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Effects of Ligustrazine on Airway Inflammation in A Mouse Model of Neutrophilic Asthma

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Chinese Journal of Integrative Medicine 2018年第5期24卷 353-358页

作者： LIU Xiao-ming1 WANG Yong-bin2 WU Qian2 BIAN Zhong-rui2 CHE Xiao-wen2 Department of Geriatric Medicine the Affiliated Hospital of Shandong University of Traditional Chinese Medicine Department of Respiratory Medicine the Second Hospital of Shandong University

Objective: To investigate the effects of ligustrazine(LTZ) on airway inflammation in a mouse model of neutrophilic asthma(NA). Methods: Forty healthy C57 BL/6 female mice were randomly divided into 4 groups using a random number table, including the normal control, NA, LTZ and dexamethasone(DXM) groups, with 10 rats in each group. The NA mice model was established by the method of ovalbumin combined with lipopolysaccharide sensitization. At 0.5 h before each challenge, LTZ and DXM groups were intraperitoneally injected with LTZ(80 mg/kg) or DXM(0.5 mg/kg) for 14 d, respectively, while the other two groups were given the equal volume of normal saline. After last challenge for 24 h, the aerosol inhalation of methacholine was performed and the airway reactivity was measured. The bronchoalveolar lavage fluid(BALF) was collected. The Wright-Giemsa staining was used for total white blood cells and differential counts. The levels of cytokines interleukin(IL)-17 and IL-10 were detected by enzyme-linked immunosorbent assay. The pathological change of lung tissue was observed by hematoxylin eosin staining. Results: The airway responsiveness of the NA group was significantly higher than the normal control group(Pvel in BALF was significantly increased and the IL-10 level in BALF was significantly decreased in the NA group(P<0.05). LTZ and DXM treatment

关键词： ligustrazine neutrophilic asthma airway inflammation cytokine

Hydraulic characteristics of converse curvature section and aerator in high-head and large discharge spillway tunnel

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Science China(Technological Sciences) 2011年第S1期54卷 33-39页

作者： LIU ZhiPing 1,2,ZHANG Dong 2,ZHANG HongWei 2 &WU YiHong 1,2 1 State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin,Beijing 100038,China 2 China Institute of Water Resources and Hydropower Research,Beijing 100038,China 1. State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin Beijing 100038 China2. China Institute of Water Resources and Hydropower Research Beijing 100038 China

The hydraulic characteristics and cavitation erosion near the converse curvature section in the high-head and large discharge spillway tunnel have been important issues of concern to the hydropower *** this paper,the evolutions of hydraulic elements such as pressure,flow velocity,wall shear stress,*** the converse curvature section are analyzed and the impacts of bottom aerator on hydraulic characteristics are discussed,with the commercial software FLUENT6.3 as a platform and combining the k-model and VOF *** flow pattern in the converse curvature section of spillway tunnel is given by the three-dimensional numerical *** indicates that the pressure changes rapidly with great pressure gradient from the beginning to the end of the *** also shows that the shear stress on side wall just downstream the end of the converse curvature curve is still increasing;the aeration cavity formed downstream the bottom aerator may cause the side wall pressure decreased to worsen the cavitation characteristics near the side *** means of the physical model experiment,the three-dimensional aerator composed of side wall baffling aerator and bottom aerator is studied,the baffling aerator suitable for the water flow conditions with water depth of 6.0 to 8.0 m and flow velocity of 35 to 50 m/s is proposed.

关键词： spillway tunnel baffling aerator converse curvature section hydraulic characteristics

Progress of synthesizing methods and properties of fluorinated carbon nanotubes

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Science China(Technological Sciences) 2010年第5期53卷 1225-1233页

作者： LI Yu1,2,CHEN YanFang1,2,FENG YiYu1,2,ZHAO ShengLing1,2,Lü Peng1,2,YUAN XiaoYan1,2 & FENG Wei1,2 1School of Materials Science and Engineering,Tianjin University,Tianjin 300072,China 2Tianjin Key Laboratory of Composite and Functional Materials,Tianjin 30072,China 1. School of Materials Science and Engineering Tianjin University Tianjin 300072 China2. Tianjin Key Laboratory of Composite and Functional Materials Tianjin 30072 China

In this paper,the recent development of fluorinated carbon nanotubes(F-CNTs) was *** synthesizing methods of F-CNTs,including direct fluorination and plasma treatment,were discussed in detail,and the effects of factors,such as the temperature and pressure in fluorination as well as the kind of fluorine source and carbon nanotubes,on the structures and properties of F-CNTs were also *** the mean time,the special physical and chemical properties of F-CNTs and the relevant applied fields were described briefly,the exisiting problems of F-CNTs were summed up,and the direction of future development was also discussed in the end.

