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Assessing anthropogenic pressure and threats on Paeonia emodi *** Royle habitats in Garhwal Himalaya

Journal of Mountain Science 2023年第3期20卷 810-820页

作者： Praveen JOSHI Prem PRAKASH vijay kant purohit Department of Botany Govt.M.B.P.G.CollegeHaldwani 263641Indial High Altitude Plant Physiology Research Centre H.N.B.Garhwal Central UniversitySrinagar Garhwal 263671India

The Garhwal Himalaya is among the major repositories of immensely valuable wild edible plants and provides food security to the local *** the valuable plant species that grow in this region,Paeonia emodi(family Paeoniaceae)is an important wild edible species that found in temperate regions with an altitude range between 1800 and 2800 *** species is facing a severe threat to its sustainability due to overharvesting,habitat disturbances,and a lack of effort regarding *** the first time,this study investigated anthropogenic pressure,population decline perceptions in the natural habitat,and vulnerability assessment of *** under selected study sites(n=23 villages).A semi structured questionnaire was used to interview approximately 45%of the local inhabitants,including herbal practitioners(Vaidhyas or Dais)of each *** the basis of demographic characteristics,the perceptions and responses of 464 local people were documented regarding potential causes of deterioration and feasible options for sustainable *** the weight survey method,we estimated the actual amount of collection based on personal interaction and direct *** order to determine the threats status,a rapid vulnerability assessment(RVA)was performed and were used based on the current exploitation and *** present study revealed that leaf(100%)was the most frequently harvested part,followed by stem(95.65%),seed(26.09%),root(21.74%)and flower(13.04%).The village Triyuginarayan and Pothivasa recorded the highest collection scores while the purpose of the collection was mostly edible(100%),medicinal(100%),and least commercial(8.70%).According to the literature review and the present survey,the RVA(total=21)is categorized as category II(intermediate side of the RVA index),indicating a degree of *** study revealed that *** faces extinction in the Garhwal *** this species through agro-production techniques may alleviate th

关键词： Anthropogenic pressure Conservational strategies Garhwal Himalaya Paeonia emodi Rapid vulnerability assessment Wild edibles

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Systems-based approaches to study immunometabolism

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Cellular & Molecular Immunology 2022年第3期19卷 409-420页

作者： Vinee purohit Allon Wagner Nir Yosef vijay K.Kuchroo Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA Broad Institute of MIT and Harvard CambridgeMA02141USA Department of Electrical Engineering and Computer Science University of CaliforniaBerkeleyCA94720USA Center for Computational Biology University of CaliforniaBerkeleyCA94720USA

Technical advances at the interface of biology and computation,such as single-cell RNA-sequencing(scRNA-seq),reveal new layers of complexity in cellular *** emerging area of investigation using the systems biology approach is the study of the metabolism of immune *** diverse spectra of immune cell phenotypes,sparsity of immune cell numbers in vivo,limitations in the number of metabolites identified,dynamic nature of cellular metabolism and metabolic fluxes,tissue specificity,and high dependence on the local milieu make investigations in immunometabolism challenging,especially at the single-cell *** this review,we define the systemic nature of immunometabolism,summarize cell-and system-based approaches,and introduce mathematical modeling approaches for systems interrogation of metabolic changes in immune *** close the review by discussing the applications and shortcomings of metabolic modeling *** systems-oriented studies of metabolism expected to become a mainstay of immunological research,an understanding of current approaches toward systems immunometabolism will help investigators make the best use of current resources and push the boundaries of the discipline.

关键词： Immunometabolism Metabolic techniques GSMM Metabolic modeling Systems biology

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Intraoperative blood loss in orthotopic liver transplantation:The predictive factors

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World Journal of Gastrointestinal Surgery 2015年第6期7卷 86-93页

作者： Chandra kant Pandey Anshuman Singh Kamal Kajal Mandeep Dhankhar Manish Tandon vijay kant Pandey Sunaina Tejpal Karna Department of Anaesthesiology Institute of Liver and Biliary Sciences

