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Journal of Mountain Science 2023年第9期20卷 2453-2467页

作者： victor SOTO hugo deLGADO-GRANADOS carlos M.WELSH Kenji YOSHIKAWA centro de ciencias de la Tierra Universidad VeracruzanaXalapaVeracruz 91090México Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Water and Environmental Research center University of Alaska FairbanksFairbanksAlaska 99775USA

despite being within the intertropical region of the planet,the Mexican territory still has glacier-covered *** recent dec.des,important advances have been made in studies on glaciology and periglacial environment in Mexico both for current and past ***,in spite of cofre de Perote volcano(4200 m a.s.l.)being a strategically located mountain,it has not yet been studied in regards to the glacial and periglacial processes;in fact,those dynamics have modified the mountain massifs in the *** complement the series of studies on glacial history in the high mountain environment of México,this study reconstructs the glacial cover and the periglacial environment of the volcano surface during the final stage of the Late Pleistocene based on climatic retrospective and through the identification of geomorphological *** findings indicate the existence of a large glacier(ice cap)that covered the northern,western,and southern slopes of the mountain;while in the eastern sector there were two small glaciers,one being of cirque type,and the other of valley *** current temperature conditions prevent the occurrence of permanent ice bodies;at the same time,it was found that the periglacial blockfields of the slopes is a legacy of the climatic conditions that prevailed at the end of Late Pleistocene.

关键词： cofre de Perote Glacial cover Periglacial environment climatic retrospective Palaeoclimatic modelling

development of Extraction and detection Method for a chemotherapeutic Drug with Phenytoin in Biological Samples

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Advances in Biological chemistry 2024年第4期14卷 103-110页

作者： Michael Arnot Nicolas Brice Adan Garcia victor Lomeli My Phuong Vu Karno Ng department of chemistry & Biochemistry California State University San Marcos San Marcos CA U.S.A.

dexamethasone is classified as a corticosteroid and is commonly used among cancer patients to decrease the amount of swelling around the tumor. Among patients with cancer, in particular brain tumors, seizures can become a daily routine in their everyday lives. To counteract the seizures, an antiepileptic drug such as phenytoin is administered to act as an anticonvulsant. Phenytoin and dexamethasone are frequently administrated concurrently to brain cancer patients. A previous study has shown that phenytoin serum concentration decreases when administrated concurrently with dexamethasone. Thus, it is important to monitor the concentration of these two drugs in biological samples to ensure that the proper dosages are administrated to the patients. This study aims to develop an effective extraction and detection method for dexamethasone and phenytoin. A reverse-phase high-performance liquid chromatography (HPLc) method with UV/Vis detection has been developed to separate phenytoin and dexamethasone at 219 nm and 241 nm respectively from urine samples. The mobile phase consists of a mixture of 0.01 M KH2PO4, acetonitrile, and methanol adjusted to pH 5.6 (48:32:20) and is pumped at a flow rate of 1.0 mL/min. calibration curves were prepared for phenytoin and dexamethasone (r2 > 0.99). An efficient solid-phase extraction (SPE) method for the extraction of dexamethasone and phenytoin from urine samples was developed with the use of c-18 cartridges. The percent recovery for phenytoin and dexamethasone is 95.4% (RSD = 1.15%) and 81.1% (RSD = 3.56%) respectively.

关键词： dexamethasone Phenytoin cancer Drug Interaction Solid Phase Extraction

Effects of Phytoremediation on Soil contaminated with Pb and cd in Tolerant Bacterial Populations

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Journal of Environmental Science and Engineering(A) 2024年第4期13卷 122-127页

作者： Alejandra Vásquez María Montes Melissa cervantes María Alvarado Pedro García victor Aguilar department of Environmental Engineering Institute for EngineeringUniversity of VeracruzBoca del RioVer.94294Mexico department chemical Engineering Faculty of Chemical SciencesUniversity of VeracruzBoca del RíoVer.94294Mexico Faculty of Environmental Engineering Popular Autonomous University of the State of PueblaBarrio de Santiago 72410PueblaPueMexico department of Administration Open Education SystemUniversity of VeracruzBoca del RioVer.94294Mexico

Bacterial populations isolated from treated soil,artificially contaminated with lead(Pb)and cadmium(cd)and undergoing a phytoremediation process were studied to determine their potential application in soil *** physicochemical parameters evaluated in the soil varied *** bacterial strains were selected from each polluted soil to test tolerance and growth in contaminated *** concentrations of heavy metals tested were 1,000 ppm for lead and 850 ppm for *** strains were morphologically identified through Gram *** strains showing the most significant growth in both contaminants were then selected to verify their tolerance to different concentrations of heavy *** results demonstrated that the selected bacteria have high tolerance to Pb,resisting inhibition up to 2,000 *** contrast,strains exposed to cadmium tended to slow their growth as the concentration increased.

