检索结果-南通市图书馆

Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab

引用

World Journal of Gastroenterology 2015年第17期21卷 5352-5358页

作者： Aflah Roohullah Hui-Li Wong Katrin M Sjoquist Peter Gibbs Kathryn Field Ben Tran Jeremy Shapiro Joe Mckendrick Desmond Yip Louise Nott val Gebski Weng Ng Wei Chua Timothy Price Niall Tebbutt Lorraine Chantrill Macarthur Cancer Therapy Centre CampbelltownNSW 2560Australia NHMRC Clinical Trials Centre CamperdownNSW 2050Australia Department of Medical Oncology Royal Melbourne HospitalParkvilleVIC 3052Australia Melbourne Medical School University of MelbourneMelbourneVIC 3000Australia Department of Medical Oncology Box Hill HospitalBox HillVIC 3128Australia St George Cancer Care Centre KogarahNSW 2217Australia Department of Medical Oncology Western HospitalFootscrayVIC 3011Australia Department of Medical Oncology Cabrini HealthMelbourneVIC 3000Australia Department of Medical Oncology the Canberra HospitalGarranACT 2605Australia ANU Medical School Australia National UniversityCanberraACT 2600Australia Department of Medical Oncology Royal Hobart HospitalHobartTAS 7000Australia Liverpool Cancer Therapy Centre LiverpoolNSW 2170Australia Department of Medical Oncology the Queen Elizabeth HospitalWoodvilleSA 5011Australia Department of Medical Oncology Austin HealthHeidelbergVIC 3084Australia the Kinghorn Cancer Centre Garvan Institute of Medical ResearchDarlinghurstNSW 2010Australia

AIM:To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal ***:We compared rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving first-line chemotherapy with and without bevacizumab in three distinct cohorts:(1) the AGITG MAX trial(Phase Ⅲ randomised clinical trial comparing capecitabine vs capecitabine and bevacizumab vs capecitabine,bevacizumab and mitomycin C);(2) the prospective Treatment of Recurrent and Advanced Colorectal Cancer(TRACC) registry(any first-line regimen ± bevacizumab);and(3) two cancer centres in New South Wales,Australia [Macarthur Cancer Therapy Centre and Liverpool Cancer Therapy Centre(NSWCC) from January 2005 to Decenber 2012,(any first-line regimen ± bevacizumab).For the AGITG MAX trial capecitabine was compared to the other two arms(capecitabine/bevacizumab and capecitabine/bevacizumab/mitomycin C).In the AGITG MAX trial and the TRACC registry rates of gastrointestinal perforation were also collected in patients who did not have peritoneal *** endpoints included progression-free survival,chemotherapy duration,and overall ***-toevent outcomes were estimated using the Kaplan-Meier method and compared using the log-rank ***:Eighty-four MAX,179 TRACC and 69 NSWCC patients had peritoneal *** were no gastrointestinal perforations recorded in either the MAX subgroup or the NSWCC *** the patients without peritoneal disease in the MAX trial,4/300(1.3%) in the bevacizumab arms had gastrointestinal perforations compared to 1/123(0.8%) in the capecitabine alone *** the TRACC registry 3/126(2.4%) patients who had received bevacizumab had a gastrointestinal perforation compared to 1/53(1.9%) in the chemotherapy alone *** a further analysis of patients without peritoneal metastases in the TRACC registry,the rate of gastrointestinal p

关键词： Peritoneal neoplasms Colorectal neoplasms Bevacizumab Intestinal perforation Capecitabine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

地理编码方法对长期城市空气污染暴露与肺功能之间关联的影响

引用

环境与职业医学 2013年第12期30卷 969-969页

作者： Bénédicte Jacquemin Johanna Lepeule Anne Boudier Caroline Arnould Meriem Benmerad Claire Chappaz Joane Ferran Francine Kauffmann Xavier Morelli Isabelle Pin Christophe Pison Isabelle Rios Sofia Temam Nino Künzli Rémy Slama valérie Siroux

[背景]地址地理编码中的错误可能会影响空气污染对健康影响的估计。[目的]研究4种地理编码技术对采用小尺度(10m×10m)分散模型估计的城市空气污染与成人肺功能之间关联的影响。[方法]测量法国格勒诺布尔市354名成年居民的1秒用力呼气容... 详细信息