Liver transplantation has been associated with massive blood loss and considerable transfusion requirements. Bleeding in orthotopic liver transplantation is multifactorial. Technical difficulties inherent to this complex surgical procedure and pre operative derangements of the primary and secondary coagulation system are thought to be the principal causes of perioperative hemorrhage. Intraoperative practices such as massive fluid resuscitation and resulting hypothermia and hypocalcemia secondary to citrate toxicity further aggravate the preexisting coagulopathy and worsen the perioperative bleeding. Excessive blood loss and transfusion during orthotopic liver transplant are correlated with diminished graft survival and increased septic episodes and prolonged ICU stay. With improvements in surgical skills, anesthetic technique, graft preservation, use of intraoperative cell savers and overall perioperative management, orthotopic liver transplant is now associated with decreased intra operative blood losses. The purpose of this review is to discuss the risk factors predictive of increased intra operative bleeding in patients undergoing orthotopic liver transplant.

关键词： Liver transplantation Intraoperative bloodloss Liver disease

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Atypical Olfactory Neuroblastoma Presenting as Sinonasal Polyposis with Nasopharyngeal Extension: A Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第5期4卷 394-400页

作者： Jagdish Prasad purohit Chandra Bhan Bhoopendra Singh Ajay Pratap Singh Siva Selvaraj Manish Pandey vijay Krishna Sharma Department of ENT Head and Neck Surgery MLB Medical College Jhansi India

Background: Olfactory neuroblastoma also known as Esthesioneuroblastoma (ENB) is a tumor arising from the basal layer of olfactory epithelium in the superior recess of the nasal cavity in the region of cribriform plate. Incidence peaks once in 11 - 20 years of age and again in 50 - 60 years of age. It is equally found in men and women. Aim: The main aim of this case report is to characterize the clinical features of ENB showing nasopharyngeal involvement and its importance in the differential diagnosis of sinonasal neuroendocrine malignancies. Case presentation: Two cases are reported. The first case was a 21-year-old male with symptoms of nasal obstruction, recurrent epistaxis, nasal discharge, headache and paresthesia over the face with an evolution of 1 year with no previous history of trauma. Diagnostic nasal endoscopy revealed reddish gray mass filling bilateral nasal cavities. Posterior rhinoscopy revealed mass coming through choanae and filling the nasopharynx. Endoscopic resection of tumor was done and postoperatively all the symptoms of the patient resolved. The second case was a 62-year-old male with complaints of nasal obstruction, nasal discharge, recurrent epistaxis, anosmia and difficulty in swallowing. On computed tomography, anteriorly, the mass was extending up to external nares and posteriorly up to the nasopharynx, superiorly up to nasal roof and inferiorly up to hard palate. No obvious erosion of floor of anterior cranial fossa was seen. No intracranial extension was seen. Surgery was advised but patient refused to undergo any treatment. Conclusion: This study highlights the characteristics and clinical features of ENB showing nasopharyngeal involvement and their importance in the differential diagnosis of sinonasal neuroendocrine malignancies.

关键词： Esthesioneuroblastoma Cribriform Plate Neuroectodermal

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在有经历非肝的外科的肝疾病的病人的 Perioperative 风险因素

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World Journal of Gastrointestinal Surgery 2012年第12期4卷 267-274页

作者： Chandra kant Pandey Sunaina Tejpal Karna vijay kant Pandey Manish Tandon Amit Singhal Vivek Mangla Department of Anaesthesiology Institute of Liver and Biliary Sciences Vasant Kunj New Delhi 110070 India Department of HPB Surgery Institute of Liver and Biliary Sciences Vasant Kunj New Delhi 110070 India

The patients with liver disease present for various surgical interventions. Surgery may lead to complications in a significant proportion of these patients. These complications may result in considerable morbidity and mortality. Preoperative assessment can predict survival to some extent in patients with liver disease undergoing surgical procedures. A review of literature suggests nature and the type of surgery in these patients determines the peri-operative morbidity and mortality. Optimization of premorbid factors may help to reduce perioperative mortality and morbidity. The purpose of this review is to discuss the effect of liver disease on perioperative outcome; to understand various risk scoring systems and their prognostic significance; to delineate different preoperative variables implicated in postoperative complications and morbidity; to establish the effect of nature and type of surgery on postoperative outcome in patients with liver disease and to discuss optimal anaesthesia strategy in patients with liver disease.

关键词： Cirrhosis Liver disease Perioperative risk

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