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Effect of the rearing diet on gene expression of antimicrobial peptides in Hermetia illucens(Diptera:Stratiomyidae)

Insect Science 2023年第4期30卷 933-946页

作者： valentina Candian Carlotta Savio Marco Meneguz Laura Gasco Rosemarie Tedeschi Dipartimento di Scienze Agrarie Forestali eAlimentari(DISAFA)University of TorinoGrugliascoItaly NRAE MicalisGMEUniversity of Paris SaclayJouy-en-JosasFrance Laboratory of Entomology Wageningen UniversityWageningenThe Netherlands BEF Biosystems TorinoItaly

Insect proteins have been proposed for human and animal food *** the health status of insects in mass rearing allows to obtain high-quality products and to avoid severe economic losses due to ***,new strategies for preserving insect health must be *** of the insect im-mune system through the diet is one such *** evaluated gene expression of two antimicrobial peptides(one defensin and one cecropin)in Hermetia illucens(L.)(Diptera:Stratiomyidae)reared on different *** were performed on prepupae and 10-day-old larvae reared on cereal-and municipal organic waste-based diets and on only prepupae reared on a cereal-based diet supplemented with sunflower,corn,or soybean *** inclusion of sunflower oil at different points in the cereal-based diet was also ***,diet-driven differences in the inhibitory activity of the hemolymph were tested against Escherichia coli DH5αand Micrococcus yunnanensis HI55 using diffusion assays in solid *** showed that a municipal organic waste-based diet produced a significant overexpression of antimicrobial peptides only in *** of veg-etable oils caused an upregulation of at least one peptide,except for the corn *** expression of both genes was observed when sunflower oil was added 5 days before *** hemolymph samples showed an inhibitory activity against bacteria *** results suggest that municipal organic waste-based diet and vegetable oil-added diet may successfully impact the immune system of *** alternatives may also exist forotherspeciesofeconomic interest.

关键词： cecropin cereal defensin hemolymph organic municipal solid waste vegetable oil

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From unstructured texts to semantic story maps

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International Journal of Digital Earth 2023年第1期16卷 234-250页

作者： valentina Bartalesi Gianpaolo Coro Emanuele Lenzi Pasquale Pagano NicolòPratelli Istituto di Scienza e Tecnologie dell’Informazione‘A.Faedo’del Consiglio Nazionale delle Ricerche PisaItaly

Digital maps greatly support storytelling about territories,especially when enriched with data describing cultural,societal,and ecological aspects,conveying emotional messages that describe the territory as a *** maps are interactive online digital narratives that can describe a territory beyond its map by enriching the map with text,pictures,videos,and other multimedia *** paper presents a semi-automatic workflow to produce story maps from textual documents containing territory *** expertfirst assembles one territory-contextual document containing text and ***,automatic processes use natural language processing and Wikidata services to(i)extract key concepts(entities)and geospatial coordinates associated with the territory,(ii)assemble a logically-ordered sequence of enriched story-map events,and(iii)openly publish online story maps and an interoperable Linked Open Data semantic knowledge base for event exploration and inter-story correlation *** workflow uses an Open Science-oriented methodology to publish all processes and *** our workflow,we produced story maps for the value chains and territories of 23 rural European areas of 16 *** numerical evaluation,we demonstrated that territory experts considered the story maps effective in describing their territories,and appropriate for communicating with citizens and stakeholders.

关键词： Story maps semantic web ontology natural language processing narratives e-infrastructures virtual research environments

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Interferon-gamma and neuropathy: balance between pain and neuroprotection

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Neural Regeneration Research 2022年第12期17卷 2700-2701页

作者： valentina Ferrara Alessandra Toti Carla Ghelardini Lorenzo Di Cesare Mannelli Department of Neuroscience PsychologyDrug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology SectionUniversity of FlorenceFlorenceItaly

Chronic pain is sustained by a phenomenon of hyper-activation of nociceptive neurons both at peripheral(peripheral sensitization)and central(central sensitization)*** onset and maintenance of pain,however,is to be found in the interaction among the various cell populations in the nervous tissue including neurons and glia(Nam et al.,2016).The pathogenesis of neuropathic pain is extremely complex depending on the primary cause of nerve damage,*** nerve injury is associated with a robust inflammatory response while chemotherapy-induced pain is characterized by a modest phlogistic component(Di Cesare Mannelli et al.,2013).Despite these differences,a powerful common concept to explain the cellular mechanisms underlying pain is the activation of glia.

