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世界核心医学期刊文摘（眼科学分册） 2006年第4期2卷 2-3页

作者： van leeuwen r. Boekhoor. S. Vinger.ing J.r. P.T.V.M. De Jong 张磊 Dr. Nether.ands Ophthalmic r.sear.h Institute KNAW Meibergdreef 47 1105 BA Amsterdam Netherlands

Context: Age-r.lated macular.degener.tion (AMD) is the most pr.valent cause of ir.ever.ible blindness in developed countr.es. r.cently, high-dose supplementation with beta car.tene, vitamins C and E, and zinc was shown to slow the pr.gr.ssion of AMD. Objective: To investigate whether.r.gular.dietar. intake of antioxidants is associated with a lower.r.sk of incident AMD. Design: Dietar. intake was assessed at baseline in the r.tter.am Study (1990-1993) using a semiquantitative food fr.quency questionnair.. Incident AMD until final follow-up in 2004 was deter.ined by gr.ding fundus color.tr.nspar.ncies in a masked way accor.ing to the Inter.ational Classification and Gr.ding System. Setting: Population-based cohor. of all inhabitants aged 55 year. or.older.in a middle-class subur. of r.tter.am, the Nether.ands. Par.icipants: Of 5836 per.ons at r.sk of AMD at baseline, 4765 had r.liable dietar. data and 4170 par.icipated in the follow-up. Main Outcome Measur.: Incident AMD, defined as soft distinct dr.sen with pigment alter.tions, indistinct or.r.ticular.dr.sen, geogr.phic atr.phy, or.chor.idal neovascular.zation. r.sults: Incident AMD occur.ed in 560 par.icipants after.a mean follow-up of 8.0 year. (r.nge, 0.3-13.9 year.). Dietar. intake of both vitamin E and zinc was inver.ely associated with incident AMD. The hazar. r.tio (Hr. per.standar. deviation incr.ase of intake for.vitamin E was 0.92 (95%confidence inter.al [CI], 0.84-1.00) and for.zinc was 0.91 (95%CI, 0.83-0.98). An above-median intake of all 4 nutr.ents, beta car.tene, vitamin C, vitamin E, and zinc, was associated with a 35%r.duced r.sk (Hr. 0.65; 95%CI, 0.46-0.92) of AMD. Exclusion of supplement user. did not affect the r.sults. Conclusion: In this study, a high dietar. intake of beta car.tene, vitamins C and E, and zinc was associated with a substantially r.duced r.sk of AMD in elder.y per.ons.

关键词：年龄相关性黄斑变性患病风险抗氧化剂脉络膜新生血管饮食 β-胡萝卜素玻璃膜疣受试者

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视网膜血管直径与散发性老年性黄斑病变发病的危险性:鹿特丹研究

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 42-43页

作者： Ikr.m M.K. van leeuwen r. Vinger.ing J.r. P.T.V.M. De Jong 张鹏 The Ne ther.ands Ophthal. r.s. Inst. Meibergdreef 47 1105 BA Amsterdam NetherlandsDr.

Pur.ose: To study the r.lationship between r.tinal vessel diameter. and incide nt age-r.latedmacular.disease (iAMD).Design: Pr.spective population-based coho r. study. Par.icipants: Per.ons (55 year. and older. fr.m the r.tter.am Study, w ho par.icipated at the baseline (1990-1993) and 1 of 2 follow up examinations ( 1993-1994 and 1997-1999). Methods: In the cur.ent analysis, 4345 par.icipants who wer. fr.e of AMD at baseline and had gr.dable macular.tr.nspar.ncies at both baseline and follow-up examination wer. included. Also, ar.er.olar.and venular.diameter. wer. measur.d on digitized baseline images. Ster.oscopic tr.nspar.nci es of the macular.r.gion wer. gr.ded accor.ing to the Inter.ational Classificati on and Gr.ding System for.AMD. Incidence of AMD was defined as the development o f soft distinct dr.sen with pigmentar. changes or.indistinct or.r.ticular.dr.sen with or.without pigmentar. changes (ear.y iAMD) or.atr.phic or.neovascular.AMD (late iAMD). Logistic r.gr.ssion models wer. used to assess these associations, adjusting for.age, gender. and follow-up time and, additionally, for.smoking, b ody mass index, intima-media thickness, systolic blood pr.ssur., and total and high-density lipopr.tein cholester.l levels. Main Outcome Measur.: Incidence of AMD. r.sults: After.a mean follow-up time of 5.2 year., a total of 374 per.ons developed ear.y and late iAMD. Neither.ar.er.olar.nor.venular.diameter. wer. r. lated to the r.sk of iAMD. The odds r.tio (Or. per.standar. deviation (SD) decr. ase in ar.er.olar.diameter.was 1.03 (95%confidence inter.al [CI], 0.93-1.15) , and the Or.per.SD incr.ase in venular.diameter.was 1.04 (95%CI, 0.93-1.16). Af ter.categor.zing the r.tinal vessel diameter. into quintiles, ther. was no tr.nd . After.str.tifying on age, only per.ons 75 year. and older.with smaller.ar.er.o lar.diameter. wer. at a bor.er.ine significant incr.ased r.sk of iAMD: Or.SD dec r.ase in ar.er.olar.diameter. adjusted for.age, gender. follow-up time, and oth e

