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Hepatolithiasis:Epidemiology,presentation,classification and management of a complex disease

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World Journal of Gastroenterology 2024年第13期30卷 1836-1850页

作者： Rodrigo V.Motta Francesca Saffioti vasileios k.mavroeidis Translational Gastroenterology and Liver Unit Nuffield Department of MedicineUniversity of OxfordOxford OX39DUUnited Kingdom Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustJohn Radcliffe HospitalOxford OX39DUUnited Kingdom UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit Royal Free Hospital and University College LondonLondon NW32QGUnited Kingdom Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Transplant Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom Department of Gastrointestinal Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom

The term hepatolithiasis describes the presence of biliary stones within the intrahepatic bile ducts,above the hilar confluence of the hepatic *** disease is more prevalent in Asia,mainly owing to socioeconomic and dietary factors,as well as the prevalence of biliary *** the last century,owing to migration,its global incidence has *** main pathophysiological mechanisms involve cholangitis,bile infection and biliary strictures,creating a self-sustaining cycle that perpetuates the disease,frequently characterised by recurrent episodes of bacterial infection referred to as syndrome of“recurrent pyogenic cholangitis”.Furthermore,long-standing hepatolithiasis is a known risk factor for development of intrahepatic *** classifications have aimed at providing useful insight of clinically relevant aspects and guidance for *** management of symptomatic patients and those with complications can be complex,and relies upon a multidisciplinary team of hepatologists,endoscopists,interventional radiologists and hepatobiliary surgeons,with the main goal being to offer relief from the clinical presentations and prevent the development of more serious *** comprehensive review provides insight on various aspects of hepatolithiasis,with a focus on epidemiology,new evidence on pathophysiology,most important clinical aspects,different classification systems and contemporary management.

关键词： Cholelithiasis Intrahepatic stones Cholangiocarcinoma Biliary parasites Recurrent pyogenic cholangitis Oriental cholangiohepatitis Hepatectomy Cholangioscopy Liver transplant Paediatric

Pancreatic surgery and tertiary pancreatitis services warrant provision for support from a specialist diabetes team

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World Journal of Diabetes 2024年第4期15卷 598-605页

作者： vasileios k.mavroeidis Jennifer knapton Francesca Saffioti Daniel L Morganstein Department of HPB Surgery Bristol Royal InfirmaryUniversity Hospitals Bristol and Weston NHS Foundation TrustBristol BS28HWUnited Kingdom Department of Gastrointestinal Surgery Southmead HospitalNorth Bristol NHS TrustBristol BS105NBUnited Kingdom Department of Academic Surgery Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustOxford OX39DUUnited Kingdom UCL Institute for Liver and Digestive Health University College LondonLondon NW32PFUnited Kingdom Department of Endocrinology Chelsea and Westminster Hospital NHS Foundation TrustLondon SW109NHUnited Kingdom Department of Gastrointestinal Unit Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom

Pancreatic surgery units undertake several complex operations,albeit with consi-derable morbidity and mortality,as is the case for the management of complicated acute pancreatitis or chronic *** centralisation of pancreatic surgery services,with the development of designated large-volume centres,has contribu-ted to significantly improved *** this editorial,we discuss the complex associations between diabetes mellitus(DM)and pancreatic/periampullary disease in the context of pancreatic surgery and overall management of complex pancreatitis,highlighting the consequential needs and the indispensable role of specialist diabetes teams in support of tertiary pancreatic *** 3c pan-creatogenic DM,refers to DM developing in the setting of exocrine pancreatic disease,and its identification and management can be challenging,while the glycaemic control of such patients may affect their course of treatment and *** preoperative diabetes assessment is warranted to aid identification of patients who are likely to need commencement or escalation of glucose lowering therapy in the postoperative *** incidence of new onset diabetes after pancreatic resection is widely variable in the literature,and depends on the type and extent of pancreatic resection,as is the case with pancreatic parenchymal loss in the context of severe *** involvement of a specialist diabetes team is essential to ensure a holistic *** the current era,large volume pancreatic surgery services commonly abide by the principles of enhanced recovery after surgery,with inclusion of provisions for optimisation of the perioperative glycaemic control,to improve *** various guidelines are available to aid perioperative management of DM,auditing and quality improvement platforms have highlighted deficiencies in the perioperative management of diabetic patients and areas of required *** need for perioperative support of diabetic

关键词： Pancreatectomy Pancreatoduodenectomy Whipple’s Pancreatitis Diabetes specialist Type 3c pancreatogenic diabetes mellitus

Modeling and optimization of non-isothermal convective drying process of Lavandula×allardii

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Information Processing in Agriculture 2024年第1期11卷 1-13页

