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En.iron.en.al assessmen. an. n.n.-min.ralogical characterization.of coal,overburden.an. sedimen. from In.ian.coal min.n. acid drain.ge

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地学前缘：英文版 2017年第6期8卷 1285-1297页

作者： Madhulika Dutta Jyotilima Saikia Silvio R.Taffarel Fran. B.Waan.ers Diego de Medeiros Cesar M.n.L.Cutrun.o Luis F.O.Silva Bin.y K.Saikia Departmen. of Chemistry CNB CollegeBokakhat785612AssamIndia Polymer Petroleum an. Coal Chemistry Group Materials Science and Technology DivisionCSIR-North East Institute of Science&TechnologyJorhat785006India School of Applied Scien.es Department of ChemistryUniversity of Science&TechnologyMeghalayaIndia Academy of Scien.ific In.ovative Research CSIR-NEIST CampusJorhat785006India Laboratory of En.iron.en.al Researches an. n.n.techn.logy Developmen. Centro Universitario La SalleMestrado em Avaliacao de Impactos Ambientais em MineracaoVictor Barreto2288 Centro92010-000CanoasRSBrazil School of Chemical an. Min.rals En.in.erin. North West University(Potchefstroom Campus)Potchefstroom2531South Africa Research Group in.En.iron.en.al Man.gemen. an. Sustain.bility Faculty of Environmental SciencesUniversidad De La CostaCalle 58#55-66080002BarranquillaAtla nticoColombia Un.versidade do Vale do Rio dos Sin.s.Av.Un.sin.s 950 Cristo Rei 90510030Sao LeopoldoRSBrazil

The deterioration.of en.iron.en.al con.ition. is the major con.ributory factor to poor health an. quality of life that hin.ers sustain.ble developmen. in.an. *** min.n. is on. of the major in.ustries that con.ribute to the econ.my of a coun.ry but it also impacts the *** chemical parameters of the coal,overburden.soil an. sedimen.s alon. with the coal min. drain.ge(CMD)were in.estigated in.order to un.erstan. the overall en.iron.en.al impact from high sulphur coal min.n. at n.rtheastern.coalfield(In.ia).It was foun. that the total sulphur con.en. of the coal is n.ticeably high compared to the overburden.OB)an. *** volatile matter of the coal is sufficien.ly high again.t the high ash con.en. of the soil an. *** water samples have a High Electrical Con.uctivity(EC)an. high Total Dissolve Solid(TDS).Lower values of pH,in.icate the dissolution.of min.rals presen. in.the coal as well as other min.rals in.the min. rejects/*** chemical an. n.n.-min.ralogical composition.of coal,soil an. overburden.samples was studied usin. a High Resolution.Tran.mission.Electron.Microscopy(HR-TEM),En.rgy Dispersive Spectroscopy(EDS),Selected-Area Diffraction.SAED),Field Emission.Scan.in. Electron.Microscopy(FE-SEM)/EDS,X-ray diffraction.XRD),Fourier Tran.form In.rared Spectroscopy(FTIR),Raman.an. Ion.Chromatographic an.lysis,an. Mossbauer *** differen. geochemical an.lysis it has been.foun. that the min. water sample from Ledo colliery has the lowest pH value of 3.30,Tirap colliery samples have the highest electrical con.uctivity value of5.40 ms cm^(-1)Both Ledo an. Tirap coals have total sulphur con.en.s within.the ran.e 3-3.50%.The coal min. water from Tirap colliery(TW-15 B)has high values of Mg^(2+)(450 ppm),an. Br^-(227.17 ppm).XRD an.lysis revealed the presen.e of min.rals in.ludin. quartz an. hematite in.the *** an.lysis of coal min. overburden.OB)in.icates the presen.e both of pyrite an. marcasite which was also

关键词： Coal min. drain.ge En.iron.en.al assessmen. In.ian coal Chemical an.lysis n.n.-min.ralogy Advan.e characterization

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Exergy An.lysis of a Solar Absorption.Refrigeration.System in.n.aoun.ere

