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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： victor v.Chizhikov Igor Y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-valle-Anton and Borrell,2022).

关键词： epithelium Figure center

In situ spontaneous emission control of MoSe2-WSe2 interlayer excitons with high quantum yield

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Photonics Research 2025年第1期13卷 210-224页

作者： BO HAN CHIRAG C.PALEKAR FREDERIK LOHOF SvEN STEPHAN victor N.MITRYAKHIN JENS-CHRISTIAN DRAWER ALEXANDER STEINHOFF LUKAS LACKNER MARTIN SILIES BáRBARA ROSA MARTIN ESMANN FALK EILENBERGER CHRISTOPHER GIES STEPHAN REITZENSTEIN CHRISTIAN SCHNEIDER Institut für Physik Fakult?t VCarl von Ossietzky Universit?t Oldenburg Institut für Festk?rperphysik Technische Universit?t Berlin Institute for Theoretical Physics and Bremen Center for Computational Material Science Universit?t Bremen Institute for Lasers and Optics Hochschule Emden/Leer Fraunhofer-Institute for Applied Optics and Precision Engineering IOF Institute of Applied Physics Abbe Center of PhotonicsFriedrich Schiller Universit?t Jena Max Planck School of Photonics

Optical resonators are a powerful platform to control the spontaneous emission dynamics of excitons in solidstate nanostructures. We study a MoSe2-WSe2heterostructure that is integrated in a cryogenic open optical microcavity to gain insights into fundamental optical properties of the emergent interlayer excitons. First, we utilize a low-quality-factor planar open cavity and investigate the modification of the excitonic lifetime as on-and offresonance conditions are met with consecutive longitudinal modes.

关键词： Cavity quantum electrodynamics Nanostructures Optical properties Optical resonators Quantum fluctuations Zeeman effect

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Methods for recording the time profile of single ultrashort pulses of electron beams and discharge currents in real-time mode

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High voltage 2016年第1期1卷 43-51页

作者： victor F.Tarasenko Dmitry v.Rybka Institute of High Current Electronics Siberian Branch Russian Academy of SciencesTomsk 634055Russia

The collectors for measuring the time profile of a current pulse of the runaway electron beam that are generatedunder atmospheric pressure are described. An analysis of changes in pulse shape depending on the bandwidth of theregistration path with a temporal resolution of up to 20 ps was performed. It is shown that the electron beam detectedbehind small-diameter diaphragms has a complex structure, which depends on the parameters of the gas diode. Thereis a design of the current shunts with a temporal resolution of up to 100 ps in this study. Measurement techniques ofvoltage pulses with subnanosecond and nanosecond duration are briefly described.

关键词： ultrashort pulse recording

Formation of diffuse and spark discharges between two needle electrodes with the scattering of particles

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Plasma Science and Technology 2024年第9期26卷 32-39页

作者： victor F TARASENKO Dmitry v BELOPLOTOv Alexei N PANCHENKO Dmitry A SOROKIN Institute of High Current Electronics Siberian BranchRussian Academy of SciencesTomsk 634055Russia National Research Tomsk State University Tomsk 634050Russia

The development of a nanosecond discharge in a pin-to-pin gap filled with air at atmospheric pressure has been studied with high temporal and spatial resolutions from a breakdown start to the spark *** and negative nanosecond voltage pulses with an amplitude of tens of kilovolts were ***-resolved images of the discharge development were taken with a fourchannel Intensified Charge Coupled Device(ICCD)*** minimum delay between the camera channels could be as short as≈0.1 *** made it possible to study the gap breakdown process with subnanosecond *** was observed that a wide-diameter streamer develops from the high-voltage pointed *** ionization processes near the grounded pin electrode started when the streamer crossed half of the *** bridging the gap by the streamer,a diffuse discharge was *** development of spark leaders from bright spots on the surface of the pointed electrodes was observed at the next *** was found that the rate of development of the spark leader is an order of magnitude lower than that of the wide-diameter *** thin luminous tracks were observed against the background of a discharge plasma *** has been established that the tracks are adjacent to brightly glowing spots on the electrodes and are associated with the flight of small particles.

关键词： needle electrodes short voltage pulses atmospheric air streamer breakdown diffuse and spark discharges scattering metal particles

vortex model of plane turbulent air flows in channels

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Advances in Aerodynamics 2024年第1期6卷 442-458页

作者： victor L.Mironov Sergey v.Mironov Institute for Physics of Microstructures RAS Nizhny Novgorod 603950Russia

We present a theoretical model of plane turbulent flows based on the previously pro-posed equations,which take into account both the longitudinal motion and the vor-tex tube *** the simple model of eddy viscosity,we obtain the analytical expressions for the mean velocity profiles of stationary turbulent *** particular,we consider the near-wall flow over a flat plate in a wind tunnel as well as Couette and Poiseuille flows in rectangular *** all these cases,the calculated velocity profiles are in good agreement with experimental data and results of direct numerical simulations.

