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Extended criteria brain-dead organ donors:Prevalence and impact on the utilisation of livers for transplantation in Brazil

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World Journal of Hepatology 2023年第2期15卷 255-264页

作者： victoria s braga Amanda P C s Boteon Heloisa B Paglione Rafael A A Pecora Yuri L Boteon Faculdade Israelita de Ciências da saúde Albert Einstein Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Transplant Centre Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil

BACKGROUND Despite its association with higher postoperative morbidity and mortality,the use of extended criteria donor(ECD)livers for transplantation has increased globally due to the high demand for the *** To investigate the prevalence of ECD in donation after brain death(DBD)and its impact on organ acceptance for *** Retrospective analysis of DBD organ offers for liver transplantation between 2017 and 2020 in a high-volume transplant *** incidence of the Eurotransplant risk factors to define an ECD(ET-ECD)among DBD donors and the likelihood of organ acceptance over the years were *** relationship between organ refusal for transplantation,the occurrence,and the number of ET-ECD was assessed by simple and multiple logistic regression *** A total of 1619 organ donors were *** these,78.31%(n=1268)had at least one ET-ECD *** was an increase in the acceptance of ECD DBD organs for transplantation(1 criterion:from 23.40%to 31.60%;2 criteria:from 13.10%to 27.70%;3 criteria:From 6.30%to 13.60%).For each addition of one ETECD variable,the estimated chance of organ refusal was 64.4%higher(OR 1.644,95%CI 1.469-1.839,Pserum sodium>165 mmol/L(P=0.310),all ET-ECD criteria increased the estimated chance of organ refusal for *** A high prevalence of ECD DBD was *** the increase in their utilisation,the presence and the number of extended donor criteria were associated with an increased likelihood of their refusal for transplantation.

关键词： Liver transplantation Extended criteria donors Donation after brain death Organ donation

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Current and future therapeutic strategies for the treatment of retinal neurodegenerative diseases

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Neural Regeneration Research 2022年第1期17卷 103-104页

作者： victoria Maneu Pedro Lax Nicolás Cuenca Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain

The complex and mostly multiple and unknown aetiology of neurodegenerative diseases always give way to an intricate scenario of dying tissue that involves multiple cell mediators and cell *** neurodegenerative diseases of the central nervous system(CNs)share common mechanisms,regardless their origin:oxidative stress,neuroinflammation and cell ***,retinal degenerative diseases,with or without a genetic cause,as retinitis pigmentosa(RP),glaucoma,agerelated macular degeneration(AMD)or diabetic retinopathy(DR)do not differ in their basic mechanisms of cell death neither one to another,nor from those observed in other CNs diseases as Parkinson’s or Alzheimer’s(Cuenca et al.,2014).Indeed,the therapeutic findings should be able to be more or less easily extrapolated between these conditions,as far as they are directed to common dartboards.

关键词： diseases degenerative therapeutic

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Contrast-enhanced harmonic endoscopic ultrasound imaging: Basic principles, present situation and future perspectives

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World Journal of Gastroenterology 2014年第42期20卷 15549-15563页

作者： María-victoria Alvarez-sánchez Bertrand Napoléon Department of Gastroenterology H?pital Privé Jean Mermoz Department of Gastroenterology Complejo Hospitalario de Pontevedra

