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铝对玉米生长和硝酸还原酶活性的影响

植物生理学报（0257-4829) 1998年第4期24卷 347-353页

作者：刘保国 vesna Hadzi-Taskovic Sukalovic 西南农业大学农学系重庆400716 DepartmentofPlantPhysiology MaizeResearchInstitute

测定了生长在Al2（SO4）100μmol／L氮素营养液中的两个玉米品种（SC704和VA35的根系和叶片）的NADH-硝酸还原酶（EC1．6．6．）和NAD（P）H-硝酸还原酶（EC1．6．6．2）活性。结果表明铝的存在阻碍了玉米根系和叶片的生长、降低了营养... 详细信息

测定了生长在Al2（SO4）100μmol／L氮素营养液中的两个玉米品种（SC704和VA35的根系和叶片）的NADH-硝酸还原酶（EC1．6．6．）和NAD（P）H-硝酸还原酶（EC1．6．6．2）活性。结果表明铝的存在阻碍了玉米根系和叶片的生长、降低了营养液的pH值，降低了叶片的NADH-及NAD（P）H-硝酸还原酶活性（酶活性降低的程度SC704低于VA35），增加了根系的NADH-和NAD（P）H-硝酸还原酶活性（VA35根系的比活性除外）。铝胁迫下根系的NADH-和NAD（P）H-硝酸还原酶活性的增加SC704大于VA35。耐铝品种SC704的高NR活性以及在铝胁迫下能维持更高的NR活性的特点说明硝酸还原酶与植物组织的Al解毒机制有关。同时，在铝胁迫下的硝酸盐代谢中NAD（P）H-硝酸还原酶具有更重要的作用。

关键词：铝玉米生长硝酸还原酶

Issuing the Antibiotics for Children with and without Prescription in Pharmacies in Republic of Macedonia

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Journal of Pharmacy and Pharmacology 2016年第1期4卷 5-9页

作者： Bistra Angelovska Elena Drakalska Marija Atanasova vesna Kostic Jasmina Trajkoska University "GoceDelcev " Faculty of Medical Sciences Krste Misirkov bb POB 201 Stip R. Macedonia

The use of medicines for infants and children is presenting one unique set of challenges, because children are the most vulnerable population in any society. In this study, we set out to present the characteristics and classification of antibiotics recommended for children according to WHO, EMA and EBM. Also, the aim of this study was to analyze the most prescribed pediatric antibiotics in 2013 in Republic of Macedonia compared with standard treatments. Presented data was collected according to the number of prescribed recipes of pediatric dosage forms covered by the Fund of Republic of Macedonia. The obtained results showed that the most prescribed pediatric antibiotic is amoxicillin with clavulanic acid (875mg + 125mg) in form of tablet, with 280 863 prescribed recipes which corresponds to the recommendations of EBM.

关键词：抗生素共和国儿童处方循证医学克拉维酸阿莫西林平板电脑

Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B

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World Journal of Gastroenterology 2007年第30期13卷 4096-4099页

作者： Paolo Del Poggio Maurizio Zaccanelli Maria Oggionni Silvia Colombo Carlo Jamoletti vesna Puhalo Hepatology Unit Treviglio Hospital (Bg) Italy Blood Bank (Molecular Biology Section) Treviglio Hospital (Bg) Italy

AIM: To study the efficacy of tenofovir disoproxil fumarate (TDF) at low dose in a small open trial of chronic hepatitis B patients with advanced stage disease. METHODS: Eleven patients were treated with TDF 75 mg for a median period of 80 (range, 24-576) wk and then 7 cases were shifted to an adefovir 10 mg treatment group. All patients had been pre-treated with lamivudine: 5 had YMDD resistant mutants and 6 wild- type virus. When TDF was started, 4 patients had low- level viremia and 6 were PCR-negative. RESULTS: During TDF treatment, PCR remained negative in 10 patients, transaminase levels were normal and no significant viral breakthrough was observed. The drug was well tolerated in all cases. When TDF 75 mg was substituted with adefovir 10 mg, 3 out of 7 patients had a persistent viral rebound (2700-130 000 copies/mL), in whom lamivudine had to be reintroduced. CONCLUSION: Low-dose TDF monotherapy can control HBV viremia for an extended period of time without the emergence of resistance and is more potent than adefovir at the standard dosage. The use of a reduced dose of TDF could diminish the cost of therapy in low-income countries, but further studies in a larger population and in HBeAg-positive subjects are needed.