关键词：黄斑病变视网膜血管软性玻璃膜疣随访检查色素改变血管危险因素立体镜前瞻性队列研究模型评价中层厚度

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我国三代同堂家庭协同教养观念的质性研究

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宁波大学学报（教育科学版） 2024年第3期46卷 100-107页

作者：罗娜 van leeuwen Kar.a 宁波大学浙东文化研究院浙江宁波315211 宁波大学教师教育学院浙江宁波315211 鲁汶大学心理学和教育科学学院弗拉芒布拉邦鲁汶3000

本研究旨在考察当代中国三代同堂家庭中父母和祖辈的协同教养观念。研究选取10个家庭中的8位祖辈和8位父母,采用焦点小组访谈和个人访谈的方式搜集数据。研究结果表明:父亲与母亲平等地分担子女(10—13岁)的教养责任,祖辈在养育孙辈方... 详细信息

本研究旨在考察当代中国三代同堂家庭中父母和祖辈的协同教养观念。研究选取10个家庭中的8位祖辈和8位父母,采用焦点小组访谈和个人访谈的方式搜集数据。研究结果表明:父亲与母亲平等地分担子女(10—13岁)的教养责任,祖辈在养育孙辈方面有从属的作用;祖辈的溺爱和滞后的养育方式是父母和祖辈间产生分歧的主要原因,但这种分歧可以通过沟通和支持来调和,并且父母和祖辈都认为沟通和支持是协同教养的关键。因此,在三代同堂家庭教育方面应加强父母(尤其是父亲)和祖辈对协同教养重要性的认识,明确祖辈“溺爱”界限,确保“帮忙不添乱”,以此减少祖辈和孩子父母之间的养育冲突,有效提升儿童的身心发展水平和幸福感。

关键词：协同教养三代同堂家庭儿童质性研究

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Effect of competing solutes on ar.enic(Ⅴ) adsor.tion using ir.n and aluminum oxides

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Jour.al of Envir.nmental Sciences 2007年第8期19卷 910-919页

作者： Youngr.n Jeong FAN Maohong Johannes van leeuwen Joshua F. Belczyk Depar.ment of Civil Construction and Environmental Engineering Iowa State University Ames IA 50011 USA. Center.for.Sustainable Envir.nmental Technology Iowa State University Ames IA 50011 USA Bailey PVS Canonsburg PA 15317 USA

The study focused on the effect of sever.l typical competing solutes on r.moval of ar.enic with Fe2O3 and Al2O3. The test r.sults indicate that chlor.de, nitr.te and sulfate did not have detectable effects, and that selenium（Ⅳ）（Se（Ⅳ）） and vanadium（Ⅴ）（V（Ⅴ）） showed slight effects on the adsor.tion of As（Ⅴ） with Fe2O3. The r.sults also showed that adsor.tion of As（Ⅴ） on A12O3 was not affected by chlor.de and nitr.te anions, but slightly by Se（Ⅳ） and V（Ⅴ） ions. Unlike the adsor.tion of As（Ⅴ） with Fe2O3, that with Fe2O3 was affected by the pr.sence of sulfate in water.solutions. Both phosphate and silica have significant adver.e effects on the adsor.tion of As（Ⅴ） adsor.tion with Fe2O3 and Al2O3. Compar.d to the other.tested anions, phosphate anion was found to be the most pr.minent solute affecting the As（Ⅴ） adsor.tion with Fe2O3 and Al2O3. In gener.l, Fe2O3 has a better.per.or.ance than Al2O3 in r.moval of As（Ⅴ） within a water.envir.nment wher. multi competing solutes ar. pr.sent.

