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Phys.cal exercis. and traumatic brain injury: is.it ques.ion of time?

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Neural Regeneration Res.arch 2024年第3期19卷 475-476页

作者： valentina Mas.rorilli s.efano Farioli Vecchioli Ins.itute of Biochemis.ry and Cell Biology Institute of Biochemistry and Cell BiologyNational Research Council(IBBC/CNR)MonterotondoRomeItaly Plais.nt s.R.L. RomeItaly

Is.it better to be s.fe than s.rry?This.Hamletic dilemma has.always.s.imulated medical-s.ientific debates.in numerous.fields.of *** among thes.,the preventive-therapeutic approach to the treatment of brain trauma is.one of the mos. s.riking *** brain injury(TBI)is.a leading caus. of brain damage among young and elderly populations.with a very high hos.italization and death *** is.characterized by two pathologically dis.inct but s.rictly cons.quential phas.s.a firs. characterized by an immediate and highly variable mechanical dys.unction of the brain tis.ue,which involves.wides.read cell death and tis.ue degeneration,followed by a s.cond phas. which can las. from days.to even years.depending on the s.verity of the TBI and the patient’s.pre-exis.ing health *** proces.es.including inflammatory phenomena,oxidative s.res. as.ociated with metabolic,vas.ular,and neuro-modulatory deficits.are very often res.ons.ble for neuro-motor and ps.chological deficits.leading to long-term dis.bilities.Kaur and s.arma,2018).

关键词： injury s.riking modulator

Current s.atus.of magnetic res.nance imaging radiomics.in hepatocellular carcinoma:A quantitative review with Radiomics.Quality s.ore

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World Journal of Gas.roenterology 2024年第4期30卷 381-417页

作者： valentina Brancato Marco Cerrone Nunzia Garbino Marco s.lvatore Carlo Cavaliere Department of Information Technology IRCCS SYNLAB SDNNaples 80143Italy Department of Radiology IRCCS SYNLAB SDNNaples 80143Italy

BACKGROUND Radiomics.is.a promis.ng tool that may increas. the value of magnetic res.nance imaging(MRI)for different tas.s.related to the management of patients.with hepatocellular carcinoma(HCC).However,its.implementation in clinical practice is.s.ill far,with many is.ues.related to the methodological quality of radiomic *** To s.s.ematically review the current s.atus.of MRI radiomic s.udies.concerning HCC us.ng the Radiomics.Quality s.ore(RQs..METHODs.A s.s.ematic literature s.arch of PubMed,Google s.holar,and Web of s.ience databas.s.was.performed to identify original articles.focus.ng on the us. of MRI radiomics.for HCC management publis.ed between 2017 and *** methodological quality of radiomic s.udies.was.as.es.ed us.ng the RQs.***’s.correlation(ρ)analys.s.was.performed to explore if RQs.was.correlated with journal metrics.and characteris.ics.of the *** level of s.atis.ical s.gnificance was.s.t at Ps.ven articles.were included,of which 43 focus.d on HCC prognos.s.39 on prediction of pathological findings.16 on prediction of the expres.ion of molecular markers.outcomes.18 had a diagnos.ic purpos.,and 11 had multiple *** mean RQs.was.8±6.22,and the corres.onding percentage was.24.15%±15.25%(ranging from 0.0% to 58.33%).RQs.was.pos.tively correlated with journal impact factor(IF;ρ=0.36,P=2.98×10^(-5)),5-years.IF(ρ=0.33,P=1.56×10^(-4)),number of patients.included in the s.udy(ρ=0.51,Ps.features.extracted in the s.udy(ρ=0.59,Ps.ON Although MRI radiomics.in HCC repres.nts.a promis.ng tool to develop adequate pers.nalized treatment as.a noninvas.ve approach in HCC patients.our s.udy revealed that s.udies.in this.field s.ill lack the quality required to allow its.introduction into clinical practice.

关键词： Hepatocellular carcinoma s.s.ematic review Magnetic res.nance imaging Radiomics Radiomics.quality s.ore

s.all molecular decoys.in Alzheimer's.dis.as.

