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Juicy Stories on Female Reproductive Tissue Development: Coordinating the Hormone Flows

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Journal of Integrative plant Biology 2013年第9期55卷 847-863页

作者： veronica A.Grieneisen Athanasius F.M.Marée Lars φstergaard Computational and Systems Biology John Innes Centre Norwich Research ParkNorwich NR4 7UH UK Crop Genetics John Innes Centre Norwich Research ParkNorwich NR4 7UH UK

In the past 20-30 years, developmental biologists have made tremendous progress in identifying genes required for the specifica-tion of individual cell types of an organ and in describing how they interact in genetic networks. In comparison, very little is known about the mechanisms that regulate tissue polarity and overall organ patterning. Gynoecia and fruits from members of the Brassicaceae family of flowering plants provide excellent model systems to study organ patterning and tissue specification because they become partitioned into distinct domains whose formation is determined by polarity establishment both at a cellular and whole tissue level. Interactions among key regulators of Arabidopsis gynoecium and fruit development have revealed a network of upstream transcription factor activities required for such tissue differentiation. Regulation of the plant hormone auxin is emerging as both an immediate downstream output and input of these activities, and here we aim to provide an overview of the current knowledge regarding the link between auxin and female reproductive development in plants. In this review, we will also demonstrate how available data can be exploited in a mathematical modeling approach to reveal and understand the feedback regulatory circuits that underpin the polarity establishment, necessary to guide auxin flows.

关键词： Auxin dynamics brassicaceae cell and tissue polarity fruit gynoecium mathematical modelling organ patterning ROps wavepinning

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian Garcia-Medina Karolina Sienkiewicz S.Anand Narayanan eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn e.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher e.Mason Department of physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced pattern Analysis&Human performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems engineering Colorado State UniversityFort CollinsCO 80523USA element Biosciences San DiegoCA 10055USA Department of environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative pCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIp)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIp in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low earth orbit(LeO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

Spectrum and visual outcomes of Vogt-Koyanagi-Harada disease in Argentina

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International Journal of Ophthalmology(english edition) 2017年第1期10卷 98-102页

作者： veronica e.Giordano Ariel Schlaen Martin J.Guzman-Sanchez Cristobal Couto Department of Ophthalmology Inflammatory Eye Diseases ServiceHospital de Clinicas Jose de San MartinBuenos Aires C1120AARArgentina Department of Ophthalmology Oculoplastic ServiceAssociation for the Prevention of Blindness in MexicoVicente Garcia Torres 46San Lucas 04030CoyoacanMexico CityMexico

AIM： To review all cases of Vogt-Koyanagi-Harada （VKH） disease in an Inflammatory eye Disease Service in Argentina and to describe the clinical profile and outcomes of ***： The records from patients with VKH disease between January 1980 and December 2008 were retrospectively analyzed for clinical profile, complications, and treatment. patients were classified according to their initial treatment in group 1： high corticosteroid dose [≥1 mg/（kg·d）] within 2wk of illness onset; group 2： high corticosteroid dose, 2 to 4wk of onset and group 3： patients who received the high dose after 1mo of illness onset, patients who received lower oral doses than 1 mg/（kg·d） without regarding the time of beginning of the ***： A total of 210 eyes of 105 patients were included. The mean age at presentation was 32.6±13y （range： 10-74y）, and 86.7% were female. The mean duration of follow up was 144±96.6mo. patients in the group 1 had significantly higher visual acuity than the other groups （p〈0.0001）, none had （loss of, or no） light perception at the end of follow up, whereas 24.7% patients in group 3 ended in light perception （p〈0.004）.CONCLUSION： patients with early high dose corticosteroid treatment have better visual acuity and fewer complications. proper timing in referral and treatment is critical for better visual outcome in VKH disease.

关键词： Vogt-Koyanagi-Harada disease Argentine population clinical spectrum treatment

Don’t stop me now, I’m having such a good time! Czechoslovakian wolfdogs renovate the motivation to play with a bow

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Current Zoology 2023年第1期69卷 50-58页

作者： veronica Maglieri Anna Zanoli Fosca Mastrandrea elisabetta palagi Unit of ethology Department of BiologyUniversity of PisaPisa 56126Italy Department of Life Sciences and Systems Biology University of TurinTorino 10123Italy

Dogs engage in play behavior at every age and the play bow is their most iconic playful ***,the function of this posture is still under ***,we selected the Czechoslovakian Wolfdog(CWD)as a model breed to clarify the function of the play *** analyzed frame-by-frame 118 sessions of 24 subjects and recorded 76 play bow *** found that all the play bows were performed in the visual field of the playmate suggesting that the sender takes into account the attentional state of the receiver when releasing the *** drawing survival curves and using log-rank test we found that play bow was mainly performed during a short pause in an ongoing session and that its performance triggered the playmate’s reaction *** findings show that play bow functions in restoring the partner motivation to ***,by using a sequential analysis and a generalized mixed model,we found no evidence supporting the metacommunicative function of the play *** signal did not necessarily precede a contact offensive behavior(e.g.,play biting and play pushing)and it was not affected by the level of asymmetry of the play *** conclusion,in CWDs play bow can be considered a visual signal useful to maintain the motivation to play in the ***,we suggest that the mismatched number of play bows emitted by the 2 players in a given session can be predictive of their different motivations to play.