关键词： pain sustained

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The long-COVID-19 in older adults: facts and conjectures

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Neural Regeneration Research 2022年第12期17卷 2679-2681页

作者： Tino Emanuele Poloni valentina Medici Antonio Zito Arenn Faye Carlos Department of Neurology-Neuropathology and Abbiategrasso Brain Bank Golgi-Cenci Foundation&Department of RehabilitationASP Golgi-Redaelli-AbbiategrassoMilanItaly Department of Neurology-Neuropathology and Abbiategrasso Brain Bank Golgi-Cenci Foundation-AbbiategrassoMilanItaly Department of Brain and Behavioral Disorders University of Pavia&IRCCS Mondino FoundationPaviaItaly

The coronavirus disease-19(COVID-19)has greatly affected the overall health of the elderly population through direct biological(infection-related)and indirect psychosocial(quarantine-and isolation-related)*** the severe form of COVID-19 most frequently targets this population,the prevalence of long-term sequelae is expected to rise consequentially in people≥65 years *** prominent neuropsychiatric consequences of COVID-19 and the cognitive frailty seen in older adults can both have a negative impact on their mental *** explore the behavioral,neurological,and psychosocial consequences of COVID-19,we conducted separate studies on different populations of older adult people residing in Lombardy-the Italian epicenter of the first pandemic wave in spring 2020.

关键词： consequences Italian COV

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Endoluminal vacuum-assisted therapy as a treatment for anastomotic leakage in colorectal surgery

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World Journal of Gastroenterology 2022年第28期28卷 3747-3752页

作者： Maria Michela Chiarello valentina Bianchi Pietro Fransvea Giuseppe Brisinda Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Emergency Surgery and Trauma Center Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168taly Medical and Surgical Sciences Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

Anastomotic leakage(AL)has a wide range of clinical features ranging from radiological only findings to peritonitis and sepsis with multiorgan *** early diagnosis of AL is essential in order to establish the most appropriate treatment for this *** AL continues to be a dreadful complication after colorectal surgery,there has been no consensus on its ***,based on patient’s presentation and timing of the AL,there has been a gradual shift to a more conservative management,keeping surgery as the last option Reoperation for sepsis control is rarely necessary especially in those patients who already have a diverting stoma at the time of the leak.A nonoperative management is usually preferred in these *** are several treatment options,also for patients without a stoma who do not require a reoperation for a contained pelvic leak,including recently developed endoscopic procedures,such as clip placement or endoluminal vacuum-assisted *** conservative treatments could be an option in patients who are clinically stable or in presence of a small defect.

关键词： Anastomotic leakage Colorectal cancer Colorectal surgery Mortality Morbidity

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Endarterectomy for symptomatic non-stenotic carotids: a systematic review and descriptive analysis

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Stroke & Vascular Neurology 2022年第1期7卷 6-12页

作者： Anthony Larson valentina Nardi Waleed Brinjikji John Benson Giuseppe Lanzino Luis Savastano Department of Radiology Mayo ClinicRochesterMinnesotaUSA Neurosurgery Mayo ClinicRochesterMinnesotaUSA

Objective To systematically analyse prior reports of carotid endarterectomy(CEA)performed in cases of≤50%carotid stenosis in order to understand patient tolerance and potential *** A systematic review and descriptive analysis was performed in concordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** English-language search was performed of online databases using librarian-selected search *** were reviewed for relevance which included mention of carotid endarterectomy and *** or retrospective observational cohort studies that reported series of patients who underwent endarterectomy for minimal(≤50%)luminal stenosis with reported outcomes were *** Six studies(which included our institutional series)with a total of 143 patients met the inclusion *** weighted mean age at the time of CEA was 72.3 years;113(79.0%)were male.55.8%of patients with available data had recurrent ipsilateral ischaemic events despite medical *** patients out of 129 with available perioperative data(1.6%)had perioperative MRI findings of acute ischaemic stroke,both within the hemisphere contralateral to the side of *** the 138 patients with available follow-up(mean,36 months),none had recurrent ipsilateral ischaemic *** Endarterectomy for symptomatic carotid disease causing≤50%stenosis may be a potentially beneficial strategy to prevent stroke *** with robust methodology are needed to draw more definitive conclusions in terms of the safety and efficacy of endarterectomy for minimal stenosis with vulnerable features relative to intensive medical therapy.

