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Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient

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World Journal of Gastroenterology 2015年第36期21卷 10475-10479页

作者： Maria Salvado victor vargas Marta Vidal Macarena Simon-Talero Jessica Camacho Josep Gamez ALS Unit Neurology DepartmentHospital Universitari Vall d'HebronVall d'Hebron Research InstituteAutonomous University of Barcelona Liver Unit Department of MedicineHospital Universitari Vall d'HebronVall d'Hebron Research InstituteAutonomous University of BarcelonaBarcelona. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)Instituto de Salud Carlos IIIMadridSpain Pathology Department Hospital Universitari Vall d’HebronVall d’HebronAutonomous University of Barcelona

We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient. Hepatotoxicity induced by masitinib,a tyrosine kinase inhibitor,is usually transient with mild elevation of transaminases,although acute hepatitis has been not reported to date. The hepatitis was resolved after masitinib was discontinued and a combination of prednisone and azathioprine was started. The transaminases returned to baseline normal values five months later. This is the first case in the hepatitis literature associated with masitinib. The autoimmune role of this drug-induced liver injury is discussed. Physicians should be aware of this potential complication.

关键词： Drug-induced liver injury Masitinib Amyotrophic la

Root Secretion of Phytochemicals in Arabidopsis Is Predominantly Not Influenced by Diurnal Rhythms

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Molecular Plant 2010年第3期3卷 491-498页

作者： Dayakar V. Badri victor M. Loyola-vargas Corey D. Broeckling Jorge M. Vivanco Center for Rhizosphere Biology Colorado State University Fort Collins CO 80523 USA 30 Col. Chuburna de Hidalgo Merida Yucatan Mexico

Root-secreted phytochemicals mediate multiple interactions in the rhizosphere. The root exudation process can be altered by various biotic factors, including pathogenic and non-pathogenic microbes, and abiotic factors like temperature and soil moisture. It has been suggested that root secretion of specific flavonoids is influenced by diurnal rhythms （by light or dark） but a comprehensive analysis of the overall secretion of phytochemicals in response to diurnal rhythms has not been studied. In this study, we analyzed the effect of light/dark cycles on root exudation profiles using Arabidopsis as a model plant. Our results reveal that the root secretion of phytochemicals is partly regulated by the diurnal light cycle and follows two main patterns of secretion：（1） the large majority of phytochemicals in the exudates showed no diurnal pattern in their secretion, and （2） a few compounds showed a diurnal pattern in their secretion： three compounds increased in secretion only under light; two compounds increased in secretion only while it was dark; and two compounds increased in secretion during the transition from dark to light. Root-specific ABC transporters have been implicated in root exudation; an analysis of the gene expression patterns of ABC transporters in the roots of Arabidopsis at specific time points revealed that none of the ABC transporters followed a diurnal expression pattern, suggesting that they are expressed constantly during the day and night. Similarly, we analyzed the expression in roots of genes involved in secondary metabolite biosynthesis and found that some of the genes involved in phenylpropanoid and glucosinolate biosynthesis （i.e. 4-coumarate-CoA ligases （4CL1 and 4CL2）, flavonol synthases （FSl and FS2）, and CYP79B3） followed distinct diurnal expression patterns. Overall, we have discovered that while root exudation of the majority of phytochemicals is constitutive, the secretion of a few compounds follows a diurnal rhythm, which is in accor

关键词： Arabidopsis diurnal rhythm root exudates ABC transporters secondary metabolite biosynthesis.