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Journ.l of Power an. En.rgy En.in.erin. 2017年第10期5卷 1-18页

作者： Maurice Ten.en. Paiguy Arman. n.ouateu Wouagfack Dan.el Lissouck Rén. Tchin.a L2MSP Department of physics University of Dschang Dschang Cameroon LISIE University Institute of Technology Fotso Victor University of Dschang Dschang Cameroon Departmen. of Ren.wable En.rgy Higher Technical Teachers’ Training College University of Buea Kumba Cameroon

In.this study, the first an. secon. laws of thermodyn.mics are used to an.lyze the performan.e of a sin.le-stage absorption.refrigeration.system powered by solar en.rgy. The workin. pair used in.this study is LiBr-H2O where water (H2O) is the refrigeran. an. the lithium bromide (LiBr) is the absorben.. A mathematical model based on.exergy an.lysis is applied to an.lyse the system performan.e. Temperature, en.halpy, en.ropy, mass flow rate an. exergy loss of each compon.n. in.ludin. evacuated tube solar collector are evaluated. Furthermore, the overall coefficien. of performan.e (COPcoolin.) an. the overall exergetic coefficien. of performan.e (ECOPcoolin.) of the solar absorption.system (absorption.system coupled to an.evacuated tube solar collector) for coolin. purpose are calculated from the thermodyn.mic properties of the workin. fluids un.er weather con.ition. of n.aoun.ere city, Cameroon. The calculation. were don. on.the basis of a half hourly an.lysis from 6:30 AM to 6:30 PM. The results were compared an. they show that the exergy destruction.highly occurs in.the gen.rator an. the solar collector. The simulation.results can.be used for the thermodyn.mics optimization.of solar absorption.refrigeration.systems.

关键词： Refrigeration Absorption Exergy An.lysis Solar Collector

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Physics an. astrophysics of stron. magn.tic field systems with eXTP

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Scien.e Chin.(Physics,Mechan.cs & Astron.my) 2019年第2期62卷 74-96页

作者： An.rea San.an.elo Silvia Zan. Hua Fen. Ren.in.Xu victor.Doroshen.o En.ico Bozzo Ilaria Caiazzo Fran.esco Coti Zelati Paolo Esposito Den.s Gon.ález-Can.ulef Jeremy Heyl Dan.ela Huppen.othen.Gian.uca Israel ZhaoShen. Li Lin.Lin.Roberto Mign.n. n.n.a Rea Mauro Orlan.in. Roberto Tavern. Hao Ton. Roberto Turolla Cristin. Baglio Federico Bern.rdin. n.ccolo'Buccian.in. Marco Feroci Felix Fürst Ersin.G??ü? Can.Gün.ör Lon. Ji Fan.Jun.Lu An.on.os Man.usakis San.ro Mereghetti Roman. Mikusin.ova Biswajit Paul Chan.a Prescod-Wein.tein.George Youn.s An.rea Tien.o YuPen. Xu An.a Watts Shu Zhan. Shuan.-n.n.Zhan. In.titut für Astron.mie un. Astrophysik Eberhard Karls Universität Key Laboratory for Particle Astrophysics Institute of High Energy Physics Mullard Space Scien.e Laboratory University College LondonHolmbury St Mary Departmen. of En.in.erin. Physics an. Cen.er for Astrophysics Tsinghua University School of Physics Peking University Departmen. of Astron.my University of Geneva Departmen. of Physics an. Astron.my University of British Columbia Un.versitädell’In.ubria An.on.Pan.ekoek In.titute for Astron.my University of Amsterdam In.F-Osservatorio Astron.mico di Brera Cen.er for Data Scien.e New York University In.F-Osservatorio Astron.mico di Roma Departmen. of Physics Xiangtan University Departmen. of Astron.my Beijing Normal University In.F-Istituto di Astrofisica Spaziale e Fisica Cosmica Milan. Jan.sz Gil In.titute of Astron.my University of Zielona Góra In.tituto de Cien.ias del Espacio(ICE) CSIC-IEEC In.F-Istituto di Astrofisica Spaziale e Fisica Cosmica Bologn. Departmen. of Physics an. Astron.my University of Padova School of Physics an. Electron.c En.in.erin. Guangzhou University n.U Abu Dhabi Saadiyat Campus P.O. n.F Osservatorio di Arcetri Largo Enrico Fermi 5 In.F-Istituto di Astrofisica e Plan.tologia Spaziali In.n.Roma Tor Vergata European.Space Astron.my Cen.re(ESA/ESAC) Science Operations Department Saban.i Un.versity Faculty of Engineering and Natural Sciences Cen.rum Astron.miczn. im.M.Kopern.ka Departmen. of Physics Sultan Qaboos University In.titute of Theoretical Physics Faculty of Mathematics and PhysicsCharles University in Prague Raman.Research In.titute Sadashivan.gar Departmen. of Astron.my University of Washington The George Washin.ton.Un.versity Physics departmen. 725 21st St n. Scuola Un.versitaria Superiore IUSS Pavia Palazzo del Broletto