[背景]地址地理编码中的错误可能会影响空气污染对健康影响的估计。[目的]研究4种地理编码技术对采用小尺度(10m×10m)分散模型估计的城市空气污染与成人肺功能之间关联的影响。[方法]测量法国格勒诺布尔市354名成年居民的1秒用力呼气容积(FEV1)与用力肺活量(FVC)。这些居民参加了两个特征明确的研究:遗传和环境对哮喘影响的流行病学研究(EGEA)和欧洲共同体呼吸系统健康调查(ECRHS)。使用单个建筑物匹配作为参考方法以及三种空间插值方法编码家庭地址。使用扩散模型估计在进行肺功能测量前的12个月期间,每个参加者住址的PM10和二氧化氮的平均浓度。以个体混杂因素及同日空气污染物暴露校正暴露与肺功能参数之间的关联。对地理编码技术在地理坐标之间距离、暴露估值以及暴露估值与健康影响之间关联等方面进行比较。[结果]利用建筑物匹配和三种插值技术估计坐标之间的中位数距离分别为26.4、27.9、35.6m。相对于基于建筑匹配的暴露估值,基于三种插值技术的PM10浓度往往被高估。当使用建筑物匹配估计暴露估值时,PM10每增加一个四分位数间距(3.0μg/m3),FVC%预测值下降3.72点(95%CI:-0.56～-6.88)、FEV1%预测值下降3.86点(95%CI:-0.14～-3.24)。当使用其他地理编码方法时,关联的幅度下降[例如,使用NavTEQ预测FVC%-2.81(95%CI:-0.26,-5.35),或者使用谷歌地图预测FVC%-2.08(95%CI:-4.63～0.47,P=0.11)。[结论]研究结果表明,当使用小尺度暴露模型估算空气污染暴露时,地理编码技术的选择可能会对健康影响的评估产生影响。

关键词：空气污染物肺功能参数编码方法地理城市健康影响编码技术用力呼气容积

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

用风险塑造未来专访风险管理专家瓦尔·乔纳斯

引用

项目管理评论 2021年第6期 26-28页

作者：尉艳娟瓦尔·乔纳斯不详全球风险决策集团

瓦尔·乔纳斯(val Jonas)现任全球风险决策集团(Risk Decisions Group,Global)首席执行官。作为一名经验丰富的风险管理专家,30余年来,她一直致力于推广风险管理最佳实践,分享通过风险管理提高业务绩效之道。她是PMI《风险实践标准》章... 详细信息

瓦尔·乔纳斯(val Jonas)现任全球风险决策集团(Risk Decisions Group,Global)首席执行官。作为一名经验丰富的风险管理专家,30余年来,她一直致力于推广风险管理最佳实践,分享通过风险管理提高业务绩效之道。她是PMI《风险实践标准》章节协调员,亦是(英国)项目管理协会(Association of Project Management,APM)风险管理特殊兴趣小组的成员,参与了"风险商"(Risk Quotient,RQ)系列白皮书的撰写。2021年4月,该系列之二《雪球效应白皮书》(The Snowball Effect Whitepaper)出版,就该白皮书涉及的相关话题,我们与瓦尔·乔纳斯展开了以下对话。

关键词：风险管理首席执行官协调员瓦尔兴趣小组最佳实践风险决策实践标准

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Implications of the New Operational Rules for Cantareira Water System: Re-Reading the 2014-2016 Water Crisis

引用

Journal of Water Resource and Protection 2020年第4期12卷 261-274页

作者： Karinne Reis Deusdará-Leal Luz Adriana Cuartas Rong Zhang Guilherme S. Mohor Luíz valério de Castro Carvalho Carlos Afonso Nobre Eduardo Mario Mendiondo Elisangela Broedel Marcelo Enrique Seluchi Regina Célia dos Santos Alvalá Brazilian Center for Monitoring and Early Warning of Natural Disaster-Cemaden Sao José dos Campos Brazil Department of Hydrology and Water Resources Nanjing Hydraulic Research Institute (NHRI) under the Ministry of Water Resources The Ministry of Transport and National Energy Administration Nanjing China University of Potsdam Potsdam Germany Universidade de Taubaté Taubaté Brazil Institute of Advanced Studies University of Sao Paulo Sao José dos Campos Brazil Sao Carlos School of Engineering University of Sao Paulo USP Sao Carlos Brazil Center for Education & Research of Disasters of Sao Paulo CEPED Sao Paulo Brazil