关键词： carbon nanotubes fluorination plasma treatment fluorinated carbon nanotubes substitution reaction

Liquid propellant analogy technique in dynamic modeling of launch vehicle

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Science China(Technological Sciences) 2010年第8期53卷 2102-2110页

作者： PAN ZhongWen 1,2 ,XING YuFeng 1 ,ZHU LiWen 2 ,DONG Kai 2 &SUN Mu 2 1Solid Mechanics Research Center,Beijing University of Aeronautics and Astronautics,Beijing 100191,China 2 Beijing Astronautics Systems Engineering Institute,Beijing 100076,China 1. Solid Mechanics Research Center Beijing University of Aeronautics and Astronautics Beijing 100191 China2. Beijing Astronautics Systems Engineering Institute Beijing 100076 China

The coupling effects among lateral mode,longitudinal mode and torsional mode of a launch vehicle cannot be taken into account in traditional dynamic analysis using lateral beam model and longitudinal spring-mass model *** deal with the problem,propellant analogy methods based on beam model are proposed and coupled mass-matrix of liquid propellant is constructed through additional mass in the present *** an integrated model of launch vehicle for free vibration analysis is established,by which research on the interactions between longitudinal and lateral modes,longitudinal and torsional modes of the launch vehicle can be *** examples for tandem tanks validate the present method and its necessity.

关键词： dynamic characteristics coupled mass integrative modeling propellant analogy

社交媒体用户虚假自我披露行为的认同机理、现实危机及其消解

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情报资料工作 2024年

作者：李奕扉王协舟 1.湘潭大学公共管理学院 2.湘潭大学信息资源管理与知识产权研究基地湘潭大学公共管理学院湘潭大学信息资源管理与知识产权研究基地

[目的/意义]虚假自我披露行为能对受众认知、情感与决策产生直接且显著的消极影响，有必要探讨其认同机理与现实危机。[方法/过程]基于行为参与方特征及其期望回报类型，发现虚假自我披露行为主体为追寻线上社会资本，构建数字化身、给... 详细信息

[目的/意义]虚假自我披露行为能对受众认知、情感与决策产生直接且显著的消极影响，有必要探讨其认同机理与现实危机。[方法/过程]基于行为参与方特征及其期望回报类型，发现虚假自我披露行为主体为追寻线上社会资本，构建数字化身、给予受众拟态亲密感；受众为实现虚拟共生关系，执行情感劳动、推动主体依赖；媒介为圈集平台私域流量，利用算法推荐干预受众信息接收来源、引导主体信息内容生产秩序，强化心理契约刺激主体内容生产体量。[结果/结论] 针对主体认同混乱、受众情感演绎、环境假性共识等危机，宜从主体树立情境自我意识、受众维护情感表达边界、媒介贯彻信息分配正义三方面实现虚假自我披露危机消解。

关键词：虚假自我披露用户自我披露社交媒体

High frequency complex permeability of flake-shaped Fe_(74)Cr_2Mo_2Sn_2P_(10)Si_4B_4C_2 particle composite material

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Science China(Technological Sciences) 2010年第4期53卷 1056-1059页

作者： LIU KaiHuang1,LIU TianCheng1,2,LI JianLiang1,2,ZHANG Liang1,2,ZHANG HongHao1,2,LI DeRen1,2,LU ZhiChao1,2 & ZHOU ShaoXiong1,2 1 China Iron and Steel Research Institute,Beijing 100081,China 2 Advanced Technology and Materials Co.,Ltd.,Beijing 100081,China 1. China Iron and Steel Research Institute Beijing 100081 China2. Advanced Technology and Materials Co. Ltd. Beijing 100081 China

A composite consisting of flake-shaped Fe74Cr2Mo2Sn2P10Si4B4C2 particles was *** flake-shaped particles included in the composite were prepared by planetary ball *** complex permeability of the composite material was measured at frequency range from 10 MHz to 8.5 *** permeability of the composite containing flake-shaped particles was much higher than that of the spherical *** permeability of particles was improved by means of *** contrast to the random-spatial-distributed flake-shaped particle composites,the oriented-distributed ones had a higher effective permeability.A model was proposed considering the orientation ratio,and our calculation agreed well with the experimental data.

关键词： complex permeability composite materials flake-shaped electromagnetic wave absorber

智慧医疗情境下四方主体隐私行为的交互机理及演化趋势研究

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现代情报 2024年

作者：朱光吴晗逸刘雯 1.南京信息工程大学风险治理与应急决策研究院 2.南京信息工程大学管理工程学院南京信息工程大学管理工程学院南京信息工程大学风险治理与应急决策研究院

[目的/意义] 针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足，探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程] 基于演化博弈理论，构建患者、医疗机构、智慧医疗平... 详细信息

[目的/意义] 针对智慧医疗情境下隐私行为研究在博弈主体、模型参数等方面的不足，探寻患者、医疗机构、智慧医疗平台和政府四方主体之间的隐私行为交互机理与演化趋势。[方法/过程] 基于演化博弈理论，构建患者、医疗机构、智慧医疗平台和政府四方博弈模型。根据不同参数调节下各方行为策略的收益、成本、损失等计算收益矩阵，求解主体的演化稳定策略，并考虑不同因素对主体行为策略及系统稳定状态的影响。[结果/结论] 患者的隐私披露行为与披露隐私后获得的服务收益密切相关，医疗机构的隐私保护投入成本和隐私泄露概率对其隐私保护行为有显著影响，智慧医疗平台的政府奖惩、罚款收益和投入成本是影响其严格管理行为的关键因素，政府的监管行为与奖惩机制等因素密切相关。通过应用本文模型和方法，可以动态调整隐私保护机制，明确各方职责，推动智慧医疗可持续健康发展。

关键词：智慧医疗演化博弈隐私行为四方主体隐私泄露概率

山东省统计局国家统计局山东调查总队关于印发《山东省统计行政处罚裁量基准》的通知(鲁统字〔2023〕151号)

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山东省人民政府公报 2024年第2期 143-149页

作者： 1.山东省统计局 2.国家统计局山东调查总队山东省统计局国家统计局山东调查总队

SDPR-2023-0320002各市、县统计局,各市、县国家调查队:现将《山东省统计行政处罚裁量基准》印发给你们,请加强学习宣传,严格遵照执行。2023年12月28日山东省统计行政处罚裁量基准第一条为规范统计行政处罚自由裁量权,根据《中华人民共... 详细信息

SDPR-2023-0320002各市、县统计局,各市、县国家调查队:现将《山东省统计行政处罚裁量基准》印发给你们,请加强学习宣传,严格遵照执行。2023年12月28日山东省统计行政处罚裁量基准第一条为规范统计行政处罚自由裁量权,根据《中华人民共和国统计法》(以下简称《统计法》)、《中华人民共和国行政处罚法》《中华人民共和国统计法实施条例》及相关法律法规规章,制定本裁量基准。

关键词：国家统计局裁量基准行政处罚自由裁量权学习宣传统计法相关法律法规实施条例《统计法》

山西省统计局国家统计局山西调查总队关于印发《统计行政处罚裁量基准》的通知(晋统字〔2024〕8号)

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山西省人民政府公报 2024年第5期 13-18页

作者： 1.山西省统计局 2.国家统计局山西调查总队山西省统计局国家统计局山西调查总队

各市、县(市、区)统计局,国家统计局各市、县级调查队,省统计局机关各处室、局属各事业单位,国家统计局山西调查总队机关各处室:《统计行政处罚裁量基准》已经中共山西省统计局党组和中共国家统计局山西调查总队党组会议审议通过,经国... 详细信息

各市、县(市、区)统计局,国家统计局各市、县级调查队,省统计局机关各处室、局属各事业单位,国家统计局山西调查总队机关各处室:《统计行政处罚裁量基准》已经中共山西省统计局党组和中共国家统计局山西调查总队党组会议审议通过,经国家统计局批准,现印发给你们,请认真贯彻执行。

关键词：裁量基准党组会议国家统计局事业单位中共通知山西省印发