： M. MEHTA G.M. reddy A.v. RAO A. DE Production Engineering Department BVM Engineering College Defense Metallurgical Research Laboratory Mechanical Engineering Department

Friction stir welding using the tools with polygonal pins is often found to improve the mechanical strength of weld joint in comparison to the tools with circular pins. However, the impacts of pin profile on the peak temperature, tool torque and traverse force, and the resultant mechanical stresses experienced by the tool have been rarely reported in a systematic manner. An estimation of the rate of heat generation for the tools with polygonal pins is challenging due to their non-axisymmetric cross-section about the tool axis. A novel methodology is presented to analytically estimate the rate of heat generation for the tools with polygonal pins. A three-dimensional heat transfer analysis of friction stir welding is carried out using finite element method. The computed temperature field from the heat transfer model is used to estimate the torque, traverse force and the mechanical stresses experienced by regular triangular, square, pentagon and hexagon pins following the principles of solid mechanics. The computed results show that the peak temperature experienced by the tool pin increases with the number of pin sides. However, the resultant maximum shear stress experienced by the pin reduces from the triangular to hexagonal pins.

关键词：搅拌摩擦焊接多边形管脚数值模拟摩擦搅拌焊接机械强度峰值温度机械应力

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Robust Attack Detection Approach for IIoT Using Ensemble Classifier

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Computers, Materials & Continua 2021年第3期66卷 2457-2470页

作者： v.Priya I.Sumaiya Thaseen Thippa reddy Gadekallu Mohamed K.Aboudaif Emad Abouel Nasr School of Information Technology and Engineering Vellore Institute of TechnologyVellore632014India Advanced Manufacturing Institute King Saud UniversityRiyadh11421Saudi Arabia Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

Generally,the risks associated with malicious threats are increasing for the Internet of Things(IoT)and its related applications due to dependency on the Internet and the minimal resource availability of IoT ***,anomaly-based intrusion detection models for IoT networks are *** detection methodologies need to be developed for the Industrial Internet of Things(IIoT)network as threat detection is a significant expectation of *** learning approaches are considered to be evolving techniques that learn with experience,and such approaches have resulted in superior performance in various applications,such as pattern recognition,outlier analysis,and speech *** techniques and tools are not adequate to secure IIoT networks due to the use of various protocols in industrial systems and restricted possibilities of *** this paper,the objective is to develop a two-phase anomaly detection model to enhance the reliability of an IIoT *** the first phase,SvM and Naïve Bayes,are integrated using an ensemble blending technique.K-fold cross-validation is performed while training the data with different training and testing ratios to obtain optimized training and test *** blending uses a random forest technique to predict class *** Artificial Neural Network(ANN)classifier that uses the Adam optimizer to achieve better accuracy is also used for *** the second phase,both the ANN and random forest results are fed to the model’s classification unit,and the highest accuracy value is considered the final *** proposed model is tested on standard IoT attack datasets,such as WUSTL_IIOT-2018,N_BaIoT,and Bot_*** highest accuracy obtained is 99%.A comparative analysis of the proposed model using state-of-the-art ensemble techniques is performed to demonstrate the superiority of the *** results also demonstrate that the proposed model outperforms traditional techniques and thus improv

关键词： Blending ensemble intrusion detection Industrial Internet of Things(IIoT)

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Effect of welding processes and consumables on fatigue crack growth behaviour of armour grade quenched and tempered steel joints

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Defence Technology（防务技术） 2014年第1期10卷 47-59页

作者： G.MAGUDEESWARAN v.BALASUBRAMANIAN G.MADHUSUDHAN reddy Department of Mechanical Engineering PSNA College of Engineering & Technology Kothandaraman Nagar Muthanampatti Centre for Materials Joining & Research Department of Manufacturing Engineering Annamalai University Metal Joining Group Solidification Technology Division Defence Metallurgical Research LaboratoryKanchanbagh

