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Establishing research priorities in prevention and control of vector-borne diseases in urban areas:a collaborative process

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Infectious Diseases of Poverty 2018年第1期7卷 860-869页

作者： Christian Dagenais Stephanie Degroote Mariam Otmani Del Barrio Clara Bermudez-Tamayo valery Ridde Department of Psychology University of MontrealPavillon Marie-VictorinBureau C-355C.P.6128succursale Centre-ville.MontrealQC H3C 3J7Canada University of Montreal Public Health Research Institute MontrealQCCanada Vector Environment and Society UnitSpecial Programme for Research and Training in Tropical Diseases(TDR)World Health OrganizationGenevaSwitzerland Andalusian School of Public Health GranadaSpain CIBER of Epidemiology and Public Health(CIBERESP) MadridSpain IRD(French Institute for Research on Sustainable Development) CEPED(IRD-Universite Paris Descartes)Universites Paris Sorbonne CitesERL INSERM SAGESUDParisFrance.

Background:In 2015,following a call for proposals from the Special Programme for Research and Training in Tropical Diseases(TDR),six scoping reviews on the prevention and control of vector-borne diseases in urban areas were *** reviews provided a clear picture of the available knowledge and highlighted knowledge gaps,as well as needs and opportunities for future *** on the research findings of the scoping reviews,a concept mapping exercise was undertaken to produce a list of priority research needs to be ***:Members of the six research teams responsible for the“VEctor boRne DiseAses Scoping reviews”(VERDAS)consortium’s scoping reviews met for 2 days with decision-makers from Colombia,Brazil,Peru,Pan-American Health Organization,and World Health Organization.A total of 11 researchers and seven decision-makers(from ministries of health,city and regional vector control departments,and vector control programs)completed the concept mapping,answering the question:“In view of the knowledge synthesis and your own expertise,what do we still need to know about vector-borne diseases and other infectious diseases of poverty in urban areas?”Participants rated each statement on two scales from 1 to 5,one relative to‘priority’and the other to‘policy relevance’,and grouped statements into clusters based on their own individual criteria and ***:The final map consisted of 12 *** considered those entitled“Equity”,“Technology”,and“Surveillance”to have the highest *** cluster considered the most important concerns equity issues,confirming that these issues are rarely addressed in research on vector-borne *** the other hand,the“Population mobility”and“Collaboration”clusters were considered to be the lowest priority but remained identified by participants as research *** average policy relevance scores for each of the 12 clusters were roughly the same as the priority scores for all ***

关键词： Concept mapping Research priorities Vector-borne diseases Urban areas

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Characterization of Virulence Factors in Enteroaggregative and Atypical Enteropathogenic Escherichia coli Strains Isolated from Children with Diarrhea

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Advances in Infectious Diseases 2012年第4期2卷 135-142页

作者： Thiago Azevedo Feitosa Ferro Francyelle Costa Moraes Andreia Meneses da Silva Claude Porcy Leandro Amorim Soares Cristina Andrade Monteiro Nyla Thyara Melo Lobao Francisco Amazonas Assis de Mello valério Monteiro-Neto Patrícia de Maria Silva Figueiredo Research Group of Endemic and Parasitic Diseases CEUMA UniversitySao LuisBrazil Federal Institute of Maranhao Sao LuisBrazil Health and Biological Sciences Center Federal University of MaranhaoSao LuísBrazil

Enteroaggregative (EAEC) and atypical enteropathogenic (EPEC) Escherichia coli are important bacterial etiologic agents causing diarrhea among children. The aim of the present study was to examine the impact of virulence factors predisposes to diarrhea. In this study some virulence properties were examined on 11 EAEC and 8 EPEC strains identified by Polymerase Chain Reaction (PCR), isolated from stool samples of children were analyzed genotypically and phenoltypically for the prevalence of virulence factors. The most frequently detected factor was resistance to serum (94%), followed by curli fimbriae (78%), biofilm production (73%), and gene coding for Extended-Spectrum Beta-Lactamase (ESBL) (68%). EPEC isolates showed at least three of the evaluated properties, while EAEC isolates showed at least two. The prevalence of these virulence factors between the two strains showed no statistical difference. This study showed the heterogeneity of the virulence profile of the isolates of EAEC and atypical EPEC strains and suggests that this diversity may influence in the disease severity.

