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Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting

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Journal of Molecular Cell Biology 2019年第4期11卷 306-316页

作者： Yaw sing Tan Yasmina Mhoumadi Chandra s. verma Bioinformatics Institute Agency for Science Technology and Research Singapore 138671 school of Biological sciences Nanyang Technological University Singapore 637551 Department of Biological sciences National University of Singapore Singapore 117543

The transcription factor p53 plays pivotal roles in numerous biological processes, including the suppression of tumours. The rich availability of biophysical data aimed at understanding its structure–function relationships since the 1990s has enabled the application of a variety of computational modelling techniques towards the establishment of mechanistic models. Together they have provided deep insights into the structure, mechanics, energetics, and dynamics of p53. In parallel, the observation that mutations in p53 or changes in its associated pathways characterize several human cancers has resulted in a race to develop therapeutic modulators of p53, some of which have entered clinical trials. This review describes how computational modelling has played key roles in understanding structural-dynamic aspects of p53, formulating hypotheses about domains that are beyond current experimental investigations, and the development of therapeutic molecules that target the p53 pathway.

关键词： p53 structure computational modelling therapeutic targeting

A novel reconfiguration of the solar array to enhance peak power and efficiency under partial shading conditions:experimental validation

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Clean Energy 2023年第4期7卷 824-842页

作者： Vijay Laxmi Mishra Yogesh K.Chauhan K.s.verma EED KNIT SultanpurU.P.Pin-228118India

Non-homogeneous irradiation patterns and temperature levels immensely affect the performance of solar photovoltaic *** shading conditions on solar arrays reduce the peak power and *** paper provides a new remedy called a novel Ramanujan reconfiguration(NRR)to eliminate this physical shading problem in solar photovoltaic *** is a static-based reconfigured technique that is built using a three-diode model with the help of the MATLAB®/simulink®*** special feature of the proposed NRR technique is that when shade occurs on the solar modules,it gets realigned in a particular row,column,diagonal,corner,centre and middle peripheral *** helps over a wide range of shade dispersion on the solar *** novel topology is tested against the conventional total cross-tied(TCT)model and recently introduced advanced reconfigured models,namely odd–even topology(OET)and Kendoku topology(KDT).The results are tested under certain shading *** proposed NRR technique increases the peak power by 4.45,2.15 and 2.17 W under the first shading condition regarding TCT,OET and *** efficiency is improved by 0.51–2.18%under the third shading condition compared with other considered models in this *** addition,NRR leads to smooth output curves under the second,third and fourth shading conditions,effectively mitigating the local power *** experimental results show the proposed enhanced performance of the novel model against the other *** Abstract Remedy for physical problem correlated with solar photovoltaics Comparison with traditional and recent solar models Conclusion:NRR has effectively handled the problem related with solar *** has improved the efficiency up to 31.44%under ***,smooth output curves under s2-s4 shows its effectiveness in mitigating the local power *** power gain at 3.94%under s4 is achieved by novel ***-time verification proves the supremacy of novel proposed model over o

关键词： efficiency partial shading conditions peak power Ramanujan reconfiguration solar array total cross-tied three-diode model

size-Dependent RIs and FOM of Ag-Fe and Au-Fe Bimetallic Alloys in Triangular Prism: A DDA study

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Photonic sensors 2019年第3期9卷 246-258页

作者： Pradeep BHATIA s. s. verma M. M. sINHA Department of Physics Sant Lo ngowal Institute of Engineering and Technology Sangrur-148106 Punjab India

In this paper, the localized surface plasmon resonance (LsPR) peak of Ag-Fe and Au-Fe alloy nanoparticles for the triangular prism is calculated by using the discrete dipole approximation (DDA) method. We investigate the variation of the resonance wavelength, refractive index sensitivity, and figure of merit with the particles size and alloy compositions. We perform a comparative study on the refractive index sensitivity and figure of merit of alloys in order to find the considered (Ag-Fe and Au-Fe) alloys with high sensitivity. The refractive index sensitivity of the Au-Fe alloy is found higher than that of the Ag-Fe alloy. Therefore, to optimize the size of alloy nanoparticles (NPs) for the triangular prism, the figure of merit is calculated and observed that the optimized size is 50 nm and 20 nm for Ag-Fe and Au-Fe alloys, respectively. A comparison of Ag-Fe shows that the Au-Fe alloy NPs have greater figure of merit (FOM) and thus may be more suitable for applications in biosensing.

