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Gene expression,transcription factor binding and histone modification predict leaf adaxial-abaxial polarity related genes

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Horticultural Plant Journal 2024年第4期10卷 971-982页

作者： Wei Sun Zhicheng Zhang Guusje Bonnema Xiaowu Wang Aalt Dirk Jan van dijk State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081China Sino-Dutch Joint Lab of Vegetable Genomics Beijing 100081China Bioinformatics Group Wageningen University and Research6708 PB Wageningenthe Netherlands Plant Breeding Wageningen University and Research6708 PB Wageningenthe Netherlands Biosystems Data Analysis Swammerdam Institute for Life SciencesUniversity of Amsterdam1090 GE Amsterdamthe Netherlands

Leaf adaxial-abaxial(ad-abaxial)polarity is crucial for leaf morphology and function,but the genetic machinery governing this process remains *** uncover critical genes involved in leaf ad-abaxial patterning,we applied a combination of in silico prediction using machine learning(ML)and experimental analysis.A Random Forest model was trained using genes known to influence ad-abaxial polarity as ground *** expression data from various tissues and conditions as well as promoter regulation data derived from transcription factor chromatin immunoprecipitation sequencing(ChIP-seq)was used as input,enabling the prediction of novel ad-abaxial polarity-related genes and additional transcription *** to this,available and newly-obtained transcriptome data enabled us to identify genes differentially expressed across leaf ad-abaxial *** on these analyses,we obtained a set of 111 novel genes which are involved in leaf ad-abaxial *** explore implications for vegetable crop breeding,we examined the conservation of expression patterns between Arabidopsis and Brassica rapa using single-cell *** results demonstrated the utility of our computational approach for predicting candidate genes in crop *** findings expand the understanding of the genetic networks governing leaf ad-abaxial differentiation in agriculturally important vegetables,enhancing comprehension of natural variation impacting leaf morphology and development,with demonstrable breeding applications.

关键词： Machine learning Leaf polarity Arabidopsis thaliana Brassica rapa Transcription factor

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Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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World Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja H W M Lemlijn-Slenter Karolina ap Wijnands Gijs van der Hamsvoort Luuk P van Iperen Nico Wolter Angelique E de Rijk Ad AM Masclee Department of Social Medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social Medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIHPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of PH in patients with chronic GI-HPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIHPB disorder attending the Outpatient Department of the Maastricht University Medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with McDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P value<0.05 was considered *** The GI-HPB patients scored significantly worse in all dimensions of PH compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-HPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of PH are impaired in the GI-HPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders Hepato-pancreatico-biliary disorders Integrated care

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患有先天性心脏疾病孕妇的前瞻性心血管风险以及后代风险模型的验证与评估

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中华高血压杂志 2014年第8期22卷 764-764页

作者：刘莉叶鹏 Balci A Sollie-Szarynska KM van der Bijl AG Ruys TP Mulder BJ Roos-Hesselink JW van dijk ap Wajon EM Vliegen HW Drenthen W Hillege HL Aarnoudse JG van Veldhuisen DJ Pieper PG

对于先天性心脏病（congenital heart disease,CHD）孕妇的咨询和管理来说,孕前作好其心血管和后代风险评估十分重要。该研究旨在确定CHD孕妇风险评估最佳策略。方法：研究人员纳入203例CHD女性患者,进行前瞻性研究,评估其中213次妊娠... 详细信息

对于先天性心脏病（congenital heart disease,CHD）孕妇的咨询和管理来说,孕前作好其心血管和后代风险评估十分重要。该研究旨在确定CHD孕妇风险评估最佳策略。方法：研究人员纳入203例CHD女性患者,进行前瞻性研究,评估其中213次妊娠的临床预后。计算各例妊娠的ZAHARAⅠ（Zwangerschap bij Aangeboren HARtAfwijkingenⅠ）和CARPREG（CARdiac disease in PREGnancy）风险评分,结合该研究和其他研究的评估方法,计算心血管（TPc）或后代风险预测（TPo）因子的数目。根据疾病复杂程度（disease complexity,DC）和调整后的WHO母亲心血管风险分类方法对妊娠进行分类。结果：22例妊娠母亲发生心血管事件（10.3%）,77次妊娠后有81例后代（37.3%）发生风险事件。

