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Role of bacteria in carcinogenesis, with special reference to carcinoma of the gallbladder

World Journal of Gastroenterology 2010年第43期16卷 5395-5404页

作者： Gopal Nath Anil K Gulati vijay K shukla Department of Microbiology Institute of Medical Sciences Banaras Hindu University Department of General Surgery Institute of Medical Sciences Banaras Hindu University

Carcinoma of the gallbladder (CaGB) is the fifth commonest gastrointestinal tract cancer and is endemic in several countries. The interplay of genetic susceptibility, infections, and life style factors has been proposed to be responsible for carcinogenesis of gallbladder. Persistence of infection leading to chronic inflammation, and production of certain toxins and metabolites with carcinogenic potentials, by certain bacteria has been speculated to be involved in the transformation of the gallbladder epithelium. Therefore, any bacteria that have evolved to acquire both of the above carcinogenic mechanisms can cause cancer. Salmonella typhi has been found to be prominently associated with CaGB. Chronic typhoid carriage (persistence) and production of mediators of chronic infl ammation and a genotoxic toxin (cytotoxic distending toxin, CdtB) are also known for this bacterium. Furthermore, the natural concentrating function of the gallbladder might amplify the carcinogenic effect of the mediators of carcinogenesis. In addition to S. typhi, certain species of Helicobacter (H. bilis and H. hepaticus) and Escherichia coli have also been implicated in carcinogenesis. As the isolation rate is verypoor with the presently available culture techniques, the existence of bacteria in a viable but non-cultivable state is quite likely; therefore, sensitive and specif ic molecular techniques might reveal the etiological role of bacterial infection in gallbladder carcinogenesis. If bacteria are found to be causing cancers, then eradication of such infections might help in reducing the incidence of some cancers.

关键词： Bacteria Chronic infl ammation Carcinogen Bacterial toxins Carcinoma gallbladder DNA damage

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Role of Combination Chemotherapy with 5-Fluorouracil, Cisplatin and Paclitaxel for Advanced Gall Bladder Cancer

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Journal of Cancer Therapy 2014年第3期5卷 246-252页

作者： Mumtaz Ahmad Ansari Satyendra K. Tiwary Uday Pratap Shahi vijay K. shukla Department of General Surgery and Radiotherapy Institute of Medical Sciences Banaras Hindu University Varanasi India

Aim: The prognosis for patients with advanced Gallbladder carcinoma is poor. Due to unresectability and relatively ineffective chemotherapy available, a need exists for effective chemotherapeutic regimen. The aim of this study was to determine the efficacy and safety profile of 5-fluorouracil, cisplatin and paclitaxel in patients with advanced Gallbladder cancer. Material and Methods: From January 2002 to July 2004, 40 patients of advanced carcinoma Gallbladder received 5-fluorouracil, cisplatin and paclitaxel. On day 1, paclitaxel was given (150 mg/m2), cisplatin was given on day 2 (50 mg/m2) and 5-fluorouracil was given from day 1 to day 3 (500 mg/m2). This cycle was repeated every three weeks and patient assessment was done. Results: Forty patients were enrolled in this study. Thirty-five were assessed for response. Five patients were lost in follow up. There were thirty females and ten males. A median of three cycles of treatment (range one to seven) was administered. Two patients achieved complete response and eleven had partial responses giving an overall response rate of 32.5% in the intention-to-treat population (95% confidence interval 11.1% to 46.5%). The median response duration was 5.3 months. The median time to progression and overall survival was 4.1 months and 11.2 months, respectively. The most common grade 3 adverse effects were neutropenia (30%), nausea (20%), vomiting (15%), diarrhea (10%), stomatitis (5%), and peripheral neuropathy (5%). Only one case had febrile neutropenia. There was no treatment related death. Conclusions: The combination of 5-fluorouracil, cisplatin and paclitaxel has promising anti-tumor activity and is well tolerated in patients with advanced and metastatic Gallbladder cancer.

关键词： Advanced Gallbladder Carcinoma Combination Chemotherapy Prognosis

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优化下肢慢性创面愈合中的技术应用:共识文件(译文)

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感染．炎症．修复 2017年第2期18卷 67-83页

作者： Raj Mani Divid J.Margolis vijay shukla Sadanori Akita Miltos Lazarides Alberto Piaggesi Vincent Falanga Luc Teot 谢挺付小兵 Marco Romanelli Chris Attinger 韩春茂陆树良 Sylvie Meaume 许樟荣 vijay Viswanathan 孙晓芳肖娴上海交通大学医学院附属第九人民医院急诊科创面修复中心上海200011

目的:慢性创面处理中技术创新随处可见。尽管多种技术得到了广泛的应用,但并不总是能够确保创面愈合的结局。这份共识文件为创面标准化处理的相关诊疗技术应用提供了循证研究依据。

关键词：慢性创面技术评估 SORT分类

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GRADE指南：Ⅶ.证据质量评价--不一致性

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中国循证医学杂志 2011年第12期11卷 1444-1451页