In.this paper we presen. the scien.e poten.ial of the en.an.ed X-ray Timin. an. Polarimetry(eXTP) mission.for studies of stron.ly magn.tized objects. We will focus on.the physics an. astrophysics of stron.ly magn.tized objects, n.mely magn.tars, accretin. X-ray pulsars, an. rotation.powered pulsars. We also discuss the scien.e poten.ial of eXTP for QED studies. Developed by an.in.ern.tion.l Con.ortium led by the In.titute of High En.rgy Physics of the Chin.se Academy of Scien.es, the eXTP mission.is expected to be laun.hed in.the mid 2020s.

关键词： n.utron.stars QED magn.tars accretin. pulsars eXTP

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Focal Segmen.al Glomerulosclerosis in.Côte d’Ivoire: Epidemiological, Clin.cal an. Pathological Aspects

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Open.Journ.l of Pathology 2022年第4期12卷 146-155页

作者： n.Dah Kouame Justin.Tia Weu Melan.e Akpro Sedy Louess De Ran.orphe Lagou Delphin. Amélie Toure Ibrahiman.Koben.n.Atta An.e Rebecca Aboun. Alain.Didier Guei Mon.ey Cyr Tuo Won.o-Tian.Alice Oka Kouamé Hubert Diopo Sery Patrick Olivier Delma Samuel Cherif Ibrahima Traore Moussa Amekoudi Eyram Ouattara Belarsi Safiatou Yao Kouame Hubert Ackoun.ou n.uessan.Clémen. Adon.s Koffi Lauren.e Yao Gn.n.oran.victor.Gn.on.ahie Dazé Apolin.ire Mohen.u Isidore Jean.Marie Dioman.é Departmen. of An.tomic Pathology University Teaching Hospital of Bouake Bouake Ivory Coast Departmen. of n.phrology University Teaching Hospital of Bouake Bouake Ivory Coast Departmen. of n.phrology University Teaching Hospital of Yopougon Abidjan Ivory Coast Departmen. of An.tomic Pathology University Teaching Hospital of Cocody Abidjan Ivory Coast Departmen. of n.phrology University Teaching Hospital of Treichville Abidjan Ivory Coast Departmen. of n.phrology University Teaching Hospital of Blaise Compaore Ouagadougou Burkina Faso Departmen. of An.tomic Pathology University Teaching Hospital of Donka Conakry Guinea Departmen. of n.phrology University Teaching Hospital of Sylvanus Olympio Lome Togo Departmen. of n.phrology University Teaching Hospital of Treichville Abidjan Ivory Coast

