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A Damage Scenario for the 2012 Northern Italy Earthquakes and Estimation of the Economic Losses to Residential Buildings

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International Journal of Disaster Risk Science 2017年第3期8卷 326-341页

作者： Fabrizio Meroni Thea Squarcina vera pessina Mario Locati Marco Modica Roberto Zoboli Istituto Nazionale di Geofisica e Vulcanologia(INGV) Sezione di MilanoVia Bassini 15MilanItaly Istituto di Ricerca sulla Crescita Economica Sostenibile(IRCrES) Via Corti1220131 MilanItaly

In May 2012 a seismic sequence occurred in Northern Italy that was characterized by two main shocks with a magnitude range between 5.5 and 6. These shocks represent a good case study by which to quantify the monetary losses caused by a moderate earthquake in a densely populated and economically well-developed *** loss estimation accounts for damage to residential buildings, and considers the full effect of all the seismic aftershock events that lasted for nearly a month. The building damage estimation is based on the European Macroseismic Scale(EMS-98) definitions, which depict the effects of an earthquake on built-up areas in terms of observed intensities. Input data sources are the residential building census provided by Istituto Nazionale di Statistica—the Italian National Institute of Statistics(ISTAT)—and the official market value of real estate assets, obtained from the Osservatorio del Mercato Immobiliare—the Real Estate Market Observatory(OMI). These data make it possible to quantify the economic losses due to earthquakes, an economic indicator updated yearly. The proposed multidisciplinary method takes advantage of seismic,engineering, and economic data sets, and is able to provide a reasonable after the event losses scenario. Data are not gathered for each single building and the intensity values are not a simple hazard indicator, but, notwithstanding its coarseness, this method ensures both robust and reproducible results. As the local property value is availablethroughout the Italian territory, the present loss assessment can be effortlessly repeated for any area, and may be quickly reproduced in case of future events, or used for predictive economic estimations.

关键词： Earthquake damage Economic losses EMS-98 intensity Northern Italy 20 May 2012 earthquake

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Bcl-2 down modulation in WEHI-3B/CTRES cells resistant to Cholera Toxin(CT)-induced apoptosis

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Cell Research 2006年第3期16卷 306-312页

作者： Augusto pessina Cristina Croera Nicoletta Savalli Arianna Bonomi Loredana Cavicchini Elisa Turlizzi Fabiana Guizzardi Lucia Guido Laura Daprai Maria GraziaNeri Institute of Microbiology University of MilanVia Pascal 3620133 MilanItaly ECVAM Institute for Health and Consumer ProtectionEuropean Commission Joint Research CentreIspra 21020Italy UCLA Department of AnesthesiologyLos AngelesCA 90095USA

The very different effects of Cholera Toxin (CT) on cell growth and proliferation may depend on the type of ganglio-side receptors in cell membranes and different signal transduction mechanisms triggered,but other functions relatedto the drug resistance mechanisms can not be *** effect of CT treatment on the "in vitro" clonogenicity,thePopulation Doubling Time (PDT),apoptosis,PKA activation and Bax and Bcl-2 expression was evaluated in WEHI-3Bcell line and its CT-resistant subclone (WEHI-3B/CTRES).In WEHI-3B parental cells the dramatic accumulation ofcAMP induced by CT correlated well with PKA activation,increased PDT value,inhibition of clonogenicity and apop-tosis.H-89 treatment inhibited PKA activation by CT but did not protect the cells from apoptosis and growth *** WEHI-3B/CTRES no significant CT-dependent accumulation of cAMP occurred with any increase of PKA activityand *** CT resistant cells (WEHI-3B/CTRES),Bcl-2 expression was down regulated by both CT or drug treatment(eg.,ciprofloxacin,CPX) although these cells were protected from CT-dependent apoptosis but not from *** from other cell models described,down regulation of Bcl-2 is proved to be independent on cAMPaccumulation and PKA *** observations support the implication of cAMP dependent kinase (PKA) in theinhibition of WEHI-3B cells growth and suggest that,in WEHI-3B/CTRES,Bcl-2 expression could be modulated byCT in the absence of cAMP *** in consideration of many contradictory data reported in literature,ourcell models(of one sensitive parental cell strain and two clones with different uncrossed specific resistance to CT andCPX)provides a new and interesting tool for better investigating the relationship between the CT signal transductionmechanisms and Bcl-2 expression and function.

