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Negative Feedback Regulation of Auxin Signaling by ATHB8/ACL5-BUD2 Transcription Module

Molecular Plant 2014年第6期7卷 1006-1025页

作者： Simona Baima valentina forte Marco Possenti Andres Penalosa Guido Leoni Sergio Salvi Barbara Felici Ida Ruberti Giorgio Morelli Food and Nutrition Research Centre Agricultural Research Council Via Ardeatina 546 00178 Rome Italy Present address: Department of Physics Sapienza University of Rome Rle A Moro 5 00185 Rome Italy Present address: Soil-Plant System Studies Research Centre Agricultural Research Council Via della Navicella 2-4 00184 Rome Italy Institute of Biology Molecular Medicine and NanoBiotechnology National Research Council Rle A. Moro 5 00185 Rome Italy

The role of auxin as main regulator of vascular differentiation is well established, and a direct correlation between the rate of xylem differentiation and the amount of auxin reaching the （pro）cambial cells has been proposed. It has been suggested that thermospermine produced by ACAULIS5 （ACL5） and BUSHY AND DWARF2 （BUD2） is one of the factors downstream to auxin contributing to the regulation of this process in Arabidopsis. Here, we provide an in-depth characterization of the mechanism through which ACL5 modulates xylem differentiation. We show that an increased level of ACL5 slows down xylem differentiation by negatively affecting the expression of homeodomain-leucine zipper （HD- ZIP） III and key auxin signaling genes. This mechanism involves the positive regulation of thermospermine biosynthesis by the HD-ZIP III protein ARABIDOPSIS THALIANA HOMEOBOX8 tightly controlling the expression of ACL5 and BUD2. In addition, we show that the HD-ZIP III protein REVOLUTA contributes to the increased leaf vascularization and long hypocotyl phenotype of acl5 likely by a direct regulation of auxin signaling genes such as LIKE AUXIN RESISTANT2 （LAX2） and LAX3. We propose that proper formation and differentiation of xylem depend on a balance between positive and negative feedback loops operating through HD-ZIP III genes.

关键词： auxin procambium thermospermine autoregulation auxin influx transporters Arabidopsis.

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Biodegradability of bioplastics in different aquatic environments:A systematic review

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Journal of Environmental Sciences 2024年第8期142卷 169-181页

作者： Maria Cristina Lavagnolo valentina Poli Anna Maria Zampini valentina Grossule Department of Civil Environmental and Architectural Engineering-Laboratory of Environmental EngineeringUniversity of PadovaLungargine Rovetta 8Padova 35100Italy

Bioplastics were first introduced as environmentally friendly materials,with properties similar to those of conventional plastics.A bioplastic is defined as biodegradable if it can be decomposed into carbon dioxide under aerobic degradation,or methane and CO_(2)under anaerobic conditions,inorganic compounds,and new cellular biomass,by the action of naturally occurring *** definition however does not provide any information on the environmental conditions,timescale and extent at which decomposition processes should *** regard to the aquatic environment,recognized standards have been established to assess the ability of plastics to undergo biodegradation;however,these standards fail to provide clear targets to be met to allow labelling of a bioplastic as ***,these standards grant the user an extensive leeway in the choice of process *** these reasons,the comparison of results deriving from different studies is *** authors analysed and discussed the degree of biodegradability of a series of biodegradable bioplastics in aquatic environments(both fresh and salt water)using the results obtained in the laboratory and from on-site testing in the context of different research *** Oxygen Demand(BOD),CO_(2)evolution,surface erosion and weight loss were the main parameters used by researchers to describe the percentage of *** results showed a large variability both in weight loss and BOD,even when evaluating the same type of *** confirms the need for a reference range of values to be established with regard to parameters applied in defining the biodegradability of bioplastics.

关键词： Biodegradation Bioplastic Plastic Natural environment Plastic waste

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Physical exercise and traumatic brain injury: is it question of time?