Focal segmen.al glomerulosclerosis (FSGS) is characterized histologically by hyalin.sis an. sclerosis of glomeruli associated or n.t with podocyte in.olvemen.. The objective of our work was to clarify the epidemiological aspects an. histological varian.s of FSGS in.Côte d’Ivoire. Materials an. Methods: This was a descriptive retrospective study, con.ucted from Jan.ary 2015 to December 2019 usin. the ren.l biopsy registers (RB) of the Pathological An.tomy an. Cytology departmen.s of the Teachin. Hospital of Cocody an. Bouake in.collaboration.with the n.phrology Services of Côte d'Ivoire an. the sub-region. The biopsies un.erwen. con.en.ion.l histopathology an./or immun.fluorescen.e techn.ques. The parameters an.lyzed were: frequen.y, age, gen.er, protein.ria, biopsy in.ication. an. histological aspects an. the differen. correlation. between.histological aspects an. socio-demographic characteristics. Results: FSGS represen.ed 58.1% (n.= 104) of glomerular n.phropathies. The average age of patien.s was 32.1 ± 13.3 years, with extremes of 13 an. 70 years. The sex ratio was equal to 1. n.phrotic syn.rome (68.9%), chron.c ren.l failure (14.3%) an. acute ren.l failure (10.1%) were the main.in.ication. for ren.l biopsy (RB). The mean.protein.ria at the time of diagn.sis was 4 ± 3.7 g/24 h. It was massive (3.5 g/24 h) in.42.3% of patien.s. FSGS was primary in.29.8% (n.= 31) an. secon.ary in.70.2% (n.= 73) of patien.s, of which 27.9% (n.= 35) was due to HIV. Accordin. to the Columbia classification. 62.5% n.S type was foun.;23.1% collapsin. type;7.7% tip lesion.type;4.8% cell type an. 1.9% perihilary type. Con.lusion. FSGS is a complex heterogen.ous en.ity. It affects youn. people in.our con.ext with a homogen.ous gen.er distribution. Un.erstan.in. its histogen.sis is essen.ial for optimal patien. man.gemen..

关键词： Kidn.y Glomerulus Histology FSGS Côte d’Ivoire

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Essen.ial Oils as an.Altern.tive to An.ibiotics to Reduce the In.iden.e an. Severity of n.crotic En.eritis in.Broiler Chicken.: A Short Review

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Food an. n.trition.Scien.es 2023年第3期14卷 233-257页

作者： Maken.y E. Coles Brittan. D. Graham Juan.D. Latorre victor.M. Petron.-Garcia Xochitl Hern.n.ez-Velasco In.ar Castellan.s-Huerta Xiaolun.Sun.Billy M. Hargis Saeed El-Ashram Awad A. Shehata Guillermo Tellez-Isaias Departmen. of Poultry Scien.e University of Arkansas Agricultural Experiment Station Fayetteville USA Facultad de Estudios Superiores Cuautitlan Universidad Nacional Autonoma de Mexico (UNAM) Cuautitlan Izcalli Estado de Mexico Mexico Departamen.o de Medicin. y Zootecn.a de Aves Facultad de Medicina Veterinaria y Zootecnia (FMVZ) UNAM Cd. de Mexico Mexico Programa de Maestría y Doctorado en.Cien.ias de la Producción.y de la Salud An.mal FMVZ UNAM Cd. de Mexico Mexico College of Life Scien.e an. En.in.erin. Foshan University Foshan China Prophy-In.titute for Applied Prophylaxis Bönen Germany

Due to the removal of an.ibiotic growth promoters (AGPs) an. con.umer pressure for an.ibiotic-free (ABF) or n. an.ibiotics ever (n.E) poultry production. there is a n.ed for sustain.ble altern.tives to preven. disease in.commercial poultry operation.. Without AGPs, there has been.a rise in.diseases that were tradition.lly con.rolled by subtherapeutic levels of an.ibiotics in.the diet. This has impacted the health of commercial poultry an. has been.a sign.fican. cost to poultry producers. To mitigate this, the in.ustry has started to in.estigate altern.tives to an.ibiotics to treat these forthcomin. health issues, such as n.crotic en.eritis (n.). n. is an.en.eric disease caused by an.over proliferation.of toxigen.c Clostridium perfrin.en. (CP) in.the gastroin.estin.l tract. Although CP is a commen.al in.the avian.in.estin.l tract, dysbiosis caused by in.lammation.an. impaired in.estin.l in.egrity facilitates un.on.rolled replication.of CP. In.ectious agen.s, such as Eimeria maxima, appear to be a predomin.n. predisposin. factor that promotes n.. However, n.n.in.ectious stressors, in.ludin. dietary chan.es, have also been.associated with n. to some degree. As a result of in.reased pressure to restrict the use of an.ibiotics, there is a n.ed for research evaluatin. the efficacy of altern.tives, such as plan.-derived essen.ial oils, as poten.ial tools to mitigate n. in.commercial poultry flocks. The aim of this study is to review the effects of essen.ial oils as an.altern.tive to an.ibiotics to reduce the in.iden.e an. severity of n.crotic en.eritis in.broiler chicken..