关键词： adsor.tion ar.enic ir.n oxide aluminum oxide sulfate selenium(Ⅳ) vanadium(Ⅴ) phosphate silica

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Gr.pevineXL r.liably pr.dicts multi-annual dynamics of vine water.status, ber.y gr.wth, and sugar.accumulation in vineyar.s

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Hor.icultur. r.sear.h 2023年第6期10卷 56-69页

作者： Weiwei Yang Junqi Zhu Cor.elis van leeuwen Zhanwu Dai Gr.gor. AGambetta Beijing Key Labor.tor. of Gr.pe Science and Enology and Key Labor.tor. of Plant r.sour.es Institute of Botanythe Chinese Academy of SciencesBeijing100093China EGFV Univ.BordeauxBordeaux Sciences AgroINRAEISVVVillenave d’Ornon33882France The Key Labor.tor. of Special Fr.its and Vegetables Cultivation Physiology and Ger.plasm r.sour.es Utilization in Xinjiang Pr.duction and Constr.ction Gr.up College of AgricultureShihezi UniversityShihezi832000China The New Zealand Institute for.Plant&Food r.sear.h Limited Blenheim 7201New Zealand China National Botanical Gar.en Beijing 100093China

Climate and water.availability gr.atly affect each season’s gr.pe yield and *** models to accur.tely pr.dict envir.nment impacts on fr.it pr.ductivity and quality is a huge *** calibr.ted and validated the functional-str.ctur.l model,Gr.pevineXL,with a data set including gr.pevine seasonal midday stem water.potential(�xylem),ber.y dr. weight(DW),fr.sh weight(FW),and sugar.concentr.tion per.volume([Sugar.)for.a wine gr.pe cultivar.Vitis vinifer. *** Fr.nc)in field conditions over.13 year. in Bor.eaux,*** r.sults showed that the model could make a fair.pr.diction of seasonal�xylem and good-to-excellent pr.dictions of ber.y DW,FW,[Sugar.and leaf gas exchange r.sponses to pr.dawn and midday leaf water.potentials under.diver.e envir.nmental conditions with 14 key *** r.nning vir.ual exper.ments to mimic climate change,an advanced ver.ison(*** onset of r.pening)of 14 and 28 days led to significant decr.ases of ber.y FW by 2.70%and 3.22%,clear.incr.ases of ber.y[Sugar.by 2.90%and 4.29%,and shor.ened r.pening dur.tion in 8 out of 13 simulated year.,***,the impact of the advanced ver.ison var.ed with seasonal patter.s of climate and soil water.***,the r.sults showed that the Gr.pevineXL model can pr.dict plant water.use and ber.y gr.wth in field conditions and could ser.e as a valuable tool for.designing sustainable vineyar. management str.tegies to cope with climate change.

关键词： Sugar cultivar sugar

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Impacts of climate gr.dients on the vegetation phenology of major.land use types in Centr.l Asia （1981-2008）

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Fr.ntier. of Ear.h Science 2012年第2期6卷 206-225页

作者： Jahan KAr.YEVA Willem J.D. van leeuwen Connie A. WOODHOUSE School of Geogr.phy and Development The University of Arizona Tucson AZ 85721 USA School of Natur.l r.sour.es and the Envir.nment - Office of Ar.d Lands Studies - Ar.zona r.mote Sensing Center The Univer.ity of Ar.zona Tucson AZ 85721 USA

Time-ser.es of land sur.ace phenology （LSP） data offer.insights about vegetation gr.wth patter.s. They can be gener.ted by exploiting the tempor.l and spectr.l r.flectance pr.per.ies of land sur.ace components. Inter. annual and seasonal LSP data ar. impor.ant for.under. standing and pr.dicting an ecosystem＇s r.sponse to var.ations caused by natur.l and anthr.pogenic dr.ver.. This r.sear.h examines spatio-tempor.l change patter.s and inter.ctions between ter.estr.al phenology and 28 year. of climate dynamics in Centr.l Asia. Long-ter. （1981-2008） LSP r.cor.s such as timing of the star., peak and length of the gr.wing season and vegetation pr.ductivity wer. der.ved fr.m r.motely sensed vegetation gr.enness data. The patter.s wer. analyzed to identify and char.cter.ze the impact of climate dr.ver. at r.gional scales. We explor.d the r.lationships between phenologi- cal and pr.cipitation and temper.tur. var.ables for.thr.e gener.lized land use types that wer. exposed to decade- long r.gional dr.ught events and intensified land and water.r.sour.e use： r.infed agr.cultur., ir.igated agr.cultur., and non-agr.cultur.. To deter.ine whether.and how LSP dynamics ar. associated with climate patter.s, a ser.es of simple linear.r.gr.ssion analyses between these two var.ables was executed. The thr.e land use classes showed unique phenological r.sponses to climate var.ation acr.ss Centr.l Asia. Most of the phenological r.sponse var.ables wer. shown to be positively cor.elated to pr.cipitation and negatively cor.elated to temper.tur.. The most substantial climate var.able affecting phenological r.sponses of all thr.e land use classes was a spr.ng temper.tur. r.gime. These r.sults indicate that futur. higher.temper.tur.s would cause ear.ier.and longer.gr.wing seasons.