关键词： E.coli Diarrhea Virulence Factors

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南美圭亚那地盾热带森林淘金热的起因及后果

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AMBIO－人类环境杂志 2007年第B12期36卷 623-631页

作者： David S. Hammond valéry Gond Benoit de Thoisy Pierre-Michel Forget Bart P. E. DeDijn 王胜（译） NWFS咨询公司负责人 Département Forēt du CIRAD UPR 36 Route de Montabo BP 165 97323 Cayenne cedex French Guiana Association Kwata BP 672 F-97335 Cayenne cedex French Guiana Muséum National d＇Histoire Naturelle Département Ecologie et Gestion de la Biodiversite UMR 5176 CNRS-MNHN 4 av.du Petit Chāteau F- 91800 Brunoy Bart De Dijinenvironmental consultancy Koffielaan 30 Paramaribo Suriname 不详

历史时间序列及遥感数据的统计与空间分析都表明,在亚马孙东北部的圭亚那地盾上,黄金生产的空间分布和增长之间存在着关联。结果表明,在一个不断扩大的区域中,产量呈指数增长,这主要是对1971～1978年国际金价市场浮动的滞后反应。随后,... 详细信息

历史时间序列及遥感数据的统计与空间分析都表明,在亚马孙东北部的圭亚那地盾上,黄金生产的空间分布和增长之间存在着关联。结果表明,在一个不断扩大的区域中,产量呈指数增长,这主要是对1971～1978年国际金价市场浮动的滞后反应。随后,平均虚价(实价)上升了10倍(2倍),这造成了极具吸引力的经济刺激,导致了低等级金矿的大量开采。采矿行为的地面分布及遥感分布与那些在该区域黄金地质中占优势的矿床密切相关。在保护区和可持续发展的木材生产地区内,这些含金地层的出现触发了该区域的社会矛盾,导致环境退化。有25万多km^2被划为保护区和可持续经营的热带林区处于无人管理状态,由于缺乏综合资源利用规划,没有进行恢复工作,对非法作业失去控制,受价格驱动的采金业繁荣最终会将这些地区推入危险境地。在无节制的采矿环境中充斥着严重的公共卫生问题,这进一步抵消了采金获得的财政收入。本研究部分地证明,那些曾成功地稳定了更为著名的全球经济中心的国际经济政策是如何对偏远的商品新地域造成了无意识却又深刻的环境和社会影响。

关键词：圭亚那淘金热带森林地盾南美公共卫生问题遥感数据环境退化

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21-氨基类固醇抗石英细胞毒性及抑制其促成纤维细胞生长的研究

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中华劳动卫生职业病杂志 2000年第1期18卷 42-44页

作者：黄曙海樊建康王力珩 val vallyathan 广西壮族自治区职业病防治研究所中毒毒理研究室南宁530021 美国职业安全与卫生研究所

目的　研究 2 1 氨基类固醇 (Lazaroid ,U 75 412E)在体外对石英毒性的抑制作用。方法　观察体外培养的肺泡巨噬细胞 (AM)释放H2 O2 、乳酸脱氢酶 (LDH)、超氧化物歧化酶 (SOD)和β N 乙酰氨基葡萄糖苷酶 (NAG)的水平 ,评价U 75 412E对... 详细信息