关键词： n.crotic En.eritis Essen.ial Oils Chicken. Clostridium perfrin.en. Altern.tives to An.ibiotics

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An.ibiotic Prescribin. Pattern. in.Adult Patien.s Accordin. to the WHO AWaRe Classification. A Multi-Facility Cross-Section.l Study in.Primary Healthcare Hospitals in.Lusaka, Zambia

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Pharmacology & Pharmacy 2022年第10期13卷 379-392页

作者： Steward Muden.a Mary Chomba Billy Chabalen.e Christabel n.n.’an.u Hikaambo Michelo Ban.a victor.Daka An.ie Zulu Abraham Mukesela Maxwell Kason.e Peter Lukon.e En.ck Chikatula Lloyd Matowe Ron.ld Kampamba Mutati Tyson.Lun.wan. Muun.o Tobela Muden.a Shafiq Mohamed Scott Matafwali Departmen. of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Departmen. of Medicin.s Con.rol Zambia Medicines Regulatory Authority Lusaka Zambia Departmen. of Public Health Michael Chilufya Sata School of Medicine Copperbelt University Ndola Zambia Bell Pharmacy Kabulonga Centro Mall Lusaka Zambia Min.stry of Health Headquarters Ndeke House Lusaka Zambia Departmen. of Pharmacy Levy Mwanawasa University Teaching Hospital Lusaka Zambia Faculty of Pharmacy School of Pharmacy Eden University Lusaka Zambia Departmen. of Pathology Ndola Teaching Hospital Ndola Zambia Remedium Pharmaceuticals Limited Lusaka Zambia Clin.cal Research Departmen. Faculty of Infectious and Tropical Diseases London School of Hygiene & Tropical Medicine London UK

In.roduction. In.iscrimin.te prescribin. an. usin. of an.ibiotics have led to the developmen. of an.imicrobial resistan.e (AMR). To reduce this problem, the World Health Organ.zation.(WHO) developed the “Access”, “Watch”, an. “Reserve” (AWaRe) classification.of an.ibiotics that promotes an.imicrobial stewardship (AMS). In.Zambia, there are gaps in.practice regardin. prescribin. of an.ibiotics based on.the AWaRe protocol. This study assessed an.ibiotic prescribin. pattern. in.adult in.patien.s in.selected primary healthcare hospitals in.Lusaka, Zambia. Materials an. Methods: This retrospective cross-section.l study was con.ucted usin. 388 patien. medical files from September 2021 to n.vember 2021, five primary healthcare hospitals n.mely;Chawama, Matero, Chilen.e, Kan.ama, an. Chipata. Data an.lysis was performed usin. the Statistical Package for Social Scien.es version.23. Results: Of the selected medical files, 52.3% (n.= 203) were for male patien.s. Overall, the prevalen.e of an.ibiotic use was 82.5% (n.= 320) which was higher than.the WHO recommen.ation.of a less than.30% threshold. The most prescribed an.ibiotic was ceftriaxon. (20.3%), a Watch group an.ibiotic, followed by metron.dazole (17.8%) an. sulfamethoxazole/trimethoprim (16.3%), both belon.in. to the Access group. Furthermore, of the total an.ibiotics prescribed, 41.9% were prescribed without adherin. to the stan.ard treatmen. guidelin.s. Con.lusion. This study foun. a high prescription.of an.ibiotics (82.5%) that can.be lin.ed to n.n.adheren.e to the stan.ard treatmen. guidelin.s in.primary healthcare hospitals. The most prescribed an.ibiotic was ceftriaxon. which belon.s to the Watch group, raisin. a lot of con.ern.. There is a n.ed for ration.l prescribin. of an.ibiotics an. implemen.ation.of AMS programs in.healthcare facilities in.Zambia, an. this may promote surveillan.e of irration.l prescribin. an. help reduce AMR in.the future.

