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Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening

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World Journal of Gastroenterology 2007年第2期13卷 192-218页

作者： Ekaterina I Galanzha valery v Tuchin vladimir P Zharov Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States

Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed.

关键词： Lymph microcirculation Transmission digital microscopy Rat mesentery Flow cytometry Photothermal technique

Shedding light on biology and healthcare--preface to the special issue on Biomedical Optics

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Light(Science & Applications) 2022年第7期11卷 1315-1317页

作者： Peng Xi Xunbin Wei Junle Qu valery v.Tuchin Department of Biomedical Engineering College of Future TechnologyPeking University100871BeijingChina Department of Biomedical Engineering Peking University100081BeijingChina Center for Biomedical Optics and Photonics(CBOP)&College of Physics and Optoelectronic Engineering Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of EducationShenzhen University518060ShenzhenChina Saratov State University 83 Astrakhanskaya str.Saratov410012Russia

During the past decade,there has been an explosion in the development of novel optical techniques in biomedical research and clinical *** progress has been made in optical imaging and detection to provide necessary biological information for disease diagnosis and in-depth understanding of biological ***,recent advances integrating laser technology with biomarkers have enabled novel diagnostic and treatment approaches for different types of diseases.

关键词： optical integrating diagnosis

INTRODUCTION:SPECIAL ISSUE ON ADvANCES IN BIOPHOTONICS AND BIOMEDICAL OPTICS-PART I

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 16-17页

作者： Dan Zhu valery v.Tuchin Qingming Luo Huazhong University of Science and Technology WuhanP.R.China Saratov State University SaratovRussia

The 5th Russian-Chinese Workshop on Biophotonics and Biomedical Optics was hosted in Saratov,Russia on 26-28,September,*** bilateral Workshop brought together both Russian and Chinese scientists,engineers and clinical researchers from a variety of disciplines engaged in applying optical science,photonics and imaging technologies to problems in biology and *** the W orkshop,2 plenary lectures,11 invited presentations,4 oral presentations and 13 poster reports were presented.A special Internet session with 5 presentations-1 plenary,2 invited,and 2 posters was also *** special issue selects some papers from the attendees,and is made up of 12 original research articles and one *** articles will be presented in vol.6 No.1 of JIOHS,while the remaining five articles will be presented in vol.6 No.2.

关键词： Russian photonics engineer

OPTICAL PROPERTIES OF SKIN,SUBCUTANEOUS,AND MUSCLE TISSUES:A REvIEW

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Journal of Innovative Optical Health Sciences 2011年第1期4卷 9-38页

作者： ALEXEY N.BASHKATOv ELINA A.GENINA valery v.TUCHIN Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410028Russia

The development of optical methods in modern medicine in the areas of diagnostics,therapy,and surgery has stimulated the investigation of optical properties of various biological tissues,since the efficacy of laser treatment depends on the photon propagation and fluence rate distribution within irradiated *** this work,an overview of published absorption and scattering properties of skin and subcutaneous tissues measured in wide wavelength range is *** principles of measurements of the tissue optical properties and techniques used for processing of the measured data are outlined.

关键词： Absorption coefficient scattering coefficient anisotropy factor reduced scattering coefficient refractive index

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FOREWORD

Journal of Innovative Optical Health Sciences 2009年第1期2卷 I0001-I0002页

作者： Elina A.Genina Kirill v.Larin valery v.Tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Department of Biomedical Engineering University of Houston Houston USA Research-Educational Institute of Optics and Biophotonics Saratov State University Institute of Precise Mechanics and Control RAS Saratov Russia

Special Issue Optical Technologies in the Study of Tissues and Biological Fluids We are pleased to present this special issue of JIOHS,which focuses on optical technologies in the study of tissues and biological *** selected papers were presented during Saratov Fall Meeting—XII International School for Junior Scientists and Students on Optics,Laser Physics and Biophotonics(September 23–26,2008,Saratov,Russia)in the framework of the following workshops:“Optical Technologies in Biophysics and Medicine,”“Nanostructures and Nanoparticles,”“Microscopic and Low-Coherence Methods in Biomedical Applications,”and“Internet Biophotonics.”All eight papers in this special issue are research papers.

关键词： Junior photonics Russia

Foreword to the Special Issue on Optical Technologies in Biophysics and Medicine

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 1-2页

作者： Elina A.Genina Dan Zhu valery v.Tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University SaratovRussia Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology(HUST)Wuhan P.R.China Research-Educational Institute of Optics and Biophotonics Saratov State University Institute of Precise Mechanics and Control RAS Saratov Russia

We are pleased to present the third issue of JIOHS,which focuses on optical technologies of diagnosticsand therapy,These are selected papers presented during Saratov Fall Meeting,1t International Sym-posium on Optics and Biophotonics(September 24-28,2013,Saratov,Russia)in the framework of the Workshops:"Optical Technologies in Biophysics_and Medicine,"Nanobiophotonics,"and"Internet Biophotonics."

