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Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases

World Journal of Gastrointestinal Oncology 2021年第8期13卷 879-892页

作者： HMC Shantha Kumara Hiromichi Miyagaki Sajith A Herath Erica Pettke Xiaohong Yan vesna Cekic Richard L Whelan Division of Colon and Rectal Surgery Department of SurgeryLenox Hill HospitalNorthwell HealthNew YorkNY 10028United States Department of Gastroenterological Surgery Osaka UniversitySuita 565-0862OsakaJapan Analytic Department NovartisMorris PlainsNJ 07905United States Department of Surgery Swedish Medical CenterSeattleWA 98122United States Department of Surgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNY 11549United States

BACKGROUND MMP-2 also known as gelatinase A and MMP-7(matrilysin)are members of the zinc-dependent family of MMPs(Matrix metalloproteinase).MMP-2 and MMP-7 are remodeling enzymes that digest extracellular matrix;MMP-2 is extensively expressed during development and is upregulated at sites of tissue damage,inflammation,and in stromal cells of metastatic ***-7 is expressed in the epithelial cells and in a variety of cancers including colon *** MMP-2 and MMP-7 levels were assessed before and after minimally invasive colorectal resection for cancer *** To determine plasma MMP-2 and MMP-7 levels before and after minimally invasive colorectal resection for cancer *** Patients enrolled in a plasma bank for whom plasma was available were *** obtained from preoperative(Preop)and postoperative blood samples was *** colorectal cancer(CRC)patients who underwent elective minimally invasive cancer resection with preop,post-operative day(POD)1,3 and at least 1 late postop sample(POD 7-34)were *** samples were bundled into 7 d blocks(POD 7-13,14-20,etc.)and treated as single time *** MMP-2 and MMP-7 levels were determined via enzyme-linked immunosorbent assay in *** Total 88 minimally invasive CRC resection CRC patients were studied(right colectomy,37%;sigmoid,24%;and LAR/AR 18%).Cancer stages were:1,31%;2,30%;3,34%;and 4,5%.Mean Preop MMP-2 plasma level(ng/mL)was 179.3±40.9(n=88).Elevated mean levels were noted on POD1(214.3±51.2,n=87,P<0.001),POD3(258.0±63.9,n=80,P<0.001),POD7-13(229.9±62.3,n=65,P<0.001),POD 14-20(234.9±47.5,n=25,P<0.001),POD 21-27(237.0±63.5,n=17,P<0.001,)and POD 28-34(255.4±59.7,n=15,P<0.001).Mean Preop MMP-7 level was 3.9±1.9(n=88).No significant differences were noted on POD 1 or 3,however,significantly elevated levels were noted on POD 7-13(5.7±2.5,n=65,P<0.001),POD 14-20(5.9±2.5,n=25,P<0.001),POD 21-27(6.1±3.6,n=17,P=0.002)and on POD 28-34(6.8±3.3,n=15 P<0.001,)vs p

关键词： Effects of surgery Colorectal resection Colorectal cancer Plasma MMP-2 and MMP-7 levels Angiogenesis

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Fear, Hate, and Competence:Could COVID-19 Be a Turning Point?

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China Today 2020年第9期69卷 14-15页

作者： vesna PUSIC the Croatian Parliament

THE global COVID-19 health crisis has shocked the world,making us all aware of the need for a major rethink of international relations,multilateral organizations,organized healthcare,poverty,sovereignty,and many other aspects of human ***,this crisis did not occur in a healthy,prosperous,and comprehensible *** this been the case,we might have been more prepared,more united,and less rudderless in confronting ***,it comes at the tail end of three major catastrophes in just over a *** have been disastrously disruptive,exacerbating inequality,marginalizing accountability,ridiculing and punishing solidarity,and upending the value systems that different peoples and societies have long upheld—if not exactly living by them,at least using them as a yardstick for their way of *** all these crises have in common is the prominent global resurgence of two instruments of mass mobilization:fear and hate.

关键词： inequality exactly catastrophe

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Perinatal risk factors in newborns with gastrointestinal perforation

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World Journal of Gastrointestinal Surgery 2017年第2期9卷 46-52页

作者： Sandra Prgomet Boris Luksic Zenon Pogorelic Ivo Juric vesna Capkun Adela Arapovic Natasa Boban Department of Pediatrics University Hospital of Split and University of SplitSchool of Medicine Department of Infectious diseases University Hospital of Split and University of SplitSchool of Medicine Department of Pediatric Surgery University Hospital of Split and University of SplitSchool of Medicine Department of Nuclear Medicine University Hospital of Split and University of SplitSchool of Medicine Department of Clinical Epidemiology University Hospital of Split and University of SplitSchool of Medicine

AIMTo investigate correlation of perinatal risk factors in newborns with gastrointestinal perforation (GIP).METHODSSingle-center retrospective cohort study was conducted between January 1990 and December 2012. Medical records on all newborns with GIP were reviewed (n = 35). Surgical records and histopathologic examination of all perforated intestine samples were also *** most common cause of GIP was necrotizing enterocolitis (51.4%). The most common site of perforation was large intestine. Mortality rate was 31%. Infants with GIP more frequently had very low birth weight (th percentile according to gestational age. Ponderal index was not differing between infants with GIP and control subjects. In infants with GIP anemia was more frequently found than in control *** in newborns is mostly disease of infants with birth weight below 10th percentile according to gestational age. GIP occurs more often in infants with anemia.