关键词： Lead cadmium soil bacteria remediation

comparative Study of the Widal Test against Stool culture in the Diagnosis of Suspected cases of Typhoid Fever in Some Low Income communities in the Adamawa Region of cameroon

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Journal of Biosciences and Medicines 2024年第6期12卷 178-190页

作者： Mariane Lucie Ngueguim Bernard Viban Tangwa victor Ngu Ngwa Jules Romain Ngueguim Abdoulmoumini Mamoudou School of Veterinary Medicine and Sciences University of Ngaoundere Ngaoundere Cameroon department of Veterinary Medicine University of Buea Buea Cameroon Institute de Recherhe Agricole pour le development (IRAD) Ngaoundere Cameroun

Introduction: Infectious diseases constitute a major concern of public health in developing countries. Facilities and well trained staff have been shown to be one of the major obstacles in the rapid and quality diagnosis of these diseases. As such, we carried out an analysis to compare the Widal test and stool culture to identify febrile patients with Salmonella infection. Method: A cross sectional study was conducted to diagnose salmonella infection with out-patients who demonstrated signs of salmonella infection. Serum was harvested from blood collected from 368 (Vina = 234, Mayo Banyo 65, and Djerem = 69) patients accompanied by stool, Widal test was conducted on the spot and stool was taken to a reference laboratory for culture using standard microbiological methods, sociological set up was calculated in percentages, prevalence was calculated using excel while statistical difference was calculated using SPSS. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated to compare the Widal test against stool culture. Results: A total of 368 (50.8% females and 49.2% males) participants took part in the survey. Salmonella prevalence (66.24%) in stool culture in the Vina division was significantly different (p 0.05). The sensitivity,specificity, PPV, and NPV of slide agglutination test against stool culture varied from different areas (Vina: 51.6%, 73.62%, 79.21% and 43.61%;Mayo Banyo: 60.53%, 77.78%, 79.31% and 58.33%;Djerem: 53.18%, 83.73% 73.91% and 67.39%) respectively. Slide agglutination test has a fair agreement with the stool culture (kappa, Vina = 0.202;Mayo Banyo = 0.37 and Djerem = 0.38). conclusion: Generally, in the three areas of study, the Widal test had a fair correlation with the stool culture;This means the Widal test should not be used alone but in combination with stool culture in the detection of salmonella infections.

关键词： Salmonella Infections Stool culture Widal Test Adamawa Region cameroon

Pathogenic and therapeutic role of exosomes in neurodegenerative disorders

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Neural Regeneration Research 2024年第1期19卷 75-79页

作者： christa c.Huber Hongmin Wang Division of Basic Biomedical Sciences Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affect millions of people worldwide,and the prevalence of these disorders is only projected to rise as the number of people over 65 will drastically increase in the coming *** therapies exist to aid in symptomatic relief,effective treatments that can stop or reve rse the progress of each neurodegenerative disease are ***,research on the role of extracellular vesicles as disease markers and therapeutics has been intensively ***,30-150 nm in diameter,are one type of extracellular vesicles facilitating cell-to-cell *** are thought to play a role in disease propagation in a variety of neurodegenerative diseases,such as Alzheimer's disease,Parkinson s disease,and amyotrophic lateral ***,the exosomes derived from the patients are an invaluable source of disease *** the other hand,exosomes,especially those derived from stem cells,could serve as a therapeutic for these disorders,as seen by a rapid increase in clinical trials investigating the therapeutic efficacy of exosomes in different neurological *** review summarizes the pathological burden and therapeutic approach of exosomes in neurodegenerative *** also highlight how heat shock increases the yield of exosomes while still maintaining their therapeutic ***,this review concludes with outstanding questions that remain to be addressed in exosomal research.

关键词： aging Alzheimer's disease biomarker drug exosome extracellular vesicle neurodegenerative disease Parkinson's disease therapy

On the Path to High-Temperature Josephson Multi-Junction devices

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Electromagnetic Science 2024年第3期2卷 71-78页

作者： Xu Wang Fucong chen Zefeng Lin Shibing Tian chunguang Li victor Kornev Nikolay Kolotinskiy Institute of Physics Chinese Academy of SciencesBeijing 100190China Faculty of Physics Lomonosov Moscow State UniversityMoscow 119991Russia

We report our progress in the high-temperature superconductor(HTS)Josephson junction fabrication process founded on utilizing a focused helium ion beam damaging technique and discuss the expected device performance attainable with the HTS multi-junction device *** the achievable high value of characteristic voltage V_(c)=I_(c)R_(N)of Josephson junctions and the ability to design a large number of arbitrary located Josephson junctions allow narrowing the existing gap in design abilities for lowtemperature superconductor(LTS)and HTS circuits even with using a single YBa_(2)cu_(3)O_(7-x) film layer.A one-layer topology of active electrically small antenna is suggested and its voltage response characteristics are considered.