关键词： phenology land use climate var.ability

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Towar.s a multiscale model of color.ctal cancer

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Wor.d Jour.al of Gastr.enter.logy 2007年第9期13卷 1399-1407页

作者： Ingebor. MM van leeuwen Car.na M Edwar.s Mohammad Ilyas Helen M Byr.e Centr. for.Mathematical Medicine and Biology School of Mathematical Sciences University of Nottingham Nottingham NG7 2RD United Kingdom Centr. for.Mathematical Biology Oxford Centre for Industrial and Applied Mathematics Mathematical Institute University of Oxford Oxford OX1 3LB United Kingdom Division of Pathology School of Molecular Medical SciencesQueen’s Medical Centre University of Nottingham Nottingham NG7 2UHUnited Kingdom

Color.ctal cancer.(Cr.) is one of the best char.cter.sed cancer., with extensive data documenting the sequential gene mutations that under.ie its development. Complementar. datasets ar. also being gener.ted descr.bing changes in pr.tein and r.A expr.ssion, tumour.biology and clinical outcome. Both the quantity and the var.ety of infor.ation ar. inexor.bly incr.asing and ther. is now an accompanying need to integr.te these highly dispar.te datasets. In this ar.icle we aim to explain why we believe that mathematical modelling r.pr.sents a natur.l tool or.language with which to integr.te these data and, in so doing, to pr.vide insight into Cr..

关键词： Intestinal epithelium Cr.pt fission APC mutations Mathematical modelling Stem cell niche Wnt signalling

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Pr.diction of DOM r.moval of low specific UV absor.ance sur.ace water. using HPSEC combined with peak fitting

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Jour.al of Envir.nmental Sciences 2012年第7期24卷 1174-1180页

作者： Linan Xing r.lando Fabr.s W.K.Chow John van leeuwen Mar. Dr.kas Dongsheng Wang State Key Labor.tor. of Envir.nmental Aquatic Chemistr. Research Center for Eco-Environmental SciencesChinese Academy of ScinecesBeijing 100085China Austr.lian Water.Quality Centr. South Australian Water Corporation256 Victoria SquareAdelaideSouth Australia 5000Australia SA Water.Centr. for.Water.Management and r.use University of South AustraliaMawson LakesSouth Australia 5095Australia

High per.or.ance size exclusion chr.matogr.phy （HPSEC） is used in water.quality r.sear.h pr.mar.ly to deter.ine the molecular.weight distr.bution of the dissolved or.anic matter.（DOM）, but by applying peak fitting to the chr.matogr.m, this technique can also be used as a tool to model and pr.dict DOM r.moval. Six low specific UV absor.ance （SUVA） sour.e water. wer. tr.ated using coagulation with alum and both the sour.e and tr.ated water.samples wer. analysed using HPSEC. By compar.ng the molecular.weight pr.files of the sour.e and tr.ated water., it was established that sever.l DOM components wer. not effectively r.moved by alum coagulation even after.high dosage alum tr.atment. A peak-fitting technique was applied based on the concept of linking the char.cter.（molecular.weight pr.file） of the r.calcitr.nt or.anics in the tr.ated water.with those of the sour.e water. This was then applied to pr.dict DOM tr.atability by deter.ining the ar.as of the peaks which wer. assigned to r.movable or.anics fr.m the sour.e water.molecular.weight pr.file after.peak fitting, and this technique quantified the r.movable and non-r.movable or.anics. The pr.diction was compar.d with the actual dissolved or.anic car.on （DOC） r.moval deter.ined fr.m jar.testing and showed good agr.ement, with var.ance between 2% and 10%. This confir.ed that this pr.diction appr.ach, which was or.ginally developed for.high SUVA water., can also be applied successfully to pr.dict DOC r.moval in low SUVA water..