关键词： Biophys ics photonics

Evolution of metabolic scaling among the tetrapod:effect of phylogeny,the geologic time of class formation,and uniformity of species within a class

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Integrative Zoology 2022年第5期17卷 904-917页

作者： valery M.GAvRILOv Tatiana B.GOLUBEvA Andrey v.BUSHUEv Department of vertebrate Zoology M.V.Lomonosov Moscow State UniversityMoscowRussia Zvenigorod Biological Station M.V.Lomonosov Moscow State UniversityMoscowRussia

The metabolic scaling in the animal has been discussed for over 90 years,but no consensus has been *** analysis of 2126 species of vertebrates reveals a signiﬁcant allometric exponent *** show that classes of terrestrial vertebrates exhibit the evolution of metabolic *** the allometric coefﬁcient“a”and the allometric exponent“b”change naturally,but differently depending on the geological time of group *** allometric coefﬁcient“a”shows the measure of the evolutionary development of systems that forms resting metabolism in *** classes,such as birds and mammals,have a metabolic rate that is in an order of magnitude higher than that in ectothermic classes,including amphibians and *** the terrestrial vertebrate phylogeny,weﬁnd that the metabolic scaling is characterized by 3 main allometric exponent values:b=3/4(mammals),b>3/4(ectotherms,such as amphibians and reptiles),and bvolution of *** scaling factor decreases depending on both the external design and the size(birds vs mammals)of the *** metabolic rate and uniformity of species within a class increase as the geological start date of for-mation of the class approaches the present *** higher the mass-speciﬁc standard metabolic rate in the class,the slower metabolic rate grows with increasing body size in this *** results lay the groundwork for further exploration of the evolutionary and ecological aspects of the development of metabolic scaling in animals.

关键词： geological time metabolic rate scaling

ASSESSMENT OF TISSUE OPTICAL CLEARING AS A FUNCTION OF GLUCOSE CONCENTRATION USING OPTICAL COHERENCE TOMOGRAPHY

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Journal of Innovative Optical Health Sciences 2010年第3期3卷 169-176页

作者： NARENDRAN SUDHEENDRAN MOHAMED MOHAMED MOHAMAD G.GHOSN valery v.TUCHIN KIRILL v.LARIN Department of Electrical and Computer Engineering University of Houston N308 Engineering Building 1 HoustonTX 77204USA Department of Biomedical Engineering University of Houston 2028 SERC Building HoustonTX 77204USA Department of Medicine Baylor College of Medicine HoustonTX 77030USA Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410056 Russia

One of the major challenges in imaging biological tissues using optical techniques,such as optical coherence tomography(OCT),is the lack of light penetration due to highly turbid structures within the *** clearing techniques enable the biological samples to be more optically homogeneous,allowing for deeper penetration of light into the *** study investigates the effect of optical clearing utilizing various concentrations of glucose solution(10%,30%,and 50%)on porcine skin.A gold-plated mirror was imaged beneath the tissue and percentage clearing was determined by monitoring the change in reflected light intensity from the mirror over *** ratio of percentage clearing per tissue thickness for 10%,30% and 50% glucose was determined to be 4.7±1.6%mm^(−1)(n=6),10.6±2.0%mm^(−1)(n=7)and 21.8±2.2%mm^(−1)(n=5),*** was concluded that while higher glucose concentration has the highest optical clearing effect,a suitable concentration should be chosen for the purpose of clearing,considering the osmotic stress on the tissue sample.

关键词： Glucose porcine skin percent clearing scattering coefficient optical coherence tomography

Anomalous Laterally Stressed Kinetically Trapped DNA Surface Conformations

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Nano-Micro Letters 2021年第8期13卷 263-280页

作者： valery v.Prokhorov Nikolay A.Barinov Kirill A.Prusakov Evgeniy v.Dubrovin Maxim D.Frank-Kamenetskii Dmitry v.Klinov Federal Research and Clinical Center of Physical-Chemical Medicine Malaya Pirogovskaya1aMoscow 119435Russian Federation A.N.Frumkin Institute of Physical Chemistry and Electrochemistry RASLeninsky prospect Moscow 199071 Russian Federation 3 Moscow Institute of Physics and TechnologyInstitutskiy per.9Dolgoprudny141700 MoscowRussian Federation Lomonosov Moscow State University Leninskie gory1-2Moscow 119991Russian Federation Department of Biomedical Engineering Boston University44 Cummington MallBoston MA02215USA

Up to now,the DNA molecule adsorbed on a surface was believed to always preserve its native *** belief implies a negligible contribution of lateral surface forces during and after DNA adsorption although their impact has never been ***-resolution atomic force microscopy was used to observe that stiff DNA molecules kinetically trapped on monomolecular films comprising one-dimensional periodically charged lamellar templates as a single layer or as a sublayer are oversaturated by sharp discontinuous kinks and can also be locally melted and *** argue that kink/anti-kink pairs are induced by an overcritical lateral bending stress(>30 pNnm)inevitable for the highly anisotropic 1D-1D electrostatic interaction of DNA and underlying rows of positive surface *** addition,the unexpected kink-inducing mechanical instability in the shape of the template-directed DNA confined between the positively charged lamellar sides is observed indicating the strong impact of *** previously reported anomalously low values of the persistence length of the surface-adsorbed DNA are explained by the impact of the surface-induced low-scale *** sites of the local melting and supercoiling are convincingly introduced as other lateral stress-induced structural DNA anomalies by establishing a link with DNA high-force *** results open up the study in the completely unexplored area of the principally anomalous kinetically trapped DNA surface conformations in which the DNA local mechanical response to the surface-induced spatially modulated lateral electrostatic stress is essentially *** underlying rich and complex in-plane nonlinear physics acts at the nanoscale beyond the scope of applicability of the worm-like chain approximation.

关键词： DNA surface conformations Kinetic trapping Lateral stress Periodically charged surface DNA kinks