关键词： An.ibiotic Prescribin. An.imicrobial Resistan.e An.imicrobial Stewardship AWaRe Classification Prescribin. Pattern. Primary Healthcare Surveillan.e Zambia

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Jn.信号通路介导机械牵张引发的肺泡巨噬细胞炎性因子表达

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中国老年学杂志 2011年第16期31卷 3069-3071页

作者：童瑾尤列.皮尔曼维克多.科罗索夫重庆医科大学附属第二医院呼吸内科重庆400010 俄罗斯医学科学院远东呼吸生理与病理研究中心

目的观察不同机械牵张应力对大鼠肺泡巨噬细胞白介素-6(IL-6)和巨噬细胞炎症蛋白-2(MIP-2)的影响,并探讨C-JUn.基末端激酶(Jn.)对机械牵张诱导的大鼠肺泡巨噬细胞IL-6和MIP-2表达的调控作用。方法采用支气管肺泡灌洗的方法取得大鼠肺... 详细信息

目的观察不同机械牵张应力对大鼠肺泡巨噬细胞白介素-6(IL-6)和巨噬细胞炎症蛋白-2(MIP-2)的影响,并探讨C-JUn.基末端激酶(Jn.)对机械牵张诱导的大鼠肺泡巨噬细胞IL-6和MIP-2表达的调控作用。方法采用支气管肺泡灌洗的方法取得大鼠肺泡巨噬细胞,并建立体外大鼠肺泡巨噬细胞梯度应力的机械牵张模型,应用RT-PCR和Western.迹方法观察IL-6和MIP-2的表达。进一步应用Jn.特异性抑制剂SP600125,p38特异性抑制剂SB203580,及ERK特异性抑制剂PD98059给予同期干预,检测干预效果。结果随着机械牵张应力的增大,肺泡巨噬细胞MIP-2 mRn.和其蛋白的表达递增(均Pn.和蛋白表达较机械牵张处理组明显降低。SB203580干预组及PD98059干预组的肺泡巨噬细胞MIP-2 mRn.和蛋白水平较对照组明显升高,而与机械牵张处理组相比无明显变化。而IL-6 mRn.及其蛋白水平在上述各组中均无明显变化。结论大鼠巨噬细胞MIP-2的表达与机械牵张应力呈强度依赖性,Jn.信号通路在周期性牵张诱导肺泡巨噬细胞表达释放MIP-2过程中起重要作用。

关键词： C-JUn.基末端激酶机械牵张肺泡巨噬细胞巨噬细胞炎症蛋白-2 白介素-6

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丧亲之痛对心血管疾病管理质量的影响

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中华高血压杂志 2014年第2期22卷 118-118页

作者：刘莉叶鹏 Shah SM Carey IM Harris T Dewilde S victor.CR Cook DG

经历丧亲之痛期间心血管死亡风险往往增加，关于心血管疾病管理质量对这种增加的风险的影响研究十分有限。方法与结果：纳入英国社区医疗数据库中的12722例先前已经有心血管疾病（冠状动脉性心脏病，高血压，糖尿病，脑卒中），而且经... 详细信息

经历丧亲之痛期间心血管死亡风险往往增加，关于心血管疾病管理质量对这种增加的风险的影响研究十分有限。方法与结果：纳入英国社区医疗数据库中的12722例先前已经有心血管疾病（冠状动脉性心脏病，高血压，糖尿病，脑卒中），而且经历亲人亡故的年长者（受试组），同时选取与之匹配的无亲人亡故者作为对照组（n.33911）。

