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A comparative study of Salvia miltiorrhiza Radix & Rhizoma raw material and granule products using chromatographic analysis and antioxidant activity

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Journal of Traditional Chinese Medical Sciences 2022年第3期9卷 311-320页

作者： Xian Zhou valentina razmovski-naumovski Raynold Mendoza John Truong Kelvin Chan NICM Health Research Institute Western Sydney UniversityWestmead2145Australia South West Sydney Clinical Campuses Faculty of Medicine&HealthUniversity of New South WalesSydneyNSW2170Australia School of Pharmacy and Biomolecular Sciences Liverpool John Moores UniversityLiverpoolL33AFUK

Objective: Granules of herbal extracts are a popular medicinal preparation consumed in traditional Chinese medicine clinical practice. However, their quality and efficacy evaluation are lacking. This study aimed to compare the quality and anti-oxidant activity of Dan Shen(Salvia miltiorrhiza Radix & Rhizoma)granule extracts with their herbal ***: Chromatographic method was used to determine the content of 7 marker compounds in the water extracts of the herb compared to that of 12 granule extracts. Agglomerative hierarchical clustering(AHC) and principal component analysis(PCA) distinguished the herbal and granule extracts based on the content of the marker compounds. The antioxidant activities of herbal and granule extracts were evaluated by 2, 2'-azino-bis(3-ethylbenz-thiazoline-6-sulfonic acid)(ABTS), organic chemical compound 2,2-diphenyl-1-picrylhydrazyl(DPPH) and ferric ion reducing antioxidant power(FRAP) ***: The herbal extracts group showed significantly higher contents of salvianolic acid B, sodium danshensu and cryptotanshinone compared with that of the granule group. This corresponded to significantly higher ABTS, DPPH and FRAP(P <.05) activities of the herbal extracts. The AHC and PCA analysis distinguished granule extracts from most herbal extracts predominantly by the content of salvianolic acid ***: The results confirm the need for the assessment of granule products so that healthcare practitioners and consumers are better informed of their quality and efficacy.

关键词： Dan Shen Granule Multivariate analysis Salvia miltiorrhiza Radix&rhizoma Ultra-performance liquid chromatography Antioxidant

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Aqueous Extracts of Danshen-Sanqi Herb-pair Inhibit Lipopolysaccharide-induced Ntric Oxide Release in RAW264.7 Macrophage Cells Through the P13K Pathway

Aqueous Extracts of Danshen-Sanqi Herb-pair Inhibit Lipopoly...

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第十四届全国中药和天然药物学术研讨会

作者： Xian Zhou Antony Kam valentina razmovski-naumovski Kelvin Chan University of Western Sydney The University of Sydney

＜正＞Introduction/Aim Salvia Miltiorrhizae Radix＆Rhizoma（Danshen）is used in combination with Notoginseng Radix（Sanqi）in traditional Chinese medicine（TCM）formulations for managing cardiovascular *** individual ...

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Determination of Nitric Oxide Inhibitory Activities of Selected Raw and Processed Chinese Materia Medica

Determination of Nitric Oxide Inhibitory Activities of Selec...

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第十四届全国中药和天然药物学术研讨会

作者： John Truong Xian Zhou valentina razmovski-naumovski Cheang Khoo Kelvin Chan University of Western Sydney The University of Sydney

＜正＞Introduction Inflammation is a complex pathophysiological process and is implicated in the pathogenesis of many age-related diseases such as Alzheimer’s *** oxide（NO）serves as an important biomarker in acute and chronic inflammatory *** materia medica（CMM）and its processed derivatives have been used for centuries to promote good health

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Biodegradability of bioplastics in different aquatic environments:A systematic review

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Journal of Environmental Sciences 2024年第8期142卷 169-181页

作者： Maria Cristina Lavagnolo valentina Poli Anna Maria Zampini valentina Grossule Department of Civil Environmental and Architectural Engineering-Laboratory of Environmental EngineeringUniversity of PadovaLungargine Rovetta 8Padova 35100Italy

Bioplastics were first introduced as environmentally friendly materials,with properties similar to those of conventional plastics.A bioplastic is defined as biodegradable if it can be decomposed into carbon dioxide under aerobic degradation,or methane and CO_(2)under anaerobic conditions,inorganic compounds,and new cellular biomass,by the action of naturally occurring *** definition however does not provide any information on the environmental conditions,timescale and extent at which decomposition processes should *** regard to the aquatic environment,recognized standards have been established to assess the ability of plastics to undergo biodegradation;however,these standards fail to provide clear targets to be met to allow labelling of a bioplastic as ***,these standards grant the user an extensive leeway in the choice of process *** these reasons,the comparison of results deriving from different studies is *** authors analysed and discussed the degree of biodegradability of a series of biodegradable bioplastics in aquatic environments(both fresh and salt water)using the results obtained in the laboratory and from on-site testing in the context of different research *** Oxygen Demand(BOD),CO_(2)evolution,surface erosion and weight loss were the main parameters used by researchers to describe the percentage of *** results showed a large variability both in weight loss and BOD,even when evaluating the same type of *** confirms the need for a reference range of values to be established with regard to parameters applied in defining the biodegradability of bioplastics.

