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Cardiac remodeling in postischemic end-stage human hearts: Involvement of extracellular matrix and angiogenesis-related molecules

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World Journal of Cardiovascular Diseases 2013年第1期3卷 91-99页

作者： Loredana Postiglione Luca De Santo Gaetano Di Spigna Clotilde Castaldo Germano Guerra Paolo Ladogana Alessandro Arcucci Diego Calabrese Bianca Covelli Serena Vitale valentina mele Stefania Montagnani Department of Cardiothoracic Sciences Second University of Naples c/o Monaldi Hospital Naples Italy. Department of Public Health “Federico II” University of Naples Naples Italy Department of Public Health “Federico II” University of Naples Naples Italy. Department of Translational Medical Sciences “Federico II” University of Naples Naples Italy

Background: Extracellular matrix (ECM) participates in heart growth and influences cardiac stem-cell differentiation and migration. The modification of ECM associated with cardiomyopathies is a complex process involving a cohort of proteins. ECM proteins are involved in the regulation of neoangiogenesis in physiological and pathological conditions through their interaction with some angiogenic factors. Our aim was to investigate the role of some angiogenesis-related ECM proteins in the remodeling heart. Methods: We examined cardiac tissue samples from 21 explanted human hearts and 10 non-failing hearts before transplantation. Each specimen was submitted to morphological and biomolecular analysis. Results: We demonstrated a reduced expression of α2-chain laminin mRNA in pathological samples that could play an important role in the progression of cardiac failure by contributing to sarcolemma modifications. Reduced expression of tenascin cytotactin (TN-C) and TN-X in explanted hearts indicated chronic cardiac damage and an impaired capacity to stimulate new vessel development. The observed type IV collagen increase was not related to neoangiogenesis, as reflected by the decreased expression of vascular endothelial growth factor (VEGF)-A and VEGF receptor-2. The inverse correlation between heart dimension and VEGF-A immunopositivity seems particularly interesting. Conclusions: Our findings suggest that ECM reacts strongly to ischemic damage in failing hearts through some important modifications of its protein composition. Nevertheless, this reaction cannot completely restore myocardium structure if it is not supported by adequate neoangiogenesis. The decrease in some ECM proteins related to vessel development has a negative effect on postischemic neoangiogenesis and clinical outcome.

关键词： Heart Failure Cardiac Remodeling Vascular Endothelial Growth Factor Tenascin X α2-Chain Laminin

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西57号街公寓

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城市环境设计 2019年第2期118卷 228-239页

作者： David Brown Aleksander Tokarz Alessandro Ronfini Alessio Valmori Alvaro Mendive Benjamin Schulte Birk Daugaard Celine Jeanne Christoffer Gotfredsen Daniel Sundlin Dominyka Mineikyte Eivor Davidsen Felicia Guldberg Florian Oberschneider Soren Grunert Gabrielle Nadeau Gül Ertekin Ho Kyung Lee Hongyi Jin Julian Liang Julianne Gola Laura Youf Lucian Racovitan Marcella Martinez Maria Nikolova Maya Shopova Mitesh Dixit Nicklas A.Rasch Ola Hariri Riccardo Mariano Steffan Heath Stanley Lung Tara Hagan Thilani Rajarathna Tyler Polich valentina mele Valerie Lechene Xu Li Yi Li Aaron Hales Alessandro Ronfini Brian Foster Christoffer Gotfredsen Francesca Portesine Ho Kyung Lee Hongyi Jin Ivy Hume Jenny Chang Lauren Turner Mina Rafiee Rakel Karlsdottir Tara Hagan Thomas Fagan Tiago Barros valentina mele Iwan Baan 朱翰林

西57号街公寓结合了欧洲庭院建筑和传统曼哈顿高层的特点,并兼具两者的优点:通透的院落建筑的紧凑与高效性以及摩天楼拥有的广阔视野。通过让建筑三个角保持较低姿态而仅将东北角提升至450英尺(约137.2米),使得庭院面向哈德逊河的视野开... 详细信息

西57号街公寓结合了欧洲庭院建筑和传统曼哈顿高层的特点,并兼具两者的优点:通透的院落建筑的紧凑与高效性以及摩天楼拥有的广阔视野。通过让建筑三个角保持较低姿态而仅将东北角提升至450英尺(约137.2米),使得庭院面向哈德逊河的视野开阔,让较低的夕阳也能照进街区深处,并优雅地为一旁的Helena Tower保留河景。建筑的形式随着观察者的位置而不断变换。从西侧的高速公路上看,它

关键词： Section 局部剖面图

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Remotely Activated Nanoparticles for Anticancer Therapy

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Nano-Micro Letters 2021年第1期13卷 174-207页

作者： Luisa Racca valentina Cauda Department of Applied Science and Technology Politecnico di TorinoC.so Duca degli Abruzzi 2410129 TurinItaly

