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国外钢铁 1989年第3期14卷 61-68页

作者： vale.,m. 李凤翔

Choosing am.ng correlative, m.chanistic, and hybrid m.dels of species’ niche and distribution

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Integrative Zoology 2023年第1期18卷 93-109页

作者： Luara TOURINHO m.riana m.vale Graduate Program.in Ecology Universidade Federal do Rio de JaneiroIlha do FundãoRio de JaneiroBrazil Ecology Departm.nt Universidade Federal do Rio de JaneiroIlha do FundãoRio de JaneiroBrazil

Different m.dels are available to estim.te species’niche and *** and correlative m.dels have different underlying conceptual bases,thus generating different estim.tes of a species’niche and geographic *** m.dels,which com.ining correlative and m.chanistic approaches,are considered a prom.sing strategy;however,no synthesis in the literature assessed their applicability for terrestrial vertebrates to allow best-choice m.del considering their strengths and ***,we provide a system.tic review of studies that com.ared or integrated correlative and m.chanistic m.dels to estim.te species’niche for terrestrial vertebrates under clim.te *** goal was to understand their conceptual,m.thodological,and perform.nce differences,and the appli-cability of each *** studies we reviewed directly com.ared m.chanistic and correlative predictions in term. of accuracy or estim.ted suitable area,however,without any quantitative analysis to support ***,m.ny studies suggest that instead of com.aring approaches,m.chanistic and correlative m.thods should be integrated(hybrid m.dels).However,we stress that the best approach is highly ***-deed,the quality and effectiveness of the prediction depends on the study’s objective,m.thodological design,and which type of species’niche and geographic distribution estim.ted are m.re appropriate to answer the study’s issue.

关键词： clim.te change ecological niche m.del integrative m.del species distribution m.del vertebrates

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IL WIS系统综述

测绘译丛 1990年第1期 32-39,3页

作者： vale.,CR 李晓燕

Distributed Energy Resource Scheduling with Focus on Dem.nd Response Com.lex Contracts

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Journal of m.dern Power System. and Clean Energy 2021年第5期9卷 1172-1182页

作者： Pedro Faria Zita vale GECAD–Research Group on Intelligent Engineering and Com.uting for Advanced Innovation and Developm.nt R.Dr.António Bernardino de Almeida4314249-015PortoPortugal Polytechnic of Porto R.Dr.António Bernardino de Almeida4314249-015PortoPortugal

Dem.nd response(DR)is a flexible way to im.rove distributed energy resource *** innovative contribution of this paper is to include com.lex contracts in the m.del,which can accom.odate the constraints according to the special expectations of each *** contracts are included in the optim.zation of distributed energy resource scheduling to dispatch DR according to the expectations of ***-period DR events are *** this way,consum.rs can specify the lim.ts on the tim.,power,and rem.neration regarding participation in DR events,which has not been considered in the *** state of the art treats these aspects separately or uses a statistical approach,without providing consum.rs with options to com.ine their preferences regarding different aspects of their flexibility *** m.del has been validated for 218 consum.rs using several scenarios and different types of distributed generation,showing that it is possible to increase DR with respect to the preferences of consum.rs.

关键词： Com.lex contracts dem.nd response distributed generation virtual power player

Neurogenesis dynam.cs in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： m.awiah m.Naffaa Departm.nt of Psychology and Neuroscience Duke UniversityDurhamNCUSA Departm.nt of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons m.grating to the granule cell layer and glom.rular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit rem.deling triggered by m.m.ry and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. m.reover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory inform.tion processing. This adaptive process responds to changes in epithelial com.osition and contributes to the form.tion of olfactory m.m.ries by m.dulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions rem.ins a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around m.tral and tufted cells. This organizational pattern significantly im.acts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and m.m.ry. Additionally, this organization is further shaped by axon term.nals originating from.cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these com.lex and highly interconnected processes have not been com.rehensively studied as a whole. Therefore, this m.nuscript aim. to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These m.chanism. are thought to support olfactory learning and m.m.ry, potentially through increased