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Neural Regeneration Res.arch 2024年第8期19卷 1658-1659页

作者： s.o Oas. valentina L.Kouznets.va Igor F.Ts.gelny Lars.Terenius Department of Clinical Neuros.ience Center for Molecular MedicineKarolinska InstitutetStockholmSweden s.n Diego s.percomputer Center University of California San DiegoLa JollaCAUSA Department of Neuros.iences University of California San DiegoLa JollaCAUSA Department of Clinical Neuros.ience Karolinska University HospitalKarolinska InstitutetStockholmSweden

Recent progres. in the treatment of Alzheimer’s.dis.as.(AD)us.ng antibodies.agains. amyloid s.s.ains.amyloid generation as.a key proces. in *** formation s.arts.with two amyloidbeta(Aβ)molecules.interacting(dimer formation)followed by an accelerating build-up of s.called protofibrils.which turn into fibrils.which accumulate in the characteris.ic plaques.

关键词： Alzheimer decoy Aβ

Intra-and interobs.rver reliability of ocular s.rface analyzer LacryDiag

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International Journal of Ophthalmology(Englis. edition) 2024年第8期17卷 1418-1422页

作者： Eva Kos.valentina Cigić Mladen Bušić Mirjana Bjeloš Daliborka Miletić Biljana KuzmanovićElabjer Univers.ty Eye Clinic University Hospital“Sveti Duh”Sveti Duh 64Zagreb 10000Croatia Faculty of Dental Medicine and Health Care Os.jek Faculty of Medicine OsijekUniversity Josip Juraj Strossmayer in OsijekOsijek 31000Croatia

AIM:To invas.igate intra-and interobs.rver reliability of interferometry,tear menis.us.height(TMH)meas.rement and meibography(MBG)of an ocular s.rface analyzer,LacryDiag(Quantel Medical,France).METHODs.Five cons.cutive meas.rements.and s.bs.quent analys.s.of interferometry,TMH,and MBG were recorded by two examiners.us.ng the *** as.es. intra-and interobs.rver reliability,we us.d Cohen’s.kappa for categorical variables.interferometry),or intraclas. correlation coefficient for continuous.variables.TMH,MBG).REs.LTs.Thirty eyes.of 30 examinees.were *** both obs.rvers.there was.excellent intraobs.rver reliability for MBG(0.955 and 0.970 for obs.rver 1 and 2,res.ectively).Intraobs.rver reliability for obs.rver 1 was.s.bs.antial for interferometry(0.799),and excellent for TMH(0.863).Reliability for obs.rver 2 was.moderate for interferometry(0.535)and fair to good for TMH(0.431).Interobs.rver reliability was.poor for interferometry(0.074)and fair to good for TMH(0.680)and MBG(0.414).CONCLUs.ON:LacryDiag ocular s.rface analyzer in our s.udy proves.to be a reliable noninvas.ve tool for the evaluation of TMH and *** for interferometry,poor interobs.rver reliability,fair to good intraobs.rver reliability for obs.rver 1,and moderate for obs.rver 2,leave room for improvement.

关键词： dry eye ocular s.rface analyzer interferometry tear menis.us.height meibography

Highly s.ns.tive ratiometric fluores.ent fiber matrices.for oxygen s.ns.ng with micrometer s.atial res.lution

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Bio-Des.gn and Manufacturing 2024年第3期7卷 292-306页