关键词： vortex model of turbulence Eddy viscosity Plane wall-bounded flows Couette flow Poiseuille flow

Moving of a submarine under an ice cover in fluid of finite depth

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Journal of Hydrodynamics 2019年第3期31卷 562-569页

作者： Alexandra v. Pogorelova vitali L. Zemlyak victor M. Kozin Sholom-A leichem Priamursky State University Birobidzhan Russia Institute of Machining and Metallurgy FEB RAS Komsomolsk-na-Amure Russia

The influence of a basin depth on ice cover deflections, when a submarine moves under it in fluid, is experimentally and theoretically analyzed. For a theoretical research the ice cover is modelled by an elastic floating plate, and the submarine is modelled by a source-sink system in a fluid flow. The problem is solved by means of asymptotic analysis and integral transformations. The experimental study is conducted with submarine models in the pool with the sizes L*B*H= 10m*3m*lm . The ice cover for experiments is modelled in two ways. The first way is the thin ice plate received by freezing of the surface layer of water at low temperatures. In the second case the rubber sheet floating on a reservoir surface is used. The special velocity (the velocity at which maximum values of the wave height are reached) is analyzed. It is obtained that the decrease of the basin depth leads to decrease of the special speed. For small speeds (less than the special speed) there is the fact that the basin depth decrease leads to the increase of the height of the flexural-gravity wave.

关键词： Ice cover submarine flexural gravity wave source-sink system

Evaluation of DNA Damage in the Marine Mussel Crenomytilus grayanus as a Genotoxic Biomarker of Pollution

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Journal of Ocean University of China 2019年第1期18卷 159-164页

作者： SLOBODSKOvA valentina v. ZHURAvEL Elena v. KUKLA Sergey P. CHELOMIN victor P. Laboratory of Marine Ecotoxicology V.I.Ilichev Pacific Oceanological Institute Far Eastern Branch Russian Academy of Sciences School of Natural Sciences Far Eastern Federal University

Marine pollution affects all life processes in aquatic organisms. The genotoxic effect of pollution on the mussel Crenomytilus grayanus was assessed. Bivalves were collected from the ‘clean'(vostochnaya Cove) and polluted(Nakhodka Bay) areas in the Peter the Great Bay. The degree of DNA damage in C. grayanus was determined by alkaline comet assay as mean percentage of DNA in tail, and the genetic damage index was calculated. Our results indicate that almost one-third of DNA in cells of gills and digestive gland of C. grayanus inhabiting the Nakhodka Bay had destructive changes compared to the individuals of this species from the vostochnaya Cove. This study has shown that chronic pollution of the aquatic environment causes destructive changes to DNA in gill and digestive gland cells of C. grayanus.

关键词： genotoxicity DNA comet assay Crenomytilus grayanus pollution

Genotoxic Potential of Copper Oxide Nanoparticles in the Bivalve Mollusk Mytilus trossulus

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Journal of Ocean University of China 2017年第2期16卷 339-345页

作者： victor P.Chelomin valentina v.Slobodskova Maksim Zakhartsev Sergey Kukla Laboratory of Marine Ecotoxicology V.I.Ilichev Pacific Oceanological Institute of the Far East Branch of Russian Academy of SciencesVladivostok 600041Russia The Far Eastern Federal University School of Natural SciencesVladivostok 600091Russia University of Hohenheim Stuttgart 70599Germany

Copper oxide nanoparticles(CuO-NPs) are among the most widely used metal oxide nanoparticles,which increases the chance of their being released into the marine *** the applications of these particles have increased in recent years,their potential impact on the health of marine biota has also ***,the toxicological effects of these NPs in the marine environment are poorly *** the present study,the DNA damaging potential of CuO-NPs in the marine eastern mussel Mytilus trossulus was evaluated and compared to that of dissolved copper *** was assessed by the single cell gel electrophoresis(comet) assay in mussel gill and digestive gland *** results showed that copper in both forms(CuO-NPs and dissolved copper) was accumulated to different extents in mussel *** mussel exposed to the dissolved copper attained higher concentrations of copper in the gills than in the digestive *** contrast to these results,it was found that CuO-NPs could induce much higher copper accumulation in the digestive gland than in the gills.A clear and statistically significant increase in DNA damage was found in both tissues of the Cu-exposed group compared to the control *** results indicated that the CuO-NP exposure produced remarkable effects and increased DNA damage significantly in mussel gill cells *** should be noted that the digestive gland cells were prone to accumulation following CuO-NPs when compared to the gill cells,while the gill cells were more sensitive to the genotoxic effects of *** results also suggested the need for a complete risk assessment of engineered particles before its arrival in the consumer market.

关键词： CuO nanoparticles copper accumulation DNA damage genotoxicity Mytilus trossulus