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Implications of obesity and adiposopathy on respiratory infections;focus on emerging challenges

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World Journal of Clinical Cases 2023年第13期11卷 2925-2933页

作者： Ioannis G Lempesis vasiliki e georgakopoulou Department of Infectious Diseases-COVID-19 Unit Laiko General HospitalAthens 11527Greece

Obesity is characterized by excessive adipose tissue accumulation,which impacts physiological,metabolic,and immune *** respiratory infections,including bacterial pneumonia,influenza,and coronavirus disease 2019,appear to be linked to unfavorable results in individuals with *** may be attributed to the direct mechanical/physiological effects of excess body fat on the lungs’***,adipose tissue dysfunction is associated with a lowgrade chronic inflammatory status and hyperleptinemia,among other *** have all been linked to immune system dysfunction and weakened immune responses to these infections.A better understanding and clinical awareness of these risk factors are necessary for better disease outcomes.

关键词： COVID-19 Influenza Lung disease Immune system Obesity

Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus

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World Journal of experimental Medicine 2023年第3期13卷 7-16页

作者： Ioannis G Lempesis vasiliki e georgakopoulou Department of Infectious Diseases-COVID-19 Unit Laiko General HospitalAthens 11527Greece

Overweight,obesity,and type 2 diabetes mellitus pose global health problems that are ever-increasing.A chronic low-grade inflammatory status and the presence of various pro-inflammatory markers either in circulation or within dysfunctional metabolic tissues are well *** presence of these factors can,to some extent,predict disease development and progression.A central role is played by the presence of dysfunctional adipose tissue,liver dysfunction,and skeletal muscle dysfunction,which collectively contribute to the increased circulatory levels of proinflammatory *** loss and classical metabolic interventions achieve a decrease in many of these factors’circulating levels,implying that a better understanding of the processes or even the modulation of inflammation may alleviate these *** review suggests that inflammation plays a significant role in the development and progression of these conditions and that measuring inflammatory markers may be useful for assessing disease risk and development of future treatment methods.

关键词： Adipose tissue Biomarkers Diabetes Inflammation Obesity pathophysiology

Pleural involvement in cryptococcal infection

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World Journal of Clinical Cases 2022年第16期10卷 5510-5514页

作者： vasiliki e georgakopoulou Christos Damaskos Pagona Sklapani Nikolaos Trakas Aikaterini Gkoufa Department of Infectious Diseases Laiko General HospitalAthens 11527Greece

Pleural involvement of cryptococcal infection is uncommon and is more commonly observed in immunocompromised hosts than in immunocompetent *** involvement in cryptococcal infections can manifest with or without pleural *** presence of Cryptococcus *** the effusion or pleura is required for the diagnosis of cryptococcal pleural infection,which is commonly determined by pleural biopsy,fluid culture,and/or detection of cryptococcal antigen in the pleura or pleural fluid.

关键词： Cryptococcosis Pleural effusion Pleural diseases Fungal lung diseases Pleural Cavity Cryptococcus neoformans

COVID-19 and liver injury in individuals with obesity

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World Journal of Gastroenterology 2023年第6期29卷 908-916页

作者： Ioannis G Lempesis eleni Karlafti Petros Papalexis George Fotakopoulos Kyriakos Tarantinos Vasileios Lekakis Stavros P Papadakos evangelos Cholongitas vasiliki e georgakopoulou Institute of Metabolism and Systems Research University of BirminghamBirminghamB152TTUnited Kingdom Department of Human Biology NUTRIM School of Nutrition and Translational Research in MetabolismMaastricht University Medical CentreMaastricht 6166200Netherlands Department of emergency AHEPA University HospitalAristotle University of ThessalonikiThessaloniki 54621Greece Unit of endocrinology First Department of Internal MedicineLaiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece Department of Biomedical Sciences University of West AtticaAthens 12243Greece Department of Neurosurgery General University Hospital of LarisaLarisa 41221Greece First Pulmonology Department Sismanogleio HospitalAthens 15126Greece Department of Gastroenterology Laiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece First Department of Internal Medicine Laiko General HospitalMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Department of Infectious Diseases-COVID-19 Unit Laiko General HospitalAthens 11527Greece