作者： vasileios Chasiotis konstantinos-Stefanos Nikas Andronikos Filios Laboratory of Thermo Fluid Systems(LTFS) Department of Mechanical EngineeringUniversity of West AtticaAncient Olive Grove CampusThivon Str.250GR12244 EgaleoGreece

Non-isothermal convective drying schemes were examined for Lavandula×allardii leaves and *** process parameters were optimized using response surface methodology(RSM)to ensure the peak operational *** effects of temperature increase rate(2–4°C/h)and the airflow velocity(1–3 m/s)on the essential oil yield,drying duration and consumption,were investigated.A face-centered central composite design was deployed and the experimental data was adapted to the most suitable polynomial models,as determined by the regression *** of variance was applied to assess the effects of the process variables,their interactions and the statistical significance of the examined *** factors of temperature increase rate and airflow velocity had a significant impact on the drying *** velocity had a greater effect on leaves’essential oil yield and inflorescences’process energy consumption,whereas the rates of temperature increase had a greater influence on the inflorescences’essential oil yield and leaves’energy *** minimum drying duration and energy consumption were obtained for the maximum temperature increasing rate at 3 and 1 m/s airflow velocities respectively;and the highest essential oil yield was obtained for the least rate of temperature increase and airflow velocity for both leaves and *** optimization was performed for minimizing drying duration and energy consumption by maximizing the essential oil *** rate of temperature increases of 4°C/h and the airflow velocity of 1 m/s,were proposed as the optimum non-isothermal drying conditions for both leaves and inflorescences of Lavandula×*** values of essential oil content have been 1.387/3.05 mL/g,4.21/4.18 h drying time and 0.809/0.732 kWh energy consumption at the optimum operation point for leaves and inflorescences,*** resulted optimized non-stationary temperature scheme considerably improved the drying

关键词： Convective drying Non-isothermal drying Lavender Essential oil Process optimization

Oxidative dissolution of Cr(OH)_(3) and mixed Fe-Cr(Ⅲ)phases by aqueous Mn(Ⅲ)-pyrophosphate complex

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Journal of Environmental Sciences 2024年第5期139卷 105-113页

作者： Mismel Ruiz-Garcia Jordan Stanberry Giovanna Ballerini Ribeiro vasileios Anagnostopoulos Department of Chemistry University of Central FloridaOrlando FL 32816USA

The key role of manganese(Mn)in the biogeochemical cycle of trace elements has been of great interest in recent ***,the redox properties of aqueous Mn(Ⅲ)have been studied to a lesser ***(Ⅲ)is not stable in solution by ***,when complexed with inorganic ligands,it has shown potential to oxidize and reduce trace *** the present study,we are exploring the redox characteristics of the complex Mn(Ⅲ)-Pyrophosphate(Mn(Ⅲ)-PP).This complex is stable over a wide range of pH values but requires the ratio of Mn:PP to be less than 1:***,the redox reaction of chromium(Cr(Ⅲ))and Mn(Ⅲ)-PP is investigated.A solid,Cr(OH)_(3),is used as a source of Cr(Ⅲ).For this reaction,environmentally relevant parameters,such as pH,ionic strength,ratio Mn(Ⅲ)/Cr(Ⅲ),and excess of ligand,were *** showed that Mn(Ⅲ)can effectively oxidize Cr(Ⅲ)to Cr(Ⅵ),taking about 15 days for the reaction to *** reaction occurs only under acidic conditions(pH4),and with a low excess of *** initial Mn(Ⅲ)concentration decreases as the Cr(Ⅵ)is produced,and Cr(Ⅵ)can be adsorbed back into the Cr(OH)_(3)surface,limiting the mobility of this toxic *** this adsorption,significant amounts of Cr(VI)are release in the aqueous *** study shows the importance of a mobile species(Mn-PP complex)in the oxidation of Cr(Ⅲ)and the release of Cr(Ⅵ)to the environment.

关键词： Chromium Manganese Pyrophosphate complex Sorption Ionic strength Redox

Management of autoimmune hepatitis induced by hepatitis delta virus

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World Journal of Gastroenterology 2024年第8期30卷 799-805页

作者： Eleni Gigi vasileios Lagopoulos Aris Liakos Hepatology Unit The Second Internal Medicine DepartmentAristotle University Medical SchoolHippokrateio General HospitalThessaloniki 54642Greece Department of Surgical AHEPA General Hospital of ThessalonikiThessaloniki 54636Greece Clinical Research and Evidence-Based Medicine Unit Second Medical DepartmentHippokratio General HospitalAristotle University ThessalonikiThessaloniki 54642Greece

