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Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： victor V.Chizhikov Igor Y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Pathways for Sustainable Utilization of Waste Chicken Eggshell

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Journal of Renewable Materials 2022年第8期10卷 2217-2246页

作者： Omojola Awogbemi Daramy Vandi Von Kallon victor Sunday aigbodion Department of Mechanical and Industrial Engineering Technology University of JohannesburgJohannesburgSouth Africa African Centre of Excellence ACESPED University of NigeriaNsukkaNigeria Faculty of Engineering and the Built Environment University of JohannesburgJohannesburgSouth Africa

Chicken eggshell is one of the most common wastes generated from households,restaurants and other food processing *** Chicken Eggshells(WCES)also constitutes an environmental nuisance and ends up discarded at dumping site with no consideration of further *** main constituent of WCES is calcium carbonate from which calcium or calcium oxide can be extracted for various *** current effort reviews recently published literature on the diverse applications of *** considered utilization avenues include catalysts for biofuel production,construction industry,wastewater purification,industrial sector,food industry,medical,and agricultural *** specific areas of application apart from the transesterification reactions include cement additives and replacement in concrete,asphalt binder,adsorbent of metals and dyes,production of hydroxyapatite,food supplement and fortification,dentistry,therapeutics,bone formation,drug delivery,poultry feeds as well as organic *** most of the identified applications,the WCES is subjected to pretreatment and other modification techniques before *** conversion of WCES to valuable products is a cost-effective,safe,environmentally friendly,non-toxic and viable means of waste disposal and *** investigations are needed to further explore the benefits derivable from this bioresource.

关键词： Waste chicken eggshells catalysts food supplements medical applications waste utilization biofuel production

An Inactivated Vaccine from a Field Strain of Bovine Herpesvirus-1(BoHV-1) has High Antigenic Mass and Induces Strong Efficacy in a Rabbit Model

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Virologica Sinica 2013年第1期28卷 36-42页

作者： Julian Ruiz-Sáenz Jairo Jaime victor vera Microbiology and Epidemiology Group Faculty of Veterinary Medicine and Animal Science National University of Colombia Grupo de Investigación CENTAURO Agrarian Sciences Faculty Universidad de Antioquia A.A. 1226

Bovine Herpesvirus-1 （BoHV-1） is a DNA virus belonging to the family Herpesviridae, subfamily Alfaherpesvirinae; it is a worldwide pathogen, causing serious economic losses in livestock. In Colombia there have been multiple isolates of BoHV-1 that have been subjected to molecular characterization, classifying most of the country isolates as BoHV-I.1. In the present study we developed and evaluated an ethyleneimine binary inactivated isolate from the native BoHV-1 strain （C6rdoba-2） in a rabbit model of vaccination and infection. The vaccine was evaluated in two phases, one of immunogenicity with vaccination and a booster after 21 days, and an evaluation phase of protection against challenge with a highly virulent reference strain. The results demonstrate optimum serum-conversion, with protective neutralizing antibody titers 28 days post vaccination and optimal protection against challenge with the reference strain with decreased clinical signs of infection, protection against the onset of fever and decrease of virus excretion post challenge. In conclusion, our results show the enormous potential that an immunogenic inactivated vaccine has produced from the native BoHV-I.1 strain, which produces a high antigen mass to the vaccine to induce optimal immunity and protection, and it is a strong candidate for evaluation and possible future use in different cattle populations.

关键词： Antigenic Mass Adjuvant Binary Ethyleneimine Bovine Herpesvirus-1 Vaccine

Improving tribological and thermal properties of Al alloy using CNTs and Nb nanopowder via SPS for power transmission conductor

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Transactions of Nonferrous Metals Society of China 2020年第2期30卷 333-343页

作者： Chika O.UJAH Patricia POPOOLA Olawale POPOOLA victor aigbodion Philip OLADIJO Department of Chemical Metallurgical and Materials EngineeringTshwane University of TechnologyPretoria 0001South Africa Department of Electrical Engineering Tshwane University of TechnologyPretoria 0001South Africa Department of Metallurgical and Materials Engineering University of NigeriaNsukka 410001Nigeria Department of Chemical Materials and Metallurgical EngineeringBotswana International University of Science and TechnologyPalapye 12345Botswana Department of Mechanical Engineering University of JohannesburgJohannesburg 2000South Africa

This study aimed at improving the tribological and thermal properties of Al alloy using CNTs and Nb nanopowder as reinforcements and spark plasma sintering(SPS)as the fabrication *** SPS was conducted at 630℃,30 MPa,10 min,and 200℃/*** tribology test was run with ball-on-disc tribometer using steel ball as the counter *** the thermal test was processed with thermogravimetric analyzer(TGA)and laser flash apparatus(LFA).Results showed that the addition of 8 wt.%CNTs and 8 wt.%Nb reinforcements respectively decreased the coefficient of friction(COF)of the composite by 79%.The wear volume of the composite was decreased by 23%,and so was the wear ***,the thermal conductivity of the composite was equally improved by 44%.The tribology improvement was stimulated by a C film generated by CNTs and a protective Nb2O5 formed by Nb *** thermal conductivity was improved by the grain refining property of Nb and the high thermal conductivity of ***,these results indicated that Al-CNTs-Nb composite is a robust material for high transmission conductor capable of reducing sag and ensuring the durability of the composite.