关键词： Canis lupus familiaris first-order intentionality metacommunication motivation play fighting wolf-like traits

On a Classical Theorem on the Diameter and Minimum Degree of a Graph

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Acta Mathematica Sinica,english Series 2017年第11期33卷 1477-1503页

作者： veronica HeRNANDeZ Domingo peSTANA Jose M. RODRIGUeZ Universidad CarlosⅢde Madrid Avenida de la Universidad3028911 LeganesSpain

In this work, we obtain good upper bounds for the diameter of any graph in terms of its minimum degree and its order, improving a classical theorem due to erdos, pach, pollack and Tuza. We use these bounds in order to study hyperbolic graphs （in the Gromov sense）. To compute the hyperbolicity constant is an almost intractable problem, thus it is natural to try to bound it in terms of some parameters of the graph. Let H（n, δ0） be the set of graphs G with n vertices and minimum degree 50, and J（n, Δ） be the set of graphs G with n vertices and maximum degree A. We study the four following extremal problems on graphs： a（n,δ0） = min{δ（G）｜ G ∈H（n, δ0）}, b（n, δ0） =- max{δ（G）｜ e ∈H（n, δ0）}, α（n, Δ） = min{δ（G） [ G ∈ J（n, Δ）} and β（n,Δ） = max{δ（G） ] G∈Π（n,Δ）}. In particular, we obtain bounds for b（n, δ0） and we compute the precise value of a（n, δ0）, α（n, Δ） and w（n, Δ） for all values of n, r0 and A, respectively.

关键词： extremal problems on graphs diameter minimum degree maximum degree Gromov hyperbolicity hyperbolicity constant finite graphs

Acute hepatitis C in a chronically HIV-infected patient:evolution of different viral genomic regions

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World Journal of Gastroenterology 2003年第7期9卷 1496-1500页

作者： Diego Flichman veronica Kott Silvia Sookoian Rodolfo Campos Catedra de Virologia Facultad de Farmacia y BioquimicaUniversidad de Buenos AiresArgentina Unidad de Higado Hospital"Dr.Cosme Argerich"Argentina

AIM: To analyze the molecular evolution of different viral genomic regions of HCV in an acute HCV infected patient chronically infected with HIV through a 42-month ***: Serum samples of a chronically HIV infected patient that seroconverted to anti HCV antibodies were sequenced, from the event of superinfection through a period of 17 months and in a late sample (42nd month). Hypervariable genomic regions of HIV (V3 loop of the gp120) and HCV (HVR-1 on the e2 glycoprotein gene) were studied. In order to analyze genomic regions involved in different biological functions and with the cellular immune response, HCV core and NS5A were also chosen to be sequenced. Amplification of the different regions was done by RT-pCR and directly sequenced. Confirmation of sequences was done on reamplified material. Nucleotide sequences of the different time points were aligned with CLUSTAL W 1.5, and the corresponding amino acid ones were ***: Hypervariable genomic regions of both viruses (HVR1 and gp120 V3 loop) presented several nonsynonymous changes but, while in the gp120 V3 loop mutations were detected in the sample obtained right after HCV superinfection and maintained throughout, they occurred following a sequential and cumulative pattern in the HVR1. In the NS5A region of HCV, two amino acid changes were detected during the follow-up period, whereas the core region presented several amino acid replacements, once the HCV chronic infection had been ***: During the HIV-HCV superinfection, each genomic region analyzed shows a different evolutionary *** of the nucleotide substitutions observed are nonsynonymous and clustered in previously described epitopes,thus suggesting an immune-driven evolutionary process.

关键词： Acute Disease Adolescent Amino Acid Sequence Female Genome, Viral HIV HIV envelope protein gp120 HIV Infections Hepacivirus Hepatitis C Humans Molecular Sequence Data Research Support, Non-U.S. Gov't Superinfection Viral Nonstructural proteins Viral proteins

The physiological polyphosphate as a healing biomaterial for chronic wounds:Crucial roles of its antibacterial and unique metabolic energy supplying properties

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Journal of Materials Science & Technology 2023年第4期135卷 170-185页

作者： Werner e.G.Müller Hadrian Schepler Meik Neufurth Shunfeng Wang veronica Ferrucci Massimo Zollo Rongwei Tan Heinz C.Schröder Xiaohong Wang eRC Advanced Investigator Grant Research Group at the Institute for physiological Chemistry University Medical Center of the Johannes Gutenberg UniversityDuesbergweg 6Mainz D-55128Germany Department of Dermatology University Clinic MainzLangenbeckstr.1Mainz D-55131Germany Dipartimento di Medicina Molecolare e Biotecnologie Mediche Universitàdegli Studi di Napoli Federico IIVia Sergio Pansini 5Naples 80131Italy Ceinge Biotecnologie Avanzate Francesco Salvatore Via G.Salvatore 486Naples 80145Italy Shenzhen Lando Biomaterials Co. Ltd.Shenzhen 518107China

