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Long non-coding RNA(lncRNA):A potential therapeutic target in acute lung injury

Genes & Diseases 2022年第5期9卷 1258-1268页

作者： Almaz Zaki M.Shadab Ali vijay hadda Syed Mansoor Ali Anita Chopra Tasneem Fatma Department of Pulmonary Critical Care and Sleep MedicineAll India Institute of Medical SciencesNew Delhi 110029India Department of Biosciences Jamia Millia Islamia UniversityNew Delhi 110025India Department of Biotechnology Jamia Millia Islamia UniversityNew Delhi 110025India Lab Oncology Dr.BRA-IRCHAll India Institute of Medical SciencesNew Delhi 110029India

Acute Lung Injury(ALI)and its severe form Acute Respiratory Distress Syndrome(ARDS)are the major cause of ICU death ***/ARDS is characterized by severe hypoxemia and inflammation that leads to poor lung *** many advances in understanding and management,ALI/ARDS is still causing significant morbidity and *** non-coding RNA(lncRNA)is a fast-growing topic in lung inflammation and *** is a class of non-coding RNA having a length of more than 200 *** has been a center of research for understanding the pathophysiology of various diseases in the past few *** studies have shown that lncRNAs are abundant in acute lung injury/injuries in mouse models and cell *** targeting these long non-coding RNAs,many investigators have demonstrated the alleviation of ALI in various mouse ***,lncRNAs show great promise as a therapeutic target in *** review provides the current state of knowledge about the relationship between lncRNAs in various biological processes in acute lung injury and its use as a potential therapeutic target.

关键词： Acute lung injury Apoptosis Inflammation Long non-coding RNA(lncRNA) Macrophage polarization

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Reproducibility of diaphragm thickness measurements by ultrasonography in patients on mechanical ventilation

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World Journal of Critical Care Medicine 2017年第4期6卷 185-189页

作者： Ashesh Dhungana Gopi Khilnani vijay hadda Randeep Guleria Department of Medicine National Academy of Medical Sciences Pulmonary Medicine Department of Pulmonary Medicine and Sleep Disorders All India Institute of Medical Sciences

AIM To prospectively evaluate the reproducibility of diaphragm thickness measurement by ultrasonography at the bedside by critical care physicians in patients on invasive mechanical *** In a prospective observational study of 64 invasively ventilated patients, diaphragmatic thickness measurement was taken by 2 different observers at the same site. Three measurements were taken by each observer and averaged. The intraobserver and interobserver variability was assessed by estimation of intraclass correlation coefficient. The limits of agreement were plotted as the difference between two observations against the average of the two observations in Bland and Altman *** The mean diaphragm thickness at the functional residual capacity was 2.29 ± 0.4 mm and the lower limit of the normal, i.e., the 5 th percentile was 1.7 mm(95%CI: 1.6-1.8). The intraclass correlation coefficient for intraobserver variability was 0.986(95%CI: 0.979-0.991)with a P value of < 0.001. The intraclass correlation coefficient for interobserver variability was 0.987(95%CI: 0.949-0.997) with a P value of < 0.001. In Bland and Altman analysis, both intraobserver and interobserver measurements showed high limits of agreement. CONCLUSION Our study demonstrates that the measurement of diaphragm thickness by ultrasound can be accurately performed by critical care physicians with high degree of reproducibility in patients on mechanical ventilation.

关键词： Diaphragm Ultrasonography Mechanical ventilation

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Assessment of quadriceps muscle thickness using bedside ultrasonography by nurses and physicians in the intensive care unit:Intra- and inter-operator agreement

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World Journal of Critical Care Medicine 2019年第7期8卷 127-134页

作者： Rohit Kumar Tajamul Hussain Shah vijay hadda Pawan Tiwari Saurabh Mittal Karan Madan Maroof Ahmad Khan Anant Mohan Department of Pulmonary Critical Care and Sleep MedicineAll India Institute of Medical SciencesNew Delhi 110029India Department of Biostatistics All India Institute of Medical SciencesNew Delhi 110029India

BACKGROUND Data regarding the agreement among multiple operators for measurement of quadriceps muscle thickness by bedside ultrasonography(USG)are *** To statistically assess the agreement among 5 operators for measurement of quadriceps muscle thickness on bedside *** This was a cross-sectional observational *** 5 operators of varied experience(comprised of 1 critical care consultant,2 fellows,and 2 nurses)independently measured quadriceps muscle thickness in triplicate for 45 critically ill patients each,using ***-and interrater agreement rates among the 5 operators were assessed using intraclass correlation coefficient(ICC)and expressed with 95%confidence interval(CI).RESULTS The 5 operators produced a total of 135 readings and 675 observations for ICC calculations to determine the intraoperator and interoperator variations *** intraoperator agreement,the overall ICC(95%CI)was 0.998(0.997,0.999)for operator 1,0.998(0.997,0.999)for operator 2,0.997(0.995,0.999)for operator 3,0.999(0.998,0.999)for operator 4,and 0.998(0.997,0.999)for operator *** interoperator agreement,the overall ICC(95%CI)was 0.977(0.965,0.986;P<0.001)for reading 1,0.974(0.960,0.984;P<0.001)for reading 2,and 0.975(0.961,0.985;P<0.001)for reading *** USG measurement of quadriceps muscle thickness was not dependent on clinical experience,supporting training for nurses in it.

关键词： Agreement Intensive care unit Critical illness Muscle thickness Quadricepsmuscle Ultrasonography

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