Approximately 12-72 million people worldwide are co-infected with hepatitis B virus(HBV)and hepatitis delta virus(HDV).This concurrent infection can lead to several severe outcomes with hepatic disease,such as cirrhosis,fulminant hepatitis,and hepatocellular carcinoma,being the most *** the past few decades,a correlation between viral hepatitis and autoimmune diseases has been ***,autoantibodies have been detected in the serum of patients co-infected with HBV/HDV,and autoimmune features have been ***,to date,very few cases of clinically significant autoimmune hepatitis(AIH)have been reported in patients with HDV infection,mainly in those who have received treatment with pegylated ***,there are some patients with HBV infection and AIH in whom HDV infection is unearthed after receiving treatment with ***,several questions remain unanswered with the challenge to distinguish whether it is autoimmune or“autoimmune-like”hepatitis being the most ***,it remains uncertain whether autoimmunity is induced by HBV or delta ***,we investigated whether the cause of AIH lies in the previous treatment of HDV with pegylated *** pressing issues should be elucidated to clarify whether new antiviral treatments for HDV,such as Bulevirtide or immu-nosuppressive drugs,are more appropriate for the management of patients with HDV and AIH.

关键词： Autoimmune hepatitis Hepatitis delta virus Bulevirtide Prednisolone

A novel multi-channel porous structure facilitating mass transport towards highly efficient alkaline water electrolysis

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Journal of Energy Chemistry 2024年第6期93卷 511-518,I0013页

作者： Xinge Jiang vasileios kyriakou Chen Song Xianbin Wang Sophie Costil Chunming Deng Taikai Liu Tao Jiang Hanlin Liao Universitéde technologie de Belfort Montbéliard Centre national de la recherche scientifiqueLaboratoire Interdisciplinaire Carnot de BourgogneBelfort 90010France Department of Chemical Engineering Engineering and Technology Institute Groningen(ENTEG)University of GroningenGroningen 9747 AGThe Netherlands The Institute of New Materials Guangdong Academy of ScienceGuangzhou 510650GuangdongChina

An advantageous porous architecture of electrodes is pivotal in significantly enhancing alkaline water electrolysis(AWE)efficiency by optimizing the mass transport *** effect becomes even more pronounced when aiming to achieve elevated current ***,we employed a rapid and scalable laser texturing process to craft novel multi-channel porous ***,the obtained electrodes exhibit the lowest Tafel slope of 79 mV dec^(-1)(HER)and 49 mV dec^(-1)(OER).As anticipated,the alkaline electrolyzer(AEL)cell incorporating multi-channel porous electrodes(NP-LT30)exhibited a remarkable improvement in cell efficiency,with voltage drops(from 2.28 to 1.97 V)exceeding 300 mV under 1 A cm^(-1),compared to conventional perforated Ni plate *** enhancement mainly stemmed from the employed multi-channel porous structure,facilitating mass transport and bubble dynamics through an innovative convection mode,surpassing the traditional convection ***,the NP-LT30-based AEL cell demonstrated exceptional durability for 300 h under 1.0 A cm^(-2).This study underscores the capability of the novel multi-channel porous electrodes to expedite mass transport in practical AWE applications.

关键词： Alkaline water electrolysis Mass transport Bubble dynamics Innovative convection mode Multi-channel porous structure

金属原子诱导的微环境调控在聚合氮化碳光催化析氢中的研究

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Science China Materials 2024年第6期67卷 1765-1779页

作者：赵大明杨雨骁 vasileios Binas 沈少华 School of Advanced Energy Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’an 710049China Institute of Electronic Structure and Laser(IESL) Vasilika VoutonHeraklion GR-71110Greece Physical Chemistry Laboratory Chemistry DepartmentAristotle University of ThessalonikiThessaloniki 54124Greece

开发高效稳定的半导体光催化剂对光催化技术迈向实际应用至关重要.聚合物氮化碳(CN)因其优异的物理化学性质而被视为最具发展前景的制氢光催化剂之一.在过去几十年中,从热力学或动力学角度开发的一系列改性策略已经显著提升了CN的光催... 详细信息

开发高效稳定的半导体光催化剂对光催化技术迈向实际应用至关重要.聚合物氮化碳(CN)因其优异的物理化学性质而被视为最具发展前景的制氢光催化剂之一.在过去几十年中,从热力学或动力学角度开发的一系列改性策略已经显著提升了CN的光催化制氢性能.近期,金属原子修饰策略为CN改性提供了一条新途径,这种策略可以精确调控CN的微环境.本文全面回顾了金属原子修饰的CN光催化剂在光催化分解水制氢领域的最新研究进展,包括金属单原子修饰的CN、金属双原子修饰的CN、金属单原子与团簇共修饰的CN,重点阐述了金属原子对提升光催化性能的关键作用.此外,本文还全面总结了发展先进的金属原子修饰的CN光催化剂所面临的挑战与机遇.

