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Recent Progress in Deciphering the Biosynthesis of Aspartate-Derived Amino Acids in Plants

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Molecular Plant 2010年第1期3卷 54-65页

作者： Georg Jander vijay Joshi Boyce Thompson Institute for Plant Research 1 Tower Road Ithaca NY 14850 USA

Plants are either directly or indirectly the source of most of the essential amino acids in animal diets. Four of these essential amino acids--methionine, threonine, isoleucine, and lysine--are all produced from aspartate via a well studied biosynthesis pathway. Given the nutritional interest in essential amino acids, the aspartate-derived amino acid pathway has been the subject of extensive research. Additionally, several pathway enzymes serve as targets for econom- ically important herbicides, and some of the downstream products are biosynthetic precursors for other essential plant metabolites such as ethylene and S-adenosylmethionine. Recent and ongoing research on the aspartate-derived family of amino acids has identified new enzyme activities, regulatory mechanisms, and in vivo metabolic functions. Together, these discoveries will open up new possibilities for plant metabolic engineering.

关键词： Metabolic regulation primary metabolism Arabidopsis.

Approximation by q Baskakov Beta Operators

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 569-580页

作者： vijay GUPTA Ali ARAL School of Applied Sciences Netaji Subhas Institute of TechnologySector 3 DwarkaNew Delhi-110078India Department of Mathematics Kirikkale UniversityFaculty of Science and ArtsYah sihanKirikkaleTurkey

In the present paper we introduce the q analogue of the Baskakov Beta operators. We establish some direct results in the polynomial weighted space of continuous functions defined on the interval [0, ∞）. Then we obta... 详细信息

关键词： q-Baskakov operators q-Baskakov-Beta operators modulus of continuity K-functional weighted approximation rate of approximation q-Beta integral

Effect of hydrogen bond formation/replacement on solubility characteristics, gastric permeation and pharmacokinetics of curcumin by application of powder solution technology

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Acta Pharmaceutica Sinica B 2016年第6期6卷 600-613页

作者： vijay Sharma Kamla Pathak Department of Pharmaceutics Rajiv Academy for Pharmacy

The present research aimed to improve the dissolution rate and bioavailability of curcumin using the potential of liquisolid technology. Twelve drug-loaded liquisolid systems (LS-1 to LS-12) were prepared using different vehicles (PEG 200, PEG 400 and Tween 80) and curcumin concentrations in vehicle (40%, 50%, 60% and 70%, w/w). The carrier [microcrystalline cellulose (MCC) PH102] to coat (Aerosil®) ratio was 20 in all formulations. The systems were screened for pre-compression properties before being compressed to liquisolid tablets (LT-1 to LT-12). Post compression tests and in vitro dissolution of LTs were conducted and the results compared with those obtained for a directly compressed tablet (DCT) made of curcumin, MCC PH102 and Aerosil®. LTs exhibited higher cumulative drug release (CDR) than the DCT and the optimum formulation, LT-9 (made using Tween 80), was studied by powder XRD, DSC, SEM and FTIR. Ex-vivo permeation of curcumin from LT-9 through goat gastrointestinal mucosa was significantly (P50) of LT-9 towards NCL 87 cancer cells was 40.2 µmol/L substantiating its anticancer efficacy. Accelerated stability studies revealed insignificant effects of temperature and humidity on LT-9. In summary, solubility enhancement of curcumin in LTs produced significant improvements in its permeation and bioavailability.