关键词： network adaptability neurogenesis neuronal com.unication olfactory bulb olfactory learning olfactory m.m.ry synaptic plasticity

m.tochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflam.aging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología m.lecular Severo Ochoa(CBm. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” com.s from.the Latin senescens, m.aning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from.stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri J.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

Helicobacter pylori infection- recent developm.nts in diagnosis

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World Journal of Gastroenterology 2014年第28期20卷 9299-9313页

作者： Ana Isabel Lopes Filipa F vale.m.nica Oleastro Centro Académ.co de m.dicina de Lisboa Faculdade de Medicina da Universidade de Lisboa Centro de Patogénese m.lecular Unidade dos Retrovírus e Infec??es AssociadasInstituto de Medicina Molecular e Instituto de Investiga??o do MedicamentoFaculdade de FarmáciaUniversidade de Lisboa Laboratório Nacional de Referência das Infe??es Gastrintestinais Departamento de Doen?as InfeciosasInstituto Nacional de Saúde Dr Ricardo Jorge

Considering the recom.ended indications for Helicobacter pylori(***)eradication therapy and the broad spectrum.of available diagnostic m.thods,a reliable diagnosis is m.ndatory both before and after eradication *** highly accurate tests should be used in clinical practice,and the sensitivity and specificity of an adequate test should exceed 90%.The choice of tests should take into account clinical circum.tances,the likelihood ratio of positive and negative tests,the cost-effectiveness of the testing strategy and the availability of the *** review concerns som. of the m.st recent developm.nts in diagnostic m.thods of *** infection,nam.ly the contribution of novel endoscopic evaluation m.thodologies for the diagnosis of *** infection,such as m.gnifying endoscopy techniques and *** addition,the diagnostic contribution of histology and the urea breath test was explored recently in specific clinical settings and patient *** studies recom.end enhancing the num.er of biopsy fragm.nts for the rapid urease *** culture from.the gastric biopsy is the gold standard technique,and is recom.ended for antibiotic susceptibility *** is used for initial screening and the stool antigen test is particularly used when the urea breath test is not available,while m.lecular m.thods have gained attention m.stly for detecting antibiotic resistance.

关键词： Helicobacter pylori Diagnosis Endoscopy Histology Culture Urea breath test Stool antigen test Serology m.lecular m.thods

Search for m.croglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Departm.nt of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflam.atory states in the central nervous system.CNS)are the hallm.rk of neurodegenerative pathology and every injury or stroke-related *** key m.diators of these neuroinflam.atory states are glial cells known as m.croglia,the resident im.une cell at the core of the inflam.atory event,and astroglia,which encapsulate inflam.atory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** m.st neuroinflam.ation is exclusively based on the responses of said m.croglia,their phenotypes are suggested to follow those of m.crophages;m. and m. are opposites of pro-and ***,m.croglial phenotypes have been identified to be on an inflam.atory spectrum.encom.assing developm.ntal,hom.ostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue form.tion.

关键词： inflam.ation pathology death

SBL-JP-0004: A prom.sing dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m.Otifi Departm.nt of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) rem.ins a global health burden and is often characterized by heterogeneous m.lecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, m.king them.attractive targets for therapeutic interventions.m.thods:This study applied a com.utational and m.lecular dynam.cs sim.lation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by m.lecular docking scores and m.lecular dynam.cs sim.lations. Binding interactions and Gibbs binding free energy estim.tes confirm.d stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-m.xim.l inhibitory concentration (IC) value of 118.9 nm.against JAK2 kinase and 200.9 nm.against PI3KCD enzym.s. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-m.xim.l growth inhibitory concentration (GI) values of 250.8 and 516.3 nm. respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatm.nt com.ared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a prom.sing dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 m.lecular docking m.lecular dynam.cs sim.lation PI3KCD SBL-JP-0004