Cancer has nowadays become one of the leading causes of death *** anticancer approaches are associated with different ***,innovative methodologies are being investigated,and several researchers propose the use of remotely activated nanoparticles to trigger cancer cell *** idea is to conjugate two different components,i.e.,an external physical input and *** are given in a harmless dose that once combined together act synergistically to therapeutically treat the cell or tissue of interest,thus also limiting the negative outcomes for the surrounding *** both the properties of the nanomaterial and the involved triggering stimulus,it is possible furthermore to achieve not only a therapeutic effect,but also a powerful platform for imaging at the same time,obtaining a nano-theranostic *** the present review,we highlight the role of nanoparticles as therapeutic or theranostic tools,thus excluding the cases where a molecular drug is *** thus present many examples where the highly cytotoxic power only derives from the active interaction between different physical inputs and *** perform a special focus on mechanical waves responding nanoparticles,in which remotely activated nanoparticles directly become therapeutic agents without the need of the administration of chemotherapeutics or sonosensitizing drugs.

关键词： Anticancer therapy Remotely activated nanomedicine Stimuli-responsive nanoparticles Physical stimulation Radiofrequency Nanoparticle-assisted ultrasound Hyperthermia

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Biodegradability of bioplastics in different aquatic environments:A systematic review

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Journal of Environmental Sciences 2024年第8期142卷 169-181页

作者： Maria Cristina Lavagnolo valentina Poli Anna Maria Zampini valentina Grossule Department of Civil Environmental and Architectural Engineering-Laboratory of Environmental EngineeringUniversity of PadovaLungargine Rovetta 8Padova 35100Italy

Bioplastics were first introduced as environmentally friendly materials,with properties similar to those of conventional plastics.A bioplastic is defined as biodegradable if it can be decomposed into carbon dioxide under aerobic degradation,or methane and CO_(2)under anaerobic conditions,inorganic compounds,and new cellular biomass,by the action of naturally occurring *** definition however does not provide any information on the environmental conditions,timescale and extent at which decomposition processes should *** regard to the aquatic environment,recognized standards have been established to assess the ability of plastics to undergo biodegradation;however,these standards fail to provide clear targets to be met to allow labelling of a bioplastic as ***,these standards grant the user an extensive leeway in the choice of process *** these reasons,the comparison of results deriving from different studies is *** authors analysed and discussed the degree of biodegradability of a series of biodegradable bioplastics in aquatic environments(both fresh and salt water)using the results obtained in the laboratory and from on-site testing in the context of different research *** Oxygen Demand(BOD),CO_(2)evolution,surface erosion and weight loss were the main parameters used by researchers to describe the percentage of *** results showed a large variability both in weight loss and BOD,even when evaluating the same type of *** confirms the need for a reference range of values to be established with regard to parameters applied in defining the biodegradability of bioplastics.

关键词： Biodegradation Bioplastic Plastic Natural environment Plastic waste

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Simulating bicycle traffic by the intelligent-driver model-Reproducing the traffic-wave characteristics observed in a bicycle-following experiment

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第1期7卷 19-29页

作者： valentina Kurtc Martin Treiber Institute of Applied Mathematics and Mechanics Peter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251Russia Institute for Transport and Economics Technische Universitat DresdenDresden 01062Germany

Bicycle traffic operations become increasingly important and yet are largely ignored in the traffic flow community,until *** hypothesize that there is no qualitative difference between vehicular and bicycle traffic flow dynamics in single-file case,so the latter can be described by reparameterized car-following *** test this proposition,we reproduce German(Andresen et al.,2014)and Chinese(Jiang et al.,2016)bicycle experiments on a ring with the intelligent-driver model(IDM)and compare its fit quality(calibration)and predictive power(validation)with that of the necessary-deceleration-model(NDM),which is specifically designed for bike *** find similar quality metrics for both models,so the above hypothesis of a qualitative equivalence cannot be ***,calibration errors of the IDM turn up to be slightly smaller compared to the NDM *** NDM represents significant calibration errors for high flow densities,which correspond to flow states,when stop-and-go wave *** to validation tests,the IDM outperforms the NDM as *** two types of validation techniques we discover that inter-driver variation is much higher than the intra-driver variation for bicycle *** coincides with the results obtained from vehicular traffic experiments(NGSIM trajectory data).In addition,we suggest the measure for quantitative comparison of two microscopic fundamental diagrams,which are derived from experimental data and simulated *** analysis of speed-density relations provides more or less the same results for both models.