Over the last decade, the development of stabilised microbubble contrast agents and improvements in available ultrasonic equipment, such as harmonic imaging, have enabled us to display microbubble enhancements on a greyscale with optimal contrast and spatial resolution. Recent technological advances made contrast harmonic technology available for endoscopic ultrasound(EUs) for the first time in 2008. Thus, the evaluation of microcirculation is now feasible with EUs, prompting the evolution of contrast-enhanced EUs from vascular imaging to images of the perfused tissue. Although the relevant experience is still preliminary, several reports have highlighted contrast-enhanced harmonic EUs(CHEUs) as a promising noninvasive method to visualise and characterise lesions and to differentiate benign from malignant focal lesions. Even if histology remains the gold standard, the combination of CH-EUs and EUs fine needle aspiration(EUs-FNA) can not only render EUs more accurate but may also assist physicians inmaking decisions when EUs-FNA is inconclusive,increasing the yield of EUs-FNA by guiding the puncture with simultaneous imaging of the *** development of CH-EUs has also opened up exciting possibilities in other research areas,including monitoring responses to anticancer chemotherapy or to ethanolinduced pancreatic tissue ablation,anticancer therapies based on ultrasound-triggered drug and gene delivery,and therapeutic adjuvants by contrast ultrasound-induced *** harmonic imaging is gaining popularity because of its efficacy,simplicity and noninvasive nature,and many expectations are currently resting on this *** its potential is confirmed in the near future,contrast harmonic imaging will become a standard practice in EUs.

关键词： Microbubbles Contrast agents Contrast-enhanced harmonic endoscopic ultrasound Pancreatic tumour Gastrointestinal submucosal tumour

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Review of endoscopic radiofrequency in biliopancreatic tumours with emphasis on clinical benefits, controversies and safety

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World Journal of Gastroenterology 2016年第37期22卷 8257-8270页

作者： María-victoria Alvarez-sánchez Bertrand Napoléon Department of Gastroenterology Complejo Hospitalario Universitario de Pontevedra Instituto de Investigación Sanitaria Galicia Sur Department of Gastroenterology Ramsay Générale de Santé Private Hospital Jean Mermoz

Most pancreatic cancers and extrahepatic cholangiocarcinomas are unresectable at the time of diagnosis, and even in case of a resectable cancer, for elderly or patients with coexistent comorbidities, surgery is not an option. Current treatment alternatives in these scenarios are very limited. Biliary stenting with selfexpanding metal stents(sEMs) is the mainstay palliative treatment of biliary obstruction due to unresectable pancreatic cancer or cholangiocarcinoma. Nevertheless, more than 50% of sEMs become occluded after 6 mo due to tumour over- and ingrowth, leading to hospital readmissions and reinterventions that significantly impair quality of life. Regimes of chemotherapy or chemoradiotherapy also provide minimal survival benefits. Therefore, novel therapies are eagerly awaited. Radiofrequency(RF) energy causes coagulative necrosis leading to local destruction of the accessed malignant tissue and has an established role in the treatment of malignancies in several solid organs, especially liver cancers. However, pancreatic and extrahepatic biliary cancers are not easily accessed by a percutaneous route, making the procedure dangerous. Over the past five years, the development of dedicated devices compatible with endoscopic instruments has offered a minimally invasive option for RF energy delivery in biliopancreatic cancers. Emerging experience with endoscopic RF ablation(RFA) in this setting has been reported in the literature, but little is known about its feasibility, efficacy and safety. A literature review makes it clear that RFA in biliopancreatic tumours is feasible with high rates of technical success and acceptable safety profile. Although available data suggest a benefit of survival with RFA, there is not enough evidence to draw a firm conclusion about its efficacy. For this reason, prospective randomized trials comparing RFA with standard palliative treatments with quality-of-life and survival endpoints are required. Anecdotal reportshave also highlig

关键词： Radiofrequency ablation Pancreatic tumour Endobiliary radiofrequency Cholangiocarcinoma Biliary stricture

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New horizons in the endoscopic ultrasonography-based diagnosis of pancreatic cystic lesions

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World Journal of Gastroenterology 2018年第26期24卷 2853-2866页

作者： María-victoria Alvarez-sánchez Bertrand Napoléon Instituto de Investigación sanitaria Galicia sur Complejo Hospitalario Universitario de Pontevedra Department of Gastroenterology Ramsay Générale de Santé Private Hospital Jean Mermoz

