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World Journal of Gastroenterology 2015年第4期21卷 1081-1090页

作者： Ammar Hassanzadeh Keshteli vickie E Baracos Karen L Madsen Department of Medicine University of AlbertaEdmontonAlberta T6G 2E1Canada Department of Oncology University of AlbertaCross Cancer InstituteEdmontonAlberta T6G 2E1Canada

Homocysteine is an amino acid generated metabolically by the S-adenosylmethionine-dependent transmethylation pathway. In addition to being a well-known independent risk factor for coronary heart disease, is also a risk factor for cancer. Patients suffering from inflammatory bowel diseases(IBD) including ulcerative colitis and Crohn's disease are at increased risk of developing colorectal cancer in comparison to healthy individuals. Furthermore, the risk of hyperhomocysteinaemia is significantly higher in IBD patients when compared with controls. In the present article, we review the mechanisms in which hyperhomocysteinemia may contribute to increased risk of colorectal cancer in IBD patients.

关键词： Hyperhomocysteinemia Colorectal cancer Inflammator

Convergent plate boundary environments for formation of≥3800 Ma mafic-ultramafic assemblages(Isua area,Greenland):Implications for early global geodynamics

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Geoscience Frontiers 2024年第3期15卷 119-136页

作者： Allen P.Nutman Clark R.L.Friend vickie C.Bennett School of Earth Atmospheric and Life SciencesUniversity of WollongongWollongongNSW 2522Australia Glendale TiddingtonOxon OX92LQUK Research School of Earth Sciences Australian National UniversityCanberraACT 2601Australia

In the gneiss terrane on the south side of the Eoarchean Isua supracrustal belt,ultramafic rocks with relict abyssal peridotite mineralogy(Bennett et al.,2002;Friend et al.,2002;Nutman et al.,2007;Rollinson,2007;van de Löcht et al.,2020),layered gabbros with cumulate ultramafic rocks,basalts and associated siliceous sedimentary rocks were tectonically-imbricated,prior to and during intrusion of ca.3800 Ma *** with3800 Ma basalts in the Outer Arc Group of the nearby Isua supracrustal belt,the composition of all these mafic rocks(e.g.,Th-Hf-Nb systematics,high Th/Yb,Ba/Nb,Ba/Yb ratios and negative Nb and Ti anomalies)shows affinity with modern suprasubduction rocks whose genesis involved fluid fluxing of the upper ***,the majority of these samples have Ba/Nb and Ba/Yb values less than in modern island arc magmas,but similar to many backarc basin magmas(e.g.,Pearce and Stern,2006).It is unknown whether these ca.3800 Ma mafic rocks are,(i)arc rocks where the Ba/Nb and Ba/Yb signatures reflect lower surficial Ba in Eoarchean oceanic settings,or(ii)in direct comparison with Phanerozoic suites,these signatures reflect a back-arc setting with interplay between fluid fluxing and decompressional *** tectonic intercalation of upper mantle with lower and upper crustal rocks,combined with the fluid-fluxing influences seen in chemistry of all the mafic rocks is best accommodated in a compressional Eoarchean convergent plate boundary setting within a mobile-lid *** stagnant lid scenarios of crust formation,if operative,must have co-existed or alternated with mobile-lid regimes by 3800 Ma.

关键词： Eoarchean Fluid-fluxing Plate tectonics Suprasubduction Crustal evolution

Seeing through the magnetite:Reassessing Eoarchean atmosphere composition from Isua(Greenland) ≥3.7 Ga banded iron formations

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Geoscience Frontiers 2017年第6期8卷 1233-1240页

作者： Allen P.Nutman vickie C.Bennett Clark R.L.Friend GeoQuEST Research Centre School of Earth and Environmental SciencesUniversity of WollongongWollongongNSW 2522Australia Research School of Earth Sciences Australian National UniversityCanberraACT 0200Australia Glendale TiddingtonOxonOX9 2LQUK

Estimates of early atmosphere compositions from metamorphosed banded iron formations(BIFs)including the well-studied ≥3.7 BIFs of the Isua supracrustal belt(Greenland)are dependent on knowledge of primary versus secondary Fe-mineralogical *** new observations from locally well preserved domains,we interpret that a previously assumed primary redox indicator mineral,magnetite,is secondary after sedimentary Fe-clays(probably greenalite)±*** ~3.7 Ga Isua BIF,pre-tectonic nodules of quartz+Fe-rich amphibole±calcite reside in a finegrained(≤100 μm)quartz+magnetite *** interpret the Isua nodule amphibole as the metamorphosed equivalent of primary Fe-rich clays,armoured from diagenetic oxidative reactions by early silica ***,in another low strain lacunae,~3.76 Ga BIF layering is not solid magnetite but instead fine-grained magnetite+quartz *** magnetite+quartz aggregates are interpreted as the metamorphosed equivalent of Fe-clay-rich layers that were oxidised during diagenesis,because they were not armoured by early *** almost all Isua BIF exposures,this evidence has been destroyed by strong ductile *** Fe-clays likely formed by abiotic reactions between aqueous Fe^(2+)and *** clays along with silica±carbonate were deposited below an oceanic Fe-chemocline as the sedimentary precursors of *** of the clays on the sea floor may have been by anaerobic oxidation of Fe^(2+),a mechanism compatible with iron isotopic data previously published on these *** new determinations of the primary redoxsensitive Fe-mineralogy of BIF significantly revise estimates of early Earth atmospheric oxygen and CO_2 content,with formation of protolith Fe-rich clays and carbonates compatible with an anoxic Eoarchean atmosphere with much higher CO_2 levels than previously estimated for Isua and in the present-day atmosphere.