Insufficient metabolic energy,in the form of adenosine triphosphate(ATp),and bacterial infections are among the main causes for the development of chronic *** we showed that the physi-ological inorganic polymer polyphosphate(polyp)massively accelerates wound healing both in animals(diabetic mice)and,when incorporated into mats,in patients with chronic ***,we focused on a hydrogel-based gel formulation,supplemented with both soluble sodium polyp(Na-polyp)and amor-phous calcium polyp nanoparticles(Ca-polyp-Np).exposure of human epidermal keratinocytes to the gel caused a significant increase in extracellular ATp level,an effect that was even enhanced when Na-polyp was combined with ***,it is shown that the added polyp in the gel is converted into a coacervate,leading to encapsulation and killing of *** data on human chronic wounds showed that the administration of hydrogel leads to the complete closure of these *** analysis of biopsies showed an increased granulation of the wounds and an enhanced microvessel *** results indicate that the polyp hydrogel,due to its properties to entrap bacteria and generate metabolic energy,is a very promising formulation for a new therapy for chronic wounds.

关键词： Inorganic polyphosphate Nanoparticles Hydrogel Coacervate Human chronic wounds Antibacterial activity Metabolic energy

Assessment of sanitary conditions of unregistered pig slaughter slabs and post mortem examination of pigs for Taenia solium metacestodes in Kaduna metropolis, Nigeria

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Infectious Diseases of poverty 2014年第1期3卷 424-429,423页

作者： Agnes U edia-Asuke Helen I Inabo veronica J Umoh Clement MZ Whong Sunday Asuke Richard e edeh Department of Microbiology Ahmadu Bello UniversityZariaKadunaNigeria Biological Sciences University of KwaZulu-NatalWestville CampusDurbanSouth Africa Department of Community Medicine Ahmadu Bello University Teaching HospitalShika ZariaKadunaNigeria Faculty of Veterinary Medicine Ahmadu Bello UniversityZariaKadunaNigeria

Background:A number of studies document the prevalence of Taenia solium infections in Nigeria,yet these studies do not cover porcine cysticercosis in private home slaughter slabs where there is no routine meat inspection and backyard pig keeping,slaughtering and sale are common ***:An environmental and sanitary assessment was conducted within two unregistered home pig slaughter slabs in selected parts of the Kaduna metropolis in *** premises were inspected for availability of basic facilities and questionnaires were used to elicit necessary informative *** were examined for taeniasis by stool microscopy and copro-antigen enzyme linked immunosorbent assay(copro-Ag eLISA)to ascertain *** slaughtered at the premises were examined for ***:Home slaughter conditions were substandard,unhygienic and lacked the basic facilities of a proper *** of porcine cysticercosis was 9.3%.The butchers participating in the study had very poor knowledge of *** infections and 30%tested positive for taeniasis by copro-Ag eLISA at the time of the ***:Home slaughter of pigs in the areas studied should be considered and integrated as a component of prevention and control programmes-particularly through educational interventions-in order to equip individuals involved with a good understanding of the risks associated with animal husbandry and human practices.

关键词： pig slaughter slabs Home slaughter Copro-Ag eLISA Taenia solium metacestodes Kaduna Nigeria

Diverse morphologies of zinc oxide nanoparticles and their electrocatalytic performance in hydrogen production

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Journal of energy Chemistry 2021年第5期30卷 162-170页

作者： veronica M.Sofianos Junqiao Lee Debbie S.Silvester pralok K.Samanta Mark paskevicius Niall J.english Craig e.Buckley Department of physics and Astronomy Fuels and Energy Technology InstituteCurtin UniversityPerthBentley 6102Australia University College Dublin School of Chemical and Bioprocess EngineeringBelfieldDublin 4Ireland Curtin Institute for Functional Moleailes and Interfaces School of Molecular and Life SciencesCurtin UniversityPerthBentley 6102Australia

Hydrogen is considered an attractive alternative to fossil fuels,but only a small amount of it is produced from renewable energy,making it not such a clean energy carrier after *** hydrogen through water electrolysis is promising,but using a cost-effective and high-performing catalyst that has longterm stability is still a *** study exploits,for the first time,the potential of zinc oxide nanoparticles with diverse morphologies as catalysts for the electrocatalytic production of hydrogen from *** morphology of the nanoparticles(wires,cuboids,spheres)was easily regulated by changing the concentration of sodium hydroxide,used as the shape controlling agent,during the *** spherical morphology exhibited the highest electrocatalytic activity at the lowest potential *** spherical nanoparticles had the highest number of oxygen vacancies and lowest particle size compared to the other two morphologies,features directly linked to high catalytic ***,the nanowires were much more stable with repeated ***-functional theory showed that the presence of oxygen vacancies in all three morphologies led to diminished band gaps,which is of catalytic interest.

关键词： ZnO nanoparticles Nanocatalysts electrocatalysis Hydrogen production Water splitting