关键词： Gastrointestinal perforation Newborn Necrotizing enterocolitis Ponderal index

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Hepatic abscess secondary to a rosemary twig migrating from the stomach into the liver

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World Journal of Gastroenterology 2007年第41期13卷 5530-5532页

作者： Aleksandar R Karamarkovic Srdjan P Djuranovic Nada N Popovic vesna D Bumbasirevic Ana D Sijacki Ivan V Blazic Center for Emergency Surgery Clinical Center of SerbiaSchool of MedicineUniversity of BelgradeBelgradeSerbia Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaSchool of MedicineUniversity of BelgradeBelgradeSerbia Institute of Anaesthesiology Clinical Center of SerbiaSchool of MedicineUniversity of BelgradeBelgradeSerbia

The ingestion of a foreign body that penetrates the gastric wall and migrates to the liver,where it causes an abscess is uncommon. A case of an ingested rosemary twig perforating the gastric antrum,then migrating to the liver,complicated by hepatic abscess and Staphylococcus aureus sepsis is reported. A 59-year-old man without a history of foreign body ingestion was admitted to our hospital because of sepsis and epigastralgia,which had progressively worsened. No foreign body was identified at preoperative imaging,but a rosemary twig was discovered during laparotomy. The liver abscess and sepsis were controlled successfully with surgery and antibiotics. This unusual condition should be kept in mind when dealing with cases of hepatic abscess,or even sepsis of unknown origin. Despite the improvement of non-surgical techniques such as percutaneous drainage and interventional endoscopy,surgery still remains important in the treatment of hepatic abscess caused by an ingested foreign body.

关键词： Foreign Body Gastrointestinal perforation Hepatic Abscess Ingestion Migration

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期刊生产率分布动态特性的定量研究

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国外情报科学 1994年第3期12卷 47-56页

作者： vesna,Ov 俞培果

本文在一个扩展的时间区间上,考察分布曲线与数据内部结构特征之间的关系,发现分布曲残形态随时间变化,并且趋向为“s”形,是因为数据内部结构变化所致。在经验数据的分析中,使用了把收集数据的时域划分为若干子时域,从而把所取得的数... 详细信息

本文在一个扩展的时间区间上,考察分布曲线与数据内部结构特征之间的关系,发现分布曲残形态随时间变化,并且趋向为“s”形,是因为数据内部结构变化所致。在经验数据的分析中,使用了把收集数据的时域划分为若干子时域,从而把所取得的数据襄划分为若干子数据桌的方法。

关键词：期刊生产率分布曲线定量研究

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Synthesis and Structure of bc-Dichloro-af-dihydroxo-de-bis(N-3-pyridinylmethanesulfonamide)platinum(Ⅳ) Diydrate

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Chinese Journal of Structural Chemistry 2012年第10期31卷 1476-1482页

作者： Nicolay I. DODOFF Boris L. SHIVACHEV Rositsa P. NIKOLOVA Maria LALIA-KANTOURI vesna MILETI Tamara I. PAJPANOVA Acad. R. Tsanev Institute of Molecular Biology Bulgarian Academy of Sciences Acad. G. Bonchev Str. Block 21 1113 Sofia Bulgaria Institute of Mineralogy and Crystallography Bulgarian Academy of Sciences Acad. G. Bonchev Str. Block 107 1113 Sofia Bulgaria Department of Chemistry Faculty of Sciences Aristotle University of Thessaloniki P.O. Box 135 54124 Thessaloniki Greece Institute of Chemistry Faculty of Science University of Kragujevac 34000 Kragujevac Serbia

The Pt（IV） complex cis,cis,trans-[Pt（PMSA）2Cl2（OH）2]·2H2O（1）, where PMSA = N-3-pyridinylmethanesulfonamide, has been synthesized and characterized by elemental analysis, molar electric conductivity and IR spectrum. X-ray crystallography revealed that the title compound crystallizes in the monoclinic C2/c space group with unit cell dimensions a = 16.5424（7）, b = 8.6973（3）, c = 16.6079（6） A, β = 117.185（5）° and Z = 4. Pt（IV） has an octahedral coordination geometry and the PMSA ligands are coordinated via the pyridine N atom. They are in a transoid orientation between each other and are inclined in the same direction with respect to the Pt-C1-Cli-N-Ni plane at an angle of 64.6（1）° （symmetry operation：（i） 1- x, y, 3/2-z）. The structure is stabilized by a system of hydrogen bonds involving the complex and water molecules.