关键词：特洛福韦乙型肝炎核苷酸治疗效果

Detection of gelatinase B activity in serum of gastric cancer patients

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World Journal of Gastroenterology 2006年第1期12卷 105-109页

作者： vesna V Dragutinovi Neboja S Radovanovi Lidija T Izrael-■ivkovi Miroslav M Vrvi Institute of Chemistry School of MedicineUniversity of BelgradeViegradska 2611 000 BelgradeSerbia and Montenegro Institute of Digestive Diseases Center of Esophagogastric SurgeryClinical Center of SerbiaKoste Todorovia 611 000 BelgradeSerbia and Montenegro Faculty of Chemistry University of BelgradeStudentski trg 1611001 BelgradeSerbia and Montenegro

瞄准：在有肿瘤的阶段的胃的癌症病人和他们的关联的浆液决定明胶酶 B 的解朊的活动和表示。方法：从作为控制组作为试验性的组并且从 11 为主要胃的癌症经历了外科的 23 个病人的血清被用来由乙二胺四乙酸和 1,10-phenanthroline 决定... 详细信息

瞄准：在有肿瘤的阶段的胃的癌症病人和他们的关联的浆液决定明胶酶 B 的解朊的活动和表示。方法：从作为控制组作为试验性的组并且从 11 为主要胃的癌症经历了外科的 23 个病人的血清被用来由乙二胺四乙酸和 1,10-phenanthroline 决定解朊的活动和它的抑制。明胶酶 B 活动被 SDS polyacrylamide 胶化电气泳动(SDS 页) 和 SDS 页 zymography 检测。结果：当时，解朊的酶活动在胃的癌症病人被增加与控制组相比(P < 0.05 ) 。朊酶决心是在有特定的 metalloproteinase 禁止者 1,10-phenanthroline 的抑制测试之上的 metalloproteinases (P < 0.05 ) 并且乙二胺四乙酸(P < 0.01 ) 。SDS 页和 SDS 页 zymography 揭示了明胶酶 B (proMMP-9 ) 活动和它 92 ku 的分子的团。结论：朊酶活动完了在胃的癌症病人的浆液表示了。在浆液的明胶酶 B 在胃的癌症的前进起一个重要作用。ProMMP-9 能为胃的癌症的侵略海角被用作一个标记。

关键词：白明胶酶B 酶活性精子胃癌

An unusual presentation of “silent” disseminated pancreatic neuroendocrine tumor

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World Journal of Gastroenterology 2004年第19期10卷 2919-2921页

作者： Dragomir Marisavljevic Natasa Petrovic Nikola Milinic vesna Cemerikic Miodrag Krstic Olivera Markovic Dragoljub Bilanovic Medical Center"Bezanijska kosa" BelgradeYugoslavia Clinical Center Serbia BelgradeYugoslavia

To present a patient diagnosed with pancreatic carcinoidthat was extremely rare and produced an atypical carcinoidsyndrome. We reported a 58-year old male patient whopresented with long standing, prominent cervicallymphadenopathy and occasional watery *** and immunohistochemical examinationof lymph node biopsy showed a metastatic neuroendocrinetumor, which was histological type A of carcinoid (EMA+,cytokeratin+, CEA-, NSE+, chromogranin A+, synaptophysin+,insulin-). Bone marrow biopsy showed identical *** site of the tumor was pancreas and diagnosis wasmade according to cytological and immunocytochemicalanalysis of the tumor cells obtained with aspiration biopsyof pancreatic mass (12 mm in diameter) under endoscopicultrasound guidance. However, serotonin levels in bloodand urine samples were normal. It is difficulty to establishthe precise diagnosis of a "functionally inactive" pancreaticcarcinoid and aspiration biopsy of pancreatic tumor underendoscopic ultrasound guidance can be used as a newpotent diagnostic tool.

