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Resolving the inner jet of PKS 1749+096 with super-resolution VLBA images at 7 mm

Research in Astronomy and Astrophysics 2021年第4期21卷 202-206页

作者： Lang Cui Ru-Sen Lu Wei Yu Jun Liu victor m.Patino-Alvarez Qi Yuan Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany Instituto Nacional de Astroffsica Optica y ElectronicaLuis Enrique Erro#1TonantzintlaPuebla 72840Mexico University of Chinese Academy of Sciences Beijing 100049China

High resolution imaging of inner jets in Active Galactic Nuclei(AGNs)with Very Long Baseline Interferometry(VLBI)at millimeter wavelengths provides deep insight into the launching and collimation mechanisms of relativistic *** BL Lac object,PKS 1749+096,shows a core-dominated jet pointing toward the northeast on parsec-scales revealed by various VLBI *** order to investigate the jet kinematics,in particular,the orientation of the inner jet on the smallest accessible scales and the basic physical conditions of the core,in this work we adopted a super-resolution technique,the Bi-Spectrum maximum Entropy method(BSmEm),to reanalyze VLBI images based on the Very Long Baseline Array(VLBA)observations of PKS 1749+096 within the VLBA-BU-BLAZAR 7 mm monitoring *** observations include a total of 105 epochs covering the period from 2009 to *** found that the stacked image of the inner jet is limb-brightened with an apparent opening angle of 50°.0±8°.0 and 42°.0±6°.0 at the distances of 0.2 and 0.3 mas(0.9 and 1.4 pc)from the core,corresponding to an intrinsic jet opening angle of 5°.2±1°.0 and 4°.3±0°.7,*** addition,our images show a clear jet position angle swing in PKS 1749+096 within the last ten *** discuss the possible implications of jet limb brightening and the connection of the position angle with jet peak flux density and gamma-ray brightness.

关键词： galaxies:quasars:individual:PKS 1749+096 galaxies:jets radio continuum:galaxies

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Letter to the Editor

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Advances in Enzyme Research 2013年第3期1卷 37-38页

作者： victor m. Bolanos-Garcia Department of Biological and medical Sciences Oxford Brookes University Oxford England

Letter to Advances in Enzyme

关键词： Letter Advances in Enzyme Research

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Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

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The Journal of Biomedical Research 2010年第2期24卷 87-99页

作者： Aarti Ruparelia Frances Wiseman Olivia Sheppard victor L.J.Tybulewicz Elizabeth m.C.Fisher Department of Neurodegenerative Disease UCL Institute of Neurology mRC National Institute for medical Research

Elizabeth Fisher and victor collaboratively for many years on Tybulewicz have worked the Down syndrome mouse model project. Elizabeth Fisher＇s background is in molecular genetics and mouse models, with an interest in anueploidy. victor Tybulewicz is an immunologist whose primary interest is in signal transduction from the antigen receptors of B and T cells.

关键词： Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

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Clinical Outcome Event Adjudication in a 10-Year Prospective Study of Nucleos(t)ide Analogue Therapy for Chronic Hepatitis B

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Journal of Clinical and Translational Hepatology 2020年第4期8卷 377-384页

作者： Joseph K Lim Alex Y Chang Atif Zaman Paul martin Conrado m Fernandez-Rodriguez mete Korkmaz Simona Rossi James m Ford Tamara Noonan Elizabeth Cooney victor Navarro Luis Colombato Yale University School of medicine New HavenCTUSA Johns Hopkins School of medicine BaltimoreMDUSA and Johns Hopkins SingaporeSingapore Oregon Health&Science University PortlandORUSA University of miami miller School of medicine MiamiFLUSA Hospital Universitario Fundación Alcorcón MadridSpain OSF Saint Anthony Center for Cancer Care RockfordILUSA Einstein Healthcare Network PhiladelphiaPAUSA Stanford University School of medicine StanfordCAUSA Bristol-myers Squibb WallingfordCTUSA Hospital Británico UCA School of MedicineBuenos AiresArgentina