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Neural Regeneration Research 2024年第3期19卷 475-476页

作者： valentina Mastrorilli Stefano Farioli Vecchioli Institute of Biochemistry and Cell Biology Institute of Biochemistry and Cell BiologyNational Research Council(IBBC/CNR)MonterotondoRomeItaly Plaisant S.R.L. RomeItaly

Is it better to be safe than sorry?This Hamletic dilemma has always stimulated medical-scientific debates in numerous fields of *** among these,the preventive-therapeutic approach to the treatment of brain trauma is one of the most striking *** brain injury(TBI)is a leading cause of brain damage among young and elderly populations with a very high hospitalization and death *** is characterized by two pathologically distinct but strictly consequential phases:a first characterized by an immediate and highly variable mechanical dysfunction of the brain tissue,which involves widespread cell death and tissue degeneration,followed by a second phase which can last from days to even years depending on the severity of the TBI and the patient’s pre-existing health *** processes,including inflammatory phenomena,oxidative stress associated with metabolic,vascular,and neuro-modulatory deficits,are very often responsible for neuro-motor and psychological deficits leading to long-term disabilities(Kaur and Sharma,2018).

关键词： injury striking modulator

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A Statistical Study of Magnetic Flux Emergence in Solar Active Regions Prior to Strongest Flares

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Research in Astronomy and Astrophysics 2024年第4期24卷 147-160页

作者： Alexander S.Kutsenko valentina I.Abramenko Andrei A.Plotnikov Crimean Astrophysical Observatory p/o NauchnyCrimea298409Russia

Using the data on magnetic field maps and continuum intensity for Solar Cycles 23 and 24,we explored 100 active regions(ARs)that produced M5.0 or stronger *** focus on the presence/absence of the emergence of magnetic flux in these ARs 2-3 days before the strong flare *** found that 29 ARs in the sample emerged monotonically amidst quiet-Sun.A major emergence of a new magnetic flux within a pre-existing AR yielding the formation of a complex flare-productive configuration was observed in another 24 *** 30 ARs,an insignificant(in terms of the total magnetic flux of pre-existing AR)emergence of a new magnetic flux within the pre-existing magnetic configuration was observed;for some of them the emergence resulted in a formation of a configuration with a small δ-sunspot;11 out of 100 ARs exhibited no signatures of magnetic flux emergence during the entire interval of *** six cases the emergence was in progress when the AR appeared on the Eastern limb,so that the classification and timing of emergence were not *** conclude that the recent flux emergence is not a necessary and/or sufficient condition for strong flaring of an *** flux emergence rate of flare-productive ARs analyzed here was compared with that of flare-quiet ARs analyzed in our previous *** revealed that the flare-productive ARs tend to display faster emergence than the flare-quiet ones do.

关键词： Sun:activity Sun:flares Sun:magnetic fields

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Age and geochemical evolution of granite magmatism in Olkhon region from Caledonian syncollisional ore-free granite to the rare metal granite and pegmatite of Middle Paleozoic intraplate setting

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China Geology 2024年第1期7卷 63-79页

作者： Viktor Antipin valentina Makrygina Larisa Kushch Nataliya Sheptyakova Vinogradov Institute of Geochemistry SB RAS664033 IrkutskRussia

The detailed description of two granite complexes in the Olkhon subterrane is *** Early Paleozoic Sharanur complex was formed by granitization of gneisses of the Olkhon *** includes migmatites,granite-gneisses,granites and pegmatites of normal alkalinity;they belong to the type of syncollisional *** Middle Paleozoic Aya granite complex includes mother Aya massif of amazonite-bearing granites and several types of rare-metal *** have elevated alkalinity,low of Ba,Sr,and high LILE and HFSE elements *** Aya pegmatites lie in northwest cracks of stretching and associated with the rise of the territory under the influence of the North Asian *** cracks and pegmatites mark the beginning of a new intraplate geodynamic *** geochemical types are distinguished among the pegmatites of this *** are amazonite pegmatites of Li-F type with Ta mineralization and complex type pegmatite with Be-Rb-Nb-Ta and Li-F mineralization(the Ilixin vein).The Tashkiney pegmatite vein is similar to Ilixin,but lies in the gneisses of the Olkhon *** shows high concentrations of Be,Nb,Ta,as well as W,Sn,but lacks Li and F,due to a greater depth and higher temperature of the melt crystallization of this pegmatite.