作者： Gordon H.Guyatt Andrew D.Oxman Regina Kunz James Woodcock Jan Brozek Mark Helfand Pablo Alonso-Coello Paul Glasziou Roman Jaeschke Elie A.Akl Susan Norris Gunn Vist Philipp Dahm vijay K.shukla Julian Higgins Yngve Falck-Ytter Holger J.Schünemann 代表GRADE小组李幼平杨晓妍王莉蔡羽嘉陈群飞机构不详

本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性。证据本身不会因不同研究结果具有一致性而升级,但可能因不一致而降低质量级别。衡量一致性的标准包括点估计值的相似性、可信区间的重叠程度以及统计学判定标准包括异质... 详细信息

本文针对二分类变量结局指标相对(而非绝对)治疗效果的不一致性。证据本身不会因不同研究结果具有一致性而升级,但可能因不一致而降低质量级别。衡量一致性的标准包括点估计值的相似性、可信区间的重叠程度以及统计学判定标准包括异质性检验和I2。系统评价作者应提出并检验少数几个与患者、干预措施、结局指标以及方法学相关的先验假设以探寻异质性来源。当不一致性很大且无法解释时,因不一致性而降低质量级别是恰当的,特别当某些研究显示有显著益处而其他显示无益甚至有害时(而非仅是疗效大与疗效小的比较)。明显的亚组效应可能不可靠。如果亚组效应满足以下条件,其可信度将会增加:基于少数几个有具体方向的先验假设、亚组比较来自研究内而非研究间、交互检验的P值小、结果有生物学意义。

关键词： GRADE 不一致性异质性变异性亚组分析交互作用

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Whipple’s operation with a modified centralization concept:A model in low-volume Caribbean centers

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World Journal of Clinical Cases 2022年第22期10卷 7620-7630页

作者： Shamir O Cawich Neil W Pearce vijay Naraynsingh Parul shukla Rahul R Deshpande Department of Clinical Surgical Sciences University of the West IndiesSt Augustine 000000Trinidad and Tobago University Surgical Unit Southampton General HospitalSouthampton SO166YDUnited Kingdom Department of Surgery Weill Cornell Medical CollegeNew YorkNY 10065United States Department of Surgery Manchester Royal InfirmaryManchester M139WLUnited Kingdom

Conventional data suggest that complex operations,such as a pancreaticoduodenectomy(PD),should be limited to high volume ***,this is not practical in small,resource-poor countries in the *** these settings,patients have no option but to have their PDs performed locally at low volumes,occasionally by general *** this paper,we review the evolution of the concept of the high-volume center and discuss the feasibility of applying this concept to low and middle-income ***,we discuss a modification of this concept that may be considered when incorporating PD into low-volume and resource-poor countries,such as those in the *** paper has two ***,we performed a literature review evaluating studies published on outcomes after PD in high volume *** data in the Caribbean is then examined and we discuss the incorporation of this operation into resource-poor hospitals with modifications of the centralization *** the authors’opinions,most patients who require PD in the Caribbean do not have realistic opportunities to have surgery in high-volume centers in developed *** these settings,their only options are to have their operations in the resource-poor,low-volume settings in the ***,post-operative outcomes may be improved,despite low-volumes,if a modified centralization concept is encouraged.

关键词： Pancreas Surgery Pancreatectomy Whipple’s Pancreaticoduodenectomy

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On Bounded Variation Functions by General MKZD Operators

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Acta Mathematica Sinica,English Series 2007年第8期23卷 1457-1462页

作者： vijay GUPTA School of Applied Sciences Netaji Subhas Institute of TechnologyAzad Hind Fauj MarySector 3 Dwarka New Delhi-110075India

In this paper, we study the rate of convergence for functions of bounded variation for the recently introduced Bzier variant of the Meyer-Knig-Zeller-Durrmeyer operators.

关键词： approximation by positive operators rate of convergence degree of approximation functions of bounded variation total variation

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Effect of calcium lactate on compressive strength and self-healing of cracks in microbial concrete

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Frontiers of Structural and Civil Engineering 2019年第3期13卷 515-525页

作者： Kunamineni vijay Meena MURMU Department of Civil Engineering National Institute of TechnologyRaipur 492010India

This paper presents the effect on compressive strength and self-healing capability of bacterial concrete with the addition of calcium *** to normal concrete,bacterial concrete possesses higher durability and engineering concrete *** production of calcium carbonate in bacterial concrete is limited to the calcium content in *** calcium lactate is externally added to be an additional source of calcium in the *** influence of this addition on compressive strength,self-healing capability of cracks is highlighted in this *** bacterium used in the study is bacillus subtilis and was added to both spore powder form and culture form to the *** subtilis spore powder of 2 million cfu/g concentration with 0.5%cement was mixed to *** lactates with concentrations of 0.5%,1.0%,1.5%,2.0%,and 2.5%of cement,was added to the concrete mixes to test the effect on properties of *** other samples,cultured bacillus subtilis with a concentration of 1×10^cells/mL was mixed with concrete,to study the effect of bacteria in the cultured form on the properties of *** of 100 mm×100 mm×100 mm were used for the *** cubes were tested after a curing period of 7,14,and 28 d.A maximum of 12%increase in compressive strength was observed with the addition of 0.5%of calcium lactate in *** electron microscope and energy dispersive X-ray spectroscopy examination showed the formation of ettringite in pores;calcium silicate hydrates and calcite which made the concrete denser.A statistical technique was applied to analyze the experimental data of the compressive strengths of cementations *** surface methodology was adopted for optimizing the experimental *** regression equation was yielded by the application of response surface methodology relating response variables to input *** method aids in predicting the experimental results accurately with an acceptable range