关键词： Pt(IV) complex sulfonamide pyridine crystal structure cytostatic

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Plasma and wound fluid levels of eight proangiogenic proteins are elevated after colorectal resection

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World Journal of Gastrointestinal Oncology 2019年第6期11卷 470-488页

作者： HMC Shantha Kumara Xiao-Hong Yan Erica Pettke vesna Cekic Nipa Dilip Gandhi Geoffrey A Bellini Richard L Whelan Division of Colon and Rectal Surgery Department of SurgeryMount Sinai West HospitalNew YorkNY 10019United States Department of Surgery Mount Sinai Icahn School of MedicineNew YorkNY 10029United States

BACKGROUND Colorectal resection is associated with 3-5 wk long elevations in the plasma levels of at least 11 proangiogenic proteins that may stimulate tumor angiogenesis *** increases during the first week after surgery may be related to the acute inflammatory response;the cause(s)of the week 2-5 increases is *** wounds are a possible source because of the important role that angiogenesis plays in the healing *** main hypothesis of the study is that wound fluid levels of the proteins studied will be elevated well beyond plasma levels which,in turn,are elevated from preoperative baseline *** To determine plasma and wound fluid levels of 8 proangiogenic proteins after colorectal resection for cancer and benign *** Blood and wound fluid samples were taken simultaneously on postoperative(postop)day 1,3,and later time points until wound drain removal in 35 colorectal cancer patients and 31 benign disease patients undergoing colorectal resection in whom closed wound drains had been placed in either the pelvis or the subcutaneous space of the abdominal *** plasma levels were compared to preop plasma and postop wound fluid levels(separate analyses for cancer and benign groups).RESULTS Sixty-six colorectal disease patients were studied(35 cancer,31 benign pathology).Most patients underwent minimally invasive surgery(open surgery in 11%of cancer and 6%of benign patients).The majority in the cancer group had rectal resections while in the benign group sigmoid or right colectomy *** levels of all 8 proteins were significantly elevated from baseline (P<0.05) at all post-operative time points in the cancer group and at 90% of time points(29/32) in the benign *** levels of all 8 proteins were 3-106 times higher (P<0.05) than plasma levels at 87-90 percent of postop time points;of note,wound levels were more than 10 times higher at 47-50% of time *** Plasma protein levels were elevat

关键词： Effects of surgery Colorectal resection Colorectal cancer Plasma protein levels Wound protein levels Angiogenesis

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The Chaotic Saving Growth Model： G7

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Chinese Business Review 2011年第5期10卷 317-326页

作者： vesna D. Jablanovic University of Belgrade Belgrade Serbia

关键词：混沌理论增长模型混沌系统保存确定性模型敏感依赖性非周期性经济运动

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Labour Productivity and the Chaotic Economic Growth Model： G7

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Chinese Business Review 2012年第5期11卷 500-510页

作者： vesna D. Jablanovic University of Belgrade Belgrade Serbia

Chaos theory is used to prove that erratic and chaotic fluctuations can indeed arise in completely deterministic models. Chaos theory reveals structure in aperiodic, dynamic systems. The number of nonlinear business cycle models use chaos theory to explain complex motion of the economy. Almost three years after the crisis, the G7 countries continue to be challenged with economic volatility. The global economy has slowed. Growth in the United States has weakened. In Europe, economic instability is generated by the financial and economic imbalances. Europe is gripped with financial strains from the sovereign debt crisis in the euro area periphery. How these G7 economies confront their fiscal challenges will profoundly affect their economic stability. The basic aim of this paper is to provide a relatively simple chaotic economic growth model that is capable of generating stable equilibria, cycles, or chaos. This paper looks in more detail at the GDP growth stability issues in each of the G7 countries in the period 1990-2012 （Retrieved from http：//www, ***）. A key hypothesis of this work is based on the idea that the coefficient π =[p（s_p-i-n/pb-p_mb_m）] plays a crucial role in explaining local stability of the gross domestic product growth, where, p---the coefficient of labour productivity; p.,--the coefficient of the marginal labour productivity, sp-private saving rate;i--investment rate; b-percent of the gross domestic product which belongs to budget deficit; bm-marginal budget deficit coefficient; n-net capital outflow rate.

关键词： stability budget deficit labour productivity the gross domestic product chaos

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The Chaotic Real-Exchange-Rate Growth Model

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Journal of Modern Accounting and Auditing 2013年第4期9卷 582-586页

作者： vesna D. Jablanovic University of Belgrade Belgrade Serbia

关键词： real exchange rate growth appreciation chaos

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