检索结果-南通市图书馆

中国营养学会第四届全国学术会议

作者：赵熙和闻芝梅 Caraln Meredith Dwight E,Matthews Dennism Biery vernon r.young

用同位素标记氨基酸恒速输液法可以动态地观察在不同营养状况下氨基酸的代谢。这是根据当机体处于平衡状态下,某些氨基酸进入游离氨基酸体池的量应与离开的量相等。以苏氨酸为例。

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model

引用

Burns & Trauma 2013年第2期1卷 87-94页

作者： Zhe-Wei Fei vernon r. young Xiao-Ming Lu Andrew B. rhodes ronald G.Tompkins Alan J. Fischman Yong-Ming Yu Shriners Burns Hospital and Burn & Trauma Service Massachusetts General Hospital Harvard Medical School Boston MA 02114 Shriners Burns Hospital and Burn & Trauma Service Massachusetts General Hospital Harvard Medical School Boston MA 02114 Laboratory of Human Nutrition Massachusetts Institute of Technology Cambridge MA 02142 USA

Previous studies from our laboratories revealed a reduced rate of whole-blood (WB) glutathione (GSH) synthesis in severely burned patients. To determine whether WB GSH metabolism is an indicator of the status of GSH metabolism in one or more of the major organs, we used a burn rabbit model to determine GSH concentrations and rates of synthesis in WB, liver, lungs, kidney, and skeletal muscle. L-[1-13C]-cysteine was infused intravenously for 6 h in rabbits at 3 days post-burn and in sham burn controls. WB and organ 13C-enrichment of cysteine and GSH was determined by gas chromatography/mass spectrometry. Plasma cysteine metabolic flux was increased significantly (P rn injury. WB, liver, and lung GSH concentrations (P = 0.054, P respectively) and fractional rates of GSH synthesis (P respectively) were reduced at 3 days post-burn. Kidney was unaffected. There also appears to be an increased rate of GSH transport out of the liver after burn injury. Hence, there is a differential impact of burn injury on tissue and organ GSH status, with WB qualitatively reflecting the changes in lung and liver. It will be important to determine whether these changes are due to alterations in the intrinsic capacity for GSH synthesis and/or availability of amino acid precursors of GSH.

关键词： Burn injury glutathione glutathione concentration synthesis rate whole blood

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arginine: New and Exciting Developments for an“Old”Amino Acid

引用

Biomedical and Environmental Sciences 1996年第2期9卷 296-315页

作者： LOUIS BEAUMIEr LETICIA CASTILLO YONG-MING YU ALFrED M. AJAMI AND vernon r. young(Laboratory of Human Nutrition, School of Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA Shriners Burns Institute,Boston, MA, 02114 USA mass Tra Laboratory of Human Nutrition School of Science Massachusetts Institute of Technology Cambridge 02139 USA.

Arginine (2-amino-5-guanidino pentanoic acid) was shown in 1895 by Hedin to be present in the proteins of horn. Metabolic nitrogen balance studies, conducted in 1957 by rose in human adults and in 1959 by Snyderman and coworkers in young infants, revealed that a dietary source of this amino acid was not an obligatory requirement for growth and maintenance of nitrogen homeostasis in healthy individuals. Hence, It was initially classified as a non-essential (dispensable) amino acid and, perhaps, for reasons of this classification arginine did not receivc the earlier atteniion it now deserves, in relation to an understanding of the nutritional biochemistry and physiology of its metabolism in humans subjects. However, there is currently a considerable interest in the cellular and tissue functions, as well as clinical, therapeutic significance, of arginine. In this paper we review the multiple functions of arginlne, including its role in the L-arginine-nitric oxide pathway,cellular regeneration, immune function, protein synthesis and protein breakdown. We then consider some in vivo aspects of the physiology of arginine metabolism, which varies greatly among eukaryotes, with particular reference to humans. Against this background, studies of arginine in the nutrition of humans under various pathophysiological conditions are reviewed briefly. Finally, a new, updated concept for the metabolic basis for the 'conditional essentiality' of arginine is proposed

关键词： Amino Acid USA Old Arginine New and Exciting Developments for an

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：