关键词：先天性心脏疾病心血管风险风险评估风险模型后代孕妇妊娠母亲先天性心脏病

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城市空间何以影响城市产业选择?——以荷兰埃因霍温的空间演变为例

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国际城市规划 2024年第3期39卷 137-144页

作者：陈悦特里·范戴克邵甬澳门科技大学人文艺术学院中国澳门荷兰格罗宁根大学空间科学学院城市规划系同济大学建筑与城市规划学院高密度人居环境生态与节能教育部重点实验室

城市空间是否可以主动地影响产业转型?本文从完整的历史演变视角考察城市空间与产业之间的互动关系,引入路径依赖方法来构建城市与产业互动演变的分析框架,并应用该框架对荷兰的工业城市埃因霍温展开实证研究,详细分析该城市在三个历史... 详细信息

城市空间是否可以主动地影响产业转型?本文从完整的历史演变视角考察城市空间与产业之间的互动关系,引入路径依赖方法来构建城市与产业互动演变的分析框架,并应用该框架对荷兰的工业城市埃因霍温展开实证研究,详细分析该城市在三个历史时期的三次成功的产业转型过程,尤其重点分析城市空间在产业转型中发挥的积极作用。通过研究发现:城市空间在每个关键节点都影响着城市的产业选择,且在不同时代以不同形式影响着产业选择。因此,对于面临产业转型的中国城市而言,应当冷静地审视自身的产业发展历史和固有的城市空间条件,或许可以从中发现适合本城市的产业转型方向。

关键词：产业转型城市空间城市演变路径依赖埃因霍温

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A Review of Self-healing Metals: Fundamentals, Design Principles and Performance

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Acta Metallurgica Sinica(English Letters) 2020年第9期33卷 1167-1179页

作者： Shasha Zhang Niels van dijk Sybrand van der Zwaag College of Materials and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of Materials Preparation and Protection for Harsh Environment(Nanjing University of Aeronautics and Astronautics) Ministry of Industry and Information TechnologyNanjing 211106China Fundamental Aspects of Materials and Energy Group Faculty of Applied SciencesDelft University of TechnologyMekelweg 152629 JB DelftThe Netherlands Novel Aerospace Materials Group Faculty of Aerospace EngineeringDelft University of TechnologyKluyverweg 12629 HS DelftThe Netherlands School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

Self-healing metals possess the capability to autonomously repair structural damage during service. While self-healing concepts remain challenging to be realized in metals and metallic systems due to the small atomic volume of the mobile atoms, the slow diffusion unless at high temperatures and the strong isotropic metallic bonds, the scientific interest has increased sharply and promising progress is obtained. This article provides a comprehensive and updated review on the developments and limitations associated with the various modes of potentially healable damage induced in metals and alloys, i.e., stressinduced damage, irradiation-induced damage in bulk materials and contact damage in corrosion protective coatings. The spontaneous intrinsic healing mechanisms not requiring external assistance other than the material operating at the right temperature and an assisted healing mechanism with external intervention are reviewed. Promising strategies to achieve self-healing in metals are identified. Finally, we give some prospects for future research directions in self-healing metals.