Pancreatic cystic lesions(PCLs) are increasingly being identified because of the widespread use of highresolution abdominal imaging. These cysts encompass a spectrum from malignant disease to benign lesions, and therefore, accurate diagnosis is crucial to determine the best management strategy, either surgical resection or surveillance. However, the current standard of diagnosis is not accurate enough due to limitations of imaging and tissue sampling techniques, which entail the risk of unnecessary burdensome surgery for benign lesions or missed opportunities of prophylactic surgery for potentially malignant PCLs. In the last decade, endoscopic innovations based on endoscopic ultrasonography(EUs) imaging have emerged, aiming to overcome the present limitations. These new EUs-based technologies are contrast harmonic EUs, needle-based confocal endomicroscopy, through-the-needle cystoscopy and through-the needle intracystic biopsy. Here, we present a comprehensive and critical review of these emerging endoscopic tools for the diagnosis of PCLs, with a special emphasis on feasibility, safety and diagnostic performance.

关键词： Intraductal papillary mucinous neoplasm Pancreatic cystic lesions Endoscopic ultrasonography Confocal endomicroscopy Mucinous cystadenoma Through-the-needle cystoscopy serous cystadenoma Through-the-needle forceps biopsy Contrast harmonic endoscopic ultrasonography

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Molecular mechanisms underpinning sarcomas and implications for current and future therapy

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signal Transduction and Targeted Therapy 2021年第7期6卷 2135-2153页

作者： victoria Damerell Michael sPepper sharon Prince Division of Cell Biology Department of Human BiologyFaculty of Health SciencesUniversity of Cape TownObservatoryCape TownSouth Africa lnstitute for Cellular and Molecular Medicine Department of ImmunologySAMRC Extramural Unit for Stem Research and TherapyFaculty of Health SciencesUniversity of PretoriaPretoriaSouth Africa

sarcomas are complex mesenchymal neoplasms with a poor *** clinical management is highly challenging due to their heterogeneity and insensitivity to current *** there have been advances in understanding specific genomic alterations and genetic mutations driving sarcomagenesis,the underlying molecular mechanisms,which are likely to be unique for each sarcoma subtype,are not fully *** is in part due to a lack of consensus on the cells of origin,but there is now mounting evidence that they originate from mesenchymal stromal/stem cells(MsCs).To identify novel treatment strategies for sarcomas,research in recent years has adopted a mechanism-based search for molecular markers for targeted therapy which has included recapitulating sarcomagenesis using in vitro and in vivo MsC *** review provides a comprehensive up to date overview of the molecular mechanisms that underpin sarcomagenesis,the contribution of MsCs to modelling sarcomagenesis in vivo,as well as novel topics such as the role of epithelial-to-mesenchymal-transition(EMT)/mesenchymal-to-epithelial-transition(MET)plasticity,exosomes,and microRNAs in *** also reviews current therapeutic options including ongoing pre-clinical and clinical studies for targeted sarcoma therapy and discusses new therapeutic avenues such as targeting recently identified molecular pathways and key transcription factors.

关键词： sarcoma neoplasms alterations

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Carbon Materials in Perovskite solar Cells: Prospects and Future Challenges

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Energy & Environmental Materials 2019年第2期2卷 107-118页

作者： victoria Ferguson s.Ravi P.silva Wei Zhang Advanced Technology Institute(ATI) University of SurreyGU27XHUK

Metal halide perovskite solar cells are emerging candidates for nextgeneration thin-film photovoltaic devices with the potential for extremely low fabrication cost and high power conversion *** solar cells have demonstrated a rapid development in device performance over the last decade,from an initial 3.81%to a most recently certified 24.2%,though the challenges of long-term stability and lead toxicity still *** materials,ranging from zero-dimensional carbon quantum dots to threedimensional carbon black materials,are promising candidates for the enhancement of both efficiency and stability of perovskite solar cells,offering unique advantages for incorporation into various device *** this review article,we present a concise overview of important and exciting advancements of perovskite solar cells that incorporate different dimensions of carbon material in their device architectures in an effort to simultaneously improve device performance and long-term *** also discuss the major advantages and potential challenges of each technique that has been developed in the most recent ***,we outline the future opportunities toward more efficient and stable perovskite solar cells utilizing carbon materials.