关键词： Banded iron formation Eoarchean Early atmosphere Greenalite Magnetite

Development and optimization of thermal contrast amplification lateral flow immunoassays for ultrasensitive HIV p24 protein detection

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Microsystems & Nanoengineering 2020年第1期6卷 683-693页

作者： Li Zhan Timothy Granade Yilin Liu Xierong Wei Ae Youngpairoj vickie Sullivan Jeff Johnson John Bischof Department of Mechanical Engineering University of MinnesotaMinneapolisMNUSA Centers for Disease Control and Prevention AtlantaGAUSA Department of Biomedical Engineering University of MinnesotaMinneapolisMNUSA

Detection of human immunodeficiency virus(HIV)p24 protein at a single pg/ml concentration in point-of-care(POC)settings is important because it can facilitate acute HIV infection diagnosis with a detection sensitivity approaching that of laboratory-based ***,the limit of detection(LOD)of lateral flow immunoassays(LFAs),the most prominent POC diagnostic platform,falls short of that of laboratory protein detection methods such as enzyme-linked immunosorbent assay(ELISA).Here,we report the development and optimization of a thermal contrast amplification(TCA)LFA that will allow ultrasensitive detection of 8 pg/ml p24 protein spiked into human serum at POC,approaching the LOD of a laboratory *** achieve this aim,we pursued several innovations as follows:(a)defining a new quantitative figure of merit for LFA design based on the specific to nonspecific binding ratio(BR);(b)using different sizes and shapes of gold nanoparticles(GNPs)in the systematic optimization of TCA LFA designs;and(c)exploring new laser wavelengths and power regimes for TCA LFA ***,we optimized the blocking buffer for the membrane and running buffer by quantitatively measuring the BR using a TCA *** TCA reader interprets the thermal signal(i.e.,temperature)of GNPs within the membrane when irradiated by a laser at the plasmon resonance wavelength of the *** process results in higher detection and quantitation of GNPs than in traditional visual detection(i.e.,color intensity).Further,we investigated the effect of laser power(30,100,200 mW),GNP size and shape(30 and 100 nm gold spheres,150 nm gold-silica shells),and laser wavelength(532,800 nm).Applying these innovations to a new TCA LFA design,we demonstrated that 100nm spheres with a 100 mW 532 nm laser provided the best performance(i.e.,LOD=8pg/ml).This LOD is significantly better than that of the current colorimetric LFA and is in the range of the laboratory-based p24 *** summary,this TCA LFA for p24 prote

关键词： optimization approaching flow

Entrepreneurs'Share Their Tips and Outlook for 2022

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城市漫步（GBA版） 2022年第3期 36-39页

作者： vickie Wang 不详

2021 was not a normal *** much as we all shouted,"Happy New Year!"hoping we would be putting the madness and uncertainties of 2020 behind us,2021 still kicked our *** entrepreneurs seem built for butt-kicking *** unlque ablity to roll with the punches has ensured that many of their buslness endeavors have not only survlved but thrlved in the COVID-19 era.

关键词： Outlook Share Tips COV

Entrepreneurs’ Share Their Tips and Outlook for 2022

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城市漫步（上海版、英文） 2022年第3期 36-39页

作者： vickie Wang 不详

2021 was not a normal *** much as we all shouted,"Happy New Year!0 hoping we would be putting the madness and uncertainties of 2020 behind us,2021 still kicked our butts・Most entrepreneurs seem built for butt-kicking years・Their unique ability to roll with the punches has ensured that many of their business endeavors have not only survived but thrived in the COVID9 era・These self-starters sell B2B software,performance-driven children's clothes,overseas investments and even trees・Here are some of their pearls of wisdom as we head into the Year of the Tiger.

