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Geoscience Frontiers 2020年第6期11卷 1915-1934页

作者： Vasiliy P.Sukhorukov valentina B.Savel’eva Yingde Jiang Zhiyong Li V.S.Sobolev Institute of Geology and Mineralogy SB RAS 3 Koptyuga Av.Novosibirsk630090Russia Novosibirsk State University 2 Pirogova St.Novosibirsk630090Russia Institute of the Earth Crust SB RAS 128 Lermontova St.Irkutsk664033Russia State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China

The first data on P-T metamorphic conditions coupled with U-Pb monazite and zircon age obtained for the Neoarchean Kitoy granulite-gneiss terrane(SW Siberian Craton).Alumina gneisses of the Kitoy terrane indicate two-staged metamorphic *** first stage of regional metamorphism(M1)occurred at high-amphibolite facies conditions at T=780-800℃ and P=8-9 *** second stage(M2)belongs to MT-HT/LP type of metamorphism with the wide temperature interval 600-750℃ and pressure 2-4 *** age peaks were established on the basis of U-Pb monazite and zircon dating in garnet-anthophyllite *** of them correspond to the Neoarchean age:the age of M1 falls into the interval of ca.2489-2496 Ma,the age of M2-ca.2446-2456 *** high-temperature metamorphism of the Kitoy block and nearly coeval granitoid magmatism can be an evidence for the Neoarchean collision in SW Siberian craton.

关键词： Siberian craton Neoarchean Kitoy terrane Metamorphism P-T path

Neuroendocrine tumors of the gastro-entero-pancreatic system

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World Journal of Gastroenterology 2008年第35期14卷 5377-5384页

作者： Sara Massironi valentina Sciola Maddalena Peracchi Clorinda Ciafardini Matilde Pia Spampatti Dario Conte Gastroenterology Unit Ⅱ Fondazione IRCCS Ospedale Maggiore PoliclinicoMangiagalli e Regina ElenaMilan 20122Italy

Gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs) are rare neoplasms, although their prevalence has increased substantially over the past three decades. Moreover, there has been an increased clinical recognition and characterization of these neoplasms. They show extremely variable biological behavior and clinical course. Most NETs have endocrine function and secrete peptides and neuroamines that cause distinct clinical syndromes, including carcinoid syndrome; however, many are clinically silent until late presentation with mass effects. Investigation and management should be individualized for each patient, taking into account the likely natural history of the tumor and general health of the patient. Management strategies include surgery for cure or palliation, and a variety of other cytoreductive techniques, and medical treatment including chemotherapy, and biotherapy to control symptoms due to hormone release and tumor growth, with somatostatin analogues (SSAs) and alphainterferon. New biological agents and somatostatintagged radionuclides are under investigation. Advances in the therapy and development of centers of excellence which coordinate multicenter studies, are needed to improve diagnosis, treatment and therefore survival of patients with GEP NETs.

关键词： Gastro-entero-pancreatic neuroendocrine tumors Carcinoids Entero-endocrine tumors Pancreatic tumors Medical treatment Moleculartargeted therapy

Correction to:Remotely Activated Nanoparticles for Anticancer Therapy

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Nano-Micro Letters 2021年第2期13卷 110-111页

作者： Luisa Racca valentina Cauda Department of Applied Science and Technology Politecnico di TorinoC.so Duca degli Abruzzi 2410129 TurinItaly

Correction to:Nano-Micro Lett.(2021)13:11 https://***/10.1007/s40820-020-00537-8 In the original publication figures 7 and 11 need to be updated with correct *** correct version of Figs.7 and 11 is provided in this **... 详细信息

关键词： corrected correction. s.

A Composite State Convergence Scheme for Bilateral Teleoperation Systems

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IEEE/CAA Journal of Automatica Sinica 2019年第5期6卷 1166-1178页

作者： Muhammad Usman Asad Umar Farooq Jason Gu Ghulam Abbas Rong Liu valentina E.Balas the Department of Electrical &Computer Engineering Dalhousie UniversityN.S.Canada the Department of Electrical & Computer Engineering Dalhousie UniversityN.S.Canada the Department of Electrical Engineering University of the Punjab LahorePakistan the Department of Electrical Engineering The University of LahorePakistan the Department of Biomedical Engineering Dalian University of TechnologyChina the Department of Automatics &Applied Software “Aurel Vlaicu” University of AradRomania

State convergence is a novel control algorithm for bilateral teleoperation of robotic systems. First, it models the teleoperation system on state space and considers all the possible interactions between the master and slave systems. Second, it presents an elegant design procedure which requires a set of equations to be solved in order to compute the control gains of the bilateral loop. These design conditions are obtained by turning the master-slave error into an autonomous system and imposing the desired dynamic behavior of the teleoperation system. Resultantly, the convergence of master and slave states is achieved in a well-defined manner. The present study aims at achieving a similar convergence behavior offered by state convergence controller while reducing the number of variables sent across the communication channel. The proposal suggests transmitting composite master and slave variables instead of full master and slave states while keeping the operator's force channel intact. We show that,with these composite and force variables;it is indeed possible to achieve the convergence of states in a desired way by strictly following the method of state convergence. The proposal leads to a reduced complexity state convergence algorithm which is termed as composite state convergence controller. In order to validate the proposed scheme in the absence and presence of communication time delays, MATLAB simulations and semi-real time experiments are performed on a single degree-of-freedom teleoperation system.