关键词： Josephson junctions High-temperature superconductors YBa_(2)cu_(3)O_(7-x)(YBcO) Focused helium ion beam fabrication technique Josephson multi-junction devices Superconducting quantum interference device Active electrically small antenna

Predictors of Abnormal Vaginal Discharge among Women of Reproductive Age in Southeast Nigeria

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International Journal of clinical Medicine 2024年第7期15卷 240-256页

作者： Jideuma Egwim victor Dike Hope Igbonagwam Nkechinyere Oke Uzoma Amajo Akuchi Okafor Angela Izegbune Ijedimma Okafor department of Family Medicine Federal University Teaching Hospital Owerri Nigeria department of Public Health Central Michigan University Mount Pleasant Michigan USA department of Ophthalmology Enugu State University Teaching Hospital Enugu Nigeria department of Family Medicine Lagos University Teaching Hospital Lagos Nigeria department of Internal Medicine Alex Ekwueme Federal University Teaching Hospital Ebonyi State Nigeria Field Office World Health Organisation Imo State Nigeria department of Internal Medicine Ebonyi State University College of Health Sciences Ebonyi State Nigeria

Background: An abnormal vaginal discharge is a common complaint among women of reproductive age, and it can indicate serious conditions like pelvic inflammatory disease and cervical cancer. This study aimed to assess the predictors of abnormal vaginal discharge in women of reproductive age group in Imo State, Southeast Nigeria. Methods: A cross-sectional study was conducted among 368 women of reproductive age group attending the clinic at Federal University Teaching Hospital Owerri, in Imo State, Nigeria. Respondents were recruited using a systematic sampling technique. Data were collected using a pre-tested interviewer-administered questionnaire. Multivariable analysis was performed to determine predictors of abnormal vaginal discharge. Statistical significance was set at p Results: The mean age of the respondents was 30 ± 4.5 years. Predictors of abnormal vaginal discharge were: age 36 - 45 years (OR: 4.5;95% c.I: 1.023 - 8.967, p = 0.041), being a student (OR: 2.4: 95% c.I: 1.496 - 7.336, p = 0.003), use of oral contraceptives (OR: 3.4;95% c.I: 1.068 - 6.932, p = 0.010), use of water cistern (OR: 4.7;c.I: 1.654 - 5.210, p = 0.028) anal hygiene practices (OR: 2.7;95% c.I: 1.142 - 4.809, p conclusion: These findings suggest that targeted sexual and reproductive health interventions should be provided to reduce the risk of abnormal vaginal discharge in women of reproductive age group.

关键词： Predictors Abnormal Vaginal Discharge

Distribution and Relation of Primes with Tesla Numbers 3, 6, and 9

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1021-1027页

作者： Javier Mendoza-Navarrete Huetzin Perez Ismael Ojeda victor Verdugo Gabriel Luna Sandoval Ricardo Jimenez Garcia Jaime Alvarez departametno de Matemá ticas CBTis 256 DGETI Cabo San Lucas M&#233xico DcI departamento de Fisica Mé dica Universidad de Guanajuato Leon M&#233xico Divisió n de Ingenieria en Sistemas Computacionales Tecnol&#243gico Nacional de M&#233xico ITES Los Cabos Cabo San Lucas M&#233xico departamento de Ingenieria Industrial en Manufactura Universidad Estatal de Sonora Navojoa M&#233xico departamento de Elé ctrica-Electr&#243nica Tecnol&#243gico Nacional de M&#233xico Campus Mexicali Mexicali M&#233xico Guanajuato M&#233xico

This work presents a different approach to twin primes, an approach from the perspective of the Tesla numbers and gives a refresh and new observation of twin primes that could lead us to an answer to the Twin Prime conjecture problem. We expose a peculiar relation between twin primes and the generation of prime numbers with Tesla numbers. Tesla numbers seem to be present in so many domains like time, vibration and frequency [1], and the space between twin primes is not the exception. Let us say that twin primes are more than just prime numbers plus 2 or minus 2, and Tesla numbers are more involved with twin primes than we think, and hopefully, this approach give us a better understanding of the distribution of the twin pairs.

