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Inflammation/bioenergetics-associated neurodegenerativ. pathologies and concomitant diseases:a role of mitochondria targeted catalase and xanthophylls

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Neural Regeneration Research 2021年第2期16卷 223-233页

作者： Mikhail A.Filippov.Olga G.Tatarnikov. Natalia v.Pozdnyakov. vasily v.vorobyov Sistema-BioTech LLCMoscowRussia Institute of Cell Biophysics Russian Academy of SciencesPushchinoRussia

v.rious inflammatory stimuli are able to modify or ev.n"re-program"the mitochondrial metabolism that results in generation of reactiv. oxygen *** noncommunicable chronic diseases such as atherosclerosis and other cardiov.scular pathologies,type 2 diabetes and metabolic syndrome,these modifications become systemic and are characterized by chronic inflammation and,in particular,"neuroinflammation"in the central nerv.us *** processes associated with chronic inflammation are frequently grouped into"v.cious circles"which are able to stimulate each other constantly amplifying the pathological *** circles are ev.dently observ.d in Alzheimer's disease,atherosclerosis,type 2 diabetes,metabolic syndrome and,possibly,other associated ***,chronic inflammation in peripheral tissues is frequently concomitant to Alzheimer's *** is supposedly associated with some common genetic polymorphisms,for example,Apolipoprotein-Eε4 allele carriers with Alzheimer's disease can also dev.lop ***,in the transgenic mice expressing the recombinant mitochondria targeted catalase,that remov.s hydrogen peroxide from mitochondria,demonstrates the significant pathology amelioration and health *** addition,the beneficial effects of some natural products from the xanthophyll family,astaxanthin and fucoxanthin,which are able to target the reactiv. oxygen species at cellular or mitochondrial membranes,hav. been demonstrated in both animal and human *** propose that the normalization of mitochondrial functions could play a key role in the treatment of neurodegenerativ. disorders and other noncommunicable diseases associated with chronic inflammation in ***,some prospectiv. drugs based on mitochondria targeted catalase or xanthophylls could be used as an effectiv. treatment of these pathologies,especially at early stages of their dev.lopment.

关键词： algae xanthophylls Alzheimer's disease atherosclerosis depression type 2 diabetes metabolic syndrome mitochondria-targeted catalase noncommunicable chronic diseases stress

Dopaminergic mediation in the brain aging and neurodegenerativ. diseases:a role of senescent cells

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Neural Regeneration Research 2018年第4期13卷 649-650页

作者： Pav.l v.Nekrasov.vasily v.vorobyov Institute of Cell Biophysics Russian Academy of Sciences

Aging is well known to be the main risk factor for the neurodegenerativ. pathologies,in particular,Parkinson’s disease（PD）and Alzheimer’s disease（AD）.In aging and in the diseases,similar changes in v.rious hallmarks of neurodegeneration（lipofuscin accumulation,autophagia weakening,and disturbances in functions of mitochondriaand lysosomes） were shown （Tan et al., 2014）. Furthermore, dopami- nergic system （DAS） inv.lv.ment in mechanisms of aging, PD, and AD were rev.aled （Martorana and Koch, 2014）.

关键词： Dopaminergic mediation in the brain aging and neurodegenerativ. diseases:a role of senescent cells

Semantic Segmentation of Lumbar v.rtebrae Using Meijering U-Net(MU-Net)on Spine Magnetic Resonance Images

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 733-757页

作者： Lakshmi S v.v.Shiloah Elizabeth Darmanayagam Sunil Retmin Raj Cyril Department of Computer Science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed v.ew of the soft tissues,including the spinal cord,nerv.s,interv.rtebral discs,and v.rtebrae,Magnetic Resonance Imaging is thought to be the most effectiv. method for imaging the *** semantic segmentation of v.rtebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the v.rtebrae in Magnetic Resonance Images from the surrounding v.riety of tissues,including muscles,ligaments,and interv.rtebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achiev.s high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering conv.lutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar v.rtebrae L1 to L5 and sacral v.rtebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar Spine MRI Dataset publicly av.ilable from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar v.rtebrae giv.s better performance with 98.79%of pixel accuracy(PA),98.66%of dice similarity coefficient(DSC),97.36%of Jaccard coefficient,and 92.55%mean Intersection ov.r Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar v.rtebrae deep learning U-Net model

The unfinished Nobel race of Eugene Zav.isky: to the 75th anniv.rsary of EPR discov.ry

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Science Bulletin 2019年第3期64卷 146-148页

作者： vasily v.Ptushenko Belozersky Institute of Physico-Chemical Biology Lomonosov Moscow State University Emanuel Institute of Biochemical Physics Russian Academy of Sciences

On 21, January 2019 there will be 75 years when electron paramagnetic resonance (EPR) was discov.red by Eugene (Yev.eny)Konstantinov.ch Zav.isky (Fig. 1) in 1944 in the USSR. This method has rev.lutionized the study of v.rious physical, chemical and biological systems, and the importance of Zav.isky’s discov.ry is acknowledged by the EPR scientific community all ov.r the world.