关键词： Nanoparticles alloys refractive index sensitivity figure of merit

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三维电磁成像在钻石勘探中的应用

石油地球物理勘探 2004年第B11期39卷 146-147页

作者： verma s K 印度国家地球物理研究所

电磁测量是勘探风化的金伯利岩的一种有效方法，这是因为黏性物质的存在使得风化的金伯利岩顶部地层成为良导层，即使被盖层覆盖住，它也有很好的电性或电磁响应。

关键词：三维电磁成像技术钻石勘探技术多频电磁法时域电磁法金伯利岩

Phenylboronic acid modified mucoadhesive nanoparticle drug carriers facilitate weekly treatment of experimentally- induced dry eye syndrome

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Nano Research 2015年第2期8卷 621-635页

作者： shengyan Liu Chu Ning Chang Mohit s. verma Denise Hileeto Alex Muntz Ulrike stahl Jill Woods LyndonW. Jones Frank X. Gu Department of Chemical Engineering University of Waterloo Waterloo N2L 3G1 Canada Waterloo Institute for Nanotechnology University of Waterloo Waterloo N2L3G1 Canada Centre for Contact Lens Research University of Waterloo Waterloo N2L3G1 Canada

Topical formulations, commonly applied for treatment of anterior eye diseases, require frequent administration due to rapid clearance from the ocular surface, typically through the lacrimal drainage system or through over-spillage onto the lids. We report on a mucoadhesive nanoparticle drug delivery system that may be used to prolong the precorneal residence time of encapsulated drugs. The nanoparticles were formed from self-assembly of block copolymers composed of poly（D, L-lactide） and Dextran. The enhanced mucoadhesion properties were achieved by surface functionalizing the nanoparticles with phenylboronic acid. The nanoparticles encapsulated up to 12 wt.% of Cyclosporine A （CycA） and sustained the release for up to five days at a clinically relevant dose, which led us to explore the therapeutic efficacy of the formulation with reduced administration frequency. By administering CycA-loaded nanoparticles to dry eye-induced mice once a week, inflammatory infiltrates were eliminated and the ocular surface completely recovered. The same once a week dosage of the nanoparticles also showed no signs of physical irritation or inflammatory responses in acute （1 week） and chronic （12 weeks） studies in healthy rabbit eyes. These findings indicate that the nanoparticles may significantly reduce the frequency of administration for effective treatment of anterior eye diseases without causing ocular irritation.

关键词： biocompatibility copolymer mucoadhesion nanoparticle drug delivery ophthalmology

ARABIDOPsIs LsT8 proteins interact with target of rapamycin and over-expression of LsT8 results in plants being hypersensitive to light

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ARABIDOPSIS LST8 proteins interact with target of rapamycin ...

A sUsPENsION MODEL FOR BLOOD FLOW THROUGH A CATHETERIZED ARTERY

从植物科学到农业发展——2012全国植物生物学大会

作者： Jayanta Chatterjee Desh Pal s verma Department of Molecular Genetics and Plant Biotechnology Center The Ohio State University

LsT8(GpL) negatively regulates amino acid biosynthesis as a component of the TOR pathway in *** are two homologs of LsT8 in Arabidopsis,AtLsT8.1(At2g22040) and AtLsT8.2(At3gl8140).Here we demonstrate that both AtLsT8.1 and AtLsT8.2 interact with TOR ***8.2 complements the function of yeast LsT8,while AtLsT8.1 does ***8.1 and AtLsT8.2 have differential expression levels in plant ***8.1 only transcribed and expressed in *** expression of AtLsT8.1 in wild type Arabidopsis down regulates the expression of AtLsT8.2 and represses the primary bolting with increased ***8.2 is an essential gene for plant development as three T-DNA insertion mutants showed that disruption of AtLsT8.2 leads to embryo *** expression of AtLsT8.2 in wild type plants down regulates its own expression,and increases the expression of AtLsT8.1,resulting in the plants that are hypersensitive to light *** strong light halts the growth of AtLsT8.2-transgenic *** of GFP with AtLsT8.2 and its expression revealed that AtLsT8.2 is present in *** PGK1,a glycolytic enzyme which is also expressed in chloroplast,reverses the response to AtLsT8.2 expression *** data suggest that AtLsT8 proteins play an important role in photosynthesis and possibly amino acid metabolism in plants.

关键词： LsT8 proteins TOR hypersensitive light photosynthesis

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