关键词： carbon materials long-term stability metal halide perovskite photovoltaics

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Distribution of the related weevil species sitophilus oryzae and s. zeamais in Brazil

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Insect science 2013年第6期20卷 763-770页

作者： Alberto s. Correa Luiz Orlando de Oliveira Lucas s. braga Raul Narciso C. Guedes Departamento de Entomologia Universidade Federal de Vicosa Vicosa Brazil Departamento de Bioquimica e Biologia Molecular Universidade Federal de Vicosa Vicosa Brazil

The genus sitophilus （Coleoptera： Curculionidae） encompasses species of great economic importance as stored grain pests worldwide. Among these species, the maize and the rice weevils （sitophilus zeamais and sitophilus oryzae, respectively） are partic- ularly important in warmer climates. These two weevils exhibit closely morphological and ecological resemblance making difficult their proper identification and recognition of their distribution in grain-producing regions. Both species are recorded in south America and particularly in Brazil, but their respective distribution and prevalence were not yet assessed in the region. Therefore, several insect samples throughout Brazil were collected and subjected to morphological identification using male genitalia and also using molec- ular identification with species-specific primers designed for clear recognition of both the species. The primers were designed for the specific amplification of a gene fragment of the cytochrome oxidase subunit I, which exhibited high specificity during our prelimi- nary experiments with insects from six populations of known species （either s. zeamais or s. oryzae）. Both identification strategies provided the same results indicating preva- lence of the maize weevil s. zeamais throughout the country. Two hypotheses may explain such prevalence：（i） the likely host preference ofs. zeamais for maize because this is the most cultivated cereal in Brazil, and （ii） the prevalence ofs. zeamais in tropical regions as compared with s. oryzae, which is more disseminated in subtropical and temperate regions.

关键词： cytochrome oxidase subunit I distribution maize weevil rice weevil south America

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Modelling the nesting-habitat of threatened vulture species in the caucasus:An ecosystem approach to formalising environmental factors in species distribution models

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Avian Research 2023年第4期14卷 572-585页

作者： Rustam Pshegusov victoria Chadaeva Tembotov Institute of Ecology of Mountain Territories of Russian Academy of science I.Armand Str.37а360051NalchikRussia

Abiotic factors play an important role in species localisation,but biotic and anthropogenic predictors must also be considered in distribution modelling for models to be biologically *** this study,we formalised the biotic predictors of nesting sites for four threatened Caucasian vultures by including species distribution models(wild ungulates,nesting tree species)as biotic layers in the vulture Maxent *** was applied in the R dismo package and the best set of the model parameters were defined in the R ENMeval *** metrics were continuous Boyce index,Akaike's information criterion,the area under receiver operating curve and true skill *** also calculated and evaluated the null *** density estimation method was applied to assess the overlap of vulture ecological niches in the environmental *** accessibility of anthropogenic food resources was estimated using the Path Distance measure that considers elevation *** availability of pine forests(scots Pine)and wild ungulates(Alpine Chamois and Caucasian Goat)contributed the most(29.6%and 34.3%)to Cinereous Vulture(Aegypius monachus)nesting site *** ungulate distribution also contributed significantly(about 46%)to the Bearded Vulture(Gypaetus barbatus)*** scavenger nests in the highlands of the Caucasus at a minimum distance of 5–10 km from anthropogenic *** contrast,livestock as a food source was most important in colony distribution of Griffon Vulture(Gyps fulvus).The contribution of distances to settlements and agricultural facilities to the model was 45%.The optimal distance from Egyptian Vulture(Neophron percnopterus)nesting sites to settlements was only 3–10 km,to livestock facilities no more than 15 km with the factor contribution of about 57%.Excluding the wild ungulate availability,the ecological niches of studied vultures overlapped *** similar foraging and nesting requirements,Caucasian vultures are no

关键词： Caucasian vultures Ecological niche differentiation Maxent Nesting sites species distribution models

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