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The germline genetics of mild-to-moderate penetrance:An intriguing role of PRAME in multiple carcinogenesis

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Genes & Diseases 2024年第3期11卷 7-10页

作者： Diaddin Hamdan van Tai nguyen Justine Paris Christophe Leboeuf Morad El Bouchtaoui Marc Espie Anne Janin Geraldine Falgarone Melanie Di Benedetto Guithem Bousquet Universite de Paris Cite INSERMUMR_S942MASCOTParis F-75006France Hopital La Porte Verte Versailles F-78004France National Cancer Hospital Cancer Research and Clinical Trials CenterHaNoi100000VietNam AP-HP-Hopital Saint Louis Centre de Maladies du SeinParisF-75010France Universite Sorbonne Paris Nord Bobigny F-93000France AP-HP-Hopital Avicenne Unite de Medecine AmbulatoireBobigny F-93000France

Germline genetics of high penetrance such as BRCA genes,mutations might be sufficient for carcinogenesis,but this only explains fewer than 10%of *** assume that most cancers are the result of germline mutations of low to moderate penetrance,combined with acquired mutations due to external carcinogenic *** their accumulation over time,aging is associated with an increased risk of multiple cancer development in a given *** decades,germline genetics have been based on familial linkage studies enabling most high-penetrance genes to be *** recently,population-wide studies have led to the identification of considerable numbers of polymorphisms associated with cancer ***,most of them are of unknown functional value,thus limiting their translational application.

关键词： carcinogenesis BRCA linkage

Effectiveness and safety of electroacupuncture analgesia in controlling intraoperative pain and hemodynamics during total thyroidectomy:A randomized controlled trial

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 165-171页

作者： Dong Phuong Tran Quoc Dung nguyen Ninh Khac nguyen van Hong Pham Senior Specialist Clinic National Hospital of AcupunctureHanoi10000Vietnam Vietnam National Association of Acupuncture Hanoi10000Vietnam Department of Training and Science National Hospital of AcupunctureHanoi10000Vietnam

Objective:To evaluate the effectiveness and safety of electroacupuncture in conjunction with additional medications in providing analgesia and stabilizing hemodynamic parameters during total ***:This randomized controlled trial included 100 patients who underwent a total thyroidectomy between October 2022 and October 2023 at the Vietnam National Hospital of *** patients were randomized into two *** electroacupuncture analgesia(EA)group received EA stimulation at five acupuncture points:Hegu(LI 4),Neiguan(PC 6),Shuitu(ST 10),Quepen(ST 12),and Yifeng(SJ 17),while the control group received a bilateral superficial cervical plexus *** outcomes included the level of analgesia and perioperative vital signs in both ***,pain thresholds and serum b-endorphin levels were measured before and after electroacupuncture in the EA ***:Complete analgesia(Level A)was attained in 86%and 76%of the patients in the EA and control groups,respectively,with no significant difference between the two groups(P¼1.00).In the EA group,the mean pain threshold after receiving EA doubled(648.7(77.4)g/s vs.305.3(45.3)g/s,P<.001),and the mean serum b-endorphin level increased by approximately 13.5 pg/mL(P<.001).All patients remained hemodynamically stable throughout the ***:EA,in conjunction with additional medications that stimulate five acupuncture points,LI 4,PC 6,ST 10,ST 12,and SJ 17,was well tolerated and effectively maintained a suitable level of analgesia and hemodynamic stability during total thyroidectomy.

关键词： Electroacupuncture Acupuncture analgesia Graves'disease Thyroidectomy Thyroid surgery b-Endorphin

采石场粉尘和海砂混合物力学性能试验和数值研究

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岩土力学 2024年第9期45卷 2728-2740页

作者： TIEP Pham Duc TU nguyen van PHONG Pham Duc CHINH Mai Viet PHONG nguyen Viet 越南勒奎东技术大学特殊工程技术研究所河内越南

越南等发展中国家的道路基础设施建设需要大量天然砂。河砂日益紧缺,其供应量将持续下降。因此,建筑行业必须实施可持续发展战略,将废弃材料与各种可利用资源相结合,以有效应对这一严峻形势。本研究的目的是测试采石场粉尘和海砂混合物... 详细信息

越南等发展中国家的道路基础设施建设需要大量天然砂。河砂日益紧缺,其供应量将持续下降。因此,建筑行业必须实施可持续发展战略,将废弃材料与各种可利用资源相结合,以有效应对这一严峻形势。本研究的目的是测试采石场粉尘和海砂混合物的力学性能,并评估其在高速公路路基层中的潜在应用。进行了一系列试验,包括材料的含水率、相对密度、休止角测试和三轴试验,以研究不同配比下混合物的组成。结合Plaxis土工试验中的校准进行了广泛的参数研究,得出了割线模量E_(50)和围压曲线。根据加州承载比CBR对公路路基层所用材料的评估结果,证明海砂和采石场粉尘混合物具有适当性能,可用于公路路基的建设。

关键词：采石场粉尘海砂土工试验模块固结试验三轴试验路基层公路加州承载比

Traveling wave solutions of the nonlinear Gilson-Pickering equation in crystal lattice theory