Confirmatory factor analysis of VISA-P scale and measurement invariance across sexes in athletes with patellar tendinopathy

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Journal of Sport and Health Science 2017年第3期6卷 365-371页

作者： Sergio Hernandez-Sanchez Ferran Abat María D.Hidalgo Antonio I.Cuesta-vargas victor Segarra Jose M.Sanchez-Ibanez Antonia Gomez-Conesa Department of Pathology and Surgery Physiotherapy AreaMiguel Hernandez UniversityValencia 03550Spain Sports Orthopaedic Surgeon ReSport ClinicBarcelona 08017Spain Department of Basic Psychology and Methodology University of MurciaMurcia 30100Spain Department of Physiotherapy Faculty of Health SciencesUniversity of MalagaMalaga 29009Spain

Background:The victorian Institute of Sport Assessment–Patella(VISA-P) scale is the most condition-specific patient-reported outcome measure used to assess symptom severity in athletes with patellar *** exploratory factor analyses have been conducted to evaluate the scale's dimensionality,with inconsistent results,and the factor structure of the scale remains *** aims of the present study were to determine the factorial structure of the VISA-P scale using confirmatory factor analysis(CFA) and test measurement invariance across ***:The study included a convenience sample of 249 Spanish athletes with patellar *** was performed to assess factorial *** 1-and 2-factor models were *** invariance across sexes was evaluated via multi-group CFA with several fit indices using EQS 6.1 ***:The internal consistency coefficient was *** CFA models were examined and the 1-factor model in which errors for Items 7 and8 were correlated showed acceptable fit in terms of comparative fit index(CFI) and goodness-of-fit index(GFI) statistics(CFI = 0.93;GFI = 0.94;standardized root mean square residual = 0.06;root mean square error of approximation = 0.10;90% confidence interval:0.08–0.13).This model was invariant across ***:The 1-factor model of the Spanish version of the VISA-P scale(VISA-P-Sp) in which errors for Items 7 and 8 were correlated demonstrated relative fit in *** obtained via VISA-P-Sp can be compared between men and women without sexes *** studies should examine the VISA-P scale and other single-score patient-reported outcome measures concurrently.

关键词： Jumper's knee Measurement invariance Patient-reported outcome measure Structural validity

Performance Quality Testing under Combined Loading of Polyethylene Pipes Reinforced with Aramid Fiber

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Journal of Mechanics Engineering and Automation 2014年第8期4卷 639-647页

作者： Hilario Hemamdez-Moreno Erik vargas-Rojas victor Manuel Sauce-Rangel Ivan Mortera-Bravo Jorge LuisGonzhlez-Velazquez Maarten P. Kruijer Margarita Navarrete-Montesinos ESIME (Escuela Superior de Ingenieria Mecanica y Electrica) Unidad Ticoman lnstituto Politecnico Nacional Distrito Federal07340 Mexico ESIQIE (Escuela Superior de Ingenieria Quimica e lndustrias Extractivas) Instituto Politecnico Nacional Distrito Federal 07300Mexico Department of Research & Development Pipelife Netherlands B. K Enkhuizen P.O. Box 380 1600 A J The Netherlands Instituto de lngenieria Universidad Nacional Autonoma de Mexico Distrito Federal 04510 Mexico

This paper presents the results of the performance quality testing of polyethylene pipes reinforced with aramid fibers, intended for applications such as discharging and gathering oil pipelines, and describes the test rig specifically designed for this purpose. The pipe specimens are submitted to impact with a device that simulates the collision of a pickaxe, and of a backhoe loader. After the impact, the pipes are tested under combined loading comprising internal pressure, and transverse loading; some pipe specimens without previous impact are tested as well. The results show that the reinforced thermoplastic pipes can fully withstand maximal operating pressure levels in the presence of damage and additional transverse loading.

关键词： Combined pressure-bending testing oil industry reinforced thermoplastic pipe composite materials.

