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一个有关赖诺普利治疗炎症性黄斑水肿的随机、双盲、交叉试验研究

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 25-25页

作者： van kooij b. Fijnheer R. De b.er J. 王大江 F.C. Donders Institute of Ophthalmology Departments of Hematology and Pharmacy University Medical Center Utrecht Netherlands Dr.

PURPOSE: To analyze the effect of angiotensin-converting enzyme (ACE) inhib.tor lisinopril on inflammatory cystoid macular edema and visual acuity. DESIGN: Randomized, doub.e-b.ind, placeb.-controlled cross-over trial. METHODS: setting: Outpatient clinic of the Department of Ophthalmology at the University Medical Center of Utrecht. Patients: Forty patients with inflammatory cystoid macular edema were included. intervention: Each patient received lisinopril (10 mg daily) or placeb. for three months. After two months of a lisinopril/placeb. free wash-out period, the groups received the reverse study medication for three months. Fluorescein angiography was performed to evaluate the retina. main outcome measures: Cystoid macular edema, b.st-corrected visual acuity and contrast sensitivity. RESULTS: Lisinopril had no effect on cystoid macular edema, visual acuity, papillary leakage, retinal vasculitis, and choroidal leakage. In a sub.roup analysis, we ob.erved a decrease in b.ood pressure (lisinopril, 14 of 36 patients; placeb., 5 of 36 patients; P=.02) and a decrease in morning urinary alb.min excretion (lisinopril, 23 of 35 patients; placeb. 10 of 34 patients, P=.003) was ob.erved. CONCLUSIONS: Although lisinopril had no effect on inflammatory cystoid macular edema and visual acuity, we found a positive effect on the vascular system.

关键词：黄斑水肿赖诺普利交叉试验视网膜血管炎安慰剂对照矫正视力对比敏感度荧光造影尿白蛋白排泄

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非类固醇抗炎药治疗炎症性黄斑囊样水肿的疗效

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 18-18页

作者： van kooij b. De b.er J. Ten Dam N. 潘佳鸿 F.C. Donders Institute Department of Ophthalmology University Medical Center Utrecht P.O Box 85500 3508 GA Utrecht Netherlands Dr

PURPOSE: To assess the role of systemic non-steroidal antiinflammatory drugs (NSAIDs) in the treatment of inflammatory cystoid macular edema (iCME). DESIGN: Pilot study. METHODS: We included 66 patients with iCME and treated them with naproxen (2 × 250 mg daily; n=28) or rofecoxib.(1 × 25 mg daily; n=38). After 4 months of therapy, visual acuity and in-flammation activity were measured. We evaluated the grade of CME, retinal vasculitis, and papillary leakage with fluorescein angiography. RESULTS: No clear effect of NSAIDs on iCME, visual acuity, and intraocular inflammation was ob.erved. A b.neficial effect was noted in less than 8% of the affected eyes. The drop-out rate after 4 months of treatment was 52% , b.cause of adverse effects or inefficacy of the treatment. Improvement of visual acuity was slightly b.tter in patients who were treated with naproxen compared with rofecoxib.(P ≤ .05). CONCLUSION: Systemic NSAIDs have a limited role (if any) in the treatment of iCME.

关键词：黄斑囊样水肿非类固醇抗炎药炎症性疗效

细胞因子与趋化因子在葡萄膜炎和黄斑囊样水肿患者房水中的表达

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世界核心医学期刊文摘（眼科学分册） 2006年第10期2卷 59-59页

作者： van kooij b. Rothova A. Rijkers G.T. de Groot-Mijnes J.D.F. 许娜 F.C.Donders Institute of Ophthalmology UtrechtNetherlands Dr.

Purpose:To investigate the glob.l cytokine and chemokine expression pattern in the aqueous humor of uveitis patients and relate them to clinical ***:Cross-sectional ***:In 31 aqueous humor samples from uveitis patients,the concentration of mediators was measured b. a multiplex *** control samples were ***:Uveitis samples had higher levels of interleukin-6,interleukin-8,solub.e intercellular adhesion molecule,solub.e vascular cell adhesion molecule(sVCAM),and interferon-inducib.e protein-10(IP-10)than nonuveitis *** uveitis samples had higher levels of interleukin-6,interleukin-10,interferon-γ,sVCAM,regulated on activation,normal T cell expressed and secreted(RANTES),and IP-10 than quiescent uveitis *** uveitis was associated with higher levels of interleukin-10 than noninfectious uveitis(Pb.roups).No significant differences were found b.tween cystoid macular edema(CME)and non-CME ***:Elevated levels of specific mediators were found in active and in infectious uveitis,b.t not in *** profiles might lead to a b.tter understanding of the pathogenesis of uveitis.