Quenched and Tempered(Q&T) steels are widely used in the construction of military vehicles due to its high strength to weight ratio and high hardness. These steels are prone to hydrogen induced cracking(HIC) in the heat affected zone(HAZ) after welding. The use of austenitic stainless steel(ASS) consumables to weld the above steel was the only available remedy because of higher solubility for hydrogen in austenitic phase. The use of stainless steel consumables for a non-stainless steel base metal is not economical. Hence, alternate consumables for welding Q&T steels and their vulnerability to HIC need to be explored. Recent studies proved that low hydrogen ferritic steel(LHF) consumables can be used to weld Q&T steels, which can give very low hydrogen levels in the weld deposits. The use of ASS and LHF consumables will lead to distinct microstructures in their respective welds. This microstructural heterogeneity will have a drastic influence in the fatigue crack growth resistance of armour grade Q&T steel welds. Hence, in this investigation an attempt has been made to study the influence of welding consumables and welding processes on fatigue crack growth behaviour of armour grade Q&T Steel joints. Shielded metal arc welding(SMAW) and Flux cored arc welding(FCAW) were used for fabrication of joints using ASS and LHF consumables. The joints fabricated by SMAW process using LHF consumable exhibited superior fatigue crack growth resistance than all other joints.

关键词：焊接工艺疲劳裂纹扩展行为消耗品钢接头装甲回火淬火

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Effect of Hardfacing Consumables on Ballistic Performance of Q&T Steel Joints

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Defence Technology（防务技术） 2013年第4期9卷 249-258页

作者： M.BALAKRISHNAN v.BALASUBRAMANIAN G.MADHUSUDHAN reddy Department of Mechanical Engineering M. Kumarasamy College of Engineering (Autonomous) Center for Materials Joining & Research (CEMAJOR) Department of Manufacturing Engineering Annamalai University Solidification Technology Division Metal Joining Group Defence Metallurgical Research Laboratory (DMRL)

This study was carried out to evaluate the effect of hardfacing consumables on ballistic performance of armour grade quenched and tempered(Q&T)steel welded *** evaluate the effect of hardfacing consumables,joints were fabricated using 4 mm thick tungsten carbide(WC)/chromium carbide(CrC)hardfaced middle layer;above and below which austenitic stainless steel(SS)layers were deposited on both sides of the hardfaced *** metal arc welding(SMAW)process were used to deposite all(hardfaced layer and SS layers)*** fabricated joints were evaluated for its ballistic performance,and the results were compared with respect to depth of penetration(DOP)on weld metal and heat-affected zone(HAZ)*** the ballistic test results,it was observed that both the joints successfully stopped the bullet penetration at weld center *** the two joints,the joint made with CrC hardfaced interlayer(CAHA)offered better ballistic resistance at weld *** is because its hardness is higher due to the presence of primary carbides of needle shape,polyhedral shape and eutectic matrix containing a mixture of gt M7C3carbides in the CrC hardfaced *** scattering hardness level in the WC interlayer,the matrix decomposition resulted lower hardness and the co-existence of d ferrite in the interface between hardfacing and SS root/SS cap could be attributed to the inferior ballistic resistance of the joint made with WC hardfaced interlayer(WAHA joint).

关键词：弹道性能耐磨堆焊 M7C3型碳化物耗材焊接金属焊缝金属初生碳化物淬火效果

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Microstructure and Mechanical Properties of Friction Stir Lap Welded Aluminum Alloy AA2014

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Journal of Materials Science & Technology 2012年第5期28卷 414-426页

作者： S. Babu G.D. Janaki Ram P.v. venkitakrishnan G. Madhusudhan reddy K. Prasad Rao Dept. of Metallurgical and Materials Engineering Indian Institute of Technology Madras Chennai India Liquid Propulsion Systems Centre Indian Space Research Organisation Tiruvananthapuram India Defence Metallurgical Research Laboratory Hyderabad India

Friction stir lap welds were produced in 3 mm thick Alclad sheets of Al alloy 2014-T4 using two different tools （with triangular and threaded taper cylindrical pins）. The effects of tool geometry on weld microstructure, lap-shear performance and failure mode were investigated. The pin profile was found to significantly influence the hook geometry, which in turn strongly influenced the joint strength and the failure mode. Welds produced in alloy 2014-T4 Alclad sheets by using triangular and threaded taper cylindrical tools exhibited an average lap-shear failure load of 16.5 and 19.5 kN, respectively, while the average failure load for standard riveted joints was only 3.4 kN. Welds produced in alloy 2014-T6 Alclad sheets and in alloy 2014-T4 bare sheets （i.e., no Alclad） were comparatively evaluated with those produced in alloy 2014-T4 Alclad sheets. While the welds made （with threaded taper cylindrical tool） in T6 and T4 conditions showed very similar lap-shear failure loads, the joint efficiency of the welds made in T6 condition （43%） was considerably lower （because of the higher base material strength） than those made in T4 condition （51%）. The Alclad layers were found to present no special problems in friction stir lap welding. Welds made with triangular tool in alloy 2014-T4 Alclad and bare sheets showed very similar lap-shear failure loads. The present work provides some useful insights into the use of friction stir welding for joining Al alloys in lap configuration.