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Journal of Ocean Engineering and Science 2024年第1期9卷 40-49页

作者： A.T.nguyen O.Nikan Z.Avazzadeh Division of Applied Mathematics Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityVietnam Faculty of Technology Van Lang UniversityHo Chi Minh CityVietnam School of Mathematics Iran University of Science and TechnologyNarmakTehranIran Department of Applied Mathematics Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

This paper focuses on obtaining the traveling wave solutions of the nonlinear Gilson-Pickering equa-tion(GPE),which describes the prorogation of waves in crystal lattice theory and plasma *** solution of the GPE is approximated via the finite difference technique and the localized meshless radial basis function generated finite *** association of the technique results in a meshless approach that does not require linearizing the nonlinear *** the first step,the PDE is converted to a system of nonlinear ODEs with the help of the radial *** the second step,a high-order ODE solver is adopted to discretize the nonlinear ODE *** global collocation techniques pose a considerable computationl burden due to the calculation of the dense algebraic *** proposed method approx-imates differential operators over the local support domain,leading to sparse differentiation matrices and decreasing the computational *** results and comparisons are provided to confirm the efficiency and accuracy of the method.

关键词： Nonlinear Gilson–Pickering equation Soliton wave solutions Meshless technique RBF LRBF-FD Optimal shape parameter

A deep neural network based surrogate model for damage identification in full-scale structures with incomplete noisy measurements

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 393-410页

作者： Tram BUI-NGOC Duy-Khuong LY Tam T TRUONG Chanachai THONGCHOM T.nguyen-THOI Laboratory for Computational Mechanics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Faculty of Mechanical-Electrical and Computer Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Faculty of Civil Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Department of Computer Science Aarhus UniversityAarhus 8000Denmark Thammasat University research unit in structural and foundation engineering Department of Civil EngineeringThammasat UniversityPathumthani 12120Thailand Laboratory for Applied and Industrial Mathematics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Thammasat School of Engineering Thammasat UniversityPathumthani 12120Thailand

The paper introduces a novel approach for detecting structural damage in full-scale structures using surrogate models generated from incomplete modal data and deep neural networks(DNNs).A significant challenge in this field is the limited availability of measurement data for full-scale structures,which is addressed in this paper by generating data sets using a reduced finite element(FE)model constructed by SAP2000 software and the MATLAB programming *** surrogate models are trained using response data obtained from the monitored structure through a limited number of measurement *** proposed approach involves training a single surrogate model that can quickly predict the location and severity of damage for all potential *** achieve the most generalized surrogate model,the study explores different types of layers and hyperparameters of the training algorithm and employs state-of-the-art techniques to avoid overfitting and to accelerate the training *** approach’s effectiveness,efficiency,and applicability are demonstrated by two numerical *** study also verifies the robustness of the proposed approach on data sets with sparse and noisy measured ***,the proposed approach is a promising alternative to traditional approaches that rely on FE model updating and optimization algorithms,which can be computationally *** approach also shows potential for broader applications in structural damage detection.

关键词： vibration-based damage detection deep neural network full-scale structures finite element model updating noisy incomplete modal data

Building the ARIMA Model for Forecasting the Production of Vietnam’s Coffee Export

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1237-1246页

作者： Duy Quang Phung Quoc Thang Trinh Quang Truong Do Ngan Giang nguyen van Ha nguyen Gia Khiem Ngo Thi Minh Ngoc Tran Faculty of Technology and Data Science Foreign Trade University Hanoi Vietnam School of Economics and International Business Foreign Trade University Hanoi Vietnam

Coffee is a significant industry, accounting for 3% of Vietnam’s GDP, with annual export turnover consistently exceeding USD 3 billion. Despite global economic challenges affecting purchasing power at various times, Vietnam’s coffee exports in December 2023 continued to surge, reaching the highest level in the past 9 months at 190,000 tons, a 59.3% increase compared to November 2023, but still a slight 3.5% decrease from the same period last year. The export turnover reached USD 538 million, a 51% increase from November 2023 and a 26.4% increase from the same period last year. Therefore, forecasting the coffee export volume holds significant importance for coffee producers nationwide. This research employs the Box-Jenkins method to construct an ARIMA model for forecasting Vietnam’s coffee export volume based on annual data published by the General Statistics Office. Results indicate that among the models considered, the ARIMA(1, 1, 2) model is the most suitable. The study also provides short-term forecasts for Vietnam’s coffee export volume. However, the current model is limited to forecasting and is not yet optimized, as the assumed linearity in the model is a simplification.

