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主动脉弓僵硬与高血压患者早期脑损伤相关

中华高血压杂志 2016年第10期24卷 998-998页

作者： Sala M van den Berg-Huysmans A van der grond j Huis man M Brandts A Westenberg jj de Roos A 陈云叶鹏

已证明在高血压患者中可以检测到脑组织微结构损伤，但是潜在的机制还没有被完全了解。该研究旨在无脑血管病临床表现的高血压患者中探讨扩散张量成像（diffusion tensor imaging，DTI）测量的脑损伤和主动脉弓脉搏波传导速度（pulse wa... 详细信息

已证明在高血压患者中可以检测到脑组织微结构损伤，但是潜在的机制还没有被完全了解。该研究旨在无脑血管病临床表现的高血压患者中探讨扩散张量成像（diffusion tensor imaging，DTI）测量的脑损伤和主动脉弓脉搏波传导速度（pulse wave velocity，PwV）的关系。

关键词：高血压患者早期脑损伤主动脉弓脉搏波传导速度僵硬扩散张量成像结构损伤临床表现

无老年痴呆症的老年患者的认知功能与生存状况刘青(译),叶鹏(摘,审校)

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中华高血压杂志 2019年第7期27卷 614-614页

作者：刘青(译) 叶鹏(摘/审校) Rostamian S de Haan S van der grond j van Buchem MA Ford I jukema jW Sabayan B 不详

特定区域认知功能的损害与死亡风险的增加相关。该研究前瞻性地评估了无痴呆老年受试者执行功能和记忆与长期死亡率的关系。此外,研究者调查了结构性大脑异常在这种关联中的作用。研究者纳入了547名无痴呆受试者(平均年龄78岁,男性占56.... 详细信息

特定区域认知功能的损害与死亡风险的增加相关。该研究前瞻性地评估了无痴呆老年受试者执行功能和记忆与长期死亡率的关系。此外,研究者调查了结构性大脑异常在这种关联中的作用。研究者纳入了547名无痴呆受试者(平均年龄78岁,男性占56.5%),他们来自高危老人服用普伐他汀的前瞻性研究(the prospective study of pravastatin in the elderlyat ***)的磁共振成像亚组。

关键词：老年痴呆症认知功能老年患者 pravastatin 磁共振成像死亡风险执行功能大脑异常

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全脑血流量增高与脑白质损害减轻有关

世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 29-29页

作者： Bisschops R.H.C. van der Graaf Y. Mali W.P.Th.M. van der grond j. 李锐 Department of Radiology E01.132 University Medical Center Utrecht PO Box 85500 3508 GA Utrecht Netherlands Dr.

Background Low cerebral blood flow (CBF) has been associated with the presence of white matter lesions (WMLs). However, the power of these studies was insufficient (n = 20- 35) to determine whether flow is associated with WMLs. Purpose The aim of this study was to investigate whether total cerebral blood flow (tCBF) is associated with the severity of white matter lesions (WMLs) in a large patient sample. Subjects and methods 228 patients with clinical symptoms of cardiovascular disease had MRI of the brain, consisting of a T2- w FLAIR and a 2D phasecontrast flow measurement of the internal carotid arteries and the basilar artery. WMLs were graded according to prevalence and size of deep and periventricular WMLs. To determine the relation between tCBF and WMLs we used linear and logistic regression analysis adjusted for age, gender, intima media thickness and hypertension. Results We observed an inverse association between the tCBF and the total number of WMLs adjusted for age, gender, intima media thickness and hypertension [B = - 1,0 WML 95 % CI (- 2.0 to 0.0, p = 0.045) per 100 mL increase in tCBF]. The adjusted odds ratio for the presence of severe WMLs in patients with high tCBF ( > 675 mL/min) was 0.5 (95% CI 0.2- 1.0) compared with patients with normal tCBF. Conclusion In this study we found that high tCBF is associated with a decrease in presence and severity of WMLs.