Coronavirus disease 2019 is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 that manifests as a variety of clinical manifestations,including liver damage commonly detected by a hepatocellular pattern from liver function *** injury is associated with a worse prognosis *** associated with the severity of the disease include obesity and cardiometabolic comorbidities,which are also associated with nonalcoholic fatty liver disease(NAFLD).The presence of NAFLD,similarly to obesity,is associated with an unfavourable impact on the coronavirus disease 2019 *** with these conditions could present with liver damage and elevated liver function tests due to direct viral cytotoxicity,systemic inflammation,ischemic or hypoxic liver damage or drug side ***,liver damage in the setting of NAFLD could also be attributed to a pre-existing chronic low-grade inflammation associated with surplus and dysfunctional adipose tissue in these *** we investigate the hypothesis that a pre-existing inflammatory status is exacerbated after severe acute respiratory syndrome coronavirus 2 infection,which embodies a second hit to the underestimated liver damage.

关键词： COVID-19 SARS-CoV-2 Non-alcoholic fatty liver disease Obesity Inflammation Liver Adipose tissue

elderly adults with COVID-19 admitted to intensive care unit:A narrative review

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World Journal of Critical Care Medicine 2021年第5期10卷 278-289页

作者： Aikaterini Gkoufa eleni Maneta Georgios N Ntoumas vasiliki e georgakopoulou Athina Mantelou Stelios Kokkoris Christina Routsi First Department of Internal Medicine Laiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece First Department of Intensive Care School of MedicineNational and Kapodistrian University of AthensAthens 10676Greece

BACKGROUND In the context of the Coronavirus disease 2019(COVID-19)pandemic,it has been reported that elderly patients are particularly at risk of developing severe illness and exhibiting increased *** many studies on hospitalized elderly patients with COVID-19 have been published,limited information is available on the characteristics and clinical outcomes of those elderly patients admitted to intensive care unit(ICU).AIM To review the available evidence of the clinical data of elderly patients admitted to the ICU due to *** We searched for published articles available in english literature to identify those studies conducted in critically ill patients admitted to the ICU due to COVID-19,either exclusively designed for the elderly or for the whole ICU population with COVID-19,provided that analyses according to the patients’age had been *** Only one study exclusively focusing on critically ill elderly patients admitted to the ICU due to COVID-19 was *** additional studies involving 17011 ICU patients and providing information for elderly patients as a subset of the whole study population have also been included in the present review *** the whole patient population,included in these studies,8310 patients were older than 65 years of age and 2630 patients were older than 70 *** manifestations were similar for all patients;however,compared to younger ones,they suffered from more comorbidities and showed a varied,albeit high *** In summary,at present,although elderly patients constitute a considerable proportion of critically ill patients admitted to the ICU due to severe COVID-19,studies providing specific information are *** evidence so far suggests that advanced age and comorbidities are associated with worse clinical *** studies exclusively designed for this vulnerable group are needed.

关键词： SARS-CoV-2 COVID-19 elderly Critically ill Intensive care unit mortality Respiratory failure

exploring unconventional attributes of red blood cells and their potential applications in biomedicine

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Protein & Cell 2024年第5期15卷 315-330页

作者： Alkmini T.Anastasiadi vasiliki-Zoi Arvaniti Krystalyn e.Hudson Anastasios G.Kriebardis Constantinos Stathopoulos Angelo D’Alessandro Steven L.Spitalnik Vassilis L.Tzounakas Department of Biochemistry School of MedicineUniversity of Patras26504 PatrasGreece Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew York CityNY 10032USA Laboratory of Reliability and Quality Control in Laboratory Hematology(HemQcR) Department of Biomedical SciencesSchool of Health&Caring SciencesUniversity of West Attica(UniWA)12243 EgaleoGreece Department of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus13001 AuroraCOUSA Present address:Institute for Fundamental Biomedical Research(IFBR) Biomedical Sciences Research Center“Alexander Fleming”Vari11527 AthensGreece

We need to talk about red blood *** cells are defined as cells containing distinct nuclei and other membranous ***,red blood cells(RBCs)lack a nucleus and organelles—perhaps to limit the generation of reactive oxygen species(Zhang et al.,2011)—and are filled with hemoglobin(Hb).This oxygen carrier is limited to the cytosol by the cell membrane and cytoskeleton,which maintain cellular integrity and deformability as RBCs pass through narrow capillaries(Gratzer,1994)to perform their primary function of gas exchange.