目的　研究 2 1 氨基类固醇 (Lazaroid ,U 75 412E)在体外对石英毒性的抑制作用。方法　观察体外培养的肺泡巨噬细胞 (AM)释放H2 O2 、乳酸脱氢酶 (LDH)、超氧化物歧化酶 (SOD)和β N 乙酰氨基葡萄糖苷酶 (NAG)的水平 ,评价U 75 412E对石英细胞毒性的消除能力 ;电子自旋共振俘获法评价U 75 412E清除石英催化H2 O2 产生·OH的作用 ;噻唑蓝比色法比较U 75 412E对矽肺大鼠肺泡AM促成纤维细胞 (FB)生长活性的抑制作用。结果　在U 75 412E作用下 ,与石英共孵的肺泡AM释放H2 O2 、SOD、LDH的水平显著下降 ,40 μmol/LU 75 412E组各值分别为 (0 .16± 0 .0 4)nmol/L、(48.6± 2 2 .2 ) μg/L、(33.0± 4.6 )U/L ,而阳性对照组分别为 (0 .6 3± 0 .0 7)nmol/L、(117.5± 30 .3) μg/L、(6 0 .3± 5 .5 )U/L。在Fenton反应体系中 ,石英催化H2 O2 生成·OH ,平均峰值为 (5 3.2 5± 2 .3)mm ;当与U 75 412E共存时 ,反应体系中的·OH水平显著下降 ,平均峰值为 (2 8.4±1.3)mm。矽肺或受石英攻击的肺泡AM培养液促进了NIH 3T3细胞增殖 (平均指数 :77.8± 8.0、85 .9± 7.0 ) ,U 75 412E显著抑制了这一活性 (平均指数 :5 8.0± 15 .4、5 2 .6± 11.8)。结论　U 75 412E具有较强的清除·OH、保护AM抵御石英细胞毒性、抑?

关键词：氨基类固醇石英毒性抑制成纤维细胞矽肺

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Lazaroid U-75412E试验性治疗大鼠矽肺研究

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中国职业医学 1999年第6期26卷 11-13页

作者：黄曙海樊建康梁德新周少诗陈作兴王力珩 val vallyathan 广西职业病防治研究所南宁市530021 美国国立职业安全与卫生研究所

目的　鉴于Ｌａｚａｒｏｉｄｓ（２１－氨基类固醇）类药物具有较强的抗铁离子依赖脂质过氧化特性，通过治疗大鼠实验性矽肺研究探讨铁离子依赖脂质过氧化与矽肺的关系并寻找新的抑制矽肺发展的药物。方法　大鼠经气管注入石英粉尘... 详细信息

目的　鉴于Ｌａｚａｒｏｉｄｓ（２１－氨基类固醇）类药物具有较强的抗铁离子依赖脂质过氧化特性，通过治疗大鼠实验性矽肺研究探讨铁离子依赖脂质过氧化与矽肺的关系并寻找新的抑制矽肺发展的药物。方法　大鼠经气管注入石英粉尘形成矽肺后，灌胃给予ＬａｚａｒｏｉｄＵ－７５４１２Ｅ进行治疗三个月后观察疗效。结果　治疗组肺灌洗液中细胞总数、白细胞数、ＳＯＤ、ＭＤＡ含量、肺组织胶原纤维化分级均显著低于矽肺对照组（Ｐ＜０－０５），治疗期间未见有明显的肝、肾毒副作用发生。结论　结果说明该药具有抑制石英所致的肺组织炎性反应、脂质过氧化反应以及纤维化发展的作用。此外，实验结果提示了铁离子依赖脂质过氧化在矽肺发病机理中起一定作用。

关键词：矽肺铁离子依赖脂质过氧化 Lazaroids

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Epidemiological and Histopathological Aspects of Chronic Gastritis at the Departmental University Teaching Hospital of Borgou Alibori (CHUD-BA) from 2011 to 2021

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Open Journal of Pathology 2023年第1期13卷 54-71页

作者： Luc valère Codjo Brun Khadidjatou Sake Alassan Marie-Claire Assomption Oloufoudi Balle Pognon Nukunté David Lionel Togbenon Marie-Noëlle Oréofè Axelle Zomahoun Raoul Gomez Moncho Adrien Hodonou Oumou Boukari Pacôme Ahouanse Wilfried Akpo Falilath Seidou Marie Thérèse Akele Akpo Faculty of Medicine University of Parakou Parakou Benin Faculty of Health Sciences University of Abomey Calavi Cotonou Benin