关键词： metal atom polymeric carbon nitride hydrogen evolution photocatalysis solar energy conversion

Translation and cross-cultural adaptation of the kidney Transplant Questionnaire 25 to Greek

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World Journal of Transplantation 2024年第2期14卷 148-154页

作者： vasileios koutlas Eirini Tzalavra vasileios Tatsis Charalampos Pappas Stavroula Vovlianou Stefanos Bellos Anila Duni Eleni Stamellou konstantinos I Tsamis Michail Mitsis Evangelia Dounousi Department of Surgery and kidney Transplant Unit University Hospital of IoanninaIoannina 45500EpirusGreece Department of Surgery Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology University Hospital of IoanninaIoannina 45500EpirusGreece Department of Nephrology General Hospital of KavalaKavala 65500Greece Department of Physiology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece

BACkGROUND kidney transplantation leads to continuous improvement in the survival rates of kidney transplant recipients(kTRs)and has been established as the treatment of choice for patients with end-stage kidney ***-related quality of life(HRQoL)has become an important outcome *** is highly important to develop reliable methods to evaluate HRQoL with disease-specific *** To translate the disease-specific instrument kidney Transplant Questionnaire 25(kTQ-25)to the Greek language and perform a cross-cultural *** The translation and adaptation of the original English version of the kTQ-25 to the Greek language were performed based on the International Quality of Life RESULTS Eighty-four kTRs(59 males;mean age 53.5±10.7 years;mean estimated glomerular filtration rate 47.7±15.1 mL/min/1.73 m2;mean transplant vintage 100.5±83.2 months)completed the Greek version of the kTQ-25 and the 36-item Short-Form Health Survey,and the results were used to evaluate the reliability of the Greek *** Cronbach alpha coefficients for all the kTQ-25 dimensions were satisfactory(physical symptoms=0.639,fatigue=0.856,uncertainty/fear=0.661,appearance=0.593,emotions=0.718,total score=0.708).The statistically significant correlation coefficients among the kTQ-25 dimensions ranged from 0.226 to *** correlation coeffi-cients of the kTQ-25 dimensions with the SF-36 physical component summary(PCS)ranged from 0.196 to 0.550;the correlation coefficients of the kTQ-25 with the SF-36 mental component summary(MCS)ranged from 0.260 to 0.655;and the correlation coefficients of the kTQ-25 with the total scores with the SF-36 PCS and MCS were 0.455 and 0.613,*** According to the findings,the Greek version of the kTQ-25 is valid and reliable for administration among kidney transplant patients in Greece.

关键词： kidney Transplant Questionnaire 25 kidney transplantation kidney transplant recipients Health-related quality of life Quality of life

Review of incidence and outcomes of treatment of cholangiocarcinoma in patients with primary sclerosing cholangitis

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1336-1366页

作者： Francesca Saffioti vasileios k.mavroeidis Department of Gastroenterology and Hepatology Oxford University Hospitals NHS Foundation TrustOxford OX39DUOxfordshireUnited Kingdom UCL Institute for Liver and Digestive Health and Sheila Sherlock Liver Unit Royal Free HospitalUniversity College LondonLondon NW32QGUnited Kingdom Department of Surgery The Royal Marsden NHS Foundation TrustLondon SW36JJUnited Kingdom Department of Transplant Surgery North Bristol NHS TrustSouthmead HospitalBristol BS105NBUnited Kingdom

Primary sclerosing cholangitis(PSC)is a premalignant condition and a welldocumented risk factor for cholangiocarcinoma(CCA)which is the most common malignancy in this setting and the leading cause of deaths in the recent years,with an increasing ***-associated CCA has a geographical distribution that follows the incidence of PSC,with an observed ascending gradient from the Eastern to the Western and from the Southern to the Northern *** may arise at any location along the biliary tree but is most common in the perihilar *** with PSC and intrahepatic or perihilar CCA are typically not suitable for liver resection,which is otherwise the treatment of choice with curative intent in patients with resectable tumours,providing a radical resection with clear margins can be *** largely relates to the commonly advanced stage of liver disease at presentation,which allows consideration for liver resection only for a very limited number of suitable patients with *** the other hand,remarkable progress has been reached in the last decades with the implementation of a protocol combining neoadjuvant chemoradiation and orthotopic liver transplantation(OLT)for the treatment of perihilar CCA,within specific *** results have been achieved particularly for PSC patients with this cancer,who seem to benefit the most from this treatment,having converted this into an accepted indication for transplantation and the standard of care in several experienced *** CCA as an indication for OLT remains controversial and has not been accepted given disappointing previous ***,as recent studies have shown favourable outcomes in early intrahepatic CCA,it may be that under defined criteria,OLT may play a more prominent role in the *** CCA in the context of PSC requires aggressive surgical treatment with curative intent,when *** review provides insight about particular features of CCA in the setting of

关键词： Cholangiocarcinoma Primary sclerosing cholangitis Liver resection Liver transplantation Neoadjuvant therapy Adjuvant therapy