关键词：基因表达播散性胰腺神经内分泌内分泌肿瘤腹泻

《郭沫若与克罗地亚诗人安东·古斯塔夫·马托斯之比较》(英文)

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《郭沫若与克罗地亚诗人安东·古斯塔夫·马托斯之比较》(英文)

电解液中Ni^(2+)/Co^(2+)比对电解Ni-Co合金粉末形貌、结构和磁学性能的影响

作者： vesna Deli Gozze Jong Lester A.C.Barnes

The exhibition which was opened in the Dubrovnik Museum House of Marin Drzic is dedicated to a great poet of Chinese modernism,Guo Moruo,on the occasion of presenting the Croatian version of his collected works Goddesses(1921).Experts from his memorial museum in Bejing,Guo Pingying and Zhongyuan Tang chose 21 examples,mostly composed of multiple sheets,which were displayed in the show-cases of the museum in *** accompanying photographs and texts displayed on the walls of the museum concisely offer an abundance of a creative ***’s skills of connecting ideas with specific images also reflect in his calligraphy showing his deep confidence in a connec-

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Transactions of Nonferrous Metals Society of China 2020年第4期30卷 1046-1057页

作者： vesna M.MAKSIMOVIC Vladan B.KUSIGERSKI Milovan M.STOILJKOVIC Jelena R.MALETASKIC NebojSa D.NIKOLIC Institute of Nuclear Sciences “Vinca”University of BelgradeP.O.Box 522Belgrade 11001Serbia Laboratory for Advanced Nuclear Energy Institute of Innovative ResearchTokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8550Japan ICTM-Department of Electrochemistry University of BelgradeNjegoseva 12P.O.Box 473Belgrade 11001Serbia

采用恒电流法在具有不同Ni^2+/Co^2+比(摩尔比)的硫酸盐电解液中制备镍钴(Ni-Co)合金粉末。利用扫描电镜(SEM)、X射线衍射仪(XRD)、原子发射光谱仪(AES)和基于SQUID的磁力仪检测粉末的形态、相结构、化学成分和磁学性能。当Ni^2+/Co^2+... 详细信息

采用恒电流法在具有不同Ni^2+/Co^2+比(摩尔比)的硫酸盐电解液中制备镍钴(Ni-Co)合金粉末。利用扫描电镜(SEM)、X射线衍射仪(XRD)、原子发射光谱仪(AES)和基于SQUID的磁力仪检测粉末的形态、相结构、化学成分和磁学性能。当Ni^2+/Co^2+比从0.25增加到4.0时,颗粒形貌从菜花状和树枝状转变为珊瑚状和海绵状。Ni-Co粉末的XRD分析表明,Ni/Co比降低(Co含量增加)导致结构变化:Ni^2+/Co^2+比为4.0、1.5和0.67时,粉末为面心立方(FCC)结构;Ni/Co比为0.25时,粉末为面心立方(FCC)和六方密堆(HCP)相的混合物。增加电解液中Ni含量导致电解机理发生变化:当电解液中Ni含量低于40%(质量分数)时为不规则共沉积;Ni含量为40%~60%(质量分数)时接近平衡共沉积,Ni含量高于60%(质量分数)时则为异常共沉积。所有获得的Ni-Co合金样品均为软磁材料,其磁性参数显示出直接的成分依赖性,因为矫顽力和饱和磁化强度几乎都随Co含量线性增大。

关键词： Ni-Co合金粉末电解氢形貌磁学性能

Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation

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Emerging Contaminants 2021年第1期7卷 219-235页

作者： Harlie A.Cope Bevin E.Blake Charlotte Love James McCord Susan A.Elmore Janice B.Harvey vesna A.Chappell Suzanne E.Fenton National Toxicology Program Laboratory Division of the National Toxicology Program(DNTP)National Institutes of Environmental Health Sciences(NIEHS)National Institutes of Health(NIH)Research Triangle ParkNCUSA Multimedia Methods Branch Center for Environmental Measurement and ModelingOffice of Research and DevelopmentU.S.Environmental Protection AgencyRTPNCUSA Cellular and Molecular Pathology Branch DNTPNIEHSNIHRTPNCUSA

