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Esophageal cell proliferation in gastroesophageal reflux disease: Clinical-morphological data before and after pantoprazole

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World Journal of Gastroenterology 2009年第8期15卷 936-941页

作者： Carlo Calabrese Davide Treré Giuseppina Liguori veronica gabusi Manuela Vici Giovanna Cenacchi Massimo Derenzini Giulio Di Febo Department of Clinical Medicine University of Bologna Bologna 40138 Italy Department of Experimental Pathology Clinical Pathology University of Bologna Bologna 40138 Italy Clinical Department of Radiologic and Histopathologic Sciences University of Bologna Bologna 40138 Italy

AIM: To evaluate esophageal mucosal defense mechanisms at an epithelial level to establish if pantoprazole treatment can induce ultrastructural healing and improvement in the proliferation activity of the esophageal epithelium in gastroesophageal reflux disease (GERD). METHODS: This was a single-blinded study for pHmonitoring, and histological, ultrastructural and MIB1 immunostaining evaluation. Fifty eight patients with GERD were enrolled and underwent 24 h pH-monitoring and endoscopy. Patients were treated for 12 and 24 mo with pantoprazole. Esophageal specimens were taken for histological and ultrastructural evaluation, before and after the treatment. RESULTS: With transmission electron microscopy, all patients with GERD showed ultrastructural signs of damage with dilation of intercellular spaces (DIS). After 3 mo of therapy the mean DIS values showed asignificant reduction and the mean MIB1-LI values of GERD showed an increase in cell proliferation. A further 3 mo of therapy significantly increased cell proliferation only in the erosive esophagitis (ERD) group. CONCLUSION: Three months of pantoprazole therapy induced ultrastructural healing of mucosal damage in 89% and 93% of ERD and non-erosion patients, respectively. Moreover, long-term pantoprazole treatment may be helpful in increasing the capability for esophageal cell proliferation in GERD, particularly in ERD patients.

关键词： Gastroesophageal reflux disease Esophagitis Cell proliferation Electron microscopy Pantoprazole

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＂Crossing the River by Feeling the Gold＂： The Asian Infrastructure Investment Bank and the FinancialSupport to the Belt and Road Initiative

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China & World Economy 2017年第5期25卷 23-45页

作者： Giuseppe gabusi Adjoint Professor of IPE and Political Economy of East Asia University of Turin Italy

China＇s Belt and Road Initiative （BRI） is, above all, a connectivity project. Asconnectivity requires financial support, in the past few years China has undertakenseveral institution-building activities at the national and international level, mainlyin the finaneial and economic sector, showing a new propensity to influence globaleconomic governance. In particular, the establishment of the Asian InfrastructureInvestment Bank （AIIB） has drawn attention worldwide. How does this institution-building process connect with BRI？ Are these institutions just a vehicle for exportingChina ＂s capital and overcapacity, or do they signal a potential wider challenge to thepost-World War II liberal international order？ By analyzing the first loans approvedby the bank, the present paper argues that far from representing a China-led challengeto the Western-led liberal order, the AIIB, while promoting Chinese commercial andgeopolitical interests, shows the resilience of the global financial regime created by theWest.

关键词： Asian Infrastructure Investment Bank, Belt and Road Initiative, China, international economic order

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