Growth Kinetics of Vegetative and Reproductive Organs of Guava(Psidium guajava L.)in Iguala Guerrero,Mexico

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Agricultural Sciences 2014年第14期5卷 1468-1475页

作者： Agustin Damian Nava victor A.Gonzalez Hernandez Manuel Nava Jaimes Elias Hernandez Castro Dolores vargas Alvarez Gemima Diaz Villasenor Francisco Palemon Alberto Blas Cruz Lagunas Academic Unit of Agricultural and Environmental Sciences The Autonomous University of GuerreroGuerreroMéxico Institute of Genetic Resources and Productivity Graduate CollegeTexcocoMexico

In the Mexican tropics the guava trees can grow and produce in any season, so they can be har-vested out of the period of high competition marketing (Summer). It?studied the growth kinetics of leaves and fruits of guava trees at the dry tropical conditions of the State of Guerrero, in guava trees of four years old and was evaluated a non-destructive method for measuring leaf area from November to May. 100 sheets of 10 randomly selected trees were cut. It was found that leaf length X the width X 0.72581647 (conversion factor) gave an estimated leaf area which?was significantly correlated with that obtained by the integrator of leaf area. Both in length and width the leaf growth kinetics were sigmoid with three growth stages: In Stage I (15 days) leaves grew 21.2% and 21.5%;in Stage II (26 days) grew 73.6% and 68%;and in Stage III (30 days). They Increased 5.2% and 10.5% in the primary and secondary sprouts. The fruit growth in its equatorial and polar diameters corresponded to a double sigmoid kinetics. In Stage I (61 days) it reached 1.9 and 2.3 cm;in Stage II (62 - 102 days) it reached 3.09 and 3.62 cm;and in Stage III (103 to 126 days) it reached 4.63 and 5.13 cm, as well the physiological maturity of fruit.

关键词： Psidium guajava Growth Kinetics Phenological Events

大气环流变化及其对中美洲降水趋势的影响:哥斯达黎加

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人类环境杂志 1994年第1期23卷 87-90页

作者： Alvaro Brenes vargas victor F.Saborio Trejos 朱志辉 Departamento de informacion Instituto Meteorologico Nacional San JoseCosta Rica Escuela de Ciencias Geograficas(Programa de Investigacion MADE) Universidad NacionalHerediaCosta Rica

本文给出过去30年(1960—1990年)81个降水资料序列的趋势分析。这些资料来自哥斯达黎加全国各地的背风面和向风面气象站,它们都受信风体系的影响。分析表明,哥斯达黎加75%以上的领土在这一时期经历了降水减少。受这一趋势影响的大部分... 详细信息

本文给出过去30年(1960—1990年)81个降水资料序列的趋势分析。这些资料来自哥斯达黎加全国各地的背风面和向风面气象站,它们都受信风体系的影响。分析表明,哥斯达黎加75%以上的领土在这一时期经历了降水减少。受这一趋势影响的大部分地区分布在山脉的背风面(这些山脉从西北到东南分隔这个国家)。而向风面的降水表现为正趋势,这暗示信风加强。对1900年以来大西洋飓风轨迹资料的分析表明飓风总数呈增加趋势,但通过加勒比海盆的飓风数目减少。通过加勒比海盆的热带气旋在中美洲的太平洋地区所产生的降水约占该地区总降水的70%,由于这些国家的经济高度依赖于农业和用于发电的水资源,因此飓风形势和与其相关联的降雨的变化可能产生重要的经济后果。

关键词：大气环流变化美洲降水哥斯达黎加

Analysis and Prediction of Risks From Rockfall in the Huancavelica City

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Journal of Environmental Science and Engineering(A) 2019年第5期8卷 203-215页

作者： Ivan Ayala Bizarro victor Paitan Sedano Edman Ventura Sullca Marco Lopez Barrantes Hugo Lujan Jeri Abdon Olivera Quintanilla Jorge Ortega vargas Carlos Gaspar Paco Department of Civil Engineering National University of HuancavelicaHuancavelica 09001Peru

