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Ten-year follow-up of a trancatheter double Corevalve aortic valve implantation

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Journal of Geriatric Cardiology 2020年第3期17卷 175-176页

作者： vasileios Kamperidis Maria Vlachou Georgios Sianos Stavros Hadjimiltiadis Haralambos Karvounis 1st Cardiology Department Aristotle University of ThessalonikiAHEPA University HospitalThessalonikiGreece

During the last decade,transcatheter aortic valve implantation(TAVI)for severe aortic stenosis has evolved as an alternative to surgical replacement in cases with high surgical risk.[1]However,long-term survival data are scarce and information about TAVI durability is lacking.[2]Hereby,we report the degeneration of the first TAVI performed in Northern Greece which happened to be a double implantation of a CoreValve device,10 years later.

关键词： Echocardiography Heart failure Transcatheter aortic valve implantation

Homogenised Monthly and Daily Temperature and Precipitation Time Series in China and Greece since 1960

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Advances in Atmospheric Sciences 2023年第7期40卷 1326-1336页

作者： Athanassios A.ARGIRIOU Zhen LI vasileios ARMAOS Anna MAMARA Yingling SHI Zhongwei YAN Laboratory of Atmospheric Physics Department of PhysicsUniversity of PatrasRio 26504Greece Key Laboratory of Regional Climate-Environment in Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Hellenic National Meteorological Service Athens 16777Greece Longyang District Meteorological Service Baoshan 678007China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

In this paper,we describe and analyze two datasets entitled“Homogenised monthly and daily temperature and precipitation time series in China during 1960–2021”and“Homogenised monthly and daily temperature and precipitation time series in Greece during 1960–2010”.These datasets provide the homogenised monthly and daily mean(TG),minimum(TN),and maximum(TX)temperature and precipitation(RR)records since 1960 at 366 stations in China and 56stations in *** datasets are available at the Science Data Bank repository and can be downloaded from https://***/10.57760/sciencedb.01731 and https://***/10.57760/*** China,the regional mean annual TG,TX,TN,and RR series during 1960–2021 showed significant warming or increasing trends of 0.27℃(10 yr)^(-1),0.22℃(10 yr)^(-1),0.35℃(10 yr)^(-1),and 6.81 mm(10 yr)-1,*** of the seasonal series revealed trends significant at the 0.05level,except for the spring,summer,and autumn RR *** Greece,there were increasing trends of 0.09℃(10 yr)-1,0.08℃(10 yr)^(-1),and 0.11℃(10 yr)^(-1)for the annual TG,TX,and TN series,respectively,while a decreasing trend of–23.35 mm(10 yr)^(-1)was present for *** seasonal trends showed a significant warming rate for summer,but no significant changes were noted for spring(except for TN),autumn,and *** RR,only the winter time series displayed a statistically significant and robust trend[–15.82 mm(10 yr)^(-1)].The final homogenised temperature and precipitation time series for both China and Greece provide a better representation of the large-scale pattern of climate change over the past decades and provide a quality information source for climatological analyses.

关键词： daily and monthly temperature precipitation homogenisation climate time series Greece China

Stereotactic radiotherapy for intrahepatic cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1478-1489页

作者： Aditya Borakati Farid Froghi Ricky H Bhogal vasileios K Mavroeidis Department of Surgery The Royal London HospitalBarts Health NHS TrustLondon E11FRUnited Kingdom Department of HPB and Liver Transplantation Surgery Royal Free Hospital NHS Foundation TrustLondon NW32QGUnited Kingdom Department of Academic Surgery The Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom

Intrahepatic cholangiocarcinoma(iCCA)is an aggressive malignancy with an increasing incidence worldwide and poor prognosis,despite several advances and continuous efforts to develop effective *** surgical resection is the mainstay of treatment and offers a potentially curative option,but is only possible in less than a third of patients,owing to advanced *** is a well-established treatment in the adjuvant and palliative setting,however,confers limited *** radiotherapy is challenging due to local *** recent advances in stereotactic ablative radiotherapy(SABR),it is now possible to focus ablative beams of radiotherapy precisely aimed at tumours to minimise damage to surrounding *** review details the history,technical background and application of SABR to iCCA,with directions for future research suggested.