关键词： Pegmatite Geochemistry Submantle plume Magmatism Caledonian collision Middle Paleozoic intraplate setting Be-Rb-Nb-Ta-Li-F mineralization Olkhon region Russia

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Current status of magnetic resonance imaging radiomics in hepatocellular carcinoma:A quantitative review with Radiomics Quality Score

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World Journal of Gastroenterology 2024年第4期30卷 381-417页

作者： valentina Brancato Marco Cerrone Nunzia Garbino Marco Salvatore Carlo Cavaliere Department of Information Technology IRCCS SYNLAB SDNNaples 80143Italy Department of Radiology IRCCS SYNLAB SDNNaples 80143Italy

BACKGROUND Radiomics is a promising tool that may increase the value of magnetic resonance imaging(MRI)for different tasks related to the management of patients with hepatocellular carcinoma(HCC).However,its implementation in clinical practice is still far,with many issues related to the methodological quality of radiomic *** To systematically review the current status of MRI radiomic studies concerning HCC using the Radiomics Quality Score(RQS).METHODS A systematic literature search of PubMed,Google Scholar,and Web of Science databases was performed to identify original articles focusing on the use of MRI radiomics for HCC management published between 2017 and *** methodological quality of radiomic studies was assessed using the RQS ***’s correlation(ρ)analysis was performed to explore if RQS was correlated with journal metrics and characteristics of the *** level of statistical significance was set at P<*** One hundred and twenty-seven articles were included,of which 43 focused on HCC prognosis,39 on prediction of pathological findings,16 on prediction of the expression of molecular markers outcomes,18 had a diagnostic purpose,and 11 had multiple *** mean RQS was 8±6.22,and the corresponding percentage was 24.15%±15.25%(ranging from 0.0% to 58.33%).RQS was positively correlated with journal impact factor(IF;ρ=0.36,P=2.98×10^(-5)),5-years IF(ρ=0.33,P=1.56×10^(-4)),number of patients included in the study(ρ=0.51,P<9.37×10^(-10))and number of radiomics features extracted in the study(ρ=0.59,P<4.59×10^(-13)),and time of publication(ρ=-0.23,P<0.0072).CONCLUSION Although MRI radiomics in HCC represents a promising tool to develop adequate personalized treatment as a noninvasive approach in HCC patients,our study revealed that studies in this field still lack the quality required to allow its introduction into clinical practice.

关键词： Hepatocellular carcinoma Systematic review Magnetic resonance imaging Radiomics Radiomics quality score

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Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis

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Neural Regeneration Research 2024年第8期19卷 1768-1771页

作者： Federica Azzolini Ettore Dolcetti Antonio Bruno valentina Rovella Diego Centonze Fabio Buttari Unit of Neurology IRCCS NeuromedPozzilliItaly Department of System Medicine University of Tor VergataRomeItaly Synaptic Immunopathology Lab Department of Systems MedicineTor Vergata UniversityRomeItaly

In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying *** r,in recent years,several data from pre-clinical and clinical studies suggested a possible role of physical exe rcise as disease-modifying therapy in multiple *** evidence is sparse and often conflicting,and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully ***,mainly derived from pre-clinical studies,suggest that exe rcise could enhance longterm potentiation and thus neuroplasticity,could reduce neuroinflammation and synaptopathy,and dampen astrogliosis and *** humans,most trials focused on direct clinical and MRI outcomes,as investigating synaptic,neuroinflammato ry,and pathological changes is not straightfo rward compared to animal *** present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies.