关键词： Metal Self-healing Creep behavior Fatigue damage Irradiation Coating

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The dorsal root ganglion as a target for neurorestoration in neuropathic pain

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Neural Regeneration Research 2024年第2期19卷 296-301页

作者： Guillermo Estivill-Torrús Ana Belen Martínez-Padilla Lourdes Sánchez-Salido Anne Baron-van Evercooren Beatriz García-Díaz Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma BIONAND) MálagaSpain Unidad Clínica de Neurociencias Hospital Regional Universitario de MálagaMálagaSpain Departamento de Biología Molecular y Bioquímica Universidad de MálagaSpain Sorbonne Université Institut du Cerveau-Paris Brain Institute-ICMINSERMCNRSAP-HPHôpital Pitié-SalpêtrièreParisFrance

Neuropathic pain is a severe and chronic condition widely found in the general *** reason for this is the extensive variety of damage or diseases that can spark this unpleasant constant feeling in *** the processing of pain,the dorsal root ganglia constitute an important region where dorsal root ganglion neurons play a crucial role in the transmission and propagation of sensory electrical ***,the dorsal root ganglia have recently exhibited a regenerative capacity that should not be neglected in the understanding of the development and resolution of neuropathic pain and in the elucidation of innovative ***,we will review the complex interplay between cells(satellite glial cells and inflammatory cells)and factors(cytokines,neurotrophic factors and genetic factors)that takes place within the dorsal root ganglia and accounts for the generation of the aberrant excitation of primary sensory neurons occurring in neuropathic *** importantly,we will summarize an updated view of the current pharmacologic and nonpharmacologic therapies targeting the dorsal root ganglia for the treatment of neuropathic pain.

关键词： cytokines dorsal root ganglia genetic factors neuropathic pain neurotrophic factors pharmacologic and nonpharmacologic therapies satellite glial cells sensory neurons

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吸力式基础设计（英文）

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Journal of Zhejiang University-Science A(applied Physics & Engineering) 2018年第8期19卷 579-599页

作者： Bas van dijk Fugro

目的:吸力式基础具有投资费用低、施工时间短、无噪音和可重复使用等优点,因此被广泛应用在海洋工程领域。本文针对吸力式基础设计中的关键问题,主要综述现有设计理论,指出理论缺陷,并给出设计建议。创新点:综述砂土、粘土和成层土中吸... 详细信息

目的:吸力式基础具有投资费用低、施工时间短、无噪音和可重复使用等优点,因此被广泛应用在海洋工程领域。本文针对吸力式基础设计中的关键问题,主要综述现有设计理论,指出理论缺陷,并给出设计建议。创新点:综述砂土、粘土和成层土中吸力式基础的安装、回收、基础承载力、基础沉降和服役性能中的关键科学问题和现有设计理论。方法:1.基于文献报道的现场试验和模型试验,针对吸力式基础安装过程中的沉贯阻力、临界吸力和土塞效应,评估现有设计理论的准确性;2.分析粘土和砂土中吸力式基础的完全排水、完全不排水和部分排水条件下静力和循环承载力计算理论;3.针对吸力式基础的长期服役性能,分析荷载引起的基础变形、固结沉降、循环再固结沉降和极端荷载下的"棘轮效应"。结论:1.现有的吸力式基础安装中沉贯阻力计算理论没有普适性;对于临界吸力的计算,由于没有考虑"土拱效应",理论计算值均低估了安装吸力。2.对于粘土中吸力式基础承载力的计算需要考虑循环作用下土体的强度弱化和基础-土间空隙引起的承载力降低,而砂土中基础承载力计算需要考虑排水条件的影响。3.对于吸力式基础的长期服役性能,特别是基础变形的计算,目前还缺少成熟的计算理论。

关键词：吸力式基础安装承载力变形

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Reliability Investigation of BiCGStab and IDR Solvers for the Advection-Diffusion-Reaction Equation

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Communications in Computational Physics 2022年第6期32卷 156-188页

作者： Chris Schoutrop Jan ten Thije Boonkkamp Jan van dijk Department of applied Physics Eindhoven University of TechnologyThe Netherlands Department of Mathematics and Computer Science Eindhoven University of TechnologyThe Netherlands