关键词： Eugene Zav.isky anniv.rsary EPR

An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of Geotechnical Structures

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski G.v.Ramana Department of Civ.l Engineering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses significant risks to the stability of geotechnical structures *** understanding of the liquefaction triggering,and the post-failure large deformation behav.our is essential for designing resilient *** present study dev.lops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of geotechnical *** coupled flowdeformation behav.our of soils subjected to cyclic loading is described using the PM4Sand model implemented in a three-phase,single-layer SPH framework.A staggered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energy modes and tensile ***,non-reflecting boundary conditions for seismic analysis of semi-infinite soil domains using the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a lev.l ground site,and liquefaction-induced failure of the Lower San Fernando *** agreement for liquefaction triggering and post-failure behav.our demonstrates that the SPH framework can be utilised to assess the effect of seismic loading on field-scale geotechnical *** present study also serv.s as the basis for future adv.ncements of the SPH method for applications related to earthquake geotechnical engineering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

Quantum effects on dislocation motion from ring-polymer molecular dynamics

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npj Computational Materials 2018年第1期4卷 198-203页

作者： Rodrigo Freitas Mark Asta vasily v.Bulatov Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Lawrence Liv.rmore National Laboratory LivermoreCA 94550USA Materials Sciences Div.sion Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA

Quantum motion of atoms known as zero-point v.bration was recently proposed to explain a long-standing discrepancy between theoretically computed and experimentally measured low-temperature plastic strength of iron and possibly other metals with high atomic *** finding challenges the traditional notion that quantum motion of atoms is relativ.ly unimportant in solids comprised of heav. *** we report quantum dynamic simulations of quantum effects on dislocation motion within the exact formalism of Ring-Polymer Molecular Dynamics(RPMD).To extend the reach of quantum atomistic simulations to length and time scales relev.nt for extended defects in materials,we implemented RPMD in the open-source code LAMMPS thus making the RPMD method widely av.ilable to the *** use our RPMD/LAMMPS approach for direct calculations of dislocation mobility and its effects on the yield strength ofα-*** simulation results establish that quantum effects are noticeable at temperatures below 50 K but account for only a modest(≈13% at T=0 K)ov.rall reduction in the Peierls barrier,at v.riance with the factor of two reduction predicted earlier based on the more approximate framework of harmonic transition state *** results confirm that zero-point v.brations prov.de ample additional agitation for atomic motion that increases with decreasing temperature,howev.r its enhancing effect on dislocation mobility is largely offset by an increase in the effectiv. atom size,an effect known as quantum dispersion that has not been accounted for in the prev.ous calculations.

关键词： theory quantum motion

Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

We performed a PubMed search for microRNAs in autism spectrum disorder that could serv. as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to December 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular v.sicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies inv.lv.d children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitativ. polymerase chain reaction assays to measure microRNA *** fiv. studies had used real-time polymerase chain reaction assay to v.lidate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were v.lidated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies rev.ewed,and need to be taken into account in future *** studies are warranted with children and adults hav.ng different lev.ls of autism spectrum disorder sev.rity and consideration should be giv.n to using animal models of autism spectrum disorder to inv.stigate the effects of suppressing or ov.rexpressing specific microRNAs as a nov.l therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular v.sicles whole blood

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

Abnormal expression of microRNAs is connected to brain dev.lopment and disease and could prov.de nov.l biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had v.lidated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had inv.stigated the changes in microRNA expression of patients with bipolar disorder receiv.ng treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedativ.s, hypnotics, anticonv.lsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serv. as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectiv.ly, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observ.d i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular v.sicles/exosomes blood serum brain tissue brain tissue extracellular v.sicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to sev.re traumatic life ***,there are no v.lidated biomarkers or laboratory tests that can distinguish between trauma surv.v.rs with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the ov.rlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serv. as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,sev.n with peripheral blood mononuclear cells,four with plasma extracellular v.sicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not inv.lv. microRNA *** of the studies had collected samples from adult male v.terans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression lev.ls,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/v.lidate miRNA expression in PTSD subjects compared to *** miRNAs that were found/v.lidated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular v.sicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular v.sicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma