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Oxidative imbalance increases the risk for colonic polyp and colorectal cancer development

World Journal of Gastrointestinal Oncology 2022年第11期14卷 2208-2223页

作者： Dimitrios Tsounis vassiliki villiotou Angeliki Melpidou Chara Pantsiou Alexandra Argyrou Charis Giannopoulou Adriani Grigoratou Dimitra Rontogianni Gerassimos J Mantzaris George Papatheodoridis Department of Gastroenterology 251 General Hospital of Hellenic Air ForceAthens 11525Greece Department of Biochemistry Metaxa Anticancer HospitalPiraeus 18537Greece Department of Biochemistry Evangelismos HospitalAthens 10676Greece Department of Nuclear Medicine and Positron Emission Tomography Computed Tomography Evangelismos HospitalAthens 10676Greece Department of Pathology Evangelismos HospitalAthens 10676Greece Department of Gastroenterology EvangelismosOphthalmiatreion Athinon and Polyclinic HospitalsAthens 10676Greece Academic Department of Gastroenterology Athens University Medical SchoolLaikon General HospitalAthens 11527Greece

BACKGROUND The role of oxidative stress in the pathogenesis of colorectal carcinoma(CRC)has garnered considerable interest *** oxidative factors have been implicated in the pathogenesis of adenomatous polyps and ultimately *** To evaluate the effect of oxidative imbalance as quantified by specific serological markers in the development of sporadic colon *** A total of 170 patients that underwent endoscopy of the lower gastrointestinal tract in a tertiary center within 3 years were included in the *** were allocated in three groups;those with sporadic colon adenocarcinoma(n=56,32.9%),those with colonic polyps(n=33,19.4%)and healthy controls(n=81,47.7%).All patients were evaluated for oxidant activity and antioxidant capacity with serum measurements of specific markers such as vitamins A,25(OH)D3,E,C,B12,folic acid,glutathione,selenium(Se),zinc(Zn),free iron(Fe^(2+)),and malondialdehyde and results were compared between *** Serum levels of vitamins C,E,D,Se,Zn,vitamin B12 and total antioxidant capacity were significantly lower in the combined neoplasia/polyp group than in the control group(P=0.002,P=0.009,P<0.001,P<0.001,P<0.001,P=0.020 and P<0.001,correspondingly).Increased levels of vitamin E(P=0.004),vitamin D(P<0.001),Se(P<0.001)and Zn(P<0.001)seem to bestow a protective effect on the development of *** vitamin D(P<0.001)and Zn(P=0.036),this effect seems to extend to the development of colon polyps as *** the other hand,elevated serum levels of malondialdehyde are associated with a higher risk of CRC(OR=2.09 compared to controls,P=0.004).Regarding colonic polyp development,increased concentrations of vitaminΑand Fe^(2+) are associated with a higher risk,whereas lower levels of malondialdehyde with a lower *** Increased oxidative stress may play an important role in the pathogenesis and progression of ***’presence may exert a protective effect in the very early stages

关键词： Oxidative imbalance Reactive oxygen species Colorectal adenocarcinoma Colonic polyps Antioxidant capacity

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