Background and Aims:In the REALm (Randomized, Obser-vational Study of Entecavir to Assess Long-Term Outcomes Associated with Nucleoside/Nucleotide monotherapy for Pa-tients with Chronic HBV Infection) study, 12,378 patients with chronic hepatitis B virus (HBV) infection received up to 10 years of randomized therapy with entecavir or another HBV nucleos(t)ide analogue. monitored clinical outcome events (COEs) included malignant neoplasms, HBV disease progres-sion events, and deaths. An external event adjudication com-mittee (EAC) was convened to provide real-time review of reported COEs to optimize data quality, and minimize poten-tial adverse effects of the large cohort, interdisciplinary out-come assessments, geographic scope, and long duration. methods:The EAC comprised an international group of hep-atologists and oncologists with expertise in diagnosis of tar-geted COEs. The EAC reviewed and adjudicated COEs according to prospectively defined diagnostic criteria cap-tured in the EAC charter. Operational processes, including da-ta collection and query procedures, were implemented to optimize efficiency of data recovery to maximize capture of adjudicated COEs, the primary study outcome measure. Results: A total of 1724 COEs were reported and 1465 of these events were adjudicated by the EAC as reported by the investigators (85.0% overall concordance). Concordance by COE type varied: deaths, 99.6%;hepatocellular carcino-ma (HCC), 83.3%;non-HCC malignancies, 88.0%;non-HCC HBV disease progression, 68.2%. Reasons for lack of con-cordance were most commonly lack of adequate supporting data to support an adjudicated diagnosis or evidence that the event pre-dated the study. Conclusions: The REALm EAC performed a critical role in ensuring data quality and consis-tency;EAC performance was facilitated by well-defined diag-nostic criteria, effective data capture, and efficient operational processes. Trial registration: *** NCT00388674.

关键词： Hepatitis B Antiviral therapy Clinical outcomes Event adjudication Liver cirrhosis

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Finite-Size Conformational Transitions: A Unifying Concept Underlying Chromosome Dynamics

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Communications in Theoretical Physics 2014年第10期61卷 607-616页

作者： Bertrand R.Caré Pascal Carrivain Thierry Forné Jean-marc victor Annick Lesne Laboratoire de Physique Théorique de la matière Condensée CNRS UMR 7600UPMC University Paris 06F-75005ParisFrance CNRS GDR 3536 UPMC University Paris 06F-75005ParisFrance Institut de Génétique Humaine CNRS UPR 1142 MontpellierFrance Institut de Génétique moléculaire de montpellier CNRS UMR 5535University of MontpellierMontpellierFrance Kavli Institute for Theoretical Physics China CAS

Investigating average thermodynamic quantities is not sufficient to understand conformational transitions of a finite-size polymer. We propose that such transitions are better described in terms of the probability distribution of some finite-size order parameter, and the evolution of this distribution as a control parameter varies. We demonstrate this claim for the coil-globule transition of a linear polymer and its mapping onto a two-state model. In a biological context, polymer models delineate the physical constraints experienced by the genome at different levels of organization,from DNA to chromatin to chromosome. We apply our finite-size approach to the formation of plectonemes in a DNA segment submitted to an applied torque and the ensuing helix-coil transition that can be numerically observed, with a coexistence of the helix and coil states in a range of parameters. Polymer models are also essential to analyze recent in vivo experiments providing the frequency of pairwise contacts between genomic loci. The probability distribution of these contacts yields quantitative information on the conformational fluctuations of chromosome regions. The changes observed in the shape of the distribution when the cell type or the physiological conditions vary may reveal an epigenetic modulation of the conformational constraints experienced by the chromosomes.

关键词： coil-globule transition helix-coil transition chromosome conformational capture two-state model

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Widefield optical coherence tomography of foveal dragging in retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1219-1223页

作者： victor m.Villegas Stephen G.Schwartz Audina m.Berrocal Timothy G.murray Harry W. Flynn Jr. Bascom Palmer Eye Institute University of Miami Miller School of Medicine Miami Florida 33136 USA murray Ocular Oncology and Retina Miami Florida 33143USA

Dear Editor,Despite substantial advances in neonatal medicine, retinopathy of prematurity (ROP) continues to be a serious therapeutic challenge⑴.Visual acuity loss in patients with ROP has been associated with structural retinal abnormalities (including retinal detachment, retinal folds, and pigmentary retinopathy), cataract, glaucoma, and amblyopia due to refractive error or strabismus[2].