关键词： carotid stenosis analysis

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Intra-abdominal myositis ossificans-a clinically challenging disease:A case report

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World Journal of Orthopedics 2023年第5期14卷 362-368页

作者： Gabriele Carbone valentina Andreasi Paola De Nardi Department of Gastrointestinal Surgery IRCCS San Raffaele HospitalMilan 20132Italy

BACKGROUND Myositis ossificans(MO)is an uncommon disorder characterized by heterotopic ossification within soft *** a few cases of intra-abdominal MO(IMO)have been described in the *** could be difficult to understand and a wrong diagnosis could lead to an improper *** SUMMARY We herein report the case of IMO in a healthy 69-year-old *** patient presented with an abdominal mass in the left lower quadrant.A computed tomography scan showed an inhomogeneous mass with multiple *** patient underwent radical excision of the *** findings were compatible with *** months later the patient showed a recurrence causing hemorrhagic shock due to intractable intralesional *** patients eventually died within three months since *** The case described could be classified as post-traumatic MO that developed close to the previously fractured iliac *** subsequent surgical procedure was ineffective and the disease rapidly *** misleading intraoperative diagnosis led to improper surgical treatment with a dramatic evolution.

关键词： Myositis ossificans Post-traumatic Diagnosis Surgical treatment Prognosis Case report

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BIOCELL 2022年第12期46卷 2525-2530页

作者： MONICA SAVIO valentina MINOIA PAOLA FULGHIERI LUCIA ANNA STIVALA VIRGINIE SOTTILE Department of Molecular Medicine University of PaviaPavia27100Italy

The nutraceutical resveratrol is associated with a range of biological effects,from antibiotic to antiinflammatory *** major axis of research has sought to harness its anti-tumour potential,with promising preclinical results and early clinical trials.A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell *** is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in *** we evoke novel developments in the field that could lead to more reliable conditions for the translational use of resveratrol-based compounds.

关键词： Resveratrol Nutraceutical Cancer Cell Differentiation Dihydroxystilbene

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Corrigendum to ‘Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes’ [Gene Dis (10) (2023),1187–1189]

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Genes & Diseases 2024年第2期11卷 1084-1084页

作者： Giovanna Forte Filomena Cariola Antonia Lucia Buonadonna Anna Filomena Guglielmi Andrea Manghisi Katia De Marco valentina Grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo Nicoletta Resta Vittoria Disciglio Cristiano Simone Medical Genetics National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Medical Genetics Department of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J) University of Bari Aldo Moro Bari 70124 Italy

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Stratigraphic analysis of intercalated graphite electrodes in aqueous inorganic acid solutions

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Nano Research 2022年第2期15卷 1120-1127页

作者： Stefania De Rosa Paolo Branchini valentina Spampinato Alexis Franquet Rossella Yivlialin Lamberto Duo Gianlorenzo Bussetti Luca Tortora LASR3 Surface Analysis Laboratory INFN Roma Trevia della Vasca Navale 8400146 RomeItaly Department of Mathematics and Physics Roma Tre Universityvia della Vasca Navale 8400146 RomeItaly Imec Kapeldreef 75B-3001 LeuvenBelgium Helmholtz-Zentrum Berlin fiir Materialen und Energie GmbH Institute for Solar Fuels(EE-IF)Hahn-Meitner-Platz 1D-14109 BerlinGermany Department of Physics Politecnico di MilanoPiazza Leonardo da Vinci 321-20133 MilanoItaly Department of Science Roma Tre Universityvia della Vasca Navale 8400146 RomeItaly

A detailed stratigraphic investigation of the intercalation mechanism when graphite electrodes are immersed inside diluted perchloric(HClO_(4))and sulfuric(H_(2)SO_(4))electrolytes is obtained by comparing results when graphite crystals are simply immersed in the same acid *** combining time-of-flight secondary ion mass spectrometry(ToF-SIMS)and in-situ atomic force microscopy(AFM),we provide a picture of the chemical species involved in the intercalation *** depth intensity profile of the ion signals along the electrode crystal clearly shows a more complex mechanism for the intercalation process,where the local morphology of the basal plane plays a crucial *** anions are mostly located within the first tens of nanometers of graphite,but electrolytes also diffuse inside the buried layers for hundreds of nanometers,the latter process is also aided by the presence of mesoscopic crystal *** material from the electrolyte solution was found localized in well-defined circular spots,which represent preferential interaction ***,blister-like micro-structures similar to those observed on the highly oriented pyrolytic graphite(HOPG)surface were found in the buried layers,confirming the equivalence of the chemical condition on the graphite surface and in the underneath layers.

关键词： highly oriented pyrolytic graphite(HOPG) intercalation graphite graphene time-of-flight secondary ion mass spectrometry(ToF-SIMS) atomic force microscopy(AFM)

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