关键词： Composite variables linear control systems state convergence teleoperation time delay

Gastric carcinoids:Between underestimation and overtreatment

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World Journal of Gastroenterology 2009年第18期15卷 2177-2183页

作者： Sara Massironi valentina Sciola Matilde Pia Spampatti Maddalena Peracchi Dario Conte Gastroenterology UnitⅡ Fondazione IRCCS Ospedale Maggiore PoliclinicoMangiagalli e Regina Elenaand Postgraduate School of GastroenterologyUniversity of Milan20122 MilanItaly

Gastric carcinoids(GCs),which originate from gastric enterochromaffin-like(ECL) mucosal cells and account for 2.4% of all carcinoids,are found increasingly in the course of upper gastrointestinal tract *** nosography includes those occurring in chronic conditions with hypergastrinemia,as the type 1 associated with chronic atrophic gastritis,and the type 2 associated with Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1,and type 3,which is unrelated to hypergastrinemia and is frequently malignant,with distant *** optimal clinical approach to GCs remains to be elucidated,depending upon type,size and number of *** there is agreement concerning the treatment of type 3 carcinoids,for types 1 and 2,current possibilities include simple surveillance,endoscopic polypectomy,surgical excision,associated or not with surgical antrectomy,or total ***,the recent introduction of somatostatin analogues represents a therapeutic option of possibly outstanding relevance.

关键词： Gastric carcinoids Endocrine tumors Well-differentiated tumors Hypergastrinemia Chronicatrophic gastritis Zollinger-Ellison syndrome Multipleendocrine neoplasia tupe 1 Enterochromaffin-like cells

Bartonella infection in asymptomatic horses and donkeys from Tuscany,Central Italy

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1077-1079页

作者： Edoardo Magni Fabrizio Bertelloni Micaela Sgorbini valentina V.Ebani Department of Veterinary Science University of PisaViale Delle Piagge 256124 PisaItaly

Objective: To investigate the occurrence of Bartonella sp. infection in asymptomatic horses and donkeys living in Tuscany, Central ***: Blood samples were collected from 77 horses and 15 donkeys and tested by indirect immunofluorescent test to detect antibodies against Bartonella sp. and by PCR to detect the ***: Fifty-four(58.69%; 95% CI: 47.95%–68.87%) animals, 9 donkeys and 45 horses, were seropositive with antibody titers ranging from 1:64 to 1:512. PCR assays detected 9 horses positive for Bartonella sp. and 3 donkeys for Bartonella henselae genotype ***: The detected sero-prevalence suggests a common and frequent exposure of equids living in Central Italy to bartonellae and PCR results show that Bartonella *** is possible both in horses and donkeys. At the best of our knowledge, this is the first report of Bartonella henselae infection in donkeys.

关键词： Bartonella Horse Donkey PCR Zoonosis

Plasma treatment for enhancement of the sorption capacity of carbon fabric

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Plasma Science and Technology 2021年第12期23卷 150-160页

作者： IIya ZADIRIEV Elena KRALKINA Vladimir SAMOILOV Victoria ELCHANINOVA valentina GORINA Ilya IVANENKO Konstantin VAVILIN Alexander NIKONOV Physical Electronics Department Faculty of PhysicsLomonosov Moscow State University119991 MoscowRussia Research Institute for Graphite-Based Structural Materials‘Nllgrafit’ 1524 MoscowRussia

In this work we carried out an experimental investigation into enhancement of the sorption capacity of carbon fabric using plasma treatment *** fabric is based on viscose fiber and is hydrophobic by *** of the fabric sorption capacity is required for its application in *** this purpose,two plasma treatment methods were considered,*** nonequilibrium radiofrequency(RF)discharge and a vacuum RF plasma source with an external magnetic *** treated by atmospheric discharge demonstrated aging effects during the first week after *** sorption capacity of samples treated by the RF plasma source was stable over the same period and reached values as high as *** of the beam created by the vacuum RF plasma source were analyzed and dependences of the fabric sorption capacity and specific surface area on plasma treatment time were *** found that sorption capacity reached its maximum value after 30 min of treatment and did not change significantly if processing was continued,while the specific surface area reached its maximum after 3 min of treatment and quickly decreased after *** was found that the micropore structure of the fabric remained almost the same during plasma *** volume of mesopores in a unit of the fabric mass(specific volume)doubled during the first 5 min of treatment and returned to initial values after 30 min of *** sorption capacity continued to increase even when the specific surface area decreased after reaching its peak *** indicates the important role of surface functional groups formed on carbon fibers during plasma *** is consistent with the results of x-ray photoelectron spectroscopy analysis showing changes in surface oxidation during plasma treatment.