During the 2014-2016 water shortage crisis, the Metropolitan Area of Sao Paulo (MASP) water supply system extracted pumping volume from the Cantareira System. Before the crisis, between 1984 and 2013, the reservoir’s average water extraction flow was 29.6 m3·s-1. During the period of pumping volume usage, the average extraction flow was 16.2 m3·s-1. Following the crisis, two new mitigation policies were implemented: a water extraction Resolution (in 2017) and a Resolution for water reallocation from another basin (in 2018). This study provides a novel investigation of the Cantareira System water crisis by assessing the mitigation policies impacts on storage level dynamics. The system storage level was evaluated using the reservoir simulation module of PDM-Cemaden hydrological model, assuming that the new policies had already been implemented prior to the crisis. A control simulation was run with observed in- and out-flow and operationally-practiced extraction flow. The storage level dynamics impacts were evaluated under 4 water mitigation policies scenarios varying the policies implementation starting date, the extraction flow range and including the water reallocation variable. Results showed that pumping volume would only need extraction during a short period (Scenarios I, III and IV), and considering the water reallocation, pumping volume extraction would not have been necessary (Scenario II). Although the pumping volume would still have been extracted during a short period, water shortage impact would have been lessened, had the policies been already implemented before the crisis. The water mitigation policies implementation supports the reservoirs storage management but does not guarantee that MASP water demand is fully met. Therefore, in order to effectively improve water security, further policies and practices to reduce water demand and enhance supply should be considered.

关键词： Cantareira System Drought Sao Paulo Brazil Dead Storage Water Crisis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Review on Housing Affordability and Housing Policy Application in Neglected Border Cities in Jordan

引用

Journal of Civil Engineering and Architecture 2021年第3期15卷 156-166页

作者： Thamer Mahmmoud Muhammad Al Jbarat Suguru Mori rie Nomura Graduate School of Engineering Hokkaido UniversityNorth 13West 8Kita-kuSapporo 060-8628Japan Faculty of Engineering Hokkaido UniversitySapporo 060-8628Japan

The main task of this paper is to examine housing affordability and housing policy application in neglected border cities in *** the Iraq war in 2003 and Syria civil war in 2011 many border cities accommodated a large number of refugees in its urban context over different periods of *** lack of affordable housing and increase of unemployment were the main challenges for its vulnerable *** cities are facing different development challenges but applying the same housing policy as *** paper studies economic attributes and social characteristics of Mafraq city to analyze housing *** concludes that houses are unaffordable in these border cities and housing policies need *** paper recommended that housing affordability in border cities must include community participation and sufficient financial aid to low income *** order to maintain houses affordable in border cities,the real estate market,community participation,urban planning and promotion for tourism are all essential.

关键词： Affordable housing Mafraq city housing plan housing development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biological and Chemical Control in Rot Root in Avocado by Phytophthora cinnamomi Rands

引用

Journal of Agricultural Science and Technology(A) 2012年第7期2卷 882-887页

作者： Ma. Blanca Nieves Lara-Chavez Teresita del Carmen Avila-val Jestus Alejandro Guerrero-Tejeda Francisco Said Barriga-Gonzalez Eulalio Venegas-Gonzalez Salvador Aguirre-Paleo Margarita Vargas-Sandoval Hector Guillen Andrade Satul Rodriguez-Lopez Universidad Michoacana de San Nicolas de Hidalgo Facultad de Agrobiologla "Presidente Juarez" Uruapan Michoacan C.P.60190 Mexico

＂Avocado sadness＂ caused by the Oomycete Phytophthora cinnamomi Rands, is one of the main diseases affecting this fruit crop in Michoacan, M6xico, without having an efficient control strategy for that. In this research three Trichoderma isolates and Ridomil Gold 4E fungicide were tested in avocado trees infected with this pathogen using the growing and coloring vegetative flow growing. Results were analyzed with an experimental design completely random with four treatments and repetitions. Different responses were presented form avocado trees to each treatment. Trichoderma erinaceum Bissett, Kubicek ＆ Szackacs treatment was the best controlling disease in trees with grade II and III damage. Trichoderma aggressivum Samuels ＆ W. Gams controlled better in trees with grade III damage. At last, Trichoderma arundinaceum Zafari, Graef. and Samuels were the best controlling trees with the highest grade damage. Fungicide Ridomil Gold 4E controlled the disease in trees with the lowest grade damage （I and II）, their medias were similar to witness.

关键词： Biological and chemical control Trichoderma aggressivum T. erinaceum T. arundinaceum Ridomil Gold 4E.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Comprehensive Bioinformatics Analysis of the Lipoxygenases Superfamily in Shewanella Woodyi Strain （Strain ATCC 519081MS32）

引用

材料科学与工程（中英文B版） 2014年第2期4卷 34-41页

作者： Silvana Pompeia val-Moraes Eliana Gertrudes de Macedo Lemos University of Estadual Paulista UNESP/FCAV Department Technology LBMP Via de Acesso Prof. Paulo Donato Castellane s/n.Jabotieabal Sao Paulo Brazil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机械力化学法合成ZnO:Eu^(3+),Li^+及其荧光性能研究