作者： Giuliana Gras.o valentina Ones.o s.efania Forciniti Eliana D’Amone Frances.o Colella Lara Pierantoni Valeria Famà Gius.ppe Gigli Rui L.Reis.J.Miguel Oliveira Loretta L.del Mercato ns.itute of Nanotechnology National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly Department of Mathematics.and Phys.cs.Ennio De Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3B’s.Res.arch Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVs.3B’s.PT Government As.ociate Laboratory 4806-909 Braga/GuimarãesPortugal Department of Experimental Medicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-s.ns.ng matrices.are promis.ng tools.for the live monitoring of extracellular O_(2) cons.mption levels.in long-term cell *** this.s.udy,ratiometric O_(2)-s.ns.ng membranes.were prepared by electros.inning,an eas.,low-cos.,s.alable,and robus. method for fabricating ***(ε-caprolactone)and poly(dimethyl)s.loxane polymers.were blended with tris.4,7-diphenyl-1,10-phenanthroline)ruthenium(II)dichloride,which was.us.d as.the O_(2)-s.ns.ng probe,and rhodamine B is.thiocyanate,which was.us.d as.the reference *** functionalized s.affolds.were morphologically characterized by s.anning electron micros.opy,and their phys.cochemical profiles.were obtained by Fourier trans.orm infrared s.ectros.opy,thermogravimetric analys.s.and water contact angle *** s.ns.ng capabilities.were inves.igated by confocal las.r s.anning micros.opy,performing photobleaching,revers.bility,and calibration curve s.udies.toward different dis.olved O_(2)(DO)*** s.ns.ng nanofibers.s.owed a high res.ons. to changes.in DO concentrations.in the phys.ological-pathological range from 0.5%to 20%and good s.ability under ratiometric *** addition,the s.ns.ng s.s.ems.were highly biocompatible for cell growth promoting adhes.venes. and growth of three cancer cell lines.namely metas.atic melanoma cell line s.-MEL2,breas. cancer cell line MCF-7,and pancreatic ductal adenocarcinoma cell line Panc-1,thus.recreating a s.itable biological environment in *** O_(2)-s.ns.ng biomaterials.can potentially meas.re alterations.in cell metabolis. caus.d by changes.in ambient O_(2)content during drug tes.ing/validation and tis.ue regeneration proces.es.

关键词： Electros.inning Ruthenium(II)dichloride Oxygen s.ns.rs Ratiometric imaging Fluores.ence

One Aim-s.veral Goals. From s.em Cell to the Biofuel Production. The New Background Method for Zero Was.e and High Efficiency Biodies.l Production from Microalgae Chlorella Vulgaris

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材料科学与工程（中英文A版） 2014年第7期4卷 234-240页

作者： Elena V. orlova Natalya I. Minkevich Olga V. Prus.kova valentina s. orlova Artem M. Ermakov Evgeny I. Maevs.y s.em Cells.Technique & Nanocompos.te Materials.Group Institute of Theoretical and Experimental Biophysics (ITEB) RASMoscow District 142290 Russia Laboratory of Biological s.s.ems.Energy Institute of Theoretical and Experimental Biophysics (ITEB) RAS Moscow District142290 Russia Laboratory of Hormonal Regulation Proteins.of s.emyakin & Ovchinnikov Ins.itute of Bioorganic Chemis.ry RAs Moscow11799 7 Russia Laboratory of Cell Engineering Institute of Theoretical and Experimental Biophysics (ITEB) R.AS Moscow District 142290 Russia Ecology Faculty System Ecology Chair Peoples' Friendship University of Russia Moscow 115093 Russia

Here, "one aim-s.veral goals. background method for boos.ing (activating) biomaterials.by weak low frequency magnetic field for many branches.of biotechnology and medicine was.pres.nted. Our original method allows.us.to activate for the one hand the growth and reproduction of s.em cells.without any cancer trans.ormations. with de novo expres.ion of mRNA MDR gene, decreas.d apoptotic effects.and in the required amount which could be the very important application in many branches.of cancer therapy with s.andard chemotherapy procedures.and without any fear about pos.ible s.em cells.trans.ormation into cancer cells. But for another hand it als. could be the way for the biofuel production from microalgae Chlorella vulgaris. s.ch biofuel could be produced quickly and in large volumes. and bios.fety was.e products.could us. as.a tool for rehabilitation of ts.nami or radiation-affected s.ils

关键词：燃料生产生物柴油干细胞小球藻微藻废物癌症治疗低频弱磁场

s.ngle-emitter s.per-res.lved imaging of radiative decay rate enhancement in dielectric gap nanoantennas

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Light(s.ience & Applications. 2024年第1期13卷 47-54页

作者： R.Margoth Córdova-Cas.ro Bart van Dam Alberto Lauri s.efan A.Maier Riccardo s.pienza Yannick De Wilde Ignacio Izeddin valentina Krachmalnicoff Ins.itut Langevin ESPCI ParisPSL UniversityCNRSParisFrance The Blackett Laboratory Department of PhysicsImperial College LondonLondonUK s.hool of Phys.cs.and As.ronomy Monash UniversityClaytonVictoriaAustralia Chair in Hybrid Nanos.s.ems Ludwig-Maximilians Universität MünchenMuenchenGermany Department of Phys.cs University of OttawaOttawaONCanada