关键词： Tesla Numbers Prime Number Twin Prime Numbers Twin Pair

Sequential Analysis in the Identification of 3rd Order System Tract in the Abidjan Margin

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Open Journal of Applied Sciences 2024年第6期14卷 1474-1489页

作者： Blandine Akissi Egoran N’guessan Donald Ahoure Fori Yao Paul Assalé Sylvain Mondé Loukou victor N’da UFR Marine Sciences San Pedro University San Pedro Cte dIvoire UFR of Sciences and Technologies Alassane Ouattara Bouak Laboratory of Plant Biology and Earth Sciences Bouak Cte dIvoire UFR/STRM Flix Houphout Boigny de Cocody Abidjan Cte dIvoire PETROcI Consultant at the Center for Analysis and Research Department of Sequential Stratigraphy Abidjan Cte dIvoire

The use of sequential stratigraphy concept, based on well logs, sedimentology, and biostratigraphy, has shed light on the complex mechanisms controlling sedimentary accumulations. consequently, identifying these mechanisms allows us to predict the hydrocarbon generation potential of source rocks. In the Ivorian offshore sedimentary basin, certain studies have contributed to understanding and characterizing the petroleum system. However, these previous works did not integrate biostratigraphic data to highlight sedimentary facies. This study, conducted on two wells in the Abidjan margin, is crucial as it helps us comprehend the geometry of fossil sediments in relation to sea level variations. It will also aid in reconstructing the basin-filling history and predicting the distribution of rocks capable of trapping oil, determining lowstand systems tracts (reservoir rocks), transgressive systems tracts, and highstand systems tracts (cap rocks). Lithological analysis revealed predominantly clayey sedimentation with sandy layers. Well log data facilitated the delineation of formation boundaries and highlighted reservoirs consisting of sands, sandstones, limestones, and occasionally intercalated shales. Integrating these analysis results with biostratigraphic interpretations based on foraminifera and palynomorphs revealed that the traversed formations were deposited in a transitional environment ranging from coniacian to Maastrichtian ages. Applying sequential stratigraphy concept from well logging resolved dating issues encountered in microfossil-poor or microfossil-free zones. The results of the coniacian-Maastrichtian age sequential subdivision were aligned with the chart.

关键词： Sequence Stratigraphy Systems Tracts Senonian côte d’Ivoire

Exploring kidney biopsy findings in congenital heart diseases:Insights beyond cyanotic nephropathy

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World Journal of Nephrology 2024年第1期13卷 25-32页

作者： Jose Daniel Juarez-Villa Iván Zepeda-Quiroz Sebastián Toledo-Ramírez victor hugo Gomez-Johnson Francisco Pérez-Allende Brian Ricardo Garibay-Vega Francisco E Rodríguez castellanos Bernardo Moguel-González Edgar Garcia-cruz Salvador Lopez-Gil department of Nephrology Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico congenital Heart Disease Instituto Nacional de Cardiología Ignacio ChavezMexico City 14080Mexico

BAcKGROUND The association between congenital heart disease and chronic kidney disease is well *** mechanisms of kidney damage associated with congenital heart disease have been *** etiology of kidneydisease has commonly been considered to be secondary to focal segmental glomerulosclerosis(FSGS),however,this has only been demonstrated in case reports and not in observational or clinical *** To identify baseline and clinical characteristics,as well as the findings in kidney biopsies of patients with congenital heart disease in our *** This is a retrospective observational study conducted at the Nephrology depart-ment of the National Institute of cardiology“Ignacio chávez”.All patients over 16 years old who underwent percutaneous kidney biopsy from January 2000 to January 2023 with congenital heart disease were included in the *** Ten patients with congenital heart disease and kidney biopsy were *** average age was 29.00 years±15.87 years with pre-biopsy proteinuria of 6193 mg/24 h±6165 mg/24 *** most common congenital heart disease was Fallot’s tetralogy with 2 cases(20%)and ventricular septal defect with 2(20%)*** the 10 cases,one case of IgA nephropathy and one case of membranoproliferative glomerulonephritis associated with immune complexes were found,receiving specific treatment after histopathological diagnosis,delaying the initiation of kidney replacement *** remaining 8 cases(80%),one case of FSGS with perihilar variety was found,while the other 7 cases were non-specific *** determining the cause of chronic kidney disease can help in delaying the need for kidney replacement *** 2 out of 10 patients in our study,interventions were performed,and initiation of kidney replacement therapy was *** studies are needed to determine the usefulness of kidney biopsy in patients with congenital heart disease.

关键词： Renal biopsy congenital heart disease chronic kidney disease Focal segmental glomerulosclerosis