关键词： Bicycle traffic Car-following model Stop-and-go waves Calibration Validation Fundamental diagram

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Meningeal T-cells in the cross-talk between memory consolidation and sleep

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Neural Regeneration Research 2023年第12期18卷 2687-2688页

作者： Rodrigo Pacheco valentina Ugalde Laboratorio de Neuroinmunología Centro Científico y Tecnológico de Excelencia Ciencia&VidaFundación Ciencia&VidaSantiagoChile Facultad de Medicina y Ciencia Universidad San SebastiánSantiagoChile

Some years ago,the infiltration of T-cells into the central nervous system(CNS) was considered a pathological condition ***,during the last two decades,a growing body of studies has shown that T-cells are essential pl... 详细信息

关键词： behavior. sleep consolidation

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Emerging role of lysosomal calcium store as a hub of neuroprotection

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Neural Regeneration Research 2022年第6期17卷 1259-1260页

作者： valentina Tedeschi Agnese Secondo Division of Pharmacology Department of NeuroscienceReproductive and Odontostomatological SciencesSchool of Medicine“Federico II”University of NaplesNaplesItaly

Filled with more than 60 different types of hydrolases,the acidic organelle lysosome governs cellular digestion by removing damaged organelles and catabolic products(Xu and Ren,2015).Beyond the canonical role in the intracellular degradative pathways,lysosome precedes nutrient sensing,autophagy,immune cell signaling,metabolism and membrane repair.

关键词： metabolism removing store

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Domestic reptiles as source of zoonotic bacteria:a mini review

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Asian Pacific Journal of Tropical Medicine 2017年第8期10卷 789-794页

作者： valentina Virginia Ebani Department of Veterinary Science University of PisaI 56124 PisaItaly

Captive reptiles, always more often present in domestic environment as pets, may harbor and excrete a large variety of zoonotic pathogens. Among them, Salmonella is the most wellknown agent, whereas there are very scant data about infections by mycobacteria, chlamydiae and leptospirae in cold-blooded animals. However, the investigations that found antibody reactions and/or the bacteria in samples collected from free-ranging and captive reptiles show that herpetofauna may be involved in the epidemiology of these infections. The present review reports the updated knowledge about salmonellosis, mycobacteriosis, chlamydiosis and leptospirosis in reptiles and underlines the risk of infection to which people, mainly children, are exposed.

关键词： Reptiles Zoonosis Salmonellosis Mycobacteriosis Chlamydiosis Leptospirosis

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Antibiotic resistance in patients with liver cirrhosis:Prevalence and current approach to tackle

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World Journal of Clinical Cases 2023年第31期11卷 7530-7542页

作者： valentina Liakina Clinic of Gastroenterology Nephrourology and SurgeryInstitute of Clinical MedicineFaculty of MedicineVilnius UniversityVilnius 01513Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental SciencesVilnius TechVilnius 10223Lithuania

Regardless of etiology,complications with bacterial infection in patients with cirrhosis are reported in the range of 25%-46%according to the most recent *** to frequent episodes of bacterial infection and repetitive antibiotic treatment,most often with broad-spectrum gram negative coverage,patients with cirrhosis are at increased risk of encountering multidrug resistant bacteria,and this raises *** such patients,extended-spectrum beta-lactamase and AmpCproducing Enterobacterales,methicillin-or vancomycin-resistant Staphylococcus aureus,vancomycin-resistant Enterococci,carbapenem-resistant Pseudomonas aeruginosa,and Acinetobacter baumannii,all of which are difficult to treat,are the most *** is why novel approaches to the prophylaxis and treatment of bacterial infections to avoid antibiotic resistance have recently been *** the same time,our knowledge of resistance mechanisms is constantly *** review summarizes the current situation regarding the burden of antibiotic resistance,including the prevalence and mechanisms of intrinsic and acquired resistance in bacterial species that most frequently cause complications in patients with liver cirrhosis and recent developments on how to deal with multidrug resistant bacteria.

关键词： Cirrhosis Bacterial complications Antibiotics Intrinsic resistance Acquired resistance Probiotics Vaccines

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Metabotropic glutamate receptors and nitric oxide in dopaminergic neurotoxicity

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World Journal of Psychiatry 2021年第10期11卷 830-840页

作者： valentina Bashkatova Laboratory of Physiology Reinforcements Anokhin Institute of Normal PhysiologyMoscow 125315Russia

Dopaminergic neurotoxicity is characterized by damage and death of dopaminergic ***'s disease(PD)is a neurodegenerative disorder that primarily involves the loss of dopaminergic neurons in the substantia ***,the study of the mechanisms,as well as the search for new targets for the prevention and treatment of neurodegenerative diseases,is an important focus of modern *** is primarily caused by dysfunction of dopaminergic neurons;however,other neurotransmitter systems are also *** reports have indicated that the glutamatergic system is involved in different pathological conditions,including dopaminergic *** the last two decades,the important functional interplay between dopaminergic and glutamatergic systems has stimulated interest in the possible role of metabotropic glutamate receptors(mGluRs)in the development of extrapyramidal ***,the specific mechanisms driving these processes are presently *** participation of the universal neuronal messenger nitric oxide(NO)in the mechanisms of dopaminergic neurotoxicity has attracted increased *** current paper aims to review the involvement of mGluRs and the contribution of NO to dopaminergic *** precisely,we focused on studies conducted on the rotenone-induced PD *** review is also an outline of our own results obtained using the method of electron paramagnetic resonance,which allows quantitation of NO radicals in brain structures.

关键词： Dopaminergic neurotoxicity Metabotropic glutamate receptors Nitric oxide Rotenone Parkinson's disease

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