关键词： Biodegradation Bioplastic Plastic Natural environment Plastic waste

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Application of ATP-FTIR Coupled with Multivariate Analyses to Discriminate Puerariae Lobatae Radix from Puerariae Thomsonii Radix

Application of ATP-FTIR Coupled with Multivariate Analyses t...

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第十四届全国中药和天然药物学术研讨会

作者： Ka H.Wong valentina razmovski-naumovski Kong M.Li George,Q.Li Kelvin Chan The University of Sydney University of Western Sydney

＜正＞Purpose Puerariae Lobatae Radix（PLR）,the root of Pueraria lobata,is used for treating diabetes and cardiovascular diseases.A closely related species,Puerariae Thomsonii Radix（PTR;the root of ***）,is often su...

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Physical exercise and traumatic brain injury: is it question of time?

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Neural Regeneration Research 2024年第3期19卷 475-476页

作者： valentina Mastrorilli Stefano Farioli Vecchioli Institute of Biochemistry and Cell Biology Institute of Biochemistry and Cell BiologyNational Research Council(IBBC/CNR)MonterotondoRomeItaly Plaisant S.R.L. RomeItaly

Is it better to be safe than sorry?This Hamletic dilemma has always stimulated medical-scientific debates in numerous fields of *** among these,the preventive-therapeutic approach to the treatment of brain trauma is one of the most striking *** brain injury(TBI)is a leading cause of brain damage among young and elderly populations with a very high hospitalization and death *** is characterized by two pathologically distinct but strictly consequential phases:a first characterized by an immediate and highly variable mechanical dysfunction of the brain tissue,which involves widespread cell death and tissue degeneration,followed by a second phase which can last from days to even years depending on the severity of the TBI and the patient’s pre-existing health *** processes,including inflammatory phenomena,oxidative stress associated with metabolic,vascular,and neuro-modulatory deficits,are very often responsible for neuro-motor and psychological deficits leading to long-term disabilities(Kaur and Sharma,2018).

关键词： injury striking modulator

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Multiple Chromatographic and Chemometric Methods for Quality Standardization of Chinese Herbal Medicines

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世界科学技术-中医药现代化 2010年第1期12卷 99-106页

作者： valentina razmovski-naumovski Wannit Tongkao-on Benjamin Kimble Vincent L. Qiao Bei-lun Lin Kong M. Li Basil Roufogalis Depo Yang Meicun Yao George Q. Li Faculty of Pharmacy University of Sydney NSW 2006 Australia Discipline of Pharmacology Faculty of Medicine University of Sydney NSW 2006 Australia School of Pharmaceutical Sciences Sun Yat-Sen University Guangzhou 510080 China

Quality standardization of complementary medicine is fundamental for industry and practice as it underpins the quality,safety and efficacy of Chinese herbal *** herbal standardizations are often based on the quantitative analysis of a single compound,which may not reflect the total characteristic,bioactive and toxic nature of the herbs or ***,there is a need to establish an internationally recognized methodology for quality standardization of Chinese herbal *** analytical methods reviewed in this article are pharmacognosy,TLC,HPLC,LCMS,CE and *** article also covers the developments and applications of these methods in quality *** advances show that a combination of these methods creates an overall chemical profile of each *** is supported by results reviewed in this article and obtained in our laboratory tests on medicinal herbs including Hypericum perforatum,Morinda officinalis and Centella *** variations in active components have been observed between herbal samples and *** is proposed that the identification of active components,pharmacological activities and eventual clinical applications are required for a comprehensive quality standardization *** findings indicate that the combination of various chromatographic and chemometric methods will advance the methodology of quality standardization and enhance the overall confidence in herbal medicine for the health practitioner and the public.

关键词：毛细管草药合理用药中医

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A Statistical Study of Magnetic Flux Emergence in Solar Active Regions Prior to Strongest Flares

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Research in Astronomy and Astrophysics 2024年第4期24卷 147-160页

作者： Alexander S.Kutsenko valentina I.Abramenko Andrei A.Plotnikov Crimean Astrophysical Observatory p/o NauchnyCrimea298409Russia