关键词： calcium lactate bacillus subtilis compressive strength self-healing of cracks

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Processing and design methodologies for advanced and novel thermal barrier coatings for engineering applications

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Particuology 2016年第4期14卷 1-28页

作者： vijay Kumar Balasubramanian Kandasubramanian Department of Materials Engineering Defence Institute of Advanced Technology Girinagar Pune 411025 India

Thermal barrier coating is a crucial thermal insulation technology that enables the underlying substrate to operate near or above its melting temperature. Such coatings bolster engineers＇ perpetual desire to increase the power and efficiency of gas turbine engines through increasing the turbine inlet tempera- ture. Advances in recent years have made them suitable for wider engineering and defense applications, and hence they are currently attracting considerable attention. A thermal barrier coating system is itself dynamic; its components undergo recurrent changes in their composition, microstructure and crystalline phases during its service life. Nevertheless, the performance of multi-layered and multi-material sys- tems tailored for high temperature applications is closely linked to the deposition process. The process improvements achieved so far are the outcome of increased understanding of the relationship between the coating morphology and the operating service conditions, as well as developments in characterization techniques. This article presents a comprehensive review of various processing techniques and design methodologies for thermal barrier coatings. The emphasis of this review is on the particle technology; the interrelationship between particle preparation, modification and the resulting properties, to assist developments in advanced and novel thermal barrier coatings for engineering applications.

关键词： Thermal barrier coatingAir plasma sprayElectron beam-physical vapor depositionThermally grown oxideYttria-stabilized zirconiaThermal conductivity

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CFD-DEM analysis of particle polydispersity on the performance of fluidised bed reactor during silane pyrolysis Author links open overlay panel

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Particuology 2024年第8期91卷 72-87页

作者： Akshayveer vijay M.Shinde MS2Discovery Interdisciplinary Research Institute Wilfrid Laurier UniversityWaterlooOntarioN2L3C5Canada Department of Chemical Engineering Indian Institute of Technology(BHU)Varanasi221005India

A CFD-DEM model is developed for chemical vapour deposition of silane in a fluidized bed reactor to investigate the effect of polydispersity on local phase dynamics,mass and heat transport,as well as the rate of Si *** gas-phase fines formation and heterogeneous deposition on the seed particle,as well as the scavenging effect for Si particle growth,are *** method is first validated against the experimentally measured Si deposition rate,percentage of fine production and minimum fluidisation ***,the properties,primarily particle intermixing,fluidisation behaviour and bubble dynamics along with the deposition process,are analyzed for several polydisperse beds under various operating *** effect of polydispersity of the bed on a fraction of the bubble size,dense phase expansion and interchange coefficient between various phases is thoroughly investigated to establish a correlation with reactor *** results show that broad-Gaussian particle size distribution(PSD)exhibits excellent improvement in fluidisation behaviour,resulting in a high deposition rate,and minimum formation of Si fines.

关键词： CFD-DEM method Chemical vapour deposition(CVD) Particle size distribution Silicon Gas-solid fluidized bed

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Hybrid Image Compression-Encryption Scheme Based on Multilayer Stacked Autoencoder and Logistic Map

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China Communications 2022年第1期19卷 238-252页

作者： Neetu Gupta Ritu vijay Computer Science&Engineering Department Banasthali VidyapithBanasthaliIndia Department of Electronics Engineering Banasthali VidyapithBanasthaliIndia.

Secure transmission of images over a communication channel, with limited data transfer capacity, possesses compression and encryption schemes. A deep learning based hybrid image compression-encryption scheme is proposed by combining stacked auto-encoder with the logistic map. The proposed structure of stacked autoencoder has seven multiple layers, and back propagation algorithm is intended to extend vector portrayal of information into lower vector space. The randomly generated key is used to set initial conditions and control parameters of logistic map. Subsequently, compressed image is encrypted by substituting and scrambling of pixel sequences using key stream sequences generated from logistic *** proposed algorithms are experimentally tested over five standard grayscale images. Compression and encryption efficiency of proposed algorithms are evaluated and analyzed based on peak signal to noise ratio(PSNR), mean square error(MSE), structural similarity index metrics(SSIM) and statistical,differential, entropy analysis respectively. Simulation results show that proposed algorithms provide high quality reconstructed images with excellent levels of security during transmission..

关键词： compression-encryption stacked autoencoder chaotic system back propagation algorithm logistic map

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