Background: Gastritis is better evaluated nowadays since the advent of upper gastrointestinal endoscopy. Despite the availability of this workup in Benin Republic, there is a scarcity of data on chronic gastritis. Objective: This work aimed to study the epidemiological and histopathological aspects of chronic gastritis in the Departmental University Teaching Hospital of Borgou Alibori (CHUD-B/A) from 2011 to 2021. Method: This was a retrospective cross-sectional study with descriptive and analytical purposes, carried out from February 23, 2022 to May 23, 2022, among patients who had undergone gastric biopsy and/or gastrectomy from January 2011 to January 2022 (10 year), and whose specimens were sent into the histopathology section of the CHUD-B/A. Non-probability sampling was performed with exhaustive recruitment. A survey form has been used to collect data from patients’ medical records. Pearson’s chi-square and Fisher’s exact tests have been used as appropriate to determine correlations between variables. Result: A total of 310 cases of chronic gastritis were diagnosed in the histopathology section of the CHUD-B/A from 2011 to 2021. This represented a chronic gastritis frequency of 91.45% for all gastric lesions diagnosed throughout the study period. Erythematous gastropathy was the most frequent (70.35%). Helicobacter pylori was present in 36.77% and dysplasia was observed in 12.26% of cases. Erythematous gastropathy was a predictive factor for the absence of gastric dysplasia in histopathology check up (p-value = 0.042). In contrast, intestinal metaplasia was predictive of the presence of gastric dysplasia in histopathology check up (p-value < 0.001). Conclusion: Chronic gastritis is very common in our setting. Systematic biopsy performance in front of an evocative clinical situation followed by histopathological examination may be encouraged.

关键词： Epidemiology Histopathology Chronic Gastritis Dysplasia Parakou (Benin)

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The growth and production modeling of individual trees of Eucalyptus urophylla plantations

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Journal of Forestry Research 2020年第5期31卷 1663-1672页

作者： Joao Victor Nobre Carrijo Ana Beatriz de Freitas Ferreira Marcela Costa Ferreira Mario Cesar de Aguiar Eder Pereira Miguel Eraldo Aparecido Trondoli Matricardi Alba valeria Rezende Department of Forestry Faculty of TechnologyUniversity of Brası´liaBrası´lia 70910-900Brazil

Individual tree models(ITMs)are classified as growth and production models for projecting current and future forest *** are more complex than other growth and production models,show a higher level of detail and,consequently,produce a better modeling ***,the accuracy and efficiency of ITMs have not been properly assessed to *** this study,we estimated the growth in height,diameter,and individual tree volume of a Eucalyptus urophylla plantation by applying an *** used a continuing forest inventory dataset in which 1554 individual trees within 29 permanent plots were measured in the field over a 6-year period(24 to 72 months).Each individual tree volume was estimated for future tree *** achieve this,we adjusted the model to predict the height and diameter growth,and the probability of mortality as a function of the competition *** ITM accuracy was assessed based on the analysis of variance results and,subsequently,the multiple mean comparison test at the 5%significance *** tree volumes predicted by the ITM for the forest stand aged 72 months,beginning at ages 24,36,48,and 60 months,were compared to the field measured tree volume acquired from the 72-month forest inventory that was used as the reference *** and observed tree volumes were similar when the estimation was based on the 48-month forest *** results might help to reduce financial costs of forest inventory because the ITM produces accurate future predictions of forest stand *** estimated ITM for Eucalyptus plantations using measurement intervals up to 2 years is recommended because it significantly reduced the projected volume discrepancy compared to the field measurements.

关键词： Competition index Forest production Forest site Simulation models Tree mortality

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Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil

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World Journal of Gastroenterology 2020年第25期26卷 3611-3624页

作者： valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman Division of Gastroenterology Department of Internal MedicineClementino Fraga Filho HospitalFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Institute for Studies in Public Health Federal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Multidisciplinary Research Laboratory Clementino Fraga Filho HospitalInstitute of Thoracic DiseasesFaculty of MedicineFederal University of Rio de JaneiroRio de Janeiro 21940-230Brazil Division of Gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of PiauíPiauí64049-550Brazil Almeida Division of GastroenterologyInflammatory Bowel Disease Outpatient ClinicRoberto Santos General Hospital(HGRS)of the Bahia State Department of HealthBahia 40110-060Brazil Division of Gastroenterology Inflammatory Bowel Disease Outpatient ClinicIrmandade Santa Casa da Misericórdia of São PauloSão Paulo 01221020Brazil Division of Gastroenterology Department of Internal MedicineHospital UniversityFaculty of MedicineFederal University of Juiz de ForaMinas Gerais 36036-247Brazil Division of Gastroenterology Inflammatory Bowel Disease Outpatient ClinicFederal District Base HospitalBrasília 70330-150Brazil Gastrointestinal Physiology Institute of Nutritional ScienceNestle Research CenterLausanne 1000Switzerland Departments of Medicine and Community Health Sciences University of CalgaryCalgary T2N4Z6Canada

BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be *** hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated *** To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development *** A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was *** regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),*** This is the first examining environmental exposures as risk factors for inflammatory bowel disease in *** of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development.

关键词： Crohn’s disease Ulcerative colitis Risk factors Environmental factors Hygiene hypothesis

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金黄色葡萄球菌表面蛋白nEBPS抗体的制备和纯化

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江苏农业学报 2015年第6期31卷 1430-1434页

作者：锡林高娃薛晓阳吴金花布日额内蒙古民族大学生命科学学院内蒙古通辽028400 内蒙古民族大学乳源性致病菌研究所内蒙古通辽028400

为了在原核细胞中表达金黄色葡萄球菌弹性纤维结合蛋白(EBPS),制备多克隆抗体,将构建的p ET30a-n EBPS重组质粒转化大肠杆菌BL21(DE3),经IPTG诱导表达后,亲和层析法纯化重组蛋白,以纯化的重组蛋白为抗原免疫新西兰大耳白兔制备多克隆抗... 详细信息

为了在原核细胞中表达金黄色葡萄球菌弹性纤维结合蛋白(EBPS),制备多克隆抗体,将构建的p ET30a-n EBPS重组质粒转化大肠杆菌BL21(DE3),经IPTG诱导表达后,亲和层析法纯化重组蛋白,以纯化的重组蛋白为抗原免疫新西兰大耳白兔制备多克隆抗体,ELISA方法检侧抗体滴度,亲和层析法纯化兔抗n EBPS多克隆抗体。结果显示,利用p ET30a-n EBPS重组质粒,经原核表达和亲和层析获得了n EBPS蛋白;利用n EBPS蛋白质制备多克隆抗体,间接ELISA检测的纯化抗体效价可达0.686(OD450值),P/N值达6.7。

关键词： nEBPS抗体多克隆抗体制备纯化

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Use of Essential Oils of the Genus Citrus as Biocidal Agents

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American Journal of Plant Sciences 2014年第3期5卷 299-305页

作者： Marcos S.Gomes Maria das G.Cardoso Maurilio JSoares Luís R.Batista Samísia M.F.Machado Milene A.Andrade Camila M.O.de Azeredo Juliana Maria valério Resende Leonardo M.A.Rodrigues Department of Chemistry Federal University of LavrasLavrasBrazil Laboratory of Cell Biology Instituto Carlos Chagas/FiocruzCuritibaBrasil Department of Food Science Federal University of LavrasLavrasBrazil Department of Chemistry Federal University of SergipeSao CristóvãoBrazil

In this study, the essential oils extracted from the peels of Citrus aurantifolia, Citrus limon and Citrus sinensis were chemically characterized and quantified. These essential oils and their standards limonene, citral and limonene + citral were evaluated (at concentrations ranging from 500 to 3.91 mL·mL-1) regarding their anti-trypanosome, antifungal and antibacterial activities. The chemical identification and quantification (by GC/FID and GC/MS) displayed the limonene as the major component of the three essential oils. It did not verified anti-trypanosome activity for all treatments. Regarding antimicrobial activity, the results were satisfactory against Gram-negative bacteria (Staphylococcus aureus, Listeria. monocytogenes and Salmonella cholerasuis) and funghi (Aspergillus niger, A. flavus and A. carbonarius), except for the bacterium Pseudomonas aeruginosa, which showed no inhibition for any treatment used.

关键词： Volatile Essential Oil Trypanosoma cruzi Gram-Negative Bactéria Funghi Antimicrobial

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