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New Method of Palladium Metal Trapping through Resins in Antiviral Drug: valacyclovir HCl

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International Journal of Organic Chemistry 2013年第4期3卷 251-255页

作者： Keshava Navin Kumar reddy Murugulla Adharvana Chari Mayur D. Khunt v. v. N. K. v. Prasada Raju Bojja Ramachandra reddy vurimidi Himabindu Ghanta Mahesh reddy Department of Chemistry Institute of Science and Technology J. N. T. University Kukatpally Hyderabad India Dr. MACS Bio-Pharma Pvt. Ltd. Western Hills Kukatpally Hyderabad India Research and Development Integrated Product Development Innovation Plaza Dr. Reddy’s Laboratories Ltd. Bachupally Quthubullapur India

This process describes a novel technique for effective trapping of “Pd” metal through resins during the process development of L-valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl) methoxy] ethyl ester, and mono hydrochloride known as a valacyclovir hydrochloride (1). This technique is suitable for large-scale production of 1 and it is described here Pd metal trapping by using different resins.

关键词： valacyclovir Hydrochloride Antiviral Drug N-Phthalimide-L-valine Ester Monomethylamine Commercially Scalable Process Less Cycle Time

Microstructure and pitting corrosion of shielded metal arc welded high nitrogen stainless steel

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Defence Technology（防务技术） 2015年第3期11卷 237-243页

作者： RAFFI MOHAMMED G.MADHUSUDHAN reddy K.SRINIvASA RAO Department of Metallurgical Engineering Andhra University Defence Metallurgical Research Laboratory

The present work is aimed at studying the microstructure and pitting corrosion behaviour of shielded metal arc welded high nitrogen steel made of Cromang-N electrode. Basis for selecting this electrode is to increase the solubility of nitrogen in weld metal due to high chromium and manganese content. Microscopic studies were carried out using optical microscopy(OM) and field emission scanning electron microscopy(FESEM). Energy back scattered diffraction(EBSD) method was used to determine the phase analysis, grain size and orientation image mapping. Potentio-dynamic polarization testing was carried out to study the pitting corrosion resistance in aerated 3.5% NaCl environment using a GillAC electrochemical system. The investigation results showed that the selected Cr-Mn-N type electrode resulted in a maximum reduction in delta-ferrite and improvement in pitting corrosion resistance of the weld zone was attributed to the coarse austenite grains owing to the reduction in active sites of the austenite/delta ferrite interface and the decrease in galvanic interaction between austenite and delta-ferrite.

关键词：耐点蚀性能高氮不锈钢焊缝金属电弧焊接研究组织屏蔽场发射扫描电子显微镜奥氏体晶粒

Piezoresistive detector for MEMS accelerometer displacement sensing

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Journal of Measurement Science and Instrumentation 2012年第3期3卷 224-227页

作者： B.Rajesh Kumar D v R Koti reddy GITAM University Visakhapatnam 530 045India Andhra University Visakhapatnam 530 003India

We have designed a piezoresistive detector to detect the displacement of an *** have used a flexible contact force and impact time detector for sensing the acceleration in the time *** advantage of using this mechanism is good linearity,compactness,scalability,and the potential to realize a higher precision accelerometer due to time-based *** estimated mechanical and electrical parameters of beam detector are *** used COMSOL Multiphysics for designing the detector and Matlab for analysis.

关键词： piezoresistive detector time-based accelerometer force detector

Simultaneous determination of asenapine and valproic acid in human plasma using LC-MS/MS:Application of the method to support pharmacokinetic study

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Journal of Pharmaceutical Analysis 2013年第6期3卷 394-401页

作者： Ambavaram vijaya Bhaskar reddy Nandigam venugopal Gajulapalle Madhavi Department of Chemistry Sri Venkateswara University

Combination of asenapine with valproic acid received regulatory approval for acute treatment of schizophrenia and maniac episodes of bipolar disorders. A simple LC-MS/MS method was developed and validated for simultaneous quantification of asenapine and valproic acid in human plasma. Internal standards were added to 300 ~L of plasma sample prior to liquid-liquid extraction using methyl tertiary butyl ether （MTBE）. Chromatographic separation was achieved on Phenomenex C18 column （50 mm ~ 4.6 mm, 5 pm） in isocratic mode at 40 ~C. The mobile phase used was 10 mM ammonium formate-acetonitrile （5：95, v/v） at a constant flow rate of 0.8 mL/min monitored on triple quadrupole mass spectrometer, operating in the multiple reaction monitoring （MRM） mode. The injection volume used for LC-MS/MS analysis was 15 taL and the run time was 2.5 min. These low run time and small injection volume suggest the high efficiency of the proposed method. The method was validated over the concentration range of 0.1-10.02ng/mL and 10-20,000ng/mL for asenapine and valproic acid respectively. The method recoveries of asenapine （81.33%）, valproic acid （81.70%）, gliclazide （78.45%） and benzoic acid （79.73） from spiked plasma samples were consistent and reproducible. The application of this method was demonstrated by a pharmacokinetic study in 8 healthy male volunteers with 5 mg asenapine and 250 mg valproic acid administration.