The reliability of BiCGStab and IDR solvers for the exponential scheme discretization of the advection-diffusion-reaction equation is *** resulting discretization matrices have real *** consider BiCGStab,IDR(S),BiCGStab(L)and various modifications of BiCGStab,where S denotes the dimension of the shadow space and L the degree of the polynomial used in the polynomial *** implementations of BiCGStab exist which are equivalent in exact arithmetic,however,not in finite precision *** modifications of BiCGStab we consider are;choosing a random shadow vector,a reliable updating scheme,and storing the best intermediate *** is shown that the Local Minimal Residual algorithm,a method similar to the“minimize residual”step of BiCGStab,can be interpreted in terms of a time-dependent advection-diffusion-reaction equation with homogeneous Dirichlet boundary conditions for the residual,which plays a key role in the convergence *** to the real eigenvalues,the benefit of BiCGStab(L)compared to BiCGStab is shown to be modest in numerical ***-sparse(*** random)shadow residual turns out to be essential for the reliability of *** reliable updating scheme ensures the required tolerance is truly *** the best intermediate solution has no significant *** is to modify BiCGStab with a random shadow residual and the reliable updating scheme,especially in the regime of large P´eclet and small Damk¨ohler *** alternative option is IDR(S),which outperforms BiCGStab for problems with strong advection in terms of the number of matrix-vector *** MATLAB code used in the numerical experiments is available on GitLab:https://***/ChrisSchoutrop/krylov-adr,a C++implementation of IDR(S)is available in the Eigen linear algebra library:http://***.

关键词： BiCGStab IDR shadow residual advection-diffusion-reaction equation

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Large-scale transportation and storage of wood pellets:Investigation of the change in physical properties

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Particuology 2021年第4期19卷 146-156页

作者： Hamid Gilvari Coen H.H.van Battum Simon A.van dijk Wiebren de Jong Dingena L.Schott Section of Transport Engineering and Logistics Department of Maritime and Transport TechnologyFaculty of MechanicalMaritime and Materials EngineeringDelft University of TechnologyThe Netherlands Chemical Services Uniper Benelux NVThe Netherlands Section of Large Scale Energy Storage Department of Process&EnergyFaculty of MechanicalMaritime and Materials EngineeringDelft University of TechnologyThe Netherlands

The change in physical properties of wood pellets,with a focus on particle size distributions due to pellet breakage and attrition,was studied in a large-scale(∼450 ton/h)transportation *** locations with a high probability of breakage through the whole transportation system were chosen and sampled to study the effect of transportation system design and operation on the mechanical properties of *** density,mechanical durability,moisture content,and particle size distribution of pellets were characterized for each *** of variance showed that there were significant differences between the percentages of small particles(<5.6 mm)in the samples taken at different locations,especially at one with a vertical free fall of 7.8 *** average,this relatively long drop increased the proportion of particles<5.6 mm in the samples from 8.73%to 14.09%,and that of particles<3.15 mm from 4.82%to 9.01%.Moreover,the measurements showed a wide deviation in the mechanical durability values,between a minimum of 90.8%and a maximum of 98.7%,which were not correlated to the sampling points but related to pellet *** can be concluded that pellet transportation systems require more dedicated design strategies to prevent breakage and attrition.

关键词： Wood pellets Large-scale transportation Durability Fines and dust Breakage Mechanical degradation

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The Quality Improvement of Stony Construction and Demolition Waste (CDW)

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Journal of Wuhan University of Technology(Materials Science) 2004年第3期19卷 78-80,85页

作者：邢伟宏 Alex Fraaij Hans Pietersen Peter Rem Koen van dijk Delft University of Technology(Netherlands)

Worldwide construction and demolition waste (CDW) is currently dumped. To close the building cycle and the building materials cycle by recycling CDW in high technical applications, the technical quality of stony materials must be improved. For this purpose, concrete rubbles and brick rubbles, the two major stony constituents of CDW, should be separated from each other. Based on the differences in density and content of Fe-2O-3 between the two materials, a wet method of jigging and a dry method of magnetic separation are effective,tested.

关键词： CDW concrete rubble masonry rubble upgradin separation technique

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