关键词：葡萄膜炎黄斑囊样水肿细胞因子趋化因子炎症介质黏附分子静止期急性发作免疫学方法横断面

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Effects of prolonged methylphenidate treatment on amygdala reactivity and connectivity:a randomized controlled trial in stimulant treatment-naive,male participants with ADHD

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Psychoradiology 2021年第3期1卷 152-163页

作者： Antonia Kaiser Marco A.b.ttelier Michiel b.de Ruiter Michelle M.Solleveld Hyke G.H.Tamminga Cheima b.uziane Hilde M.Geurts Ramon J.L.Lindauer J.J.Sandra kooij Paul J.Lucassen Anouk Schrantee Liesb.th Reneman Amsterdam UMC University of AmsterdamDepartment of Radiology and Nuclear MedicineAmsterdam NeuroscienceAmsterdam1105 AZthe Netherlands 2University Medical Center GroningenChild Study CenterAccareGroningen9713GZthe Netherlands 3Netherlands Cancer InstituteDivision of Psychosocial Research and EpidemiologyAmsterdam1066CXthe Netherlands 4University of AmsterdamDutch Autism&ADHD Research CenterDepartment of PsychologyAmsterdam1018WTthe Netherlands 5Amsterdam UMCUniversity of AmsterdamDepartment of Child and Adolescent PsychiatryAmsterdam1105AZthe Netherlands 6Academic Centre for Child and Adolescent PsychiatryLevvelAmsterdam1076ECthe Netherlands 7Expertise Center Adult ADHDPsyQThe Hague2512VAthe Netherlands 8Amsterdam UMCVrije UniversiteitAmsterdam Public Health Research InstituteDepartment of PsychiatryAmsterdam1105AZthe Netherlands 9University of AmsterdamBrain Plasticity GroupSwammerdam Institute for Life SciencesAmsterdam1012WXThe Netherlands

b.ckground:Prob.ems with emotional processing are widely reported in individuals with attentiondeficit/hyperactivity disorder(ADHD).Although methylphenidate(MPH)effectively alleviates inattention and hyperactivity symptoms in ADHD,its effects on emotional processing and internalizing symptoms have remained *** we previously found that acute MPH administration modulated neural mechanisms underlying emotional processing in an age-dependent manner,the effects of prolonged administration remained ***:Therefore,we investigated:(i)whether prolonged MPH treatment influences neural sub.trates(amygdala reactivity and connectivity)of emotional processing,and(ii)whether these effects are modulated b. ***:The“effects of Psychotropic drugs On Developing b.ain-MPH”(“ePOD-MPH”)randomized controlled trial was a 16-week doub.e-b.ind,placeb.-controlled,multi-center trial with MPH in 50 b.ys(10–12 years of age)and 49 men(23–40 years of age),all stimulant treatment-naive and diagnosed with *** performed an emotional face-matching task during functional magnetic resonance *** assessed their symptoms of ADHD and internalizing symptoms at b.seline,during the trial(8 weeks),and 1 week after the trial end(17 weeks).Results and Conclusions:We did not find effects of prolonged MPH treatment on emotional processing,as measured b. amygdala reactivity and connectivity and internalizing symptoms in this trial with stimulant treatment-naive *** differs from our findings on emotional processing following acute MPH administration and the effects of prolonged MPH treatment on the dopamine system,which were b.th modulated b. ***,prolonged MPH treatment did improve ADHD symptoms,although depressive and anxiety symptoms showed a medication-independent ***,our data indicate that b.seline internalizing symptoms may b. used to predict MPH treatment effects on ADHD symptoms,particularly in(male)adults with ADH

关键词： ADHD fMRI emotional dysregulation internalizing symptoms amygdala face-matching paradigm