关键词： tribology thermal conductivity spark plasma sintering Al-CNTs-Nb composite coefficient of friction

Molecular and in vitro Characterization of Field Isolates of Bovine Herpesvirus-1

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Virologica Sinica 2012年第1期27卷 26-37页

作者： Julian Ruiz-Saenz Jairo Jaime Gloria Ramirez victor vera Faculty of Veterinary Medicine and Animal Science National University of Colombia

Bovine Herpesvirus-1 (BoHV-1) is distributed worldwide and is a major pathogen in cattle, being the causal agent of a variety of clinical syndromes. The aim of this study was to isolate and to characterize (molecular and biological characterization) BoHV-1 from 29 immunosuppressed animals. It was possible to obtain 18 isolates, each from a different animal, such as from the respiratory and reproductive tracts. In some cases the cytopathic effect was visible 12 hours post-inoculation, and became characteristic after 36-48 hours. Biological characteristics were evaluated and compared with Iowa and Colorado-1 reference strains, and differences were found in plaque size, virus titer measured by TCID50 and PFU/mL, and one step virus curves. These results showed that some isolates had a highly virulent-like behavior in vitro, compared to the reference strains, with shorter eclipse periods, faster release of virus into the supernatants, and higher burst size and viral titer. There were no differences in glycoprotein expression of BoHV-1 isolates, measured by Western blot on monolayers. Moreover, using restriction endonucleases analysis, most of the viruses were confirmed as BoHV-1.1 and just one of them was confirmed as BoHV-1.2a subtype. These findings suggest that some wild-type BoHV-1 isolates could be useful as seeds to develop new monovalent vaccines.

关键词： Bovine herpesvirus 1 Genital infection Respiratory infection Latent infection

Association of swine influenza H1N1 pandemic virus(SIV-H1N1p) with porcine respiratory disease complex in sows from commercial pig farms in Colombia

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Virologica Sinica 2014年第4期29卷 242-249页

作者： Luisa Fernanda Mancipe Jiménez Gloria Ramírez Nieto victor vera Alfonso Jairo Jaime Correa Laboratory of Animal Virology Faculty of Veterinary Medicine and Animal Science National University of Colombia

Porcine respiratory disease complex （PRDC） is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus （PRRSV）, swine influenza virus （SIV）, Mycoplasma hyopneumoniae （Myh）, Actinobacillus pleuropneumoniae （APP）, Pasteurella multocida and Porcine circovirus 2 （PCV2）. To characterize the specific role of swine influenza virus in PRDC presentation in Colombia, 11 farms from three major production regions in Colombia were examined in this study. Nasal swabs, bronchial lavage and lung tissue samples were obtained from animals displaying symptoms compatible with SIV. Isolation of SIV was performed in 9-day embryonated chicken eggs or Madin-Darby Canine Kidney （MDCK） cells. Positive isolates, identified via the hemagglutination inhibition test, were further analyzed using PCR. Overall, 7 of the 11 farms were positive for SIV. Notably, sequencing of the gene encoding the hemagglutinin （HA） protein led to grouping of strains into circulating viruses identified during the human outbreak of 2009, classified as pandemic H1N1-2009. Serum samples from 198 gilts and multiparous sows between 2008 and 2009 were obtained to determine antibody presence of APP, Myh, PCV2 and PRRSV in both SIV-H1Nlp-negative and -positive farms, but higher levels were recorded for SIV- HI Nlp-positive farms. Odds ratio （OR） and P values revealed statistically significant differences （p〈0.05） in PRDC presentation in gilts and multiparous sows of farms positive for SIV-HINlp. Our findings indicate that positive farms have increased risk of PRDC presentation, in particular, PCV2, APP and Myh.