关键词： Aluminum alloys Friction stir welding Lap joints Lap-shear testing

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Amberlyst-15 catalyzed synthesis of alkyl/aryl/heterocyclic phosphonates

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Chinese Chemical Letters 2011年第8期22卷 895-898页

作者： U.M.Rao Kunda v.N.reddy Mudumala C.S.reddy Gangireddy B.R.Nemallapudi K.N.Sandip S.R.Cirandur Department of Chemistry Sri Venkateswara UniversityTirupati 517502.India Bio-Organic Division BARCMumbaiIndia

A novel and efficient procedure for the synthesis of alkyl phosphonates through one pot condensation of alkyl halide and trialkyl /aryl phosphite in the presence of Amberlyst-15 as catalyst under solvent free conditions was *** demonstrated several advantages such as good yields of products,simple operation,convenient separation and inexpensive catalyst.

关键词： Dialkyl/aryl alkyl phosphonates Amberlyst-15

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Investigation on 1.07 μm laser emission in Nd^(3+)-doped sodium fluoroborate glasses

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Journal of Rare Earths 2012年第5期30卷 413-417页

作者： D.Umamaheswari B.C.Jamalaiah T.Sasikala G.v.Lokeswara reddy L.Rama Moorthy Department of Physics Sri Venkateswara UniversityTirupati517 502India Department of Physics Changwon National UniversityChangwon641 773Republic of Korea

Spectroscopic and fluorescence properties of Nd 3＋ ions in sodium fluoroborate（SFB） glasses were prepared and characterized through optical absorption,emission and decay *** energy level analysis was carried out using free-ion Hamiltonian *** oscillator strengths were determined by measuring the area encompassed by the absorption peaks recorded for 1.0 mol.% Nd 3＋-doped *** Judd-Ofelt parameters（2,4,6） were used to evaluate the laser characteristic parameters such as radiative transition probability（A R）,radiative decay time（τ R）,fluorescence branching ratio（β R） and stimulated emission cross-section（σ e） for the 4 F 3/2 metastable *** fluorescence spectra for different concentrations of Nd 3＋ ions were recorded by exciting the samples at 514.5 nm Ar ＋ ion laser.

关键词： sodium fluoroborate glasses rare earth spectroscopy Judd-Ofelt theory laser materials

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Deep Learned Singular Residual Network for Super Resolution Reconstruction

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Computers, Materials & Continua 2023年第1期74卷 1123-1137页

作者： Gunnam Suryanarayana D.Bhavana P.E.S.N.Krishna Prasad M.M.K.Narasimha reddy Md Zia Ur Rahman Department of Electronics and Communications V R Siddhartha Engineering CollegeVijayawada520007India Department of Electronics and Communication Engineering Koneru Lakshmaiah Education FoundationVaddeswaramGuntur522502India Department of CSE Anil Neerukonda Institute of Technology&SciencesSangivalasaVisakhapatnam531162India

Single image super resolution(SISR)techniques produce images of high resolution(HR)as output from input images of low resolution(LR).Motivated by the effectiveness of deep learning methods,we provide a framework based on deep learning to achieve super resolution(SR)by utilizing deep singular-residual neural network(DSRNN)in training *** are obtained from the difference between HR and LR images to generate LR-residual example *** value decomposition(SvD)is applied to each LR-residual image pair to decompose into subbands of low and high frequency ***,DSRNN is trained on these subbands through input and output channels by optimizing the weights and biases of the *** fewer layers in DSRNN,the influence of exploding gradients is *** speeds up the learning process and also improves accuracy by using skip *** trained DSRNN parameters yield residuals to recover the HR subbands in the testing *** analysis shows that the proposed method results in superior performance to existingmethods in terms of subjective *** testing results on popular benchmark datasets such as set5,set14,and urban100 for a scaling factor of 4 show the effectiveness of the proposed method across different qualitative evaluation metrics.

关键词： Deep learning image reconstruction residual network singular values super resolution

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