关键词： Liquisolid tablet Powder solution technology Curcumin Hydrogen bond formation Cytotoxicity Gastric permeation Bioavailability Pharmacokinetics

SAR interferometric coherence analysis for snow cover mapping in the western Himalayan region

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International Journal of Digital Earth 2011年第1期4卷 78-90页

作者： vijay Kumar Gopalan Venkataraman Centre of Studies in Resources Engineering Indian Institute of Technology BombayPowaiMumbai 400076India

Information of snow cover(SC)over Himalayan regions is very important for regional climatological and hydrological *** monitoring of SC in the Himalayan region is essential for water supply to hydropower stations,irrigation requirements,and flood *** remote sensing has all weather,day and night earth observation capability unlike optical remote *** this study,spaceborne synthetic aperture radar interferometric(InSAR)coherence analysis is used to monitor SC over Himalayan rugged *** feasibility of monitoring SC using synthetic aperture radar(SAR)interferometry depends on the ability to maintain coherence over InSAR pair acquisition time ***-1/2 InSAR coherence and ENVISAT ASAR InSAR coherence images are analyzed for SC *** sets of winter and of snow free months of the Himalayan region are taken for interferogram *** images of the available data sets show maximum decorrelation in most of the area which indicates massive snowfall in the region in the winter season and melting in the *** showing coherence loss due to decorrelation is mapped as a snowcovered *** result is validated with field observations of snow depth and it is found that standing snow is inversely related to coherence in the Himalayan region.

关键词： SAR InSAR coherence snow cover digital earth microwave remote sensing

Automating Transfer Credit Assessment-A Natural Language Processing-Based Approach

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Computers, Materials & Continua 2022年第11期73卷 2257-2274页

作者： Dhivya Chandrasekaran vijay Mago Lakehead University Thunder BayOntarioP7B 5E1Canada

Student mobility or academic mobility involves students moving between institutions during their post-secondary education,and one of the challenging tasks in this process is to assess the transfer credits to be offered to the incoming *** general,this process involves domain experts comparing the learning outcomes of the courses,to decide on offering transfer credits to the incoming *** manual implementation is not only labor-intensive but also influenced by undue bias and administrative *** proposed research article focuses on identifying a model that exploits the advancements in the field of Natural Language Processing(NLP)to effectively automate this *** the unique structure,domain specificity,and complexity of learning outcomes(LOs),a need for designing a tailor-made model *** proposed model uses a clustering-inspired methodology based on knowledge-based semantic similarity measures to assess the taxonomic similarity of LOs and a transformer-based semantic similarity model to assess the semantic similarity of the *** similarity between LOs is further aggregated to form course to course *** to the lack of quality benchmark datasets,a new benchmark dataset containing seven course-to-course similarity measures is *** the inherent need for flexibility in the decision-making process the aggregation part of the model offers tunable parameters to accommodate different levels of *** providing an efficient model to assess the similarity between courses with existing resources,this research work also steers future research attempts to apply NLP in the field of articulation in an ideal direction by highlighting the persisting research gaps.

关键词： Articulation agreements higher education natural language processing semantic similarity

Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第16期12卷 2517-2522页

作者： Tenzin Choedon Ganeshan Mathan Soneera Arya vijay L Kumar vijay Kumar Virology Group International Centre for Genetic Engineering and BiotechnologyAruna Asaf Ali MargNew Delhi-110067India Department of Pharmacology All India Institute of Medical SciencesAnsari NagarNew Delhi-110029India

AIM： To evaluate the anticancer property of the dried latex （DL） of Calotropis procera, a tropical medicinal plant, in the X15-myc transgenic mouse model of hepatocellular carcinoma and to elucidate its mechanism of action in cell culture. METHODS： The young transgenic mice were orally fed with the aqueous suspension of DL （400 mg/kg for 5 d/wk） for 15 wk and their liver was examined for histopathological changes at 20 wk. Serum levels of vascu- lar endothelial growth factor （VEGF） were also measured in these animals. To characterize the active fraction, DL was extracted with petroleum ether followed by methanol. The methanolic extract was sub-fractionated on a silica gel G column using a combination of non-polar and polar solvents and eleven fractions were obtained. Each fraction was analysed for cytotoxic effect on hepatoma （Huh7） and non-hepatoma （COS-1） cell lines and nontransformed hepatocytes （AML12） using tetrazolium （MTT） assay. Finally, the mechanism of cell death was investigated by measuring the levels of Bcl2, caspase 3 and DNA fragmentation. RESULTS： DL treatment of mice showed a complete protection against hepatocarcinogenesis. No adverse effect was observed in these animals. The serum VEGF level was significantly lowered in the treated mice as compared to control animals. Cell culture studies revealed that the methanolic extract of DL as well as its fraction 8 induced extensive cell death in both Huh-7 and COS-1 cells while AML12 cells were spared. This was accompanied by extensive fragmentation of DNA in Huh-7 and COS-1 cells. No change in the levels of canonical markers of apoptosis such as Bcl2 and caspase 3 was observed. CONCLUSION： DL of C. procera has the potential for anti-cancer therapy due to its differentJable targets and non-interference with regular pathway of apoptosis.