关键词： Outlook Share wisdom

Failure mechanisms of a spudcan penetrating next to an existing footprint

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Theoretical & Applied Mechanics Letters 2015年第2期5卷 64-68页

作者： vickie Kong Mark J.Cassidy Christophe Gaudin Fugro-Advanced Geomechanics Centre for Offshore Foundation Systems and ARC CoE for Geotechnical Science and Engineering University of Western Australia

Reinstallation of mobile jack-up rigs next to existing footprints is a problematic operation because the spudcan located near the footprints is subjected to eccentric and/or inclined loading conditions. Geotech- nical centrifuge studies have measured these loads for combinations of changing footprint geometry, footprint soil properties and the offset of the reinstallation from the footprint centre. These tests have been of full model spudcans in order to accurately measure the combined loads developed. They have not provided information on the mechanisms of failure occurring during this complex installation. Ob- servations from a visualisation test, where a half spudcan is penetrated against a transparent window in a geotechnical centrifuge, are reported in this paper. The mechanisms of failure at different stages during the nenetrntirm are nr^nted

关键词： Jack-up Footprint Combined loading Spudcan Offshore geotechnics

The Pushtashan juvenile suprasubduction zone assemblage of Kurdistan (northeastern Iraq): A Cretaceous (Cenomanian) Neo-Tethys missing link

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Geoscience Frontiers 2017年第5期8卷 1073-1087页

作者： Sabah A.Ismail Sarmad A.Ali Allen P.Nutman vickie C.Bennett Brain G.Jones Department of Applied Geology College of Sciences Kirkuk University Kirkuk 36001 Iraq GeoQuEST Research Centre School of Earth & Environmental Sciences University of Wollongong Wollongong NSW 2522 Australia Research School of Earth Sciences Australian National University ACT 0200 Australia

The Pushtashan suprasubduction zone assemblage of volcanic rocks, gabbros, norites and peridotites occurs in the Zagros suture zone, Kurdistan region, northeastern Iraq. Volcanic rocks are dominant in the assemblage and consist mainly of basalt and basaltic andesite flows with interlayered red shale and limestone horizons. Earlier lavas tend to be MORB-like, whereas later lavas display island arc tholeiite to boninitic geochemical characteristics. Tholeiitic gabbros intrude the norites and display fractionation trends typical of crystallisation under low-pressure conditions, whereas the norites display calc-alkaline traits, suggesting their source included mantle metasomatised by fluids released from subducted oceanic crust. Enrichment of Rb, Ba, Sr, Th and the presence of negative Nb anomalies indicate generation in a suprasubduction zone setting. Trondhjemite and granodiorite intrusions are present in the volcanic rocks, gabbros and norites. SHRIMP U-Pb dating of magmatic zircons from a granodiorite yields a mean^(206)Pb/^(238)U age of 96.0 ±2.0 Ma(Cenomanian). The initial ε_(Hf) value for the zircons show a narrow range from +12.8 to+15.6, with a weighted mean of + 13.90±0.96. This initial value is within error of model depleted mantle at 96 Ma or slightly below that, in the field of arc rocks with minimal contamination by older continental crust. The compositional bimodality of the Pushtashan suprasubduction sequence suggests seafloor spreading during the initiation of subduction, with a lava stratigraphy from earlyerupted MORB transitioning into calc-alkaline lavas and finally by 96 Ma intrusion of granodioritic and trondhjemitic bodies with juvenile crustal isotopic signatures. The results confirm another Cretaceous arc remnant preserved as an allochthon within the Iraqi segment of the Cenozoic Zagros suture zone. Implications for the closure of Neo-Tethys are discussed.

关键词： Pushtashan suprasubduction assemblage Cretaceous Zircon U-Pb dating Hf isotopes Kurdistan region lraq Neo-Terhys

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改进认证保障高等教育质量的建议

教育发展研究 2006年第24期26卷 78-82页

作者： vickie Schray 华晨美国教育部高等教育发展委员会

一、概述认证在美国高等教育中起着极其重要的作用,因为高等教育界和政府都使用这项制度来促进和保证教育质量,保护公众利益.在认证中,可以反映出高等教育界对教育质量的期望,以及政府和社会对公众首要利益的认定和沟通结果.

关键词：高等教育质量认证保障美国高等教育公众利益教育界政府

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全球网上中文人文社会科学期刊的现状与趋势

大学图书馆学报 2001年第2期19卷 44-47页

作者：叶继元 vickie Fu Doll 南京大学图书馆 210093 The University of Kansas East Asia Library

目前全球网络中文人文社会科学电子期刊已有数百种，涉及较多学科和门类，其发行方式、价格、可检内容多种多样。一些网上期刊代理发行机构和行业组织也已出现。但在上网数量、检索、精审制度、汉字编码、版权、服务方式等方面尚存在不... 详细信息

目前全球网络中文人文社会科学电子期刊已有数百种，涉及较多学科和门类，其发行方式、价格、可检内容多种多样。一些网上期刊代理发行机构和行业组织也已出现。但在上网数量、检索、精审制度、汉字编码、版权、服务方式等方面尚存在不足。更多的印刷型期刊上网，更多的学术单位创办网上期刊，更好的编排、界面、链接，合理的权益和价格体系，采、编、发行、订购、检索、阅读、交流的新模式将是今后的发展趋势。

关键词：世界网络电子期刊中文期刊人文科学社会科学期刊质量期刊代理发行机构现状发展趋势