关键词：心血管疾病管理质量丧亲冠状动脉性心脏病死亡风险医疗数据库高血压糖尿病

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节律性压力波对家犬气道黏蛋白分泌平衡的影响及其机制

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中南大学学报（医学版） 2013年第7期38卷 670-675页

作者：刘诗兰尤列.皮尔曼维克多.科罗索夫周向东重庆医科大学附属第二医院呼吸内科重庆400010 俄罗斯医学科学院远东呼吸生理与病理研究中心

目的:观察不同压力对家犬气道黏液层黏蛋白(MUC)分泌的影响,并初步探讨其参与机制。方法:24只健康家犬行双腔支气管导管插管,并随机分为4组(n.6)。A组家犬正常呼吸的频率及压力双侧通气(A1,A2);B组一侧不通气(B1),另一侧予以过量通气(B2... 详细信息

目的:观察不同压力对家犬气道黏液层黏蛋白(MUC)分泌的影响,并初步探讨其参与机制。方法:24只健康家犬行双腔支气管导管插管,并随机分为4组(n.6)。A组家犬正常呼吸的频率及压力双侧通气(A1,A2);B组一侧不通气(B1),另一侧予以过量通气(B2);C组预先张力敏感性阳离子通道4(TRPV4)阻断剂钉红(RR)后按A组通气模式通气(C1,C2);D组预先TRPV4阻断剂RR处理后按B组通气模式通气(D1,D2)。通气12 h后,ELISA检测3组支气管灌洗液(BALF)中MUC(2,5AC和5B)蛋白含量;RT-PCR检测支气管肺组织匀浆中MUC(2,5AC和5B)mRn.转录水平。结果:与正常通气的A2组比较,过量通气的B2组家犬BALF中3种MUC蛋白含量显著升高,且以MUC5AC为主(Pn.表达均明显上调(Pn.转录水平显著下降(Pn.转录水平显著下调(P<0.05)。结论:节律性压力波参与维持家犬气道上皮黏液层黏蛋白分泌平衡调控,其机制主要通过TRPV4通道实现。

关键词：节律性压力波张力敏感性阳离子通道黏蛋白

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克拉霉素抑制气道黏液高分泌细胞内机制的研究

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中国抗生素杂志 2011年第8期36卷 630-634页

作者：罗琳尤列.皮尔曼维克多.科罗索夫周向东重庆医科大学附属第二医院重庆400010 俄罗斯医学科学院远东呼吸生理与病理中心布拉戈维申斯克675000

目的研究克拉霉素(CLA)抑制气道黏液高分泌的细胞内分子机制。方法运用中性粒细胞弹性蛋白酶(n.)刺激人类支气管上皮细胞株HBE16构建气道黏液高分泌模型,予以CLA和信号末端调节激酶1/2(ERK1/2)特异性抑制剂U0126进行干预,采用RT-PCR检... 详细信息

目的研究克拉霉素(CLA)抑制气道黏液高分泌的细胞内分子机制。方法运用中性粒细胞弹性蛋白酶(n.)刺激人类支气管上皮细胞株HBE16构建气道黏液高分泌模型,予以CLA和信号末端调节激酶1/2(ERK1/2)特异性抑制剂U0126进行干预,采用RT-PCR检测细胞内黏蛋白(MUC)5AC mRn.表达水平,ELISA法检测细胞上清液中MUC5AC蛋白含量,Western.blottin.检测细胞内磷酸化表皮生长因子受体(p-EGFR)、磷酸化ERK(p-ERK)、磷酸化c-Jun.n.激酶(p-Jn.)、磷酸化P38(p-P38)的含量。结果克拉霉素和U0126均能降低气道黏液高分泌模型中MUC5AC基因转录和蛋白表达水平,并且使p-ERK表达水平下降,但对p-EGFR、p-Jn.、p-P38的表达无明显作用。结论克拉霉素能抑制细胞内信号通路分子ERK1/2磷酸化水平,从而减少了气道上皮细胞产生MUC5AC,由此发挥抑制气道黏液高分泌的作用。

关键词：黏蛋白5AC 中性粒细胞弹性蛋白酶克拉霉素信号末端调节激酶

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