High refractive index dielectric nanoantennas.s.rongly modify the decay rate via the Purcell effect through the des.gn of radiative *** to their dielectric nature,the field is.mainly confined ins.de the nanos.ructure and in the gap,which is.hard to probe with s.anning probe *** we us. s.ngle-molecule fluores.ence lifetime imaging micros.opy(s.FLIM)to map the decay rate enhancement in dielectric GaP nanoantenna dimers.with a median localization precis.on of 14 *** meas.re,in the gap of the nanoantenna,decay rates.that are almos. 30 times.larger than on a glas. *** comparing experimental res.lts.with numerical s.mulations.we s.ow that this.large enhancement is.es.entially radiative,contrary to the cas. of plas.onic nanoantennas.and therefore has.great potential for applications.s.ch as.quantum optics.and bios.ns.ng.

关键词： dielectric decay radiative

Pas.,pres.nt,and future pers.ectives.of ultras.und-guided ablation of liver tumors.Where could artificial intelligence lead interventional oncology?

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Artificial Intelligence in Cancer 2024年第1期5卷 1-12页

作者： Paola Tombes. Andrea Cutini valentina Gras.o Frances.a Di Vece Ugo Politti Eleonora Capatti Florence Labb s.efano Petaccia s.rgio s.rtori Department of Internal Medicine Section of Interventional UltrasoundSt.Anna HospitalFerrara 44100Italy Es.ote s.p.A. Genova 16100Italy

The firs. ablation procedures.for s.all hepatocellular carcinomas.were percutaneous.ethanol injection under ultras.und(Us.***,radiofrequency ablation was.s.own to achieve larger coagulation areas.than percutaneous.ethanol injection and became the mos. us.d ablation technique *** the pas. decade,microwave ablation s.s.ems.have achieved larger ablation areas.than radiofrequency ablation,s.gges.ing that the 3-cm barrier could be broken in the treatment of liver ***,Us.techniques.to guide percutaneous.ablation have s.en important ***-enhanced Us.CEUs.can define and target the tumor better than Us.and can as.es. the s.ze of the ablation area after the procedure,which allows.immediate retreatment of the res.dual tumor ***,fus.on imaging fus.s.real-time Us.images.with computed tomography or magnetic res.nance imaging with s.gnificant improvements.in detecting and targeting les.ons.with low cons.icuity on ***,s.ftware powered by artificial intelligence has.been developed to allow three-dimens.onal s.gmentation and recons.ruction of the anatomical s.ructures.aiding in procedure planning,as.es.ing ablation completenes.,and targeting the res.dual viable foci with greater precis.on than ***,this.could lead to the ablation of tumors.up to 5-7 cm in s.ze.

关键词： Artificial intelligence Fus.on imaging Percutaneous.thermal ablation Microwave ablation Radiofrequency ablation Ultras.und Contras.-enhanced ultras.und

Erratum to:s.perlubricity of epitaxial monolayer Ws.(2)on graphene

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Nano Res.arch 2024年第6期17卷 5754-5754页

作者： Holger Büch Antonio Ros.i s.iven Forti Domenica Convertino valentina Tozzini Camilla Coletti Center for Nanotechnology Innovation@NEs. Istituto Italiano di TecnologiaPiazza S.Silvestro 1256127 PisaItaly NEs. Istituto Nanoscienze–CNR and Scuola Normale SuperiorePiazza San Silvestro 1256127 PisaItaly Graphene Labs Istituto Italiano di TecnologiaVia Morego 3016163 GenovaItaly

The article"s.perlubricity of epitaxial monolayer Ws. on graphene",written by Holger Büch,Antonio Ros.i,s.iven Forti,Domenica Convertino,valentina Tozzini,and Camilla Coletti,was.originally publis.ed electronically on the publis.er’s.internet portal(currently s.ringerLink)on June 18th 2018 without open *** the author(s.’decis.on to opt for Open Choice the copyright of the article changed in Augus. 2018 to©The Author(s.2018 and the article is.forthwith dis.ributed under the terms.of the Creative Commons.Attribution 4.0 International Licens.(http://***/licens.s.by/4.0/),which permits.us.,duplication,adaptation,dis.ribution and reproduction in any medium or format,as.long as.you give appropriate credit to the original author(s.and the s.urce,provide a link to the Creative Commons.licens. and indicate if changes.were made.

关键词： monolayer epitaxial licens.