关键词： Cholangiocarcinoma Intrahepatic Stereotactic ablative radiotherapy Stereotactic body radiotherapy Radiotherapy Liver cancer Hepatectomy

Ocular stem cells:a narrative review of current clinical trials

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1529-1537页

作者： Konstadinos Sotiropulos Dimitrios Kourkoutas Diamantis Almaliotis Katherine Ploumidou vasileios Karampatakis Department of Ophthalmology 417 Army Shared Fund HospitalAthens 11521Greece Department of Ophthalmology 401 Army General Hospital of AthensAthens 11525Greece Laboratory of Experimental Ophthalmology School of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece Department of Otolaryngology Children’s Hospital“Aglaia Kyriakou”Athens 11527Greece

·Stem cells are undifferentiated cells showcasing a remarkable capacity of self-replenishing and differentiating into mature *** ability to proliferate connotes that a designated stem cell source is capable of generating an unrestricted number of mature *** ever-increasing comprehension of position,activity,and function of ocular stem cells has led to rapid progress and incessant improvement of possible procedures and therapies.A narrative review was conducted to summarize the current evidence on clinical trials and respective literature,regarding current evolution in the field of ocular regenerative *** tried to ascertain the safety of experimental and clinical procedures,their effectiveness,and the ethical repercussion of their use.

关键词： stem cells cell-based therapies limbal stem cells h ESC-derived retinal pigment epithelium human induced pluripotent stem cells olfactory mucosa mesenchymal stem cells

Liver transplantation in the management of cholangiocarcinoma:Evolution and contemporary advances

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World Journal of Gastroenterology 2023年第13期29卷 1969-1981页

作者： Aditya Borakati Farid Froghi Ricky H Bhogal vasileios K Mavroeidis Department of HPB and Liver Transplantation Surgery Royal Free Hospital NHS Foundation TrustLondon NW32QGUnited Kingdom Department of Academic Surgery The Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom

Cholangiocarcinoma(CCA)is an aggressive malignancy arising from the biliary *** may occur at any location along the biliary tree with the perihilar area being the most *** is poor with 5-year overall survival at less than 10%,typically due to unresectable disease at *** surgical resection with clear margins offers a chance of cure in patients with resectable tumours,but is frequently not possible due to locally advanced *** the other hand,orthotopic liver transplantation(LT)allows for a radical and potentially curative resection for these patients,but has been historically controversial due to the limited supply of donor grafts and previously poor *** patients with perihilar CCA,within specific criteria and following the implementation of a protocol combining neoadjuvant chemoradiation and LT,excellent results have been achieved in the last decades,resulting in its increasing acceptance as an indication for LT and the standard of care in several centres with significant ***,in intrahepatic CCA,the role of LT remains controversial and owing to dismal previous results it is not an accepted ***,more recent studies have demonstrated favourable results with LT in early intrahepatic CCA,indicating that,under defined criteria,its role may increase in the *** review highlights the history and contemporary advances of LT in CCA,with particular focus on the improving outcomes of LT in intrahepatic and perihilar CCA and future perspectives.

关键词： Cholangiocarcinoma Klatskin tumor Liver transplantation Liver cancer Liver resection Neoadjuvant therapy

Pancreatic surgery and tertiary pancreatitis services warrant provision for support from a specialist diabetes team

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World Journal of Diabetes 2024年第4期15卷 598-605页

作者： vasileios K Mavroeidis Jennifer Knapton Francesca Saffioti Daniel L Morganstein Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Gastrointestinal Surgery Southmead HospitalNorth Bristol NHS TrustBristol BS105NBUnited Kingdom Department of Academic Surgery Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom UCL Institute for Liver and Digestive Health University College LondonLondon NW32PFUnited Kingdom Department of Endocrinology Chelsea and Westminster Hospital NHS Foundation TrustLondon SW109NHUnited Kingdom Department of Gastrointestinal Unit Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom

Pancreatic surgery units undertake several complex operations,albeit with consi-derable morbidity and mortality,as is the case for the management of complicated acute pancreatitis or chronic *** centralisation of pancreatic surgery services,with the development of designated large-volume centres,has contribu-ted to significantly improved *** this editorial,we discuss the complex associations between diabetes mellitus(DM)and pancreatic/periampullary disease in the context of pancreatic surgery and overall management of complex pancreatitis,highlighting the consequential needs and the indispensable role of specialist diabetes teams in support of tertiary pancreatic *** 3c pan-creatogenic DM,refers to DM developing in the setting of exocrine pancreatic disease,and its identification and management can be challenging,while the glycaemic control of such patients may affect their course of treatment and *** preoperative diabetes assessment is warranted to aid identification of patients who are likely to need commencement or escalation of glucose lowering therapy in the postoperative *** incidence of new onset diabetes after pancreatic resection is widely variable in the literature,and depends on the type and extent of pancreatic resection,as is the case with pancreatic parenchymal loss in the context of severe *** involvement of a specialist diabetes team is essential to ensure a holistic *** the current era,large volume pancreatic surgery services commonly abide by the principles of enhanced recovery after surgery,with inclusion of provisions for optimisation of the perioperative glycaemic control,to improve *** various guidelines are available to aid perioperative management of DM,auditing and quality improvement platforms have highlighted deficiencies in the perioperative management of diabetic patients and areas of required *** need for perioperative support of diabetic