关键词： cholera toxin Bcl-2 PKA apoptosis ciprofloxacin resistance

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Child abuse and psychopathy: Interplay, gender differences and biological correlates

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World Journal of Psychiatry 2021年第12期11卷 1167-1176页

作者： Ester di Giacomo Mario Santorelli Rodolfo pessina Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo Clerici School of Medicine and Surgery University of Milano BicoccaMonza 20900Italy Department of Psychiatry ASST MonzaMonza 20090Italy School of Medicine and Surgery Psychiatric Residency Training ProgramUniversity of Milano BicoccaMonza 20900Italy Department of Psychology Linguistics and Cognitive NeuroscienceUniversity of Milano BicoccaMonza 20900Italy Department of Psychiatric Residency Training Program University of GenovaGenova 16126Italy Department of Medicine and Surgery University of Milano-BicoccaMonza 20900Italy

Child abuse is an important source of mental and physical adverse consequences for victims,their family,and their *** impact of violence during childhood on the development of the victim is a very sensitive *** than internalizing symptoms,it is interesting to analyze the possibility that a victim may assume the role of *** this aim,we evaluate Literature and examine the interplay among different types of child abuse(emotional neglect,emotional abuse,physical neglect,physical abuse and sexual abuse)and the development of *** consider the role of post-traumatic stress disorder and that of personal environment as potential mediators between abuse and ***,an in-depth analysis on possible differences due to the victim's gender is ***,analysis focused on genetic variants,such as the polymorphism of 5HTT and MAO-A,or a biological alteration,like the difference in daily cortisol levels that could be related to the development of psychopathy after a trauma.

关键词： Child abuse Sexual abuse Physical abuse Psychopathy Neglect Intergenerational transmission

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Therapeutic termination of pregnancy and women’s mental health:Determinants and consequences

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World Journal of Psychiatry 2021年第11期11卷 937-953页

作者： Ester di Giacomo Rodolfo pessina Mario Santorelli Daniele Rucco Valeria Placenti Francesca Aliberti Fabrizia Colmegna Massimo Clerici School of Medicine and Surgery University Milan BicoccaMonza 20900LombardyItaly Department of Psychiatric ASST MonzaMonza 20900LombardyItaly Psychiatric Residency Training Program University Milan BicoccaMonza 20900LombardyItaly PhD Program in Psychology Linguistics and Cognitive NeuroscienceUniversity Milan BicoccaMilano 20126LombardyItaly Psychiatric Residency Training Program University of GenovaGenova 16126LiguriaItaly

The therapeutic termination of pregnancy(TToP)is an induced abortion following a diagnosis of medical *** is applied to avoid the risk of substantial harm to the mother or in cases of fetal *** type of induced abortion is provided after the second semester of gestation if fetal illness or the pregnancy cause physical danger or pathological mental distress to the *** and economic determinants could influence the desire for children and family planning in couples,as well as the use of effective contraception and the choice to perform an induced ***,pre-existing mental health problems could affect the decision between carrying on a problematic pregnancy or having ***,the TToP is a reproductive event with an important traumatic burden,but also with an intrinsic therapeutic effect and it can produce different psychological and psychopathological effects on women and *** aim of this review is to evaluate what demographic,reproductive and psychopathological determinants are involved in the choice of undergoing a TToP in ***,we will examine both positive and negative consequences of this procedure on women’s mental health,underlying which factors are related to a worse outcome in order to provide the best clinical support to vulnerable groups.

关键词： Therapeutic abortion Women’s health Depression PostTraumatic stress disorder Perinatal care Psychiatry

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Visual Composition of Complex Queries on an Integrative Genomic and Proteomic Data Warehouse

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Engineering（科研） 2013年第10期5卷 94-98页

作者： Francesco pessina Marco Masseroli Arif Canakoglu Dipartimento di Elettronica e Informazione Politecnico di Milano Milan Italy

Biomedical questions are usually complex and regard several different life science aspects. Numerous valuable and he- terogeneous data are increasingly available to answer such questions. Yet, they are dispersedly stored and difficult to be queried comprehensively. We created a Genomic and Proteomic Data Warehouse (GPDW) that integrates data provided by some of the main bioinformatics databases. It adopts a modular integrated data schema and several metadata to describe the integrated data, their sources and their location in the GPDW. Here, we present the Web application that we developed to enable any user to easily compose queries, although complex, on all data integrated in the GPDW. It is publicly available at http://***/GPKB/. Through a visual interface, the user is only required to select the types of data to be included in the query and the conditions on their values to be retrieved. Then, the Web application leverages the metadata and modular schema of the GPDW to automatically compose an efficient SQL query, run it on the GPDW and show the extracted requested data, enriched with links to external data sources. Performed tests demonstrated efficiency and usability of the developed Web application, and showed its and GPDW relevance in supporting answering biomedical questions, also difficult.