Using the data on magnetic field maps and continuum intensity for Solar Cycles 23 and 24,we explored 100 active regions(ARs)that produced M5.0 or stronger *** focus on the presence/absence of the emergence of magnetic flux in these ARs 2-3 days before the strong flare *** found that 29 ARs in the sample emerged monotonically amidst quiet-Sun.A major emergence of a new magnetic flux within a pre-existing AR yielding the formation of a complex flare-productive configuration was observed in another 24 *** 30 ARs,an insignificant(in terms of the total magnetic flux of pre-existing AR)emergence of a new magnetic flux within the pre-existing magnetic configuration was observed;for some of them the emergence resulted in a formation of a configuration with a small δ-sunspot;11 out of 100 ARs exhibited no signatures of magnetic flux emergence during the entire interval of *** six cases the emergence was in progress when the AR appeared on the Eastern limb,so that the classification and timing of emergence were not *** conclude that the recent flux emergence is not a necessary and/or sufficient condition for strong flaring of an *** flux emergence rate of flare-productive ARs analyzed here was compared with that of flare-quiet ARs analyzed in our previous *** revealed that the flare-productive ARs tend to display faster emergence than the flare-quiet ones do.

关键词： Sun:activity Sun:flares Sun:magnetic fields

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Age and geochemical evolution of granite magmatism in Olkhon region from Caledonian syncollisional ore-free granite to the rare metal granite and pegmatite of Middle Paleozoic intraplate setting

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China Geology 2024年第1期7卷 63-79页

作者： Viktor Antipin valentina Makrygina Larisa Kushch Nataliya Sheptyakova Vinogradov Institute of Geochemistry SB RAS664033 IrkutskRussia

The detailed description of two granite complexes in the Olkhon subterrane is *** Early Paleozoic Sharanur complex was formed by granitization of gneisses of the Olkhon *** includes migmatites,granite-gneisses,granites and pegmatites of normal alkalinity;they belong to the type of syncollisional *** Middle Paleozoic Aya granite complex includes mother Aya massif of amazonite-bearing granites and several types of rare-metal *** have elevated alkalinity,low of Ba,Sr,and high LILE and HFSE elements *** Aya pegmatites lie in northwest cracks of stretching and associated with the rise of the territory under the influence of the North Asian *** cracks and pegmatites mark the beginning of a new intraplate geodynamic *** geochemical types are distinguished among the pegmatites of this *** are amazonite pegmatites of Li-F type with Ta mineralization and complex type pegmatite with Be-Rb-Nb-Ta and Li-F mineralization(the Ilixin vein).The Tashkiney pegmatite vein is similar to Ilixin,but lies in the gneisses of the Olkhon *** shows high concentrations of Be,Nb,Ta,as well as W,Sn,but lacks Li and F,due to a greater depth and higher temperature of the melt crystallization of this pegmatite.

关键词： Pegmatite Geochemistry Submantle plume Magmatism Caledonian collision Middle Paleozoic intraplate setting Be-Rb-Nb-Ta-Li-F mineralization Olkhon region Russia

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Current status of magnetic resonance imaging radiomics in hepatocellular carcinoma:A quantitative review with Radiomics Quality Score

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World Journal of Gastroenterology 2024年第4期30卷 381-417页

作者： valentina Brancato Marco Cerrone Nunzia Garbino Marco Salvatore Carlo Cavaliere Department of Information Technology IRCCS SYNLAB SDNNaples 80143Italy Department of Radiology IRCCS SYNLAB SDNNaples 80143Italy

BACKGROUND Radiomics is a promising tool that may increase the value of magnetic resonance imaging(MRI)for different tasks related to the management of patients with hepatocellular carcinoma(HCC).However,its implementation in clinical practice is still far,with many issues related to the methodological quality of radiomic *** To systematically review the current status of MRI radiomic studies concerning HCC using the Radiomics Quality Score(RQS).METHODS A systematic literature search of PubMed,Google Scholar,and Web of Science databases was performed to identify original articles focusing on the use of MRI radiomics for HCC management published between 2017 and *** methodological quality of radiomic studies was assessed using the RQS ***’s correlation(ρ)analysis was performed to explore if RQS was correlated with journal metrics and characteristics of the *** level of statistical significance was set at P<*** One hundred and twenty-seven articles were included,of which 43 focused on HCC prognosis,39 on prediction of pathological findings,16 on prediction of the expression of molecular markers outcomes,18 had a diagnostic purpose,and 11 had multiple *** mean RQS was 8±6.22,and the corresponding percentage was 24.15%±15.25%(ranging from 0.0% to 58.33%).RQS was positively correlated with journal impact factor(IF;ρ=0.36,P=2.98×10^(-5)),5-years IF(ρ=0.33,P=1.56×10^(-4)),number of patients included in the study(ρ=0.51,P<9.37×10^(-10))and number of radiomics features extracted in the study(ρ=0.59,P<4.59×10^(-13)),and time of publication(ρ=-0.23,P<0.0072).CONCLUSION Although MRI radiomics in HCC represents a promising tool to develop adequate personalized treatment as a noninvasive approach in HCC patients,our study revealed that studies in this field still lack the quality required to allow its introduction into clinical practice.

关键词： Hepatocellular carcinoma Systematic review Magnetic resonance imaging Radiomics Radiomics quality score

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