关键词： carbon fabric sorption plasma treatment radiofrequency

Intra-abdominal myositis ossificans-a clinically challenging disease:A case report

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World Journal of Orthopedics 2023年第5期14卷 362-368页

作者： Gabriele Carbone valentina Andreasi Paola De Nardi Department of Gastrointestinal Surgery IRCCS San Raffaele HospitalMilan 20132Italy

BACKGROUND Myositis ossificans(MO)is an uncommon disorder characterized by heterotopic ossification within soft *** a few cases of intra-abdominal MO(IMO)have been described in the *** could be difficult to understand and a wrong diagnosis could lead to an improper *** SUMMARY We herein report the case of IMO in a healthy 69-year-old *** patient presented with an abdominal mass in the left lower quadrant.A computed tomography scan showed an inhomogeneous mass with multiple *** patient underwent radical excision of the *** findings were compatible with *** months later the patient showed a recurrence causing hemorrhagic shock due to intractable intralesional *** patients eventually died within three months since *** The case described could be classified as post-traumatic MO that developed close to the previously fractured iliac *** subsequent surgical procedure was ineffective and the disease rapidly *** misleading intraoperative diagnosis led to improper surgical treatment with a dramatic evolution.

关键词： Myositis ossificans Post-traumatic Diagnosis Surgical treatment Prognosis Case report

Human induced pluripotent stem cells for monogenic disease modelling and therapy

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World Journal of Stem Cells 2016年第4期8卷 118-135页

作者： Paola Spitalieri valentina Rosa Talarico Michela Murdocca Giuseppe Novelli Federica Sangiuolo Department of Biomedicine and Prevention Tor Vergata University

Recent and advanced protocols are now available to derive human induced pluripotent stem cells (hiPSCs) from patients affected by genetic diseases. No curative treatments are available for many of these diseases; thus, hiPSCs represent a major impact on patient’ health. hiPSCs represent a valid model for the in vitro study of monogenic diseases, together with a better comprehension of the pathogenic mechanisms of the pathology, for both cell and gene therapy protocol applications. Moreover, these pluripotent cells represent a good opportunity to test innovative pharmacological treatments focused on evaluating the efficacy and toxicity of novel drugs. Today, innovative gene therapy protocols, especially gene editing-based, are being developed, allowing the use of these cells not only as in vitro disease models but also as an unlimited source of cells useful for tissue regeneration and regenerative medicine, eluding ethical and immune rejection problems. In this review, we will provide an up-to-date of modelling monogenic disease by using hiPSCs and the ultimate applications of these in vitro models for cell therapy. We consider and summarize some peculiar aspects such as the type of parental cells used for reprogramming, the methods currently used to induce the transcription of the reprogramming factors, and the type of iPSC-derived differentiated cells, relating them to the genetic basis of diseases and to their inheritance model.

关键词： Human induced pluripotent stem cells Gene therapy Monogenic diseases Gene editing Foetal cells Reprogramming techniques Differentiation

Psychic euosmia and obsessive compulsive personality disorder

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World Journal of Psychiatry 2018年第3期8卷 105-107页

作者： Massimo Pasquini Annalisa Maraone valentina Roselli Lorenzo Tarsitani Department of Human Neurosciences Sapienza University Department of Neuro- sciences and Mental Health Umberto I General Hospital

Patients with obsessive compulsive personality disorder(OCPD) often refer to a prompt mood improvement upon encountering good scents in general, or fresh laundry borax on their clothes, pillows or home settings. The Authors propose the new term psychic euosmia in the mean of an overstated psychological predisposition for a real pleasant smell that elicits an immediate sense of pleasure, order and calm. The prompt reactions to a pleasant odor might be explained by the involvement of rhinencephalon and its proximity to mood-related limbic circuits, which bypass the cognitive awareness. Cleanliness may not preclude a subject to enjoy a good smell, even if we are representing smells that resemble freshness, in other words order. A potentially even more important argument is given by the continuum of personality disorders and their variability. Not all personality characteristics led to disturbed behaviors. In evolutionary perspectives having the ability to differentiate between unpleasant and pleasant odors should have made the difference in surviving. On the other hand, psychic euosmia could be considered a normal reaction, but in our clinical experience it is over-represented among OCPD subjects with marked orderliness and disgust. Therefore, detecting psychic euosmia might vicariously confirm the relevance of disgust as a cognitive driver of OCPD. Hereby we support research to characterize psychic euosmia as a feature of orderliness and cleanliness for OCPD.

关键词： Psychic euosmia Obsessive compulsive personality disorder Orderliness Pleasure Positive emotion Pesonality