关键词： ARIMA Forecasting Coffee Export Volume Data Science

Exploring the Interplay between Job Stress,Work Performance,and Attitudes toward Professional Psychological Help among Employees

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International Journal of Mental Health Promotion 2024年第7期26卷 531-545页

作者： Cong Minh Le Son van huynh Ky Luu Quynh-Nhi Ngoc Ho van Thi Le nguyen Vinh-Long Tran-Chi Center for Mental Health Research and Support University of Social Sciences and HumanitiesVietnam National University Ho Chi Minh CityHo Chi Minh City700000Vietnam Faculty of Psychology Ho Chi Minh City University of EducationHo Chi Minh City700000Vietnam Faculty of Tourism College of BusinessUniversity of Economics Ho Chi Minh CityHo Chi Minh City700000Vietnam Scientific Management Department Dong A UniversityDa Nang500000Vietnam

Objective:This study explores the interplay between job stress,job-related factors,work performance,and attitudes toward seeking professional psychological help among Vietnamese ***:A total of 374 employees in Vietnam were surveyed using random sampling and an online questionnaire from November 07 to November 28,*** data and self-reported from three scales:The New Job Stress Scale(NJSS),Work Performance(WP),and Attitudes Toward Seeking Professional Psychological Help(ATSPPH_SF)were ***:Significant variations were found across several variables,including forms of work,operating hours,education levels,monthly income,numbers of daily working hours,and the presence of a psychological counseling department within the *** analysis has highlighted direct relationships between key latent *** who were more open to seeking professional help tended to report higher levels of job *** negative relationship was found between job stress and attitudes toward seeking professional ***,work effort was positively associated with work *** analyses revealed the influence of co-worker support on role expectation conflict and work effort,role expectation conflict and work-life balance,as well as interactions between role expectation conflict and attitudes needed toward seeking professional *** analyses showed that work effort mediated relationships between openness to seeking professional help,co-worker support,work-life balance,role expectation conflict,and work *** toward seeking professional help also mediated relationships between work-life balance,job stress,and work ***:The study highlights the complex dynamics surrounding job stress,job-related factors,work performance,and attitudes toward seeking professional psychological help among Vietnamese *** highlights the importance of addressing help-seeking barriers,promoting work engagement

关键词： Stress co-worker support work-life balance role expectation conﬂict professional psychological help-seeking

Orange G degradation by heterogeneous peroxymonosulfate activation based on magnetic MnFe_(2)O_(4)/α-MnO_(2) hybrid

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Journal of Environmental Sciences 2023年第2期124卷 379-396页

作者： Le Thi Thao To van nguyen van Quy nguyen Ngoc Man Phan Ki Jae Kim nguyen Nhat huy nguyen Trung Dung Faculty of Physical and Chemical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Department of Energy Engineering Konkuk UniversitySeoul 05029Korea School of Chemical Engineering College of EngineeringSungkyunkwan UniversityJangan-guSuwon 16419Korea Faculty of Environment and Natural Resources Ho Chi Minh City University of Technology(HCMUT)Ho Chi Minh City 700000Vietnam Vietnam National University Ho Chi Minh City Linh Trung WardThu Duc CityHo Chi Minh City 700000Vietnam

Wastewater containing an azo dye Orange G(OG)causes massive environmental pollution,thus it is critical to develop a highly effective,environmental-friendly,and reusable catalyst in peroxymonosulfate(PMS)activation for OG *** this work,we successfully applied a magnetic MnFe_(2)O_(4)/α-MnO_(2) hybrid fabricated by a simple hydrothermal method for OG removal in *** characteristics of the hybrid were investigated by Xray diffraction,scanning electron microscopy,energy-dispersive X-ray spectroscopy,Fourier transform infrared spectroscopy,Brunauer–Emmett–Teller method,vibrating sample magnetometry,electron paramagnetic resonance,thermogravimetric analysis,and X-ray photoelectron *** effects of operational parameters(i.e.,catalytic system,catalytic dose,solution pH,and temperature)were *** results exhibited that 96.8% of OG degradation was obtained with MnFe_(2)O_(4)/α-MnO2(1:9)/PMS system in 30 min regardless of solution pH ***,the possible reaction mechanism of the coupling system was proposed,and the degradation intermediates of OG were identified by mass *** radical quenching experiments and EPR tests demonstrated that SO_(4)•̶,O_(2)•̶,and 1O2 were the primary reactive oxygen species responsible for the OG *** hybrid also displayed unusual stability with less than 30%loss in the OG removal after four sequential ***,magnetic MnFe2O4/α-MnO2 hybrid could be used as a high potential activator of PMS to remove orange G and maybe other dyes from wastewater.

关键词： MnFe_(2)O_(4)/α-MnO_(2) Peroxymonosulfate Orange G Catalytic degradation Reusability

Predicted aerodynamic damping of slender single beam structures in across-wind vibrations

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Acta Mechanica Sinica 2020年第5期36卷 990-998,I0001页

作者： Cung huy nguyen Dinh Tung nguyen Department of Civil Engineering Industrial University of Ho Chi Minh CityHo Chi Minh City 700000Vietnam Department of Civil Engineering University of NottinghamNottingham NG72RDUK

The paper presents a generalization of the conventional analytical approach where the quasisteady theory is utilised to evalu-ate the across-wind aerodynamic damping of slender single beam *** generalized theory considers the variation of structural and aerodynamic parameters along the structural height,together with the nature of the vertical wind profile and mode ***-form solutions for typical uniform and tapered tall buildings are given.A numerical application on a prototype tall building shows that the conventional method may be oversimplified,which results in incorrect predictions of the aerodynamic damping.

关键词： Aerodynamic damping Across-wind Slender structure-Galloping Tall building