关键词： Calotropis procera Transgenic mice Hepatocellular carcinoma Cytotoxicity Anticancer agent Differential killing

VLSI scaling methods and low power CMOS buffer circuit

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Journal of Semiconductors 2013年第9期34卷 92-99页

作者： vijay Kumar Sharma Manisha Pattanaik Department of Information Technology ABV-Indian Institute of Information Technology & Management

Device scaling is an important part of the very large scale integration （VLSI） design to boost up the success path of VLSI industry, which results in denser and faster integration of the devices. As technology node moves towards the very deep submicron region, leakage current and circuit reliability become the key issues. Both are increasing with the new technology generation and affecting the performance of the overall logic circuit. The VLSI designers must keep the balance in power dissipation and the circuit＇s performance with scaling of the devices. In this paper, different scaling methods are studied first. These scaling methods are used to identify the effects of those scaling methods on the power dissipation and propagation delay of the CMOS buffer circuit. For mitigating the power dissipation in scaled devices, we have proposed a reliable leakage reduction low power transmission gate （LPTG） approach and tested it on complementary metal oxide semiconductor （CMOS） buffer circuit. All simulation results are taken on HSPICE tool with Berkeley predictive technology model （BPTM） BSIM4 bulk CMOS files. The LPTG CMOS buffer reduces 95.16% power dissipation with 84.20% improvement in figure of merit at 32 nm technology node. Various process, voltage and temperature variations are analyzed for proving the robustness of the proposed approach. Leakage current uncertainty decreases from 0.91 to 0.43 in the CMOS buffer circuit that causes large circuit reliability.

关键词： LPTG buffer power dissipation propagation delay scaling nanoscale CMOS figure of merit

Single image defogging by gain gradient image filter

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Science China(Information Sciences) 2019年第7期62卷 225-227页

作者： Dilbag SINGH vijay KUMAR Computer Science and Engineering Department Apex Institute of Technology Chandigarh University Computer Science and Engineering Department Thapar Institute of Engineering and Technology

Dear editor,With the advancements in computer vision applications, the image defogging methods have received a lot of consideration. Defogging methods are extensively utilized in civil and military areas such as target detection, traffic surveillance,remote sensing. Therefore, the development of visibility restoration models has become a task of great interest and *** and Kumar [1] have proved that the dark

关键词： image Single image defogging by gain gradient image filter

Six weeks into the 2019 coronavirus disease outbreak:it is time to consider strategies to impede the emergence of new zoonotic infections

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Chinese Medical Journal 2020年第9期133卷 1118-1120页

作者： vijay Harypursat Yao-Kai Chen Division of Infectious Diseases Chongqing Public Health Medical CenterChongqing 400036China

Coronaviruses have in the past been known to be the etiologic agents of mild upper respiratory infections in humans,similar to the ubiquitous and relatively benign"common cold"-type upper respiratory illnesses induced by the human rhinoviruses in adults and *** to the severe acute respiratory syndrome(SARS)outbreak in China 2003,and the Middle East respiratory syndrome(MERS)outbreak in the Middle East in 2012,global concerns regarding the pathogenicity and epidemic/pandemic potential of novel human coronaviruses began to emerge,with some experts predicting that novel coronaviruses could likely again cross the species barrier and present humans with future pandemic-potential infections.[1]These concerns have proven prescient with the emergence,late in 2019,of the 2019 coronavirus disease(COVID-19)or novel coronavirus pneumonia.

关键词： infections acute Middle