检索结果-南通市图书馆

Effect of Aerobic Exercise on protein Expression in Muscle of Obese Mexican Adolescents: A proteomic and Bioinformatic Analysis

引用

Natural Science 2014年第9期6卷 641-650页

作者： Maciste H. Macías-Cervantes Juan M. Guzmán-Flores Katya vargas-Ortiz Francisco J. Díaz-Cisneros Joel Ramírez-Emiliano victoriano pérez-vázquez Departmento de Ciencias Aplicadas al Trabajo División de Ciencias de la Salud Universidad de Guanajuato León México Departmento de Ciencias Médicas División de Ciencias de la Salud Universidad de Guanajuato León México

The beneficial effects of exercise have been recognized for many years yet the molecular mechanisms by which exercise show benefits on health are still elusive. A combination of experimental and bioinformatics approaches can be an invaluable tool to increase the cellular understanding of the molecular mechanisms that underlie the aerobic exercise in obese adolescents. Muscle skeletal proteins were separated by 2D-pAGE and changes in protein expression were revealed by ImageMaster 2D platinum analysis software. proteins with expression changes after aerobic exercise were identified by comparison with 2D maps from SWISS-2DpAGE and interactions of proteins were analyzed with STRING and DAvID databases. After aerobic exercise, all participants decreased glucose, insulin, total cholesterol, body mass index and waist circumference. proteomic differential analysis revealed 10 overexpressed proteins after aerobic training, which correspond to carbonic anhydrase III, beta enolase, creatine kinase, ATp synthase beta subunit, aldolase A, glyceraldehyde-3-phosphate dehydrogenase, triosephosphate isomerase, pyruvate kinase, lactate dehydrogenase and adenylate kinase. Exercise increased glycolysis and oxidative phosphorylation pathways, which is likely to be regulated by ubiquitin c protein. In conclusion, our analysis suggested that obese adolescents show changes in their body mass index, waist circumference and serum glucose after aerobic exercise through improved protein expression patterns that aid, especially, glucose metabolism and increase the oxidative phosphorylation. The most likely explanation for the observed pattern is that ubiquitin c protein keeps the glycolytic enzymes bound within skeletal muscle, obtaining a non-degradative role in cell signaling.

关键词： Glycolysis Oxidative phosphorylation Ubiquitin C protein proteomics Exercise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

physical activity and cardiovascular risk factors in university students in the city of Leon, Mexico

引用

Health 2013年第11期5卷 1861-1865页

作者： Maciste H. Macías-Cervantes victoriano pérez-vázquez Antonio E. Rivera-Cisneros Andrés Martínez-Rivera Joel Ramírez-Emiliano Carlos Kornhauser Clínica SAIN 2000 University DeLa Salle Bajío León México Department of Medical Sciences University of Guanajuato León México Division of Health Sciences University of Guanajuato León México

Objectives: Recent changes in life style have increased obesity, smoking and sedentary habits in the entire population. Obesity and overweight frequency have trebled in Mexico in the last few decades. The presence and frequency of cardiovascular risk factors were determined in students at the Universidad DeLa Salle Bajío, both newly admitted and in advanced years. Material and methods: Anthropometric variables, serum glucose, total cholesterol levels, blood hemoglobin and hematocrit were obtained and assessed in 4814 students, 1507 recently admitted and 1507 advanced students. Results: The prevalence of obesity was 15.3%, sedentariness 33.8%, hypercholesterolemia 8.16%, smoking habits 15.8%, and alcohol consumption 12.1%. Body mass index (BMI) (23.5 ± 4 vs. 22.7 ± 4), waist/ abdomen index (0.84 ± 0.06 vs. 0.83 ± 0.06) and serum cholesterol (3.54 mmol/L ± 0.79 vs. 3.98 mmol/L ± 0.77) were greater in the advanced students

关键词： Cardiovascular Risk Factors University Students Smoking physical Activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intense exercise increases HDL level in children regardless of body weight

引用

Health 2013年第12期5卷 1949-1953页

作者： Daniel Romero-Gamboa victoriano pérez-vázquez Katya vargas-Ortiz Francisco J. Díaz-Cisneros Claudia Martínez-Cordero Maciste H. Macías-Cervantes Apply Work Science Department Health Science Division University of Guanajuato León México Department of Medical Sciences Health Science Division University of Guanajuato León México Hospital Regional de Alta Especialidad del Bajio León México