关键词： Asenapine Gliclazide PharmacokineticsBipolar disordersSchizophrenia valproic acid

Artificial neural network approach for analyzing mutual coupling in a rectangular MIMO antenna

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Frontiers of Electrical and Electronic Engineering in China 2012年第3期7卷 293-298页

作者： K. SRI RAMA KRISHNA K. JAGADEESH BABU J. LAKSHMI NARAYANA L. PRATAP reddy G. v. SUBRAHMANYAM Department of Electronics and Communication Engineering VRSiddhartha Engineering College Vijayawada India K. JAGADEESH BABU J. LAKSHMI NARAYANADepartment of Electronics and Communication Engineering St. Ann'sCollege of Engineering and Technology Chirala India Department of Electronics and Communication Engineering JNTUCollege of Engineering Hyderabad India Department of Electronics and Communication Engineering AcharyaNagarjuna University Guntur India

A wideband rectangular patch antenna resonat- ing at 3.5 GHz and 8 GHz frequencies is developed on a flexible substrate, which can be used for wearable applications. The proposed antenna gives a wide impe- dance bandwidth of 116%, operating from *** to 9.5 GHz, covering most of the ultra-wideband （UWB） operating frequency range. A two-element multiple-input multiple-output （MIMO） system is developed using the proposed antenna, and the mutual coupling between the two antennas for various separations and frequencies is analyzed by using artificial neural networks （ANNs）. The neural structure is trained by using different ANN algorithms and a comparative study is made between them. It is shown that, quasi-Newton （QN） and quasi- Newton multi layer perceptron （QN-MLP） algorithms are better in terms of training, testing errors, and correlation coefficient.

关键词： flexible substrate multiple input multipleoutput (MIMO) systems artificial neural networks (ANNs) mutual coupling impedance bandwidth

Magnetic and Electrical Properties of Gd Doped Ni-Cu-Zn-Fe<sub>2</sub>O<sub>4</sub>

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Advances in Materials Physics and Chemistry 2018年第10期8卷 401-410页

作者： P. venkata Srinivasa Rao T. Anjaneyulu D. v. Krishna reddy M. Rami reddy Department of Physics Acharya Nagarjuna University Guntur India Department of Physics S. S. & N. College Guntur India Department of Physics Narasaraopeta Engineering College Guntur India

Ni0.5Cu0.25Zn0.25GdxFe2-xO4 (x = 0.0, 0.025, 0.05, 0.075, 0.1) ferrites were synthesized using an oxalic-based precursor method. The TC for all the Ni0.5Cu0.25Zn0.25GdxFe2-xO4 (x = 0.0, 0.025, 0.05, 0.075, 0.1) samples was measured by using one of the double coil susceptibility setup. In all the samples it is observed that, at a certain temperature, susceptibility falls to zero indicating the Curie temperature (TC) and ferrimagnetic samples are converted into paramagnetic sample at that temperature. The electrical properties were investigated for these samples. Dielectric properties and ρdc properties were observed to decrease with the increase in the frequency for all the Gd doped ferrite samples.

关键词： Ni-Cu-Zn-Gd Nanoferrites Magnetic Properties Electrical Properties

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马来西亚人视盘面积的研究(英文)

国际眼科杂志 2008年第8期8卷 1514-1517页

作者： Nadir A M Ali v Subrayan S C reddy 马来亚大学医学院眼科

目的:评估马来西亚主要的三个种族群(马来人,中国人和印度人)的视盘参数,并且研究视盘参数和性别、眼内压、眼轴长度之间的关系。方法:本研究包括了122例244眼,均有清晰的眼介质,其中61例为开角型青光眼患者,另外61例为非青光眼个体。... 详细信息