关键词： retinopathy of prematurity(ROP) foveal dragging structural retinal abnormalities

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DNA methylation patterns in alcoholics and family controls

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World Journal of Gastrointestinal Oncology 2012年第6期4卷 138-144页

作者： manish Thapar Jonathan Covault victor Hesselbrock Herbert L Bonkovsky Department of medicine The University of Connecticut Health Center Farmington CT 06030 United States The Liver-Biliary-Pancreatic Center The University of Connecticut Health Center Farmington CT 06030 United States Department of Psychiatry The University of Connecticut Health Center Farmington CT 06030 United States The Alcohol Research Center The University of Connecticut Health Center Farmington CT 06030 United States The Liver-Biliary-Pancreatic Center Carolinas Medical Center Suite 201 Cannon Research Center 1542 Garden Terrace Charlotte NC 28203 United States

AIm: To assess whether DNA methylation patterns in chronic alcoholics are different from non-alcoholic sibling controls. mETHODS: We examined the methylation patterns in DNA samples from 25 chronic alcoholics and 22 matched siblings as controls (one per family). DNA was extracted from peripheral blood and analyzed for differences in the methylation patterns after bisulfite-conversion. We used the Illumina GoldenGate methylation Cancer Panel I (Illumina, San Diego, CA), which probes the methylation profile at 1505 CpG sites from 807 cancer related genes. We excluded the 84 X-chromosome CpG sites and 134 autosomal CpG sites that failed to show a within sample reliability score of at least 95% for all samples, leaving 1287 autosomal CpG sites (associated with 743 autosomal genes) with reliable signals for all samples. A methylation score was calculated as the average methylation for the 1287 CpG sites examined. Differences were assessed by a two-sample t-test. We also examined the average sib pair differences in methylation scores at each of the 1287 sites. All analyses were performed using SPSS, version 9.0, P methylation levels at the 1287 CpG sites averaged 28.2% for both alcoholics and controls. The mean difference in methylation scores between alcoholic and non-alcoholic sibs by CpG site was mall inter-individual variances; and only 5 CpG sites had an average sib difference > 5%. Subgroup analysis showed that methylation scores were significantly lower for the alcoholic-dependent subjects who smoked compared to their non-smoking unaffected siblings. Specifically, among smokers who are alcoholic, global methylation indices were significantly lower than in non-alcoholic sib controls, whereas among non-smoking alcoholics, the global indices were significantly higher (P = 0.008). CONCLUSION: Although we observed no effect of alcoholism alone on DNA methylation, there is a decrease in alcoholics who smoke, suggesti

关键词： DNA methylation Alcohol Epigenetics Cancer Carcinogenesis Smoking Cigarettes Tobacco

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Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo

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Acta Pharmaceutica Sinica B 2023年第10期13卷 4172-4184页

作者： Xiaosen Ouyang Willayat Y.Wani Gloria A.Benavides matthew J.Redmann Hai Vo Thomas van Groen victor m.Darley-Usmar Jianhua Zhang Department of Pathology University of Alabama at BirminghamBirminghamAL 35294USA Department of Cell Developmental and Integrative BiologyUniversity of Alabama at BirminghamBirminghamAL 35294USA Birmingham VA medical Center University of Alabama at BirminghamBirminghamAL 35294USA

The lysosome is responsible for protein and organelle degradation and homeostasis and the cathepsins play a key role in maintaining protein quality *** D(CTSD),is one such lysosomal protease,which when deficient in humans lead to neurolipofuscinosis(NCL)and is important in removing toxic protein *** studies demonstrated that CTSD germ-line knockout-CtsdKO(CDKO)resulted in accumulation of protein aggregates,decreased proteasomal activities,and postnatal lethality on Day 26±*** of wildtype CTSD,but not cathepsin B,L or mutant CTSD,decreased a-synuclein toxicity in worms and mammalian *** this study we generated a mouse line expressing human CTSD with a floxed STOP cassette between the ubiquitous CAG promoter and the *** crossing with Nestin-cre,the STOP cassette is deleted in NESTIN+cells to allow CTSD overexpression-CTSDtg(CDtg).The CDtg mice exhibited normal behavior and similar sensitivity to subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(mPTP)induced *** breeding CDtg mice with CDKO mice,we found that over-expression of CTSD extended the lifespan of the CDKO mice,partially rescued proteasomal deficits and the accumulation of Aβ42 in the *** new transgenic mouse provides supports for the key role of CTSD in protecting against proteotoxicity and offers a new model to study the role of CTSD enhancement in vivo.