This research refers to the analysis and prediction of rockfall risk,whose objective is to determine the results of the validation of the model and application of modeling in the Rocfall Software,in this way to prepare the map of risk ***,the general problem was identified:What are the results of the analysis and prediction of risks from rockfall in the city of Huancavelica?To respond to the problem posed,the following steps were carried out:obtaining field information with Drone equipment and using photogrammetric processes the topography of the study area was obtained,identification of unstable areas,trajectories,traces of the previously occurred landslides and five geomechanical *** specific weight of eight rock samples in the laboratory of the National University of Huancavelica was also calculated,which served to obtain the weight of the large-scale rock *** addition,the normal and tangential restitution coefficients were calibrated,that is,field *** the data were obtained,modeling was carried out by applying the Rocfall software,whose results of ten trajectories were:final distance reached,bounce height,kinetic energy and translational *** these values,risk maps have been prepared,taking into account the areas of housing vulnerability in the city of ***,it is proposed to mitigate these risks of rockfall,with dynamic barriers,which is important for the security of housing in the analysis sectors.

关键词： Risk prediction rockfall trajectory simulation

Bacteria in cancer therapy: beyond immunostimulation

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Journal of Cancer Metastasis and Treatment 2018年第1期4卷 44-68页

作者： Wheeler Torres victor Lameda Luis Carlos Olivar Carla Navarro Jorge Fuenmayor Adrian Perez Andres Mindiola Milagros Rojas Maria Sofia Martinez Manuel Velasco Joselyn Rojas Valmore Bermudez Endocrine and Metabolic Diseases Research Center the University of ZuliaMaracaibo 4001Venezuela Miami Veterans Affairs Medical Center Geriatric Research Education and Clinical Center(GRECC)Miami 33125FLUSA Departme nt of Pharmacology "JM Vargas"Medical SchoolCentral University of VenezuelaCaracas 1050Venezuela Division of Pulmonary and Critical Care Medicine Brigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Advaneed Frontier Studies Research Group(ALEF) Simon Bolivar UniversityCucuta 540006Colombia

Currently,conventional therapies in cancer are improving;chemotherapy,radiotherapy and surgery have increased survival *** therapies have arisen with the same goal;immunotherapy has appeared as a promising option in the fight against cancer stimulating the immune system by inducing innate and adaptive *** responses include release of pro-inflammatory cytokines,making the immune system capable to eliminate or protect against multiple ***,many of these therapies are being used in clinical settings,such as checkpoint inhibitors,monoclonal anti cytotoxic T-Lymphocyte associated protein 4(CTL-4)and programmed death protein 1(PD1),with inspiring results;however,they may decrease immunotolerance,limiting their *** the same time,chemotherapy works by passive transport across the cell membrane,limiting its capacity to penetrate in tumor *** these reasons,bacteria employment represents one of the best candidates for cancer *** can surpass these barriers with their selective colonization which also has an oncolytic effect by increasing proliferation and immunostimulation in the tumor *** strains,such as Mycobacterium bovis,Clostridium,Salmonella typhimirium and Listeria monocytogenes have been studied showing promising results in experimental ***,their application in clinical trials has shown the need to maximize their therapeutic *** engineering and synthetic biology are necessary to prove the scope that this novel approach has against cancer due to implications of cancer therapy and public health.

关键词： Bacterium cancer selective colonization salmonella clostridium listeria

Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of Cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie Hawksworth’s seventieth birthday

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Fungal Diversity 2017年第3期84卷 139-207页