目的:评估马来西亚主要的三个种族群(马来人,中国人和印度人)的视盘参数,并且研究视盘参数和性别、眼内压、眼轴长度之间的关系。方法:本研究包括了122例244眼,均有清晰的眼介质,其中61例为开角型青光眼患者,另外61例为非青光眼个体。使用蔡司FF450Plus眼底照相机对视盘参数和视盘面积进行放大校正测量。三个种族群之间的差异用方差分析检验,而诸如性别、眼内压、眼轴长度这些因素和视盘大小之间的关系通过皮尔森双变量相关分析检验。结果:总体上平均垂直视盘直径为(1.96±0.20)mm,水平视盘直径为(1.84±0.20)mm,视盘面积为(2.84±0.56)mm2。与马来人和中国人相比,印度人有较大的视盘面积。然而,差异没有统计学意义。结论:马来西亚人的视盘面积比高加索人(白种人)大。在马来西亚三个种族群中,印度人视盘面积最大,但是没有统计学意义。

关键词：视盘直径视盘面积马来人印度人中国人

Machine learning job failure analysis and prediction model for the cloud environment

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High-Confidence Computing 2023年第4期3卷 73-86页

作者： Harikrishna Bommala Uma Maheswari v. Rajanikanth Aluvalu Swapna Mudrakola Department of CSE KG Reddy College of Engineering&TechnologyHyderabad 500075India Department of CSE Chaitanya Bharathi Institute of TechnologyHyderabad 500075India Department of IT Chaitanya Bharathi Institute of TechnologyHyderabad 500075India Department of CSE Matrusri College of EngineeringHyderabad 500059India

Reliable and accessible cloud applications are essential for the future of ubiquitous computing,smart appliances,and electronic *** to the vastness and diversity of the cloud,a most cloud services,both physical and logical services have *** currently accessible traces,we assessed and characterized the behaviors of successful and unsuccessful *** devised and implemented a method to forecast which jobs will *** proposed method optimizes cloud applications more efficiently in terms of resource *** Google Cluster,Mustang,and Trinity traces,which are publicly available,an in-depth evaluation of the proposed model was *** traces were also fed into several different machine learning models to select the most reliable *** efficiency analysis proves that the model performs well in terms of accuracy,F1-score,and *** factors,such as failure of forecasting work,design of scheduling algorithms,modification of priority criteria,and restriction of task resubmission,may increase cloud service dependability and availability.

关键词： Failure prediction Mustang trace Cloud computing Trinity trace Random forest Google cluster trace Fault tolerance

A Stability Indicating UPLC Method for Finasteride and Its Related Impurities

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American Journal of Analytical Chemistry 2012年第11期3卷 737-745页

作者： Y. Koti reddy G. v. Subba reddy K. N. Jaya veera Kishore Kumar Hotha Bioanalytical Department Integrated Product Development Dr. Reddy’s Laboratories Ltd Bachupally India Department of Chemistry JNTUA College of Engineering Pulivendula India JNT University Anantapur India Sri Krishna Chaitanya College of Pharmacy Madanapalle India

The objective of the present research work is to develop a gradient, reversed-phase liquid chromatographic (RP-UPLC) method for the determination of Finasteride in pharmaceutical bulk drugs for assay and its related impurities. The chromatographic separation was achieved on a Waters ACQUITY UPLC BEH Phenyl Column (150 mm × 2.1 mm, 1.7 μm), The gradient LC method employs solutions A and B as mobile phase. The solution A Contains 2.5 mM ortho phosphoric acid (Buffer) and solution B contains a mixture of acetonitrile and water in the ratio of (90:10 v/v). The flow rate was 0.22 ml/min and the detection wavelength was 210 nm. In the developed UPLC method, the resolution between Finasteride and its potential impurities, namely Imp-1, Imp-2, Imp-3 and Imp-4 was found to be greater than 2.0. The drug was subjected to stress conditions of hydrolysis, oxidation, photolysis and thermal degradation. Considerable degradation was found to occur in alkaline medium and oxidative stress conditions. Degradation product formed during oxidative hydrolysis was found to be Imp-1. The stress samples were assayed against a qualified reference standard and the mass balance was found close to 99.5%. The developed RP-UPLC method was validated with respect to linearity, accuracy, precision and robustness. The limit of quantification of Imp-1, Imp-2, Imp-3 and Imp-4 were 0.06, 0.06, 0.05 and 0.036% (of analyte concentration, i.e. 0.5 mg/ml) with 1μl injection volume. The developed method was found to be linear in the range of 2.5 - 15 μg/mL with correlation coefficient of 0.999 for assay procedures and found to be linear in the range of 0.05 - 3 μg/mL with correlation coefficient of 0.999 for related impurities.

关键词： RP-UPLC Forced Degradation validation Finasteride Method Development