关键词：全脑血流量脑白质基底动脉颈内动脉心血管疾病膜厚度样本量线性回归临床症状测量方法

Cost projections for microwave plasma CO production using renewable energy

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journal of Energy Chemistry 2022年第8期31卷 507-513,I0014页

作者： Remko j.Detz Bob van der Zwaan Netherlands Organisation for Applied Scientific Research(TNO) Amsterdam 1043 NTThe Netherlands Faculty of Science(HIMS and IAS) University of AmsterdamAmsterdam 1090 GDThe Netherlands School of Advanced International Studies(SAIS) Johns Hopkins UniversityBologna 40126Italy

Successful deployment of renewable fuel production requires substantial cost reduction along the entire value chain of the underlying manufacturing *** improve their performance,renewable fuel production technologies should follow a cost-reducing learning *** this article,we adopt recent evidence that learning-by-doing is directly influenced by the technology unit size and explore three scenarios for microwave plasma CO_(2)conversion in which the learning rate varies between 10%,15%,and 20%.Our projections reveal that the total investments required to deploy this CO_(2)conversion technology at an exajoule scale decline from 83 down to 23 billion euros under a 10%increase in the value of the learning *** CO_(2) production costs in 2050 amount to 247–346€(2019)/t CO_(2),in which the range is determined by the value of the learning *** under substantial learning until 2050 the levelized CO production cost is unlikely to become competitive with conventional natural gas-based CO_(2) production processes,except when a CO_(2)tax is applied of up to 150€(2019)/t CO_(2).To optimally exploit effects of learning-by-doing,we recommend developing several CO production technologies simultaneously with multiple unit sizes,so as to improve the chance of ultimately selecting the process with the highest learning rate.

关键词： CO_(2)utilization Synthetic fuels Renewable chemicals Learning curves Unit size

Two-fluid modeling of Geldart A particles in gas-fluidized beds

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Particuology 2008年第6期6卷 540-548页

作者： M.A. van der Hoef j.A.M. Kuipers Faculty of Science & Technology University of Twente

We have investigated the effect of cohesion and drag models on the bed hydrodynamics of Geldart A particles based on the two-fluid （TF） model. For a high gas velocity U0 = 0.03 m/s, we found a transition from the homogeneous fluidization to bubbling fluidization with an increase of the coefficient C1, which is used to account for the contribution of cohesion to the excess compressibility. Thus cohesion can play a role in the bed expansion of Geldart A particles. Apart from cohesion, we have also investigated the influence of the drag models. When using the Wen and Yu drag correlation with an exponent n = 4.65, we find an under-prediction of the bed expansion at low gas velocities （U0 = 0.009 m/s）. When using a larger exponent （n = 9.6）, as reported in experimental studies of gas-fluidization, a much better agreement with the experimental bed expansion is obtained. These findings suggest that at low gas velocity, a scale-down of the commonly used drag model is required. On the other hand, a scale-up of the commonly used drag model is necessary at high gas velocity （U0 = 0.2 and 0.06 m/s）. We therefore conclude that scaling the drag force represent only an ad hoc way of repairing the deficiencies of the TF model, and that a far more detailed study is required into the origin of the failure of the TF model for simulating fluidized beds of fine powders.

关键词： Gas-fluidized bed Geldart A particles Two-fluid model Cohesive force Drag correlation

Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue

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World journal of Gastroenterology 2017年第6期23卷 1018-1029页

作者： Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer jeroen van der grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de jong Department of Gastroenterology and Hepatology Leiden University Medical Center C.j.Gorter Center Leiden University Medical Center Department of Radiology Leiden University Medical Center Department of Medical Statistics Leiden University Medical Center Center for Inflammatory Bowel Diseases University of California Los Angeles Department of Gastroenterology and Hepatology University Medical Center Utrecht Department of Psychiatry Leiden University Medical Center Department of Rheumatology Leiden University Medical Center Department of Neuropsychology Leiden University Medical Center Department of Radiology Leiden University Medical CenterLeiden

To evaluate brain involvement in quiescent Crohn’s disease (CD) patients with fatigue using quantitative magnetic resonance imaging (MRI).METHODSMultiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue (defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study *** glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine (P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow (P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P 1-weighted analysis. In addition, no correlation was found between mental status and MRI *** work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.