关键词： SIV-HIN1 swine influenza pandemic porcine respiratory disease complex Colombia

Effect of Tin Tailings on Some Refractory Properties of Alumino-Silicates (Alkaleri) Clay

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Journal of Minerals and Materials Characterization and Engineering 2013年第2期1卷 29-32页

作者： victor Sunday aigbodion Clement Uche Atuanya Chikaodi Cynthia Daniel Mkpume Department of Metallurgical and Materials Engineering Nnamdi Azikiwe University Awka Nigeria Department of Metallurgical and Materials Engineering University of Nigeria Nsukka Nigeria

The possibilities of upgrading some refractory properties of Alkaleri Clay (Alumino-silicates), found in Alkaleri Village, Bauchi State, Nigeria, by blending with tin tailings for the production of fireclay refractory bricks were investigated. Refractory properties such as: linear shrinkage, apparent porosity, bulk density, cold crushing strength and thermal shock resistance were tested with percentage additions of tin tailings from 5 - 30 wt% in the blend. The test was conducted using the standard test techniques in each case. The results were compared with standard refractory properties for fire clay bricks. Cold crushing strength, bulk density, refractoriness and thermal shock resistance of the bricks made from the blend clay increased, as the percentages of tin tailings increased. The Linear shrinkage and apparent porosity decreased as the percentages of tin tailings addition increased. All the values obtained from the blends are within the recommended values for dense fireclay bricks. Hence, dense fireclay can be produced from this blended.

关键词： Tin Talings Alkeri Clay Refractory Properties

“What is a Sociologist Doing Here?”An Unconventional People-Centered Approach to Improve Warning Implementation in the Sendai Framework for Disaster Risk Reduction

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International Journal of Disaster Risk Science 2020年第2期11卷 218-229页

作者： victor Marchezini Cemaden–National Early Warning and Monitoring Center of Natural Disasters Distrito de Eug8nio de Melo 12.247-016Sao Jose dos CamposSPBrazil Doctorate Program on Earth System Science National Institute for Space ResearchSao Jose dos CamposBrazil Programa de Pós-Gradua??o em Desastres Naturais ICT/Unesp-CemadenSao Jose dos Campos.Brazil

The Sendai Framework for Disaster Risk Reduction 2015–2030 recommends several actions for early warning systems(EWSs). However, there is a lack of information about their means of implementation. This article used institutional ethnography to analyze the 2012–2018 implementation of a national warning system in Brazil. The challenges related to daily activities, and the interdisciplinary works in the four axes of EWSs towards multi-hazard and people-centered approaches are discussed. This national experience is then discussed in the light of the global challenges of EWSs considering two main issues:(1) experiences of implementation and barriers related to people-centered warning systems;and(2)types of national/regional warning systems and hazards/threats that are being monitored as an important input for multi-hazard approaches. There are few multi-hazard warning systems in place and EWSs are focused on hydrometeorological hazards, mainly related to floods. The Sendai Framework needs to improve access to data and information, identify views from the frontline, consider political threats and vulnerabilities, and find ways to talk about disaster risk creation processes at a larger scale.

关键词： Risk governance Interdisciplinary research People-centered warning systems

Cryotic climate conditions and their eventual implication in the high-mountain surface of the Nevado de Toluca volcano, Mexico

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Journal of Mountain Science 2021年第9期18卷 2273-2286页

作者： SOTO victor Facultad de Ciencias Biológicas y Agropecuarias Universidad VeracruzanaPoza Rica-Tuxpan 92870México

The state of the cryosphere in tropical regions is of great importance because the temperature around the glaciers, permafrost and snow cover always fluctuates near the melting point. These thermal conditions and their high sensitivity to climate change cause the accelerated disappearance of these elements;therefore, it is important to know the climatic factors that regulate them, as well as the physical characteristics of each cryospheric element. Unlike glaciers, permafrost and snow cover have not been widely studied. In recent decades, the study of the glacial and periglacial environment has been carried out in intertropical mountains. However, despite the altitude of their relief and the frequent occurrence of snowfall in tropical high mountains, the conditions that determine such events have been barely analyzed;and in the case of Mexico, the volume of snowfall and its thickness have not been quantified either, as well as their corresponding duration. Consequently, this work is aimed to analyze the temperature and precipitation conditions that determine the snowfall at the higher part of the Nevado de Toluca volcano;at the same time, the conditions of the cryotic climate and their possible implication on the surface are studied. The analysis of data from 1965 to 2016, using frequency statistics, allowed to realize that snowfall occurs with low intensity, its accumulation being less than 10 cm thick and 10 mm of snow water equivalent, which causes the snowpack to stay only a few weeks on average. At the same time, it was determined that there is a significant increase in the number of freeze-thaw cycles. Therefore, due to the climate conditions and their influence on the mountain surface, it is probable that the bedrock is subject to a greater gelifraction dynamics, and the unconsolidated soil surface increases;the combination of the above could cause a greater geomorphological dynamic over time, particularly due to debris flows, and by water and wind erosion of

关键词： Air temperature Cryotic conditions High-mountain climatology Periglacial geomorphology Snow precipitation