引用

四川大学学报（工程科学版） 2009年第4期41卷 146-150页

作者：杨定明胡文远刘勋张铁军涂铭旌景绘山西南科技大学材料科学与工程学院四川绵阳621010 四川大学材料科学与工程学院四川成都610065 金川镍钴研究设计院甘肃兰州730101

采用机械力化学法与热分解相结合的方法制备了ZnO∶Eu3+,Li+纳米粉末,用SEM、XRD、TG-DSC、UV-Vis、FL等检测手段对样品进行表征。结果表明,Eu3+和Li+成功掺入ZnO基质中;样品颗粒分布均匀,粒径为50nm,其发射主峰位于611 nm处;其荧光性... 详细信息

采用机械力化学法与热分解相结合的方法制备了ZnO∶Eu3+,Li+纳米粉末,用SEM、XRD、TG-DSC、UV-Vis、FL等检测手段对样品进行表征。结果表明,Eu3+和Li+成功掺入ZnO基质中;样品颗粒分布均匀,粒径为50nm,其发射主峰位于611 nm处;其荧光性能与热处理温度及Eu,Li的掺杂比例密切相关。

关键词：机械力化学法 ZnO∶Eu Li 荧光性能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

“Cachacas”(Sugarcane Spirit)Aged Quantitation of Phenolic Compounds,Antibacterial and Antioxidant Activity

引用

American Journal of Plant Sciences 2014年第20期5卷 2935-3942页

作者： Leonardo Milani Avelar Rodrigues Maria das Gracas Cardoso Luís Roberto Batista Wilder Douglas Santiago Juliana Maria valério Resende Juliana de Andrade Santiago Marcos de Souza Gomes Milene Aparecida Andrade Maria Luisa Teixeira Fabiana Reinis Franca Passamani Department of Food Science Federal University of LavrasLavrasBrazil Department of Chemistry Federal University of LavrasLavrasBrazil

The “cachaça” is currently one of the fastest growing agro-industrial industries in the country as the drink considered as a symbol of Brazilian nationality. This study aimed to quantify the phenolic compounds, evaluate the antioxidant and antibacterial activity of different samples of aged “cachaça”. The physic-chemical analysis was performed at the Brandy Quality Laboratory of the Federal University of Lavras, and the determination of phenolic compounds was performed by High Performance Liquid Chromatography (HPLC). The antimicrobial activity evaluation was held at the Food Mycology Laboratory through the cavity agar diffusion technique and by steam using the micro-organisms Escherichia coli, Staphylococcus aureus, Salmonella choleraesuis, Listeria monocytogenes and Pseudomonas aeruginosa. The antioxidant activity was evaluated using the DPPH radical sequestering method. The values obtained for the phenolic compounds ranged from 0.41 to 9.69 mg/L, observing the predominance of syringaldehyde, gallic acid and vanillic acid. The phenolic extracts showed a satisfactory antibacterial activity for both Gram-negative and Gram-positive but did not show inhibition against the bacteria Pseudomonas aeruginosa. The antioxidant activity was evidenced by the DPPH test for cachaças tested and the “cachaça” aged in oak barrel showed the highest activity, followed by “cachaça” aged in jequitibá, amburana and balm barrels.

关键词： Syringaldehyde Gallic Acid Vanillic Acid Bacteria DPPH Test

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

鸟类雄性亲本的行为

引用

中国科技纵横 2018年第15期 5-11页

作者：黄大明张雪妍王瑜琪胡习蓉赤雅蓉 Ellen D.Ketterson val Nolan Jr 清华大学生命学院生态学实验室北京100084 印第安纳大学生物学与动物行为综合研究中心布鲁明顿印第安纳州 47405

雄性亲本抚育在大多数动物种类中很少见,但在鸟类中很普遍.鸟类哺育后代的形式差别很大.雄性亲本抚育中父本经常会为非血亲提供抚育.具有雄性孵化的鸟类中,性选择相对弱,雄性在外表与生理方面都更接近雌性.由于雌性要为多重婚配付出更... 详细信息

雄性亲本抚育在大多数动物种类中很少见,但在鸟类中很普遍.鸟类哺育后代的形式差别很大.雄性亲本抚育中父本经常会为非血亲提供抚育.具有雄性孵化的鸟类中,性选择相对弱,雄性在外表与生理方面都更接近雌性.由于雌性要为多重婚配付出更大代价,或者雄性孵化与持续进行性行为不相容,雄性相比之下更可能是它们所抚育的后代遗传上的父本.从历史、功能、机制和发展进化的整探讨鸟类雄性抚育.

关键词：亲本抚育婚配制度两性异形雄性移除激素表型工程

来源：评论

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：