关键词： Magnetic resonance imaging Systemic inflammation Fatigue Crohn’s disease Cognition

A Space-Time Interior Penalty Discontinuous Galerkin Method for the Wave Equation

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Communications on Applied Mathematics and Computation 2022年第3期4卷 904-944页

作者： Poorvi Shukla j.j.W.van der Vegt Department of Applied Mathematics University of TwenteP.O.Box 2177500 AE EnschedeThe Netherlands

A new higher-order accurate space-time discontinuous Galerkin(DG)method using the interior penalty flux and discontinuous basis functions,both in space and in time,is pre-sented and fully analyzed for the second-order scalar wave *** attention is given to the definition of the numerical fluxes since they are crucial for the stability and accuracy of the space-time DG *** theoretical analysis shows that the DG discre-tization is stable and converges in a DG-norm on general unstructured and locally refined meshes,including local refinement in *** space-time interior penalty DG discre-tization does not have a CFL-type restriction for *** order of accuracy is obtained in the DG-norm if the mesh size h and the time stepΔt satisfy h≅CΔt,with C a positive *** optimal order of accuracy of the space-time DG discretization in the DG-norm is confirmed by calculations on several model *** calculations also show that for pth-order tensor product basis functions the convergence rate in the L∞and L2-norms is order p+1 for polynomial orders p=1 and p=3 and order p for polynomial order p=2.

关键词： Wave equation Space-time methods Discontinuous Galerkin methods Interior penalty method A priori error analysis

Evolving management of colorectal cancer

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World journal of Gastroenterology 2008年第25期14卷 3956-3967页

作者： jochem van der Voort van Zijp Harald j Hoekstra Marc D Basson Department of Radiation Oncology Leiden University Medical Center Department of Surgery University of Groningen Medical Center john D. Dingell VA Medical Center and Wayne State University

This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ("outside in integrin signaling") is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future.

关键词： Adhesion Colorectal Signaling Cancer Surgery

The impact of prehospital blood sampling on the emergency department process of patients with chest pain:a pragmatic non-randomized controlled trial

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World journal of Emergency Medicine 2023年第4期14卷 257-264页

作者： johan L.van Nieuwkerk M.Christien van der Linden Rolf j.Verheul Merel van Loon-van Gaalen Marije janmaat Naomi van der Linden Emergency Department Haaglanden Medical Centre&Emergency Medical Services Haaglandenthe Hague 2501 CBthe Netherlands Research and Development Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Laboratory Services Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Emergency Department Haaglanden Medical Centrethe Hague 2501 CKthe Netherlands Faculty of Health University of Applied Sciences LeidenLeiden 2300 AJthe Netherlands Faculty of Technology Policy and ManagementDelft University of TechnologyDelft 2628 BXthe Netherlands

BACKGROUND:In patients with chest pain who arrive at the emergency department(ED)by ambulance,venous access is frequently established prehospital,and could be utilized to sample *** blood sampling may save time in the diagnostic *** this study,the association of prehospital blood draw with blood sample arrival times,troponin turnaround times,and ED length of stay(LOS),number of blood sample mix-ups and blood sample quality were ***:The study was conducted from October 1,2019 to February 29,*** patients who were transported to the ED with acute chest pain with low suspicion for acute coronary syndrome(ACS),outcomes were compared between cases,in whom prehospital blood draw was performed,and controls,in whom blood was drawn at the *** analyses were used to assess the association of prehospital blood draw with the time ***:Prehospital blood draw was performed in 100 *** 406 patients,blood draw was performed at the *** blood draw was independently associated with shorter blood sample arrival times,shorter troponin turnaround times and decreased LOS(P0.05).CONCLUSION:For patients with acute chest pain with low suspicion for ACS,prehospital blood sampling is associated with shorter time intervals,while there were no significant differences between the two groups in the validity of the blood samples.

关键词： Blood specimen collection Crowding Emergency medical services Troponin