关键词： Cathepsin D transgenic mouse mitochondrial bioenergetics Apoptosis Cathepsin D knockout mice Dopamine Autophagy Lysosome Life expectancy Behavior

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Biogenesis of TiO_(2) nanoparticles:An approach to prove multidisciplinary application

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Green Synthesis and Catalysis 2022年第2期3卷 150-155页

作者： W.Sherine victor S.Vijayakumar E.Vidhya V.N.Punitha m.Nilavukkarasi PG and Research Department of Botany AVVM Sri Pushpam CollegePoondi(Affiliated to Bharadhidasan University)Thanjavur 613503India Department of Nanotechnology Noorul Islam Centre for Higher EducationKumarakoilKanyakumari 629180India

Nanomaterials with countless potential applications in the Natural Science and Clinical Pharmaceutics have offered the prospects of developing new *** analysis of green TiO_(2) nanoparticles synthesized with Limonia acidissima(***)aqueous peel extract was described in this *** green fabricated TiO_(2) nanoparticles were characterized by UV-vis spectrum,XRD,FT-IR,and FE-SEm with *** TiO_(2) nanoparticles exhibited excellent antimicrobial and photodegradation *** it has demonstrated the release of reactive oxygen species(ROS)and proven mitochondrial membrane potential in a dosage manner of 0-100μg/*** statistics were also examined with P valuesmultidisciplinary applications.

关键词： Biomaterials Nanoparticles L.acidissima Anticancer Antimicrobial and photodegradation activities

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Review of recent trends in friction stir welding process of aluminum alloys and aluminum metal matrix composites

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Transactions of Nonferrous metals Society of China 2021年第11期31卷 3281-3309页

作者： John victor CHRISTY Abdel-Hamid ISmAIL mOURAD muhammad m.SHERIF B.SHIVAmURTHY mechanical Engineering Department College of EngineeringUnited Arab Emirates UniversityAl-AinP.O.Box.15551United Arab Emirates mechanical Design Department Faculty of EngineeringHelwan UniversityCairoEgypt National Water and Energy Center United Arab Emirates UniversityAl Ain 15551United Arab Emirates Civil Construction and Environmental Engineering DepartmentCollege of EngineeringUniversity of Alabama–BirminghamBirminghamALUSA Department of mechanical&manufacturing Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnatakaIndia

Welding is a vital component of several industries such as automotive,aerospace,robotics,and *** welding,these industries utilize aluminum alloys for the manufacturing of many components or ***,fusion welding of aluminum alloys is challenging due to several factors,including the presence of non-heat-treatable alloys,porosity,solidification,and liquation of *** manufacturers adopt conventional in-air friction stir welding(FSW)to weld metallic alloys and dissimilar *** researchers reported the drawbacks of this traditional in-air FSW technique in welding metallic and polymeric materials in general and aluminum alloys and aluminum matrix composites in specific.A number of FSW techniques were developed recently,such as underwater friction stir welding(UFSW),vibrational friction-stir welding(VFSW),and others,for welding of aluminum alloy joints to overcome the issues of welding using conventional ***,the main objective of this review is to summarize the recent trends in FSW process of aluminum alloys and aluminum metal matrix composites(Al mmCs).Also,it discusses the effect of welding parameters of the traditional and state-of-the-art developed FSW techniques on the welding quality and strength of aluminum alloys and Al *** among the techniques and advantages and limitations of each are *** review suggests that VFSW is a viable option for welding aluminum joints due to its energy efficiency,economic cost,and versatile modifications that can be employed based on the *** review also illustrated that significantly less attention has been paid to FSW of Al-mmCs and considerable attention is demanded to produce qualified joint.

关键词： aluminum alloys aluminum matrix composites traditional FSW techniques state-of-the-art FSW techniques microstructure mechanical properties

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