作者： Robert Lücking Manuela Dal Forno Bibiana Moncada Luis Fernando Coca Leidy Yasmín vargas-Mendoza André Aptroot Laura Juliana Arias Betty Besal Frank Bungartz Diego Mauricio Cabrera-Amaya Marcela E.S.Cáceres José Luis Chaves Sionara Eliasaro Martha Cecilia Gutiérrez Jesús E.Hernández Marin María de los Ángeles Herrera-Campos María E.Holgado-Rojas Harald Jonitz Martin Kukwa Fabiane Lucheta Santiago Madriñán Marcelo Pinto Marcelli Suzana Maria de Azevedo Martins Joel A.Mercado-Díaz Jorge Alberto Molina Eduardo A.Morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata Javier Robayo Camilo Rodríguez Diego Fernando Simijaca Edier Soto-Medina Adriano Afonso Spielmann Alejandra Suárez-Corredor Jean-Marc Torres Carlos Alberto vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk Marcela Celis Pacheco Mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick M.Gillevet Masoumeh Sikaroodi James D.Lawrey Botanical Garden and Botanical Museum Berlin KöniginLuise-Straße 6-814195 BerlinGermany Science Education The Field Museum1400 South Lake ShoreChicagoIL 60605USA Department of Botany Smithsonian InstitutionNational Museum of Natural History10th St Constitution Ave NWWashingtonDC 20560USA Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030-4444USA Licenciatura en Biologı´a Universidad Distrital Francisco Jose´de CaldasCra.4 No.26D-54Torre de LaboratoriosHerbarioBogota´D.C.Colombia Herbario Universidad de Caldas(FAUC) Edificio BicentenarioCalle 65No.26-10ManizalesA.A.275CaldasColombia ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Biologı´a Universidad del Quindı´oCarrera 15 Calle 12 NorteArmeniaQuindı´oColombia 120 Chavis Avenue LexingtonVA 24450USA Charles Darwin Foundation Puerto AyoraSanta Cruz IslandGala´pagosEcuador Schedestraße 8 53113 BonnGermany Jardı´n Bota´nico de Bogota´Jose´Celestino Mutis Avenida Calle 63 No.68-95Bogota´D.C.Colombia Departamento de Biocieˆncias Universidade Federal de SergipeAvenida Vereador Olı´mpio Grandes/n.ItabaianaCEP:49.500-000 SergipeBrazil Laboratorio de Hongos Instituto Nacional de Biodiversidad(INBio)Apdo.22-3100Santo Domingo de HerediaCosta Rica Departamento de Botaˆnica Universidade Federal do Parana´Campus Polite´cnicoSetor de Cieˆncias Biolo´gicasAv.Cel.Francisco H.dos Santoss/nJardim das Ame´ricas81531-980 CuritibaPRBrazil Ingenierı´a Ambiental Universidad Distrital Francisco Jose´de CaldasCarrera 5 Este No.15-82Av.CircumvalarBogota´D.C.Colombia Instituto Experimental Jardı´n Bota´nico Dr.Tobı´as Lasser Centro de Investigacio´n y DesarrolloUniversidad Central de VenezuelaAve.Salvador AllendeJardı´n Bota´nico de CaracasApartado#2156Caracas 1010-AVenezuela Departamento de Bota´nica Instituto de Biologı´aUniversidad Nacional Auto´noma de Me´xicoApartado Postal 70-36704510 Ciudad De Me´xicoMexico Facultad de Ciencias Escuela Profesional de Biologı´aUniv

Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 *** on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been *** of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is *** new species are:Cora accipiter Moncada,Madrin˜a´n&Lücking ***.,*** Moncada,Soto-Medina&Lücking ***.,*** Moncada,Dal Forno&Lücking ***.,*** Dal Forno,Chaves&Lücking ***.,*** Moncada,***ı´guez&Lücking ***.,*** Lücking,Moncada&*** ***.,*** Moncada,Ya´nez-Ayabaca&Lücking ***.,*** Moncada,Patin˜o&Lücking ***.,*** Lücking,***&Dal Forno ***.,*** Holgado,Rivas Plata&Perlmutter ***.,*** Dal Forno,Eliasaro&Spielmann ***.,*** Nugra,Dal Forno&Lücking ***.,*** Lücking,Martins&Lucheta ***.,*** Moncada,R.-***´rez&Lücking ***.,*** Moncada,***.&Lücking ***.,*** Moncada,CabreraAmaya&Lücking ***.,*** Moncada,R.-***´rez&***.,*** Lücking,***&Dal Forno ***.,*** Moncada,***´rez-Corredor&Lücking ***.,*** Moncada,***&Lücking ***.,***

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