关键词： Pancreatectomy Pancreatoduodenectomy Whipple’s Pancreatitis Diabetes specialist Type 3c pancreatogenic diabetes mellitus

Growth performance, nutrient digestibility, antioxidant capacity,blood biochemical biomarkers and cytokines expression in broiler chickens fed different phytogenic levels

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Animal Nutrition 2017年第2期3卷 114-120页

作者： vasileios Paraskeuas Konstantinos Fegeros Irida Palamidi Christine Hunger Konstantinos C.Mountzouris Department of Nutritional Physiology and Feeding.Agricultural University of Athens BIOMIN Holding GmbH

The effects of inclusion levels of a phytogenic feed additive(PFA), characterized by menthol anethol and eugenol, on broiler growth performance, nutrient digestibility, biochemical biomarkers and total antioxidant capacity(TAC) of plasma and meat, as well as on the relative expression of selected cytokines,were studied in a 42-d experiment. A total of 225 one-day-old male Cobb broiler chickens were assigned into 3 treatments, with 5 replicates of 15 chickens each. Chickens were fed maize-soybean meal basal diets following a 3 phase(i.e., starter, grower and finisher) feeding program. Depending on PFA inclusion level, treatments were: no PFA(PFA-0), PFA at 100 mg/kg(PFA-100) and PFA at 150 mg/kg(PFA-150).Feed and water were available ad libitum. Feed conversion ratio(FCR) during finisher phase was improved quadratically(P < 0.05) with increasing PFA level. Overall, increasing PFA level increased body weight gain(BWG) in a linear(P < 0.05) and quadratic(P < 0.05) manner with treatments PFA-100 and PFA-150 being greater(P < 0.05) compared with PFA-0. Total tract apparent digestibility of dry matter increased linearly(P < 0.05) and quadratically(P < 0.05) with increasing PFA level. The apparent metabolizable energy corrected for nitrogen(AMEn) also increased linearly(P < 0.05). Increasing PFA level resulted in a linear(P < 0.05) increase in blood plasma TAC. Expression of pro-inflammatory cytokine interleukin-18(IL-18) was reduced linearly(P < 0.05) in spleen with increasing PFA level. In conclusion, PFA inclusion at 100 mg/kg diet positively influenced performance, whereas PFA inclusion at150 mg/kg resulted in a stronger improvement in AMEn and plasma TAC. Finally, PFA inclusion resulted in a pattern of reduced pro-inflammatory biomarker IL-18 at spleen. Overall, this study provides evidence for the beneficial role of PFA as a natural growth and health promoter in broiler chickens that needs to be further confirmed in field studies.

关键词： Chicken Phytogenic Antioxidant Menthol Anethol Eugenol

Common controversies in total knee replacement surgery: Current evidence

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World Journal of Orthopedics 2014年第4期5卷 460-468页

作者： vasileios S Nikolaou Dimitrios Chytas George C Babis 2nd Department of Orthopaedics Athens University

Total knee replacement(TKR) is a widely used operation that has radically improved the quality of life of millions of people during the last few decades. However, some technical details, concerning the surgical procedure and the rehabilitation following total knee arthroplasty, are still a matter of a strong debate. In this review of the literature, we have included the best evidence available of the last decade, in an effort to shed light on some of the most controversial subjects related to TKR surgery. Posterior-stabilized or cruciate-retaining prosthesis? To use a tourniquet during operation or not? Do patients need continuous passive motion for their post-surgery rehabilitation? To resurface patella or not? These are some of the most controversial topics that until now have been persistent dilemmas for the orthopedic surgeon. Results of this systematic review of the literature are highly controversial. These conflicting results are an indication that larger and more well conducted high quality trials are needed in order to gain more secure answers. At the same time, it is becoming apparent that a meticulous operative technique, respecting the soft tissue envelope and knowing the principles of alignment and soft tissue balancing, aresome of the parameters that might contribute more to achieving the optimal results for the patients.

关键词： Total knee replacement Controversy Literature review Patella resurfacing Patella eversion Posterior stabilized Cruciate retaining Tourniquet Continuous passive motion

Thromboembolic myocardial infarction after transcatheter aortic valve implantation:a spotlight on antithrombotic treatment post-TAVI

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Journal of Geriatric Cardiology 2021年第4期18卷 316-318页

作者： vasileios Kamperidis Anastasios Kartas Georgios Sianos Antonios Ziakas Haralambos Karvounis Stavros Hadjimiltiades First Cardiology Department AHEPA University HospitalAristotle University of ThessalonikiThessalonikiGreece

The use of dual antiplatelet therapy for the first three–six months after transcatheter aortic valve implantation (TAVI) has been suggested.~([1,2]) However, the additional benefit of anticoagulant therapy during the... 详细信息

关键词： transcatheter implantation therapy