Background:Perfluorooctanoic acid(PFOA)is an environmental contaminant associated with adverse metabolic outcomes in developmentally exposed human populations and mouse *** oxide-dimer acid(HFPO-DA,commonly called GenX)has replaced PFOA in many industrial applications in the *** Europe and has been measured in global water systems from<1 to 9350 ng/L *** effects data for GenX are ***:Determine the effects of gestational exposure to GenX on offspring weight gain trajectory,adult metabolic health,liver pathology and key adipose gene pathways in male and female CD-1 ***:Daily oral doses of GenX(0.2,1.0,2.0 mg/kg),PFOA(0.1,1.0 mg/kg),or vehicle control were administered to pregnant mice(gestation days 1.5-17.5).Offspring were fed a high-or low-fat diet(HFD or LFD)at weaning until necropsy at 6 or 18 weeks,and metabolic endpoints were measured over *** and GenX serum and urine concentrations,weight gain,serum lipid parameters,body mass composition,glucose tolerance,white adipose tissue gene expression,and liver histopathology were ***:Prenatal exposure to GenX led to its accumulation in the serum and urine of 5-day old pups(P=0.007,P<0.001),which was undetectable by *** 18 weeks of age,male mice fed LFD in the 2.0 mg/kg GenX group displayed increased weight gain(P<0.05),fat mass(P=0.016),hepatocellular microvesicular fatty change(P=0.015),and insulin sensitivity(P=0.014)in comparison to control males fed *** mice fed HFD had a significant increase in hepatocyte single cell necrosis in 1.0 mg/kg GenX group(P=0.022)and 1.0 mg/kg PFOA group(P=0.003)compared to control HFD *** sexes were affected by gestational GenX exposure;however,the observed phenotype varied between sex with males displaying more characteristics of metabolic disease and females exhibiting liver damage in response to the gestational ***:Prenatal exposure to 1 mg/kg GenX and 1 mg/kg PFOA

关键词： PFOA HFPO-DA GenX Gestational exposure Metabolism PFAS Microvesicular fatty change

A 10-Year Survey of Severe Eye Injuries in Sport in Belgrade,Serbia 2000-2009

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Open Journal of Ophthalmology 2013年第3期3卷 93-96页

作者： Milos Jovanovic Dragan Vukovic vesna Jaksic Miroslav Knezevic Lepsa Zoric Milos Mirkovic Faculty of Medicine University of BelgradeBelgradeSerbia Faculty of Medicine University of Kosovska MitrovicaKosovska MitrovicaSerbia

Introduction: The eye injuries inflicted in different sport activities are relatively rare and depend upon the type of sport. They are more common in recreational sport activities. These injuries are generally minor but may be very severe and result in permanent vision impairment. One must be aware of the fact that these sport activities, either recreative or professional, are exercised by young people. Methods: All analyzed patients were hospitalized at the Clinic of Eye Diseases, Clinical Center of Serbia, Belgrade, for severe eye injuries which occurred in sport activities. The analyzed period included 10 years, from the beginning of 2000 to the end of 2009. Results: In this period, a total of 117 patients with eye injuries sustained in some of sport activities were hospitalized. There were 114 (97.5%) injured males. Mean age of the injured was 25.8 years, and there were no individuals older than 50 years of age. Closed eyeball injures were reported in 96.6% and open injuries were seen in the remaining 3.4% of cases. During recreational sports, the eye injuries occurred in 76.1%, in the school—19.6%, and in professional sport—4.3% of the time. The injured individuals were as follows: pupils—35.0%, students—17.9%, workers—22.2%, clerks—20.6% and professional players—4.3% of cases. Upon completed treatment, visual acuity was normal in 77.8%, subnormal in 16.2%, impaired in 3.4% and amaurosis in 2.6% of cases.

关键词： Eye Injuries Sport Activities Recreation Eye Protection