关键词： membranous maintain

Septic cardiomyopathy phenotype in the critically ill may depend on antimicrobial resistance

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Journal of Intensive Medicine 2024年第3期4卷 355-361页

作者： vasiliki Tsolaki Kyriaki Parisi George e.Zakynthinos efrosini Gerovasileiou Nikitas Karavidas Vassileios Vazgiourakis epaminondas Zakynthinos Demosthenes Makris Intensive Care Unit University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece Third Cardiology Clinic University of AthensSotiria HospitalAthensGreece Respiratory Department University Hospital of LarissaUniversity of Thessaly Faculty of MedicineLarissaGreece

Background Sepsis is a life-threatening organ dysfunction,and septic cardiomyopathy(SCM)may complicate the course of the *** with multidrug-resistant(MDR)pathogens has been linked with worse *** study aims to evaluate SCM in patients with infections caused by different antimicrobial-resistant *** This retrospective study included patients with sepsis/septic shock,hospitalized,and intubated in the intensive care unit of the University Hospital of Larissa between January 2022 and September 2023 with echocardiographic data during the first two days after infection *** patients were divided into two groups:non-MDR-SCM group and MDR-SCM *** cardiac function was compared between the two *** A total of 62 patients were included in the ***-four patients comprised the MDR-SCM and 18 the non-MDR-SCM ***-six patients(41.9%)presented with left ventricular(LV)systolic dysfunction,and≤35%right ventricular fractional area change(RVFAC)was present in 56.4%.LV systolic function was more severely impaired in the non-MDR-SCM group(left ventricular ejection fraction,35.8%±4.9%vs.45.6%±2.4%,P=0.049;LV outflow tract velocity time integral,[10.1±1.4]cm vs.[15.3±0.74]cm,P=0.001;LV-Strain,–9.02%±0.9%vs.–14.02%±0.7%,P=0.001).The MDR-SCM group presented with more severe right ventricular(RV)dilatation(right ventricular end-diastolic area/left ventricular end-diastolic area,0.81±0.03 vs.0.7±0.05,P=0.042)and worse RV systolic function(RVFAC,32.3%±1.9%vs.39.6%±2.7%,P=0.035;tricuspid annular plane systolic excursion,[15.9±0.9]mm vs.[18.1±0.9]mm,P=0.165;systolic tissue Doppler velocity measured at the lateral tricuspid annulus,[9.9±0.5]cm/s vs.[13.1±0.8]cm/s,P=0.002;RV-strain,–11.1%±0.7%vs.–15.1%±0.9%,P=0.002).Conclusion SCM related to MDR infection presents with RV systolic dysfunction predominance,while non-MDR-SCM is mainly depicted with LV systolic dysfunction impairment.

关键词： Septic cardiomyopathy Multidrug-resistant pathogen Left ventricular failure Right ventricular dysfunction Left/right ventricular longitudinal strain Ventriculoarterial Coupling

Iodoacetic acid exposure alters the transcriptome in mouse ovarian antral follicles

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Journal of environmental Sciences 2022年第7期34卷 46-57页

作者： Andressa Gonsioroski Mary Laws vasiliki e.Mourikes Alison Neff Jenny Drnevich Michael J.Plewa Jodi A.Flaws Department of Comparative Biosciences University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Roy J.Carver Biotechnology Center University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Department of Crop Sciences and the Safe Global Water Institute University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA

Iodoacetic acid(IAA) is an unregulated water disinfection byproduct that is an ovarian toxicant. However, the mechanisms of action underlying IAA toxicity in ovarian follicles remain unclear. Thus, we determined whether IAA alters gene expression in ovarian follicles in mice. Adult female mice were dosed with water or IAA(10 or 500 mg/L) in the water for 35-40 days. Antral follicles were collected for RNA-sequencing analysis and sera were collected to measure estradiol. RNA-sequencing analysis identified 1063 differentially expressed genes(DeGs) in the 10 and 500 mg/L IAA groups(false discovery rate FDR espectively, compared to controls. Gene Ontology enrichment analysis showed that DeGs were involved with RNA processing and regulation of angiogenesis(10 mg/L) and the cell cycle and cell division(500 mg/L). Pathway enrichment analysis showed that DeGs were involved in the phosphatidylinositol 3-kinase and protein kinase B(PI3K-Akt), gonadotropin-releasing hormone(Gn RH), estrogen, and insulin signaling pathways(10 mg/L). Pathway enrichment analysis showed that DeGs were involved in the oocyte meiosis, Gn RH, and oxytocin signaling pathways(500 mg/L). RNA-sequencing analysis identified 809 DeGs when comparing the 500 and 10 mg/L IAA groups(FDR eGs were related to ribosome, translation, m RNA processing, oxidative phosphorylation, chromosome, cell cycle, cell division, protein folding, and the oxytocin signaling pathway. Moreover, IAA exposure significantly decreased estradiol levels(500 mg/L) compared to control. This study identified key candidate genes and pathways involved in IAA toxicity and can help to further understand the molecular mechanisms of IAA toxicity in ovarian follicles.

关键词： Disinfection byproducts Iodoacetic acid Ovary Ovarian follicles Steroidogenesis endocrine disruptors

Seed Germination Traits of Loquat (eriobotrya japonica Lindl.) as Affected by Various Pre-Sowing Treatments (Cutting of Cotyledons, Removal of Perisperm, Moist Chilling and/or exogenous Application of Gibberellin)

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Phyton-International Journal of experimental Botany 2020年第3期89卷 645-656页

作者： Thiresia-Teresa Tzatzani evangelia Basdeki evangelia-vasiliki Ladikou Marios-Ioannis NSotiras Georgios Panagiotakis Sryridon Lionakis Ioannis e.Papadakis Laboratory of Subtropical Plants and Tissue Culture Institute of Olive TreeSubtropical Plants and ViticultureHellenic Agricultural Organization-DEMETERChania73134Greece Laboratory of Genetics Department of BiotechnologyAgricultural University of Athens(Member of the European University for Smart Urban Coastal Sustainability-EU-CONEXUS)Athens11855Greece Laboratory of Pomology Department of Crop ScienceAgricultural University of Athens(Member of the European University for Smart Urban Coastal Sustainability-EU-CONEXUS)Athens11855Greece Laboratory of Pomology School of Agricultural SciencesHellenic Mediterranean UniversityHeraklion71410Greece

The purpose of this study was to investigate the effects of various presowing treatments on the germinability(final germination percentage)and germination rate of loquat seeds in order to increase seedling production in nurseries(applied research)as well as provide answers for important physiological issues related to loquat seeds and their seed coat(basic research).Three experiments were carried out with various pre-sowing *** treatments included full or partial removal of seed coat(perisperm),partial cutting of cotyledons as well as moist chilling at 5℃ for 13 days and/or soaking the seeds in water or 250 ppm gibberellic acid(GA_(3))solution for 24 *** to the results,cotyledons excision resulted in delayed germination,regardless of the presence or absence of the seed coat in comparison with the decoated seeds that demonstrated the highest germination rate amongst *** addition,even the partial excision of seed coats affected positively both the germinability and the germination rate,compared to the control-intact ***,control-intact seeds had a higher germination percentage when exposed to moist chilling independently of the application or not of gibberellin;while the combination of gibberellin application and moist chilling improved both the percentage and the rate of germination of decoated *** conclusion,the role of perisperm(seed coat)in the germination procedure of loquat seeds seems to be important,indicating the existence of seed coat-imposed dormancy on loquat ***,the existence of a mild endogenous embryo-dormancy on loquat is also discussed.

关键词： Cotyledon gibberellin seed coat seed testa eriobotrya japonica plant propagation perisperm sexual propagation seedling dormancy