Childhood obesity seems to be increasing at a disturbing rate. Exercise and diet are recommended to combat this epidemic. Light and moderate physical activity is associated with health benefits, whereas intense physical activity is associated with normal BMI and low cardiovascular risk. The aim of this study was to assess the metabolic response to a graded exercise test (GXT) in children with different body weight. Eight boys and nine girls underwent a GXT on a treadmill according to Blake protocol. These children were 7-9 years old. The participants were divided into three groups according to their body weight: normal-weight, overweight, and obese. After GXT, lactate and HDL levels increased significantly in all three groups

关键词： Obesity Insulin physical Activity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dyslipidaemias and physical Activity in Children with Cerebral palsy

引用

Health 2014年第10期6卷 1030-1037页

作者： Maciste Habacuc Macías-Cervantes Martha Susana Arriola-Nunez Francisco J.Díaz-Cisneros Antonio E.Rivera-Cisneros Jose María de la Roca-Chiapas victoriano pérez-vázquez Departamento de Ciencias Medicas Division de Ciencias de la SaludUniversidad de GuanajuatoLeonMexico Universidad del valle de Atemajac GuadalajaraMexico Departamento de Ciencias Aplicadas al Trabajo Division de Ciencias de la SaludUniversidad de GuanajuatoLeonMexico Division de Ciencias de la Salud Universidad de GuanajuatoLeonMexico Departamento psicología Division de Ciencias de la SaludUniversidad de GuanajuatoLeonMexico

Cerebral palsy people present movement difficulty and are liable to develop disorders associated with sedentary lifestyles such as dyslipidaemias and cardiovascular diseases. This study aimed to assess physical activity and the prevalence of lipid abnormalities in 29 children with cerebral palsy who were being treated in two care centers in the state of Guanajuato, Mexico. physical activity was calculated using a survey. Blood glucose, total cholesterol, HDL-C, LDL-C, and triglycerides were determined. Forty-eight percent had at least one dyslipidaemia. The most frequent lipid abnormalities were hypertriglyceridaemia and low HDL-C. High prevalence of the atherogenic index was found. The physical activity of children was lower than recommended for their age. Sixty-two percent attended rehabilitation sessions, 10% attended sports classes, 14% rehabilitation plus sports and 14% did not engage in intentional physical activity. There is high frequency of lipid disorders in children with cerebral palsy. Greater participation in physical activity should be promoted in children to improve their metabolic status and quality of life, especially those suffering from cerebral palsy.

关键词： Hypertriglyceridaemia HDL-C Atherogenic Index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

引用

Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impacts of pI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

引用

Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(pI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the pI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/pI3K/AKT/connexin 43,and Notch/pI3K/AKT *** targeting the inactivation of the pI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the pI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dendritic spine degeneration:a primary mechanism in the aging process

引用

Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

引用

Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.v.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies

引用

Neural Regeneration Research 2025年第1期20卷 181-183页

作者： Francesco Ferrini Esri H.Juárez Adalberto Merighi Department of veterinary Sciences University of TurinGrugliascoTOItaly Department of psychiatry and Neuroscience UniversitéLavalQuébec CityQCCanada

Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical *** have gained significant attention in regenerative medicine due to their ability to modulate the immune system and favor tissue *** enrich the medium in which they are cultivated with a broad range of bioactive molecules,including growth factors,cytokines,chemokines,enzymes,nucleic acids,and extracellular vesicles that collectively compose the MSC *** increasing number of pre-clinical studies suggest that delivering in vivo an MSC-conditioned medium(i.e.,the medium collected from MSC cultures after at least 3 days of exposure)exerts neuroprotective and anti-inflammatory effects in a variety of neurological conditions.

关键词： protective clinical collective

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Semantic Segmentation of Lumbar vertebrae Using Meijering U-Net(MU-Net)on Spine Magnetic Resonance Images

引用

Computer Modeling in Engineering & Sciences 2025年第1期142卷 733-757页

作者： Lakshmi S v v Shiloah Elizabeth Darmanayagam Sunil Retmin Raj Cyril Department of Computer Science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar Spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(pA),98.66%of dice similarity coefficient(DSC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：