关键词： disease-modifying behaviour endocannabinoid system long-term potentiation multiple sclerosis neuroplasticity neuroprotection physical exercise synaptopathy

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Small molecular decoys in Alzheimer's disease

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Neural Regeneration Research 2024年第8期19卷 1658-1659页

作者： Sho Oasa valentina L.Kouznetsova Igor F.Tsigelny Lars Terenius Department of Clinical Neuroscience Center for Molecular MedicineKarolinska InstitutetStockholmSweden San Diego Supercomputer Center University of California San DiegoLa JollaCAUSA Department of Neurosciences University of California San DiegoLa JollaCAUSA Department of Clinical Neuroscience Karolinska University HospitalKarolinska InstitutetStockholmSweden

Recent progress in the treatment of Alzheimer’s disease(AD)using antibodies against amyloid sustains amyloid generation as a key process in *** formation starts with two amyloidbeta(Aβ)molecules interacting(dimer formation)followed by an accelerating build-up of socalled protofibrils,which turn into fibrils,which accumulate in the characteristic plaques.

关键词： Alzheimer decoy Aβ

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Urbanization does not affect red foxes’interest in anthropogenic food,but increases their initial cautiousness

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Current Zoology 2024年第3期70卷 394-405页

作者： Martina Lazzaroni Rudy Brogi valentina Napolitano Marco Apollonio Friederike Range Sarah Marshall-Pescini Domestication Laboratory Konrad Lorenz Institute of EthologyUniversity of Veterinary MedicineVienna A-1160Austria Department of Veterinary Medicine University of Sassarivia Vienna 2I-07100 SassariItaly

Human presence and activities have profoundly altered animals’habitats,exposing them to greater risks but also providing new opportunities and *** animals’capacity to effectively navigate and strike a balance between risks and benefts is crucial for their survival in the Anthropocene *** foxes(Vulpes vulpes),adept urban dwellers,exhibit behavioral plasticity in human-altered *** investigated variations in detection frequency on trail cameras and the behavioral responses(explorative,bold,and fearful)of wild red foxes living along an urbanization gradient when exposed to a metal bin initially presented clean and then flled with anthropogenic *** fox populations displayed an increased interest and similar explorative behavioral responses toward the anthropogenic food source,irrespective of the urbanization *** no impact on explorative behaviors,foxes in more urbanized areas initially showed heightened fear toward the empty bin,indicating increased apprehension toward novel ***,this fear diminished over time,and in the presence of food,urban foxes displayed slightly reduced fear compared with their less urban *** results highlight foxes’potential for adaptability to human landscapes,additionally underscoring the nuanced interplay of fear and explorative behavioral response of populations living along the urbanization gradient.

关键词： anthropization bold explorative fearful human footprint Vulpes vulpes

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Nrf2 and Her3 co-expression in cholangiocarcinoma:Possible biological pathways for potential therapeutic approach

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 317-321页

作者： Paola Parente valentina Angerilli Giuseppe Zamboni Angelo Sparaneo Fabiola Fiordelisi Leonarda Di Candia Matteo Fassan Paolo Graziano Pathology Unit Fondazione IRCCS Casa Sollievo della Sofferenza71013San Giovanni Rotondo(Foggia)Italy Department of Medicine(DIMED) Surgical Pathology UnitUniversity of Padua35128Padua(Padua)Italy Pathology Unit IRCCS Ospedale Sacro Cuore Don Calabria37024Negrar(Verona)Italy Laboratory of Oncology Fondazione IRCCS Casa Sollievo della Sofferenza71013San Giovanni Rotondo(Foggia)Italy Veneto Institute of Oncology IOV-IRCCS 35124Padua(Padua)Italy

To the Editor:Cholangiocarcinomas(CCAs)are heterogeneous group of malignancies,encompassing intrahepatic CCA(iCCA),and extrahepatic CCA(eCCA);they are also classified into common hepatic duct cholangiocarcinoma(CHDCCA),choledocus extrapancreatic cholangiocarcinoma(EPCCA)and choledocus intrapancreatic cholangiocarcinoma(IPCCA)and,finally,gallbladder carcinoma(GBCCA).CCAs are relatively uncommon but.

关键词： carcinoma gallbladder Nrf2

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