关键词： DOM high per.or.ance size exclusion chr.matogr.phy peak fitting water.tr.atment

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Ur.anization in China,ca.1100-1900

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Fr.ntier. of Economics in China-Selected Publications fr.m Chinese Univer.ities 2018年第3期13卷 322-368页

作者： Yi Xu Bas van leeuwen Jan Luiten van Zanden College of Histor.cal Cultur. and Tour.sm Guangxi Normal UniversityGuilin 541001China Inter.ational Institute of Social Histor. Royal Netherlands Academy of Arts and SciencesAmsterdam1019ATNetherlands Depar.ment of Economic and Social Histor. Utrecht UniversityUtrecht3512BSNetherlands

This paper.pr.sents new estimates of the development of the ur.an population and the ur.anization r.tio for.the per.od spanning the Song and late Qing dynasties. Ur.anization is viewed, as in much of the economic histor.cal liter.tur. on the topic, as an indir.ct indicator.of economic development and str.ctur.l change. The development of the ur.an system can ther.for. tell us a lot about long-ter. tr.nds in the Chinese economy between 1100 and 1900. Dur.ng the Song, the level of ur.anization was high, also by inter.ational standar.s—the capital cities of the Song wer. pr.bably the lar.est cities in the wor.d. This r.mained so until the late Ming, but dur.ng the Qing ther. was a downwar. tr.nd in the level of ur.anization fr.m 11%–12% to 7% in the late 18th centur., a level at which it r.mained until the ear.y 1900s. In our.paper.we analyse the r.le that socio–political and economic causes played in this decline, such as the changing char.cter.of the Chinese state, the limited impact of over.eas tr.de on the ur.an system, and the appar.nt absence of the dynamic economic effects that wer. char.cter.stic for.the Eur.pean ur.an system.

关键词： China ur.anization Song dynasty Ming dynasty Qing dynasty cities commer.ialization

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Changes in the quality of r.ver.water.befor.,dur.ng and after.a major.flood event associated with a La Nina cycle and tr.atment for.dr.nking pur.oses

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Jour.al of Envir.nmental Sciences 2014年第10期26卷 1985-1993页

作者： Mohamad Far.d Mur.hed Zeeshan Aslam r.smala Lewis Chr.stopher.Chow Dongsheng Wang Mar. Dr.kas John van leeuwen Centr. for.Water.Management and r.use Natural and Built Environments University of South Australia Austr.lian Water.Quality Centr. South Australian Water Corporation State Key Labor.tor. for.Envir.nmental Aquatic Chemistr. Research Centre for Eco-Environmental Sciences Bar.ar. Har.y Institute Natural and Built EnvironmentsUniversity of South Australia

The tr.atment of or.anics pr.sent in the lower.r.aches of a major.r.ver.system（the Mur.ay–Dar.ing Basin, Austr.lia） befor.（Mar.h–July 2010）, dur.ng（December.2010–May 2011） and after.Apr.l–December.2012） a major.flood per.od was investigated. The flood per.od（over.6 months）occur.ed dur.ng an intense La Nia cycle, leading to r.pid and high incr.ases in r.ver.flows and or.anic loads in the r.ver.water. Dissolved or.anic car.on（DOC） incr.ased（2–3 times） to high concentr.tions（up to 16 mg/L） and was found to cor.elate with r.ver.flow r.tes. The tr.atability of or.anics was studied using conventional jar.tests with alum and an enhanced coagulation model（mEnCo）. Pr.dicted mean alum dose r.tes（per.mg DOC） wer. higher.befor.（9.1 mg alum/mg DOC） and after.8.5 mg alum/mg DOC） than dur.ng the flood event（8.0 mg alum/mg DOC）,indicating differ.nces in the char.cter.of the or.anics in r.w water.. To assess the char.cter.of natur.l or.anic matter.pr.sent in r.w and tr.ated water., high per.or.ance size exclusion chr.matogr.phy with UV and fluor.scence detector. wer. used. Dur.ng the flood per.od, high molecular.weight UV absor.ing compounds（〉2 kDa） wer. mostly detected in water. collected,but wer. not evident in water. collected befor. and after.ar.s. The r.lative abundances of humic-like and pr.tein-like compounds dur.ng and following the flood per.od wer. also investigated and found to be of a higher.molecular.weight dur.ng the flood per.od. The tr.atability of the or.anics was found to var. over.the thr.e climate conditions investigated.

关键词： Alum Coagulation Flood mEnCo pr.diction dose(EnCD) La Ni?a

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