关键词： SQL Query Composition Visual Interface Integrated Data Extraction Data Warehousing Bioinformatics Database

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NUOVI SITI MESOLITICI IN PROVINCIA DI UDINE

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Natural Disaster Reduction in China 1989年第1期 251-287页

作者： ALDO CANDUSSIO ALESSANDROFERRARI UMBERTOFERRARI ANTONIO MESSORI ANDREA pessina ODDONE PEZ FRANCO QUAGLIARO ROBERTO TOSONE e BRUNO TULLIO Società Gruppo Naturalisti Spilamberto Modena. Dipartimento

Ricerche di superficie hanno portato all’individuazione di 5 siti preistorici riferibili alMesolitco. Tre stazioni (Fornaci De Mezzo; Corno-Ripudio; Cassacco) si collocano nella fascia collinarea nord di Udine nell’anfiteatro morenico del Tagliamento, ai margini di antichi bacini inframoreniciora prosciugati. Fornaci De Mezzo ha restituito un’industria di tipo Sauveterriano, forse riferibile allafase antica (prima metà del decimo millennio BP). Corno-Ripudio presenta invece caratteri che potrebbe-ro indicate una fase antica del Castelnoviano, qui attestato da due armature trapezoidali. A Cassaccosono invece numerosi i Trapezi e le tipiche lame denticolate castelnoviane. Due i siti rinvenuti nell’areadella bassa pianura friulana: Porpetto e Bertiolo. II primo ha restituito pochi elementi del MesoliticoRecente, mentre il secondo parrebbe attribuibile, con riserve, al Mesolitico Antico o alia fase finale dell’E-pigravettiano ltalico. Discovery of Mesolithic sites in the Province of Udine (Northern Italy). ArchaeologicalSurveys carried out in the Province of Udine led to the discovery of five Mesolithic sites. Three ofthese stations (Fornaci De Mezzo, Corno-Ripudio and Cassacco) lie along the shores of small basinsof the morainic arc of the river Tagliamento. Fornaci De Mezzo produced a Sauveterrian industry proba-bly to be attributed to the first half of the tenth millennium BP. Corno-Ripudio, which yielded twotrapezoidal points, might belong to the Early Castelnovian. Cassacco gave many trapezes and notchedbladelets of Castelnovian type. Two sites were also discovered in the Friuli plain, namely Porpetto andBertiolo. The first gave a few Late Mesolithic artefacts, while the second is to be attributed to the EarlyMesolithic or to the Final Epigravettian.

关键词：切创八价瓜州刃口户口

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Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine

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Horticulture Research 2016年第1期3卷 248-256页

作者： Stefano pessina Luisa Lenzi Michele Perazzolli Manuela Campa Lorenza Dalla Costa Simona Urso Giampiero Valè Francesco Salamini Riccardo Velasco Mickael Malnoy Research and Innovation Centre Fondazione Edmund Machvia Edmund Mach 1San Michele all’Adige38010Italy Wageningen UR Plant Breeding Wageningen University and Research CentrePO Box 386Wageningen6700AJThe Netherlands Department of Ecological and Biological Sciences Universitàdella TusciaVia San Camillo de LellisViterbo01100Italy Council for Agricultural Research and Economics(CREA) Rice Research UnitS.S.11 per Torino km 25Vercelli13100Italy Council for Agricultural Research and Economics(CREA) Genomics Research CentreVia San Protaso302Fiorenzuola d’Arda29017PiacenzaItaly

Erysiphe necator is the causal agent of powdery mildew(PM),one of the most destructive diseases of *** is controlled by sulfur-based and synthetic fungicides,which every year are dispersed into the *** is why PM-resistant varieties should become a priority for sustainable grapevine and wine *** resistance can be achieved in other crops by knocking out susceptibility S-genes,such as those residing at genetic loci known as MLO(Mildew Locus O).All MLO S-genes of dicots belong to the phylogenetic clade V,including grapevine genes VvMLO7,11 and 13,which are upregulated during PM infection,and VvMLO6,which is not *** adopting a gene-editing approach to knockout candidate S-genes,the evidence that loss of function of MLO genes can reduce PM susceptibility is *** paper reports the knockdown through RNA interference of VvMLO6,7,11 and *** knockdown of VvMLO6,11 and 13 did not decrease PM severity,whereas the knockdown of VvMLO7 in combination with VvMLO6 and VvMLO11 reduced PM severity up to 77%.The knockdown of VvMLO7 and VvMLO6 seemed to be important for PM resistance,whereas a role for VvMLO11 does not seem *** wall appositions(papillae)were present in both resistant and susceptible lines in response to PM *** genes involved in defense were less upregulated in infected mlo plants,highlighting